TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 269.146 | Formula: C13H12Cl2NO-
H donors: 2 H acceptors: 1 LogP: 4.03 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: NCc1cc(Cl)cc(c1O)c1ccccc1.[Cl-]
InChi: 1S/C13H12ClNO.ClH/c14-11-6-10(8-15)13(16)12(7-11)9-4-2-1-3-5-9;/h1-7,16H,8,15H2;1H/p-1
InChiKey: TYMADPAKYNFBEU-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	pyruvate kinase PyK1	0.0066	0.0233	0.0289
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.1598	0.7574	0.7571
Schistosoma mansoni	DNA polymerase eta	0.0047	0.0138	0.0168
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0078	0.0088
Echinococcus multilocularis	Niemann Pick C1 protein	0.014	0.0585	0.0759
Schistosoma mansoni	pyruvate kinase	0.0066	0.0233	0.0293
Echinococcus granulosus	pyruvate kinase	0.0066	0.0233	0.0293
Echinococcus granulosus	tumor protein p63	0.0336	0.1524	0.2001
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0043	0.0043
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1598	0.7574	1
Schistosoma mansoni	lamin	0.0027	0.0043	0.0043
Schistosoma mansoni	glutaminase	0.0271	0.1212	0.1588
Brugia malayi	isocitrate dehydrogenase	0.0031	0.0064	0.007
Schistosoma mansoni	pyruvate kinase	0.0034	0.0078	0.0088
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1598	0.7574	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0066	0.0233	0.0222
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.0064	0.0053
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.1013	0.4771	0.6294
Echinococcus multilocularis	microtubule associated protein 2	0.0718	0.3357	0.4425
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.1013	0.4771	0.9436
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.0064	0.0053
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0021	0.0014	0.0061
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1598	0.7574	1
Giardia lamblia	Pyruvate kinase	0.0066	0.0233	0.0293
Trypanosoma brucei	DNA polymerase eta, putative	0.0047	0.0138	0.0127
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0066	0.0233	0.0293
Leishmania major	pyruvate kinase	0.0066	0.0233	0.0222
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0121	0.0493	0.0634
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0031	0.0064	0.007
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0066	0.0233	0.1032
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0116	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0136	0.0249
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0153	0.0679
Loa Loa (eye worm)	glutaminase	0.0271	0.1212	0.238
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0021	0.0014	0.0004
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0031	0.0064	0.0053
Schistosoma mansoni	patched 1	0.0042	0.0116	0.0139
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.1598	0.7574	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1598	0.7574	0.7571
Echinococcus multilocularis	protein patched	0.0042	0.0116	0.0139
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0011	0.0049
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0014	0.0004
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.007	0.0252	0.1118
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1598	0.7574	0.7571
Brugia malayi	AMP-binding enzyme family protein	0.007	0.0252	0.0319
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0014	0.0004
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0014	0.0005
Echinococcus multilocularis	musashi	0.0027	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0233	0.0439
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0525	0.2432	0.3202
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0021	0.0014	0.0004
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.007	0.0252	0.1118
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.1598	0.7574	0.7571
Leishmania major	DNA polymerase eta, putative	0.0047	0.0138	0.0127
Onchocerca volvulus	Pyruvate kinase homolog	0.0066	0.0233	0.4515
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0217	0.0272
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.1598	0.7574	1
Echinococcus multilocularis	tumor protein p63	0.0336	0.1524	0.2001
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0043	0.0064
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.1598	0.7574	1
Echinococcus granulosus	expressed conserved protein	0.0092	0.0355	0.0455
Entamoeba histolytica	acyl-coA synthetase, putative	0.007	0.0252	0.0319
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0145	0.0177
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0121	0.0493	0.0638
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0014	0.0061
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.1598	0.7574	1
Plasmodium vivax	pyruvate kinase 2, putative	0.0034	0.0078	0.0085
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0525	0.2432	0.2424
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0014	0.0061
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.1598	0.7574	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0014	0.0004
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0014	0.0061
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0021	0.0014	0.0003
Loa Loa (eye worm)	oxidoreductase	0.0021	0.0014	0.0005
Plasmodium vivax	pyruvate kinase, putative	0.0066	0.0233	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0167	0.0309
Leishmania major	DNA polymerase eta, putative	0.0033	0.0072	0.0061
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0014	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0498	0.0966
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0014	0.0004
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.1598	0.7574	1
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0031	0.0064	0.0067
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.0064	0.0053
Leishmania major	4-coumarate:coa ligase-like protein	0.007	0.0252	0.0241
