Detailed information for compound 454452

Basic information

Technical information
  • TDR Targets ID: 454452
  • Name: (2S)-4-morpholin-4-yl-4-oxo-2-phenyl-N-[(1S)- 1-phenyl-2-[4-(trifluoromethoxy)anilino]ethyl ]butanamide
  • MW: 541.561 | Formula: C29H30F3N3O4
  • H donors: 2 H acceptors: 2 LogP: 4.62 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@H](c1ccccc1)CC(=O)N1CCOCC1)N[C@@H](c1ccccc1)CNc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C29H30F3N3O4/c30-29(31,32)39-24-13-11-23(12-14-24)33-20-26(22-9-5-2-6-10-22)34-28(37)25(21-7-3-1-4-8-21)19-27(36)35-15-17-38-18-16-35/h1-14,25-26,33H,15-20H2,(H,34,37)/t25-,26+/m0/s1
  • InChiKey: PSBWTPWDDHNYPT-IZZNHLLZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-4-morpholino-4-oxo-2-phenyl-N-[(1S)-1-phenyl-2-[4-(trifluoromethoxy)anilino]ethyl]butanamide
  • (2S)-4-morpholin-4-yl-4-oxo-2-phenyl-N-[(1S)-1-phenyl-2-[[4-(trifluoromethoxy)phenyl]amino]ethyl]butanamide
  • (2S)-4-keto-4-morpholino-2-phenyl-N-[(1S)-1-phenyl-2-[4-(trifluoromethoxy)anilino]ethyl]butyramide
  • (2S)-4-morpholino-4-oxo-2-phenyl-N-[(1S)-1-phenyl-2-[[4-(trifluoromethoxy)phenyl]amino]ethyl]butanamide
  • (2S)-4-keto-4-morpholino-2-phenyl-N-[(1S)-1-phenyl-2-[[4-(trifluoromethoxy)phenyl]amino]ethyl]butyramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0054 0.2913 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.3998 0.3998
Schistosoma mansoni loxhd1 0.002 0.0375 0.0375
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Echinococcus multilocularis CREB binding protein 0.0074 0.4395 0.4395
Brugia malayi Cathepsin L-like precursor 0.0036 0.1565 0.1565
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Brugia malayi hypothetical protein 0.002 0.0375 0.0375
Leishmania major cysteine peptidase A (CPA) 0.0054 0.2913 0.726
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Plasmodium vivax vivapain-2 0.0054 0.2913 0.7156
Loa Loa (eye worm) hypothetical protein 0.0045 0.2218 0.2218
Onchocerca volvulus 0.0054 0.2913 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Loa Loa (eye worm) ctsf protein 0.0054 0.2913 0.2913
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 1 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0068 0.3998 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.1565 0.2807
Brugia malayi Cathepsin L-like precursor 0.0036 0.1565 0.1565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus granulosus CREB binding protein 0.0017 0.01 0.0105
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0375 0.0375
Schistosoma mansoni lipoxygenase 0.0085 0.5274 0.5274
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0936 0.0936
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.2214 0.5324
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.2218 0.2321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0936 0.0947
Echinococcus granulosus cathepsin L 0.0028 0.0936 0.098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.8045 0.8419
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0068 0.3998 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.3998 0.3998
Echinococcus granulosus CREB binding protein 0.0106 0.6819 0.7136
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0936 0.2267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2515 0.2515
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.1565 0.2054
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.2913 0.6792
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0936 0.0936
Onchocerca volvulus 0.0036 0.1565 0.4689
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0936 0.2267
Onchocerca volvulus 0.0054 0.2913 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0016 0.0039 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0184 0.0367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.3998 1
Onchocerca volvulus 0.0036 0.1551 0.4632
Loa Loa (eye worm) acetyltransferase 0.0148 1 1
Echinococcus granulosus CREB binding protein 0.0017 0.01 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0936 0.0947
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.3998 0.4184
Echinococcus multilocularis CREB binding protein 0.0017 0.01 0.01
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0068 0.3998 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0184 0.0184
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0435 0.1002
Brugia malayi cathepsin L-like precursor 0.0036 0.1565 0.1565
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0036 0.1565 0.1565
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.2913 0.2913
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.2913 0.2913
Echinococcus multilocularis cathepsin L 0.0028 0.0936 0.0936
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.3998 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.2913 0.2913
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0936 0.2267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Loa Loa (eye worm) variant SH3 domain-containing protein 0.011 0.7127 0.7127
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0184 0.0184
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0184 0.0184
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.3998 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0936 0.1548
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0047 0.2399 0.2399
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0936 0.2267
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 1 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.1565 0.1565
