Detailed information for compound 44782

Basic information

Technical information
  • TDR Targets ID: 44782
  • Name: 1,3-diethyl-2-(4-hydroxyphenyl)indol-5-ol
  • MW: 281.349 | Formula: C18H19NO2
  • H donors: 2 H acceptors: 2 LogP: 4.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c2cc(O)ccc2n(c1c1ccc(cc1)O)CC
  • InChi: 1S/C18H19NO2/c1-3-15-16-11-14(21)9-10-17(16)19(4-2)18(15)12-5-7-13(20)8-6-12/h5-11,20-21H,3-4H2,1-2H3
  • InChiKey: QEDVQJPMYIJPHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-diethyl-2-(4-hydroxyphenyl)-5-indolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0085 0.1275
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.0088
Plasmodium falciparum telomerase reverse transcriptase 0.1742 0.2723 1
Echinococcus multilocularis Smad4 0.0017 0.0014 0.0215
Schistosoma mansoni ap endonuclease 0.002 0.002 0.0294
Echinococcus multilocularis cpg binding protein 0.0068 0.0094 0.1415
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0005 0.0078
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.0142 0.3158
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0076 0.027
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0086
Schistosoma mansoni smad1 5 8 and 0.0017 0.0014 0.0215
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0015 0.0043
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.1048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0058 0.0874
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0035 0.0117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0058 0.0874
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0011 0.0005 0.0079
Onchocerca volvulus 0.0009 0.0003 0.0003
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1742 0.2723 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0014 0.0287
Schistosoma mansoni DNA helicase recq5 0.0018 0.0017 0.0254
Trypanosoma brucei unspecified product 0.005 0.0066 0.0233
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0025 0.05
Schistosoma mansoni coup transcription factor 0.0011 0.0005 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0005 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0005 0.0078
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.0142 0.3158
Entamoeba histolytica hypothetical protein 0.001 0.0003 0.0009
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0116
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0024 0.0076
Entamoeba histolytica hypothetical protein 0.0025 0.0027 0.0227
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0015 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0005 0.0104
Loa Loa (eye worm) hypothetical protein 0.0097 0.0141 0.2817
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.002 0.0061
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.0009 0.0021
Trypanosoma brucei telomerase reverse transcriptase 0.1742 0.2723 1
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0005 0.0078
Trichomonas vaginalis glutaminase, putative 0.0289 0.0443 1
Giardia lamblia Flap structure-specific endonuclease 0.0053 0.0071 0.025
Brugia malayi nuclear receptor NHR-88 0.0011 0.0005 0.0007
Loa Loa (eye worm) nuclear factor I 0.0009 0.0003 0.0055
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0043
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0062 0.0219
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.002 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0005 0.0007
Echinococcus granulosus snurportin 1 0.0326 0.05 0.7483
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0002 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0024 0.0076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0058 0.0874
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.002 0.006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0072 0.0102 0.2031
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.002 0.0063
Brugia malayi hypothetical protein 0.001 0.0003 0.0005
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0036 0.0123
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0005 0.0005
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0116
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0072 0.0102 0.152
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0106
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0058 0.008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0027 0.0542
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0053 0.0071 0.0252
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0005 0.0104
Schistosoma mansoni cpg binding protein 0.0068 0.0094 0.1415
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0024 0.0076
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.002 0.0369
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0015 0.0219
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0027 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0005 0.0078
Entamoeba histolytica hypothetical protein 0.0201 0.0304 0.2754
Echinococcus granulosus DNA methyltransferase 2, putative 0.0021 0.0021 0.0318
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0069
Brugia malayi Telomerase reverse transcriptase 0.4635 0.7265 1
Brugia malayi Importin beta-1 subunit 0.0031 0.0036 0.005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.002 0.0294
Giardia lamblia Telomerase catalytic subunit 0.1742 0.2723 1
Brugia malayi MH1 domain containing protein 0.0017 0.0014 0.002
Treponema pallidum DNA ligase (lig) 0.001 0.0003 0.0279
Schistosoma mansoni hepatoma derived growth factor 0.0009 0.0003 0.0044
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0086
Trypanosoma brucei exonuclease, putative 0.0011 0.0005 0.0009
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0059 0.0206
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0005 0.0104