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0217	0.0407
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0014	0.0005
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0152	0.0187
Entamoeba histolytica	hypothetical protein	0.0036	0.0086	0.0099
Loa Loa (eye worm)	pyruvate kinase	0.0066	0.0233	0.0439
Trypanosoma brucei	pyruvate kinase 1, putative	0.0066	0.0233	0.0222
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.1598	0.7574	0.7571
Onchocerca volvulus	Pyruvate kinase homolog	0.0066	0.0233	0.4515
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0014	0.0004
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.1598	0.7574	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0077	0.0087
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0014	0.0004
Echinococcus multilocularis	dna polymerase eta	0.0047	0.0138	0.0168
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0121	0.0493	0.0638
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0525	0.2432	0.2424
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0585	0.2717	0.3579
Echinococcus granulosus	pyruvate kinase	0.0066	0.0233	0.0293
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0014	0.0004
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0217	0.0272
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1598	0.7574	0.7571
Loa Loa (eye worm)	pyruvate kinase	0.0066	0.0233	0.0439
Echinococcus granulosus	lamin dm0	0.0027	0.0043	0.0043
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0217	0.0272
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0217	0.0407
Brugia malayi	AMP-binding enzyme family protein	0.007	0.0252	0.0319
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0021	0.0014	0.0004
Leishmania major	pyruvate kinase	0.0066	0.0233	0.0222
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0021	0.0014	0.0003
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0153	0.0679
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0121	0.0493	0.0483
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.1598	0.7574	1
Brugia malayi	hypothetical protein	0.0235	0.1041	0.1362
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0121	0.0493	0.0956
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0021	0.0014	0.0061
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0116	0.0208
Loa Loa (eye worm)	hypothetical protein	0.007	0.0252	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0498	0.0966
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.1598	0.7574	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.007	0.0252	0.0319
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.0064	0.0067
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.1598	0.7574	1
Schistosoma mansoni	microtubule-associated protein tau	0.0718	0.3357	0.4425
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.1598	0.7574	0.7571
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0021	0.0014	0.0004
Mycobacterium ulcerans	acyl-CoA synthetase	0.007	0.0252	0.0319
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0031	0.0064	0.0105
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0011	0.0049
Echinococcus multilocularis	survival motor neuron protein 1	0.0235	0.1041	0.1362
Loa Loa (eye worm)	hypothetical protein	0.0235	0.1041	0.2042
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.007	0.0252	0.0319
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0021	0.0014	0.0004
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0078	0.0088
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0014	0.0061
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0806	0.3777	0.498
Echinococcus granulosus	pyruvate kinase	0.0034	0.0078	0.0088
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0121	0.0493	0.0956
Echinococcus multilocularis	pyruvate kinase	0.0066	0.0233	0.0293
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0217	0.0407
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0021	0.0014	0.0061
Onchocerca volvulus	Huntingtin homolog	0.0122	0.0498	1
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.1073	0.5056	1
Brugia malayi	hypothetical protein	0.0122	0.0498	0.0644
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0086	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0043	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0041	0.0059
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.007	0.0252	0.0319
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0152	0.0187
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0014	0.0004
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0014	0.0004
Entamoeba histolytica	hypothetical protein	0.0036	0.0086	0.0099
Entamoeba histolytica	hypothetical protein	0.0036	0.0086	0.0099
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0053	0.0167	0.074
Schistosoma mansoni	pyruvate kinase	0.0066	0.0233	0.0293
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0021	0.0014	0.0004
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0053	0.0167	0.0206
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0021	0.0014	0.0004
Echinococcus granulosus	pyruvate kinase	0.0034	0.0078	0.0088
Onchocerca volvulus	Huntingtin homolog	0.0122	0.0498	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0217	0.0272
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.0384	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0049	0.015	0.0276
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0066	0.0233	0.0293
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.0064	0.007
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0078	0.0088
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0021	0.0014	0.0004
Echinococcus multilocularis	pyruvate kinase	0.0052	0.0166	0.0204
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0014	0.0004
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0031	0.0064	0.0285
Brugia malayi	AMP-binding enzyme family protein	0.007	0.0252	0.0319
