Detailed information for compound 444363

Basic information

Technical information
  • TDR Targets ID: 444363
  • Name: 6-chloro-5-[(E)-prop-1-enyl]-1H-pyrimidine-2, 4-dione
  • MW: 186.596 | Formula: C7H7ClN2O2
  • H donors: 2 H acceptors: 2 LogP: 0.88 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/c1c(Cl)[nH]c(=O)[nH]c1=O
  • InChi: 1S/C7H7ClN2O2/c1-2-3-4-5(8)9-7(12)10-6(4)11/h2-3H,1H3,(H2,9,10,11,12)/b3-2+
  • InChiKey: LGYIOPWXYKUGPC-NSCUHMNNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-5-[(E)-prop-1-enyl]uracil

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0031 0.0106
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0156
Schistosoma mansoni cpg binding protein 0.0028 0.03 0.0349
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0012 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0078 0.0309
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0093 0.2271
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0408 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0078 0.0202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0329 0.0384
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0062 0.0242
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0078 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0078 0.0309
Entamoeba histolytica hypothetical protein 0.0006 0.003 0.0618
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.003 0.0077
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0062 0.0213
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0078 0.0091
Brugia malayi nuclear hormone receptor 0.001 0.0078 0.0309
Brugia malayi nuclear receptor NHR-67 0.0005 0.0012 0.0046
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0078 0.0271
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Giardia lamblia Hypothetical protein 0.0009 0.0058 0.9619
Mycobacterium ulcerans arylsulfatase, AslA 0.0009 0.0058 0.0062
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0078 0.0271
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Echinococcus granulosus FTZ F1 alpha 0.001 0.0078 0.0084
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0078 0.0309
Schistosoma mansoni coup transcription factor 0.001 0.0078 0.0091
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0062 0.0066
Toxoplasma gondii hypothetical protein 0.0009 0.0062 0.0984
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0093 0.2271
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0106
Loa Loa (eye worm) hypothetical protein 0.0182 0.2179 0.5612
Brugia malayi RasGEF domain containing protein 0.0006 0.003 0.0118
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0061 0.0061
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0408 0.0437
Onchocerca volvulus 0.0006 0.003 0.0104
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0106 0.0273
Brugia malayi Pre-SET motif family protein 0.0031 0.0329 0.1298
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0062 0.0066
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0062 0.0066
Schistosoma mansoni cpg binding protein 0.003 0.032 0.0373
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Onchocerca volvulus 0.0031 0.0329 0.1138
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0012 0.0012
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0006 0.003 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0078 0.0078
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0012 0.003
Brugia malayi tailless protein 0.0005 0.0012 0.0046
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0062 0.0158
Brugia malayi hypothetical protein 0.0005 0.0019 0.0074
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0012 0.004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0073 0.0073
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0026 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0202
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.003 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0078 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0329 0.0384
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0012 0.0046
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0215 0.0743
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0078 0.0078
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.2179 0.7528
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0202
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0058 0.0062
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0007 0.0179
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.003 0.0032
Schistosoma mansoni inositol monophosphatase 0.0037 0.0408 0.0475
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0061 0.0065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.03 0.0773
Loa Loa (eye worm) hypothetical protein 0.0005 0.0019 0.0048
Schistosoma mansoni DNA helicase recq1 0.0009 0.0061 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0078 0.0309
Brugia malayi nuclear hormone receptor 0.0005 0.0012 0.0046
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0078 0.0202
Loa Loa (eye worm) hypothetical protein 0.0005 0.0019 0.0048
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0308 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0078 0.0084
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0062 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0078 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0106
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0019 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0202
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0077
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0052 0.0056
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0077
Mycobacterium ulcerans sulfatase 0.0009 0.0058 0.0062
Brugia malayi nuclear receptor RXR 0.0005 0.0012 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0078 0.0309
Brugia malayi Cytochrome P450 family protein 0.0013 0.0106 0.0417
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0062 0.0062
Echinococcus multilocularis son of sevenless 1 0.0006 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Loa Loa (eye worm) hypothetical protein 0.0031 0.0329 0.0848
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0012 0.0012
Mycobacterium tuberculosis Possible hydrolase 0.0009 0.0058 0.0062
Echinococcus granulosus ras GTP exchange factor 0.0006 0.003 0.0032
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0006 0.003 0.0104
Giardia lamblia Hypothetical protein 0.0009 0.0058 0.9619
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0062 0.0072
Schistosoma mansoni thyroid hormone receptor 0.001 0.0078 0.0091
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0078 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0078 0.0309
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0073 0.0078
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0019 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0078 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0078 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0106
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0202
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0216 0.2601 0.2786
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.003 0.0077
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0061 0.0969
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0019
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Echinococcus multilocularis Protein son of sevenless 0.0006 0.003 0.003
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0004 0.0005 0.0158
Loa Loa (eye worm) hypothetical protein 0.0005 0.0019 0.0048