Echinococcus granulosus flap endonuclease 1 0.0053 0.0071 0.107
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0025 0.0083
Echinococcus granulosus Smad4 0.0017 0.0014 0.0215
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0024 0.0076
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0083 0.0296
Entamoeba histolytica Flap nuclease, putative 0.0053 0.0071 0.0631
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.05 1
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0003 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0085 0.1275
Loa Loa (eye worm) glutaminase 2 0.0289 0.0443 0.8855
Brugia malayi MH2 domain containing protein 0.0017 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0104
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0036 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0005 0.0007
Brugia malayi SET domain containing protein 0.0008 0.0001 0.0002
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0005 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0091 0.1367
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0021 0.0021 0.0318
Echinococcus multilocularis hepatoma derived growth factor protein 0.0009 0.0003 0.0044
Schistosoma mansoni hypothetical protein 0.0014 0.001 0.0156
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0037 0.0548
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0021 0.0172
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0055
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0005 0.0006
Echinococcus multilocularis dna polymerase kappa 0.0098 0.0142 0.2128
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0017 0.005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0014 0.0215
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0024 0.0076
Onchocerca volvulus 0.0041 0.0052 0.0052
Mycobacterium ulcerans hypothetical protein 0.0168 0.0253 0.5676
Schistosoma mansoni terminal deoxycytidyl transferase 0.0072 0.0102 0.152
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0141 0.0194
Entamoeba histolytica hypothetical protein 0.0073 0.0103 0.092
Brugia malayi Muscleblind-like protein 0.0158 0.0237 0.0326
Schistosoma mansoni flap endonuclease-1 0.0048 0.0063 0.095
Entamoeba histolytica hypothetical protein 0.0073 0.0103 0.092
Plasmodium falciparum importin beta, putative 0.0031 0.0036 0.0121
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0036 0.0123
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0021 0.0021 0.0065
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0116
Plasmodium falciparum DNA repair protein REV1, putative 0.0022 0.0024 0.0074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0092 0.1836
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0085 0.1275
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0037 0.005
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0005 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.0369 0.7384
Echinococcus granulosus dnaJ subfamily B 0.0433 0.0668 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0005 0.0078
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0003 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0005 0.0007
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0102 0.014
Echinococcus granulosus replication factor c subunit 1 0.001 0.0003 0.0052
Schistosoma mansoni topbp1 0.001 0.0003 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.0369 0.7384
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0005 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0219
Brugia malayi Flap endonuclease-1 0.0053 0.0071 0.0098
Echinococcus multilocularis flap endonuclease GEN 1 0.0011 0.0005 0.0079
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0029
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0014 0.0215
Brugia malayi hypothetical protein 0.001 0.0003 0.0005
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0043
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0005 0.0078
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0005 0.0078
Schistosoma mansoni ap endonuclease 0.002 0.002 0.0294
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0226 0.082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.0061
Trypanosoma brucei chrX additional, unordered contigs 0.0022 0.0024 0.0076
Echinococcus granulosus flap endonuclease GEN 1 0.0011 0.0005 0.0079
Echinococcus multilocularis global transcription activator snf2l2 0.0071 0.01 0.1497
Schistosoma mansoni hepatoma derived growth factor 0.0009 0.0003 0.0044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0733
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0005 0.0078
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0116
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0005 0.0078
Mycobacterium ulcerans hypothetical protein 0.0022 0.0024 0.0457
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0024 0.0076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.034
Leishmania major modification methylase-like protein 0.0021 0.0021 0.0067
Echinococcus granulosus bloom syndrome protein 0.0044 0.0058 0.0863
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0104
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0085
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0005 0.0078
Giardia lamblia DNA damage repair protein 0.0022 0.0024 0.0074
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0043 0.0645
Schistosoma mansoni phd finger protein 0.0011 0.0006 0.0088
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0015 0.0041
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0053 0.0071 0.0252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0058 0.0874
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0064 0.0225
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0085 0.1704
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0005 0.0007