Loa Loa (eye worm) hypothetical protein 0.0036 0.1551 0.1551
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Loa Loa (eye worm) hypothetical protein 0.0054 0.2913 0.2913
Plasmodium vivax unspecified product 0.0028 0.0936 0.1973
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0375 0.0393
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0024 0.0619 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.2913 0.2913
Echinococcus granulosus cathepsin l1 0.0036 0.1565 0.1638
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.2913 0.7005
Echinococcus multilocularis CREB binding protein 0.0017 0.01 0.01
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0375 0.0393
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Schistosoma mansoni rab6-interacting 0.002 0.0375 0.0375
Onchocerca volvulus Cathepsin F homolog 0.0054 0.2913 1
Onchocerca volvulus 0.0054 0.2913 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.2218 0.2218
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0036 0.1551 0.1623
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.2214 0.5495
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Brugia malayi Variant SH3 domain containing protein 0.011 0.7127 0.7127
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.3998 0.3998
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.2913 0.7005
Loa Loa (eye worm) cysteine protease 0.0054 0.2913 0.2913
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.2913 0.2913
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0068 0.3998 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.1565 0.2807
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.2215 0.5497
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.1809 0.2851
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0936 0.0936
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0068 0.3998 0.5
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0024 0.0619 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.2214 0.5495
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.2913 0.7005
Brugia malayi phospholipase C homolog 0.0026 0.0826 0.0826
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0435 0.1002
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.2218 0.2218
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0045 0.2215 0.5497
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Loa Loa (eye worm) hypothetical protein 0.0049 0.2515 0.2515
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0936 0.2267
Echinococcus multilocularis RUN 0.002 0.0375 0.0375
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0024 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0036 0.1565 0.1565
Schistosoma mansoni hypothetical protein 0.002 0.0375 0.0375
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1351 0.1351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.2215 0.1855
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.3998 0.4184
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.3998 1
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.2913 0.726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0435 0.1002
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.2913 0.3049
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0936 0.098
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0936 0.0936
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0044 0.2167 0.2167
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.1809 0.3958
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0047 0.2399 0.2399
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.1565 0.1565
Onchocerca volvulus 0.0054 0.2913 1
Onchocerca volvulus 0.0036 0.1551 0.4632
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0047 0.2392 0.2392
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0021 0.0435 0.0435
Brugia malayi hypothetical protein 0.002 0.0375 0.0375
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0375 0.0393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.2214 0.4726
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.2913 0.726
Onchocerca volvulus 0.0054 0.2913 1
Brugia malayi Doublecortin family protein 0.002 0.0375 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.2913 0.6792
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.3998 0.3998
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.2913 0.726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Echinococcus granulosus cysteine protease 0.0028 0.0936 0.098
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Onchocerca volvulus 0.0054 0.2913 1
Entamoeba histolytica cysteine protease, putative 0.0054 0.2913 0.6457
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.2913 0.6457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0068 0.3998 0.5
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Schistosoma mansoni CREB-binding protein 2 0.0106 0.6819 0.6819
Schistosoma mansoni cathepsin s 0.0018 0.0184 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0184 0.0184
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.2218 0.4737
Schistosoma mansoni rab6-interacting 0.002 0.0375 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0036 0.1565 0.1565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0026 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.2913 0.2913
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.2913 0.726