Leishmania major	4-coumarate:coa ligase-like protein	0.007	0.0252	0.0241
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0021	0.0014	0.0061
Schistosoma mansoni	hypothetical protein	0.0036	0.0086	0.0099
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.007	0.0252	0.0319
Brugia malayi	TAR-binding protein	0.0063	0.0217	0.0272
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0217	0.0272
Trichomonas vaginalis	pyruvate kinase, putative	0.0066	0.0233	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0077	0.0131
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0217	0.0272
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0525	0.2432	0.2424
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.1598	0.7574	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0167	0.0309
Toxoplasma gondii	pyruvate kinase PyKII	0.0034	0.0078	0.0085
Echinococcus granulosus	dna polymerase eta	0.0047	0.0138	0.0168
Schistosoma mansoni	hypothetical protein	0.0034	0.0077	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0252
Entamoeba histolytica	hypothetical protein	0.0036	0.0086	0.0099
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.0014	0.0004
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0021	0.0014	0.0004
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0121	0.0493	0.0638
Mycobacterium ulcerans	pyruvate kinase	0.0066	0.0233	0.0293
Plasmodium falciparum	pyruvate kinase 2	0.0034	0.0078	0.0085
Mycobacterium ulcerans	glutaminase	0.0271	0.1212	0.1588
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.1598	0.7574	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0066	0.0233	0.4515
Brugia malayi	glutaminase DH11.1	0.0271	0.1212	0.1588
Brugia malayi	RNA binding protein	0.0063	0.0217	0.0272
Echinococcus granulosus	Niemann Pick C1 protein	0.014	0.0585	0.0759
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0121	0.0493	0.0483
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.1598	0.7574	0.7571
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1598	0.7574	1
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0121	0.0493	0.0638
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.015	0.0184
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0121	0.0493	0.0483
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0217	0.0272
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0021	0.0014	0.0004
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.0384	0.0493
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.1598	0.7574	1
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.1598	0.7574	1
Trypanosoma brucei	pyruvate kinase 1	0.0066	0.0233	0.0222
Brugia malayi	ImpB/MucB/SamB family protein	0.0047	0.0138	0.0168
Onchocerca volvulus		0.0027	0.0043	0.0608
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.1598	0.7574	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0086	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0167	0.0309
Echinococcus granulosus	intermediate filament protein	0.0027	0.0043	0.0043
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0014	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0167	0.0309
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.007	0.0252	0.0319
Plasmodium vivax	acyl-CoA synthetase, putative	0.0053	0.0167	0.0202
Trypanosoma cruzi	DNA polymerase eta, putative	0.0047	0.0138	0.0127
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1013	0.4771	0.6294
Echinococcus granulosus	survival motor neuron protein 1	0.0235	0.1041	0.1362
Mycobacterium ulcerans	hypothetical protein	0.007	0.0252	0.0319
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0153	0.0679
Plasmodium falciparum	acyl-CoA synthetase	0.0053	0.0167	0.0202
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.007	0.0252	0.1063
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.1013	0.4771	0.9436
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0116	0.0139
Loa Loa (eye worm)	pyruvate kinase	0.0066	0.0233	0.0439
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2104	1	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0145	0.0177
Schistosoma mansoni	acetyl-CoA synthetase	0.0021	0.0014	0.0004
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0086	0.0099
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0066	0.0233	0.0977
Chlamydia trachomatis	pyruvate kinase	0.0066	0.0233	0.0089
Giardia lamblia	Pyruvate kinase	0.0034	0.0078	0.0088
Schistosoma mansoni	hypothetical protein	0.004	0.0109	0.0129
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.0384	0.0493
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0031	0.0064	0.0053
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.007	0.0252	0.1063
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.1598	0.7574	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.007	0.0252	0.0319
Echinococcus multilocularis	lamin dm0	0.0027	0.0043	0.0043
Echinococcus granulosus	pyruvate kinase	0.0034	0.0078	0.0088
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0153	0.0679
Echinococcus multilocularis	lamin	0.0027	0.0043	0.0043
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.0384	0.0493
Brugia malayi	Isocitrate dehydrogenase	0.0031	0.0064	0.007
Brugia malayi	hypothetical protein	0.0036	0.0086	0.0099
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0152	0.028
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0021	0.0014	0.0004
Loa Loa (eye worm)	pyruvate kinase-PB	0.0046	0.0136	0.0249
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0014	0.0003
Onchocerca volvulus		0.007	0.0252	0.4915
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0066	0.0233	0.0222
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1598	0.7574	1
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0014	0.0003
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0021	0.0014	0.0061
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.0064	0.007