Brugia malayi TAR-binding protein 0.0062 0.0085 0.0117
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0034 0.0113
Giardia lamblia Exonuclease 1 0.0011 0.0005 0.0007
Entamoeba histolytica DNA-repair protein, putative 0.0011 0.0005 0.0026
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0014 0.0215
Trypanosoma brucei mitochondrial DNA polymerase beta 0.032 0.049 0.1791
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0219
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0037 0.0548
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0021 0.0021 0.0318
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0085 0.0117
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0025 0.021
Giardia lamblia DNA repair protein RAD52 0.0706 0.1097 0.402
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0078 0.0112 0.4072
Echinococcus granulosus peregrin 0.0011 0.0006 0.0088
Brugia malayi BRM protein 0.0071 0.01 0.0138
Echinococcus multilocularis muscleblind protein 0.0158 0.0237 0.3542
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0015 0.002
Echinococcus multilocularis Chromo domain 0.0012 0.0008 0.0116
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0059
Echinococcus multilocularis BRK domain 0.0012 0.0008 0.0116
Plasmodium falciparum exonuclease I, putative 0.0011 0.0005 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0005 0.0104
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0069
Leishmania major hypothetical protein, conserved 0.0011 0.0005 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0076 0.027
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0074 0.0263
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.002 0.0294
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0041 0.0052 0.0785
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0027 0.0088
Onchocerca volvulus 0.0009 0.0003 0.0003
Schistosoma mansoni Smad4 0.0017 0.0014 0.0215
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0011 0.0005 0.0079
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0017 0.0254
Leishmania major mitochondrial DNA polymerase beta 0.032 0.049 0.1791
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0103 0.1544
Loa Loa (eye worm) hypothetical protein 0.0158 0.0237 0.4733
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0072 0.0102 0.152
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0009
Toxoplasma gondii RNA-directed DNA polymerase 0.1742 0.2723 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.0042
Echinococcus multilocularis peregrin 0.0011 0.0006 0.0088
Plasmodium vivax flap endonuclease 1, putative 0.0053 0.0071 0.0254
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0093 0.0127
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0226 0.082
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0003 0.5
Brugia malayi XPG I-region family protein 0.0011 0.0005 0.0007
Brugia malayi hypothetical protein 0.0009 0.0003 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0014 0.0287
Giardia lamblia DINP protein human, muc B family 0.0078 0.0112 0.0398
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0021 0.0021 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0005 0.0104
Loa Loa (eye worm) RecQ helicase 0.0044 0.0058 0.1153
Brugia malayi polk-prov protein 0.0048 0.0064 0.0088
Brugia malayi hypothetical protein 0.0016 0.0013 0.0018
Echinococcus granulosus global transcription activator snf2l2 0.0071 0.01 0.1497
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0011 0.0005 0.0009
Echinococcus granulosus exonuclease 1 0.0011 0.0005 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0003 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.002 0.021
Leishmania major hypothetical protein, conserved 0.0025 0.0027 0.0088
Echinococcus multilocularis smad 0.0017 0.0014 0.0215
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0011 0.0006 0.0085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.002 0.0061
Schistosoma mansoni smad1 5 8 and 0.0017 0.0014 0.0215
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0023
Loa Loa (eye worm) helicase DNA-binding protein 0.0012 0.0008 0.0154
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0005 0.0078
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0005 0.0078
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0017 0.034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0005 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0005 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0005 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0005 0.0104
Schistosoma mansoni smad 0.0017 0.0014 0.0215
Brugia malayi nuclear hormone receptor 0.0011 0.0005 0.0007
Echinococcus granulosus Chromo domain 0.0012 0.0008 0.0116
Entamoeba histolytica hypothetical protein 0.0073 0.0103 0.092
Entamoeba histolytica recQ family DNA helicase 0.0009 0.0003 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0064 0.0225
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0004
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0049 0.0168
Echinococcus granulosus disco interacting protein 2 0.0041 0.0052 0.0785
Echinococcus granulosus hepatoma derived growth factor protein 0.0009 0.0003 0.0044
Echinococcus granulosus geminin 0.0344 0.0529 0.7922
Brugia malayi MH1 domain containing protein 0.0017 0.0014 0.002
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0027 0.0088
Loa Loa (eye worm) BRM protein 0.0045 0.006 0.1194
Echinococcus granulosus smad 0.0017 0.0014 0.0215
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0029
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0022 0.0024 0.0076
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0015 0.0293
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0003 0.0045
