Detailed information for compound 454452

Basic information

Technical information
  • TDR Targets ID: 454452
  • Name: (2S)-4-morpholin-4-yl-4-oxo-2-phenyl-N-[(1S)- 1-phenyl-2-[4-(trifluoromethoxy)anilino]ethyl ]butanamide
  • MW: 541.561 | Formula: C29H30F3N3O4
  • H donors: 2 H acceptors: 2 LogP: 4.62 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@H](c1ccccc1)CC(=O)N1CCOCC1)N[C@@H](c1ccccc1)CNc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C29H30F3N3O4/c30-29(31,32)39-24-13-11-23(12-14-24)33-20-26(22-9-5-2-6-10-22)34-28(37)25(21-7-3-1-4-8-21)19-27(36)35-15-17-38-18-16-35/h1-14,25-26,33H,15-20H2,(H,34,37)/t25-,26+/m0/s1
  • InChiKey: PSBWTPWDDHNYPT-IZZNHLLZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-4-morpholino-4-oxo-2-phenyl-N-[(1S)-1-phenyl-2-[4-(trifluoromethoxy)anilino]ethyl]butanamide
  • (2S)-4-morpholin-4-yl-4-oxo-2-phenyl-N-[(1S)-1-phenyl-2-[[4-(trifluoromethoxy)phenyl]amino]ethyl]butanamide
  • (2S)-4-keto-4-morpholino-2-phenyl-N-[(1S)-1-phenyl-2-[4-(trifluoromethoxy)anilino]ethyl]butyramide
  • (2S)-4-morpholino-4-oxo-2-phenyl-N-[(1S)-1-phenyl-2-[[4-(trifluoromethoxy)phenyl]amino]ethyl]butanamide
  • (2S)-4-keto-4-morpholino-2-phenyl-N