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0106 0.2598
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0078 0.0309
Schistosoma mansoni thyroid hormone receptor 0.001 0.0078 0.0091
Treponema pallidum ATP-dependent DNA helicase 0.0005 0.0007 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0061 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0329 0.0384
Loa Loa (eye worm) hypothetical protein 0.0009 0.0062 0.0158
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0005 0.0007 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0106
Trichomonas vaginalis helicase, putative 0.0006 0.0031 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0009 0.0058 0.0201
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0408 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0106
Echinococcus multilocularis thymidine phosphorylase 0.0765 0.9336 0.9336
Loa Loa (eye worm) hypothetical protein 0.0017 0.0162 0.0417
Trypanosoma cruzi hypothetical protein 0.0006 0.003 0.0738
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0106 0.0273
Schistosoma mansoni cpg binding protein 0.003 0.032 0.0373
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0061 0.0065
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0078 0.0091
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0765 0.9336 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0012 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0012 0.0012
Mycobacterium ulcerans thymidine phosphorylase 0.0765 0.9336 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0012 0.004
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.003 0.003
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0012 0.0046
Schistosoma mansoni dep domain containing protein 0.0009 0.0062 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0078 0.0309
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0183 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0078 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Brugia malayi nuclear receptor NHR-88 0.0005 0.0012 0.0046
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0019 0.0048
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0012 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0009 0.0058 0.0201
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0072 0.0283
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0061 0.0969
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0078 0.0309
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0408 0.1408
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0329 0.0329
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0012 0.003
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0062 0.0062
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.016 0.0186
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0061 0.3307
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0058 0.015
Loa Loa (eye worm) hypothetical protein 0.0009 0.0062 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0078 0.0309
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0062 0.0072
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0106
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0408 1
Brugia malayi N-terminal motif family protein 0.0006 0.003 0.0118
Brugia malayi N-terminal motif family protein 0.0006 0.003 0.0118
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0078 0.0084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0052 0.0061
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0329 0.5269
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0012 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.003 0.0035
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0078 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0062 0.0159
Loa Loa (eye worm) DR-78 0.0005 0.0012 0.003
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0062 0.0072
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0031 0.0106
Schistosoma mansoni ras GTP exchange factor 0.0006 0.003 0.0035
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0202
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0062 0.0062
Loa Loa (eye worm) histone methyltransferase 0.001 0.0073 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0106
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0078 0.0078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0078 0.0202
Brugia malayi nuclear receptor NHR-88 0.001 0.0078 0.0309
Brugia malayi conserved hypotetical protein 0.0005 0.0012 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0012 0.0012
Schistosoma mansoni dishevelled 0.0009 0.0062 0.0072
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0202
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0007 0.0052
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.2601 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0062 0.0242
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0078 0.0084
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.013 0.3944
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0408 1
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.003 0.003
Schistosoma mansoni nuclear receptor 0.0005 0.0012 0.0013
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0408 0.6519
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Brugia malayi N-terminal motif family protein 0.0182 0.2179 0.8584
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0078 0.0078
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0215 0.0848
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Onchocerca volvulus 0.0005 0.0012 0.004
Brugia malayi nuclear receptor RXR 0.0005 0.0019 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0202
Brugia malayi hypothetical protein 0.0123 0.146 0.5753
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0106
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0052 0.0052
Schistosoma mansoni zinc finger protein 0.0005 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0058 0.015
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0058 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0078 0.0309
Echinococcus granulosus Protein son of sevenless 0.0006 0.003 0.0032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0408 0.1408
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0106 0.2598
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0012 0.0013
Brugia malayi hypothetical protein 0.0009 0.0062 0.0242
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0004 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0106
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0012 0.0046
Schistosoma mansoni DNA helicase recq5 0.0009 0.0061 0.0071
Mycobacterium tuberculosis Probable sulfatase 0.0009 0.0058 0.0062
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0019 0.0019
Brugia malayi hypothetical protein 0.0009 0.0058 0.023
Loa Loa (eye worm) inositol-1 0.0037 0.0408 0.105
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Onchocerca volvulus 0.0028 0.03 0.1037
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0078 0.0091
Onchocerca volvulus 0.0009 0.0062 0.0213
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0062 0.0062
Mycobacterium ulcerans hydrolase 0.0009 0.0058 0.0062
Brugia malayi hypothetical protein 0.0005 0.0019 0.0074
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0062 0.0066
Loa Loa (eye worm) RecQ helicase 0.0021 0.0215 0.0554
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0012 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0106
Brugia malayi hypothetical protein 0.0009 0.0062 0.0242
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0106 0.0113