Entamoeba histolytica exonuclease, putative 0.0011 0.0005 0.0026
Trichomonas vaginalis flap endonuclease-1, putative 0.0053 0.0071 0.1549
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Brugia malayi topoisomerase 0.001 0.0003 0.0005
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0059 0.0206
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0069
Leishmania major importin beta-1 subunit, putative 0.0025 0.0027 0.0089
Schistosoma mansoni hypothetical protein 0.0326 0.05 0.7483
Chlamydia trachomatis DNA ligase 0.001 0.0003 0.5
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0025 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.0142 0.0512
Echinococcus granulosus PWWP domain containing protein 2A 0.0009 0.0003 0.0044
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0027 0.0542
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0005 0.0078
Onchocerca volvulus 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0069
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0706 0.1097 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0103 0.1544
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0085 0.1275
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0052
Trichomonas vaginalis ap endonuclease, putative 0.002 0.002 0.0369
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0141 0.0194
Leishmania major DNA polymerase eta, putative 0.0097 0.014 0.0505
Echinococcus multilocularis PWWP domain containing protein 2A 0.0009 0.0003 0.0044
Echinococcus granulosus PWWP domain containing protein 2A 0.0009 0.0003 0.0044
Leishmania major DNA polymerase eta, putative 0.0047 0.0062 0.0219
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0076 0.027
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0058 0.1235
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0005 0.0078
Brugia malayi hypothetical protein 0.0025 0.0027 0.0037
Echinococcus multilocularis GPCR, family 2 0.0031 0.0037 0.0548
Schistosoma mansoni hypothetical protein 0.0344 0.0529 0.7922
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.0142 0.0512
Loa Loa (eye worm) Smad1 0.0017 0.0014 0.0287
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.0042
Trichomonas vaginalis exonuclease%2C+putative 0.0011 0.0005 0.0042
Entamoeba histolytica deoxycytidyl transferase, putative 0.0072 0.0102 0.0905
Brugia malayi steroid hormone receptor 0.0011 0.0005 0.0007
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0015 0.0045
Entamoeba histolytica hypothetical protein 0.0073 0.0103 0.092
Echinococcus granulosus GPCR family 2 0.0031 0.0037 0.0548
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0112 0.0399
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.0668 1
Echinococcus multilocularis dna polymerase eta 0.0097 0.014 0.2102
Schistosoma mansoni importin beta-1 0.0031 0.0036 0.0544
Loa Loa (eye worm) hypothetical protein 0.0134 0.0199 0.398
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0069
Echinococcus granulosus tar DNA binding protein 0.0062 0.0085 0.1275
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0005 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0005 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0141 0.2817
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0015 0.0043
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0035 0.0121
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0098 0.0142 0.3158
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0538
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0017 0.0254
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0085 0.1275
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0005 0.0009
Loa Loa (eye worm) histone methyltransferase 0.001 0.0005 0.0097
Schistosoma mansoni hypothetical protein 0.0344 0.0529 0.7922
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0037 0.0548
Plasmodium falciparum flap endonuclease 1 0.0053 0.0071 0.025
Schistosoma mansoni topbp1 0.001 0.0003 0.0052
Echinococcus multilocularis exonuclease 1 0.0011 0.0005 0.0079
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.0226 0.082
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0059 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Schistosoma mansoni DNA polymerase IV / kappa 0.0022 0.0024 0.0352
Brugia malayi hypothetical protein 0.0073 0.0103 0.0142
Trypanosoma brucei unspecified product 0.0091 0.0132 0.0475
Mycobacterium tuberculosis Conserved hypothetical protein 0.0072 0.0102 0.3649
Brugia malayi ecdysteroid receptor 0.0011 0.0005 0.0007
Echinococcus granulosus importin subunit beta 1 0.0031 0.0036 0.0544
Toxoplasma gondii exonuclease III APE 0.002 0.002 0.0061
Brugia malayi MH2 domain containing protein 0.0242 0.0369 0.0508
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0005 0.0078
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0003 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0005 0.0078
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1742 0.2723 1
Echinococcus granulosus dna polymerase eta 0.0097 0.014 0.2102
Trypanosoma brucei DNA polymerase IV, putative 0.0091 0.0132 0.0475
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0104
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0058 0.1168
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.0042
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0005 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.002 0.002 0.0369
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0053 0.0071 0.0252
Loa Loa (eye worm) RNA binding protein 0.0062 0.0085 0.1704
Loa Loa (eye worm) hypothetical protein 0.0048 0.0064 0.1283
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0005 0.0104
Loa Loa (eye worm) XPG I-region family protein 0.0011 0.0005 0.0106
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.002 1