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.2913 0.6457
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.2218 0.2218
Loa Loa (eye worm) hypothetical protein 0.0047 0.2392 0.2392
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.2218 0.4737
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.2214 0.4726
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.3998 0.3998
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0036 0.1551 0.1551
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0047 0.2392 0.5566
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Loa Loa (eye worm) hypothetical protein 0.0036 0.1551 0.1551
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0375 0.0375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Loa Loa (eye worm) hypothetical protein 0.002 0.0375 0.0375
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.2215 0.5497
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.2913 0.2913
Schistosoma mansoni lipoxygenase 0.0122 0.8045 0.8045
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Plasmodium vivax ubiquitin activating enzyme, putative 0.0047 0.2392 0.5789
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0047 0.2392 0.2503
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0936 0.0936
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0106 0.6819 0.6819
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.2913 0.726
Schistosoma mansoni phospholipase C beta 0.0035 0.1482 0.1482
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0435 0.1002
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.3998 1
Echinococcus multilocularis cysteine protease 0.0054 0.2913 0.2913
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0035 0.1482 0.1482
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.2214 0.2317
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.2913 0.2913
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.3998 0.3998
Loa Loa (eye worm) Plcb4 protein 0.0035 0.1482 0.1482
Plasmodium vivax vivapain-2 0.0054 0.2913 0.7156
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0375 0.0502
Onchocerca volvulus Cathepsin L homolog 0.0054 0.2913 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.3998 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0375 0.0375
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0047 0.2392 0.2392
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.2215 0.5497
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.8045 0.8045
Plasmodium vivax vivapain-3 0.0028 0.0936 0.1973
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.9556 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0936 0.2267
Brugia malayi TAZ zinc finger family protein 0.0106 0.6819 0.6819
Loa Loa (eye worm) fibroinase 0.0054 0.2913 0.2913
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Toxoplasma gondii cathepsin CPL 0.0054 0.2913 0.726
Echinococcus multilocularis CREB binding protein 0.0017 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.2457 0.2457
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0068 0.3998 1
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0068 0.3998 0.5
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.002 0.0375 0.0375
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Echinococcus granulosus CREB binding protein 0.0066 0.3863 0.4043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0184 0.0184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2515 0.2515
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0068 0.3998 0.3998
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.2913 0.2913
Schistosoma mansoni hypothetical protein 0.0033 0.1351 0.1351
Brugia malayi ThiF family protein 0.0047 0.2392 0.2392
Loa Loa (eye worm) hypothetical protein 0.0018 0.0184 0.0184
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0936 0.2267
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0036 0.1565 0.3856
Onchocerca volvulus Cathepsin L homolog 0.0054 0.2913 1
Echinococcus multilocularis cysteine protease 0.0054 0.2913 0.2913
Schistosoma mansoni polycystin 1-related 0.002 0.0375 0.0375
Plasmodium vivax vivapain-1 0.0028 0.0936 0.1973
Echinococcus granulosus RUN 0.002 0.0375 0.0393
Loa Loa (eye worm) hypothetical protein 0.0033 0.1351 0.1351
Toxoplasma gondii hypothetical protein 0.0047 0.2392 0.5943
Loa Loa (eye worm) CBP-B 0.0074 0.4463 0.4463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus granulosus cathepsin l1 0.0054 0.2913 0.3049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2515 0.2515
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0184 0.0367
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0021 0.0435 0.1002
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.3998 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.2913 0.3049
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0016 0.0039 0.0039
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0068 0.3998 0.5

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.261 uM Inhibition of cathepsin S ChEMBL. 17382545
Ki (binding) = 0.261 uM Inhibition of cathepsin S ChEMBL. 17382545
Ki (binding) = 10.54 uM Inhibition of cathepsin K ChEMBL. 17382545
Ki (binding) = 10.54 uM Inhibition of cathepsin K ChEMBL. 17382545
Ki (binding) = 48.37 uM Inhibition of cathepsin L ChEMBL. 17382545
Ki (binding) = 48.37 uM Inhibition of cathepsin L ChEMBL. 17382545

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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