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0078 0.0309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0078 0.0084
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0006 0.003 0.0104
Onchocerca volvulus 0.024 0.2895 1
Brugia malayi Pre-SET motif family protein 0.0211 0.2538 1
Echinococcus multilocularis cpg binding protein 0.003 0.032 0.032
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Schistosoma mansoni microtubule-associated protein tau 0.0705 0.8589 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0061 0.0061
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0012 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0078 0.0202
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0078 0.0084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.036 0.1384
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0215 0.0743
Brugia malayi RasGEF domain containing protein 0.0006 0.003 0.0118
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0625 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0078 0.0091
Brugia malayi hypothetical protein 0.0005 0.0012 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0704 0.082
Trichomonas vaginalis set domain proteins, putative 0.024 0.2895 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0408 0.0437
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.003 0.0104
Brugia malayi Sulfatase family protein 0.0009 0.0058 0.023
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.003 0.003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0078 0.0271
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0408 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0062 0.0066
Leishmania major cytochrome p450-like protein 0.0013 0.0106 0.2598
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Echinococcus granulosus son of sevenless 1 0.0006 0.003 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0078 0.0091
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0007 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0329 0.0384
Onchocerca volvulus 0.0005 0.0012 0.004
Brugia malayi CXXC zinc finger family protein 0.0028 0.03 0.1182
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0019 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0078 0.0202
Schistosoma mansoni inositol monophosphatase 0.0037 0.0408 0.0475
Brugia malayi ecdysone receptor 0.0005 0.0012 0.0046
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0052 0.0056
Brugia malayi RasGEF domain containing protein 0.0006 0.003 0.0118
Brugia malayi DIX domain containing protein 0.0009 0.0062 0.0242
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0012 0.0046
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0093 0.2271
Brugia malayi hypothetical protein 0.0005 0.0012 0.0046
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0061 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0106
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0329 0.0353
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0408 0.1408
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0078 0.0309
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0062 0.0158
Schistosoma mansoni dishevelled 0.0009 0.0062 0.0072
Trypanosoma cruzi hypothetical protein 0.0006 0.003 0.0738
Loa Loa (eye worm) hypothetical protein 0.0009 0.0062 0.0158
Echinococcus granulosus microtubule associated protein 2 0.0705 0.8589 0.92
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0215 0.0215
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0329 0.0329
Brugia malayi ecdysteroid receptor 0.001 0.0078 0.0309
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0061 0.0156
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0128 0.2044
Plasmodium vivax SET domain protein, putative 0.0031 0.0329 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0078 0.0202
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0058 0.0062
Schistosoma mansoni nuclear hormone receptor 0.001 0.0078 0.0091
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.003 0.0035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0012 0.0046
Echinococcus granulosus bloom syndrome protein 0.0021 0.0215 0.023
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0321 0.3883 1
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0058 0.0062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0078 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0078 0.0202
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0078 0.0078
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0061 0.0239
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0106
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2538 0.6537
Loa Loa (eye worm) hypothetical protein 0.0005 0.0019 0.0048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0078 0.0084
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0078 0.0309
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0202
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.003 0.0738
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.003 0.0104
Loa Loa (eye worm) hypothetical protein 0.0005 0.0019 0.0048
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0106 0.2598
Brugia malayi Cytochrome P450 family protein 0.0013 0.0106 0.0417
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0093 0.032
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0012 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0015 0.0018
Onchocerca volvulus 0.001 0.0078 0.0271
Echinococcus granulosus thymidine phosphorylase 0.0765 0.9336 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0012 0.0012
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0408 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0106 0.0273
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.2601 0.2786
Echinococcus granulosus cpg binding protein 0.003 0.032 0.0343
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0106
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0009 0.0058 0.0201
Brugia malayi Inositol-1 0.0037 0.0408 0.1606
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0093 0.2171
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0078 0.0091
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0408 0.0408
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Brugia malayi steroid hormone receptor 0.001 0.0078 0.0309
Echinococcus multilocularis microtubule associated protein 2 0.0705 0.8589 0.8589
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0058 0.0201
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0106
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.003 0.0618
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.036 0.0385
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0019 0.0022
Schistosoma mansoni nuclear receptor 0.0005 0.0012 0.0013
Mycobacterium ulcerans arylsulfatase AtsB 0.0009 0.0058 0.0062
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.003 0.0077
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0012 0.0013
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0007 0.0179
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.003 0.0035

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.17 uM Inhibition of human recombinant thymidine phosphorylase expressed in V79 cells ChEMBL. 17963370
Ki (binding) = 1.17 uM Inhibition of human recombinant thymidine phosphorylase expressed in V79 cells ChEMBL. 17963370
Ki (binding) = 1.21 uM Inhibition of human placental thymidine phosphorylase ChEMBL. 17963370
Ki (binding) = 1.21 uM Inhibition of human placental thymidine phosphorylase ChEMBL. 17963370

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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