Echinococcus granulosus nibrin 0.001 0.0003 0.0052
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0005 0.0007
Echinococcus multilocularis disco interacting protein 2 0.0041 0.0052 0.0785
Echinococcus multilocularis flap endonuclease 1 0.0053 0.0071 0.107
Entamoeba histolytica exonuclease, putative 0.0011 0.0005 0.0026
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0005 0.0078
Brugia malayi Smad1 0.0017 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0036 0.0727
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0002 0.0029
Schistosoma mansoni DNA ligase IV 0.001 0.0003 0.0052
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0006 0.0085
Trypanosoma cruzi DNA polymerase eta, putative 0.0097 0.014 0.0505
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0106
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0027 0.0542
Loa Loa (eye worm) hypothetical protein 0.0097 0.014 0.2809
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.0088
Schistosoma mansoni SET domain protein 0.0013 0.0008 0.0125
Schistosoma mansoni hypothetical protein 0.0073 0.0103 0.1544
Plasmodium vivax importin-beta 2, putative 0.0031 0.0036 0.0125
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0116
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.0061
Brugia malayi CXXC zinc finger family protein 0.0066 0.0092 0.0126
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0011 0.0005 0.0079
Schistosoma mansoni DNA helicase recq1 0.0018 0.0017 0.0254
Mycobacterium ulcerans glutaminase 0.0289 0.0443 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0058 0.0874
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0005 0.0007
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0025 0.0083
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Echinococcus granulosus muscleblind protein 0.0158 0.0237 0.3542
Entamoeba histolytica hypothetical protein 0.0009 0.0003 0.0005
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0078 0.0112 0.0399
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0548
Schistosoma mansoni DNA polymerase eta 0.0097 0.014 0.2102
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0021 0.0021 0.0067
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0036 0.0544
Schistosoma mansoni hypothetical protein 0.0012 0.0008 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0058 0.0874
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0005 0.0104
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0043
Plasmodium vivax DNA repair protein RAD2, putative 0.0011 0.0005 0.0011
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0237 0.3542
Schistosoma mansoni helicase 0.0071 0.01 0.1497
Schistosoma mansoni exonuclease 0.0011 0.0005 0.0079
Schistosoma mansoni SET domain protein 0.0033 0.0039 0.0591
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0069
Brugia malayi DKFZp564C0469 protein 0.001 0.0003 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0058 0.0874
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0003 0.0009
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0011 0.0006 0.0085
Echinococcus granulosus dna polymerase kappa 0.0098 0.0142 0.2128
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0006 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0219
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0003 0.0052
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0003 0.0002
Leishmania major DNA damage repair protein, putative 0.0022 0.0024 0.0076
Plasmodium vivax DEAD/DEAH helicase, putative 0.0011 0.0006 0.0012
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0103 0.1544
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.0008 0.0116
Leishmania major telomerase reverse transcriptase, putative 0.1742 0.2723 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0014 0.0215
Echinococcus multilocularis nibrin 0.001 0.0003 0.0052
Echinococcus multilocularis PWWP domain containing protein 2A 0.0009 0.0003 0.0044
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0017 0.005
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0033 0.0039 0.0591
Giardia lamblia hypothetical protein 0.0011 0.0005 0.0007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.002 0.0157
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0072 0.0102 0.152
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0011 0.0005 0.0079
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0017 0.0023
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0033 0.0039 0.0591
Onchocerca volvulus 0.0011 0.0005 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0005 0.0078
Brugia malayi ImpB/MucB/SamB family protein 0.0097 0.014 0.0193
Loa Loa (eye worm) hypothetical protein 0.0158 0.0237 0.4733
Brugia malayi RNA binding protein 0.0062 0.0085 0.0117
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0043
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0003 0.0052
Loa Loa (eye worm) BRM protein 0.0037 0.0046 0.0922
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0003 0.0002
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0058 0.1235
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0104
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.002 0.0027
Schistosoma mansoni hypothetical protein 0.0066 0.0093 0.1386
Schistosoma mansoni hypothetical protein 0.0433 0.0668 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0014 0.0215
Trypanosoma brucei DNA polymerase eta, putative 0.0097 0.014 0.0505
Echinococcus granulosus cpg binding protein 0.0068 0.0094 0.1415
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0104
Brugia malayi PWWP domain containing protein 0.0009 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0104
Trypanosoma brucei DNA repair protein RAD2, putative 0.0011 0.0005 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0005 0.0078