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.0064	0.007
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.111	0.5235	0.6908
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1598	0.7574	0.7571
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0005
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0116	0.0139
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0121	0.0493	0.0638
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0116	0.0139
Onchocerca volvulus		0.0048	0.0145	0.2698
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0014	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0116	0.0208
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0121	0.0493	0.0638
Schistosoma mansoni	lamin	0.0027	0.0043	0.0043
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0121	0.0493	0.0638
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0031	0.0064	0.0067
Leishmania major	acetyl-CoA synthetase, putative	0.0021	0.0014	0.0003
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.1598	0.7574	0.7571
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0144	0.0176
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2104	1	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.0064	0.0067
Brugia malayi	intermediate filament protein	0.0027	0.0043	0.0043
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0525	0.2432	0.2424
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0031	0.0064	0.007
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.1013	0.4771	0.6294
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0043	0.0043
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.1598	0.7574	1
Schistosoma mansoni	hypothetical protein	0.004	0.0109	0.0129
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0021	0.0014	0.0061
Entamoeba histolytica	pyruvate kinase, putative	0.0046	0.0136	0.0166
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0488	0.2253	1
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.1598	0.7574	1
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.1598	0.7574	1
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0021	0.0014	0.0003
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0021	0.0014	0.0004
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.1073	0.5056	1
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0121	0.0493	0.0634
Echinococcus multilocularis	pyruvate kinase	0.0066	0.0233	0.0293
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0121	0.0493	0.0638
Entamoeba histolytica	acyl-CoA synthetase, putative	0.007	0.0252	0.0319
Loa Loa (eye worm)	hypothetical protein	0.007	0.0252	0.0478
Mycobacterium leprae	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0488	0.2253	1
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0021	0.0014	0.0004
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0145	0.0177
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0121	0.0493	0.0483
Trichomonas vaginalis	glutaminase, putative	0.0271	0.1212	0.1588
Onchocerca volvulus		0.0049	0.015	0.2819
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0161	0.0298
Loa Loa (eye worm)	hypothetical protein	0.1013	0.4771	0.9436
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2104	1	1
Onchocerca volvulus		0.0027	0.0043	0.0608
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0033	0.0072	0.0077
Loa Loa (eye worm)	glutaminase 2	0.0271	0.1212	0.238
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0031	0.0064	0.007
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.0014	0.0061
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0217	0.0272
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0043	0.0064
Brugia malayi	CHE-14 protein	0.0042	0.0116	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0167	0.0309
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.1598	0.7574	0.7571
Schistosoma mansoni	hypothetical protein	0.004	0.0109	0.0129
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0014	0.0004
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.1598	0.7574	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0014	0.0004
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0121	0.0493	0.0634
Schistosoma mansoni	hypothetical protein	0.004	0.0109	0.0129
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.1598	0.7574	0.7571
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0014	0.0005
Plasmodium falciparum	pyruvate kinase	0.0066	0.0233	0.0289
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0391	0.0502
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1013	0.4771	0.6294
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.0072	0.0061
Leishmania major	4-coumarate:coa ligase-like protein	0.007	0.0252	0.0241
Echinococcus multilocularis	expressed conserved protein	0.0092	0.0355	0.0455
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.1598	0.7574	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0031	0.0064	0.007
Loa Loa (eye worm)	hypothetical protein	0.005	0.0152	0.028
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0585	0.2717	0.3578
Echinococcus granulosus	microtubule associated protein 2	0.0718	0.3357	0.4425
Trichomonas vaginalis	pyruvate kinase, putative	0.0066	0.0233	0.0293
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0014	0.0004
Echinococcus granulosus	lamin	0.0027	0.0043	0.0043
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0525	0.2432	0.2424
Leishmania major	acetyl-CoA synthetase, putative	0.0021	0.0014	0.0003
Loa Loa (eye worm)	hypothetical protein	0.007	0.0252	0.0478
Mycobacterium ulcerans	acyl-CoA synthetase	0.007	0.0252	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0384	0.0739

Activities

Activity type	Activity value	Assay description	Source	Reference
Diuretic activity (functional)	= 250	Salidiuretic activity in dog following i.v. dosing at 5 mg/kg	ChEMBL.	7452697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 145740

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 44569