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0059 0.0206
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0017 0.0254
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0005 0.0078
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0005 0.0078
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0008 0.0116
Trichomonas vaginalis flap endonuclease-1, putative 0.0011 0.0005 0.0042
Plasmodium vivax DNA repair protein REV1, putative 0.0022 0.0024 0.0078
Trichomonas vaginalis lymphoid specific helicase, putative 0.0013 0.0009 0.012
Loa Loa (eye worm) flap endonuclease-1 0.0053 0.0071 0.1429
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.049 0.1791
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0008 0.0011
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0011 0.0006 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Toxoplasma gondii hypothetical protein 0.009 0.0129 0.0463
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0548
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0005 0.0078
Brugia malayi hypothetical protein 0.0009 0.0003 0.0004
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0053 0.0071 0.0252
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0005 0.0007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0037 0.0548
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.049 0.1791
Echinococcus multilocularis geminin 0.0344 0.0529 0.7922
Onchocerca volvulus 0.0066 0.0092 0.0092
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0037 0.0733
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0058 0.0079
Schistosoma mansoni cpg binding protein 0.0068 0.0094 0.1415
Toxoplasma gondii DNA methyltransferase 2, putative 0.0021 0.0021 0.0067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.0253 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0005 0.0007
Echinococcus multilocularis snurportin 1 0.0326 0.05 0.7483
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0085 0.1704
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0024 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0005 0.0078
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0002 0.0029
Plasmodium vivax telomerase reverse transcriptase, putative 0.1742 0.2723 1
Brugia malayi MH2 domain containing protein 0.0017 0.0014 0.002
Brugia malayi RNA, U transporter 1 0.0087 0.0125 0.0172
Brugia malayi isocitrate dehydrogenase 0.0017 0.0015 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0073
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0015 0.0219
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0005 0.0007
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0058 0.0863
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0062 0.0219
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0003 0.0002
Plasmodium vivax exonuclease I, putative 0.0011 0.0005 0.0011
Toxoplasma gondii hypothetical protein 0.0052 0.0069 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0005 0.0007
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0017 0.0254
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0201 0.0304 0.2754
Loa Loa (eye worm) PWWP domain-containing protein 0.0009 0.0003 0.0059
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0021 0.0069
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0024 0.0076
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.009 0.0129 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0005 0.0007
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0009
Brugia malayi glutaminase DH11.1 0.0289 0.0443 0.0609
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0027 0.009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0005 0.0078
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0548
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0006 0.0085
Schistosoma mansoni cpg binding protein 0.0066 0.0092 0.1374
Loa Loa (eye worm) glutaminase 0.0289 0.0443 0.8855
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0005 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0085 0.1275
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0548
Trypanosoma brucei unspecified product 0.005 0.0066 0.0233
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0003 0.0002
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0011 0.0005 0.0009
Schistosoma mansoni smad1 5 8 and 0.0017 0.0014 0.0215
Leishmania major DNA polymerase kappa, putative 0.0022 0.0024 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0005 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0005 0.0078
Echinococcus granulosus BRK domain containing protein 0.0012 0.0008 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Brugia malayi Disco-interacting protein 2 homolog 0.0041 0.0052 0.0072
Loa Loa (eye worm) hypothetical protein 0.0066 0.0093 0.1852
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0037 0.005
Trichomonas vaginalis DNA polymerase eta, putative 0.0098 0.0142 0.3158
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.002 1
Plasmodium falciparum DNA repair protein RAD2, putative 0.0011 0.0005 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0005 0.0007
Leishmania major DNA polymerase kappa, putative 0.0078 0.0112 0.0399
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0005 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0142 0.0512
Schistosoma mansoni glutaminase 0.0289 0.0443 0.6626

Activities

Activity type Activity value Assay description Source Reference
RBA (binding) = 23 Relative binding affinity for the calf uterine estrogen receptor measured as the ratio of molar concentration of 17-beta-estradiol (E2) and inhibitor required to decrease the amount of bound [3H]-E2 by 50% ChEMBL. 6492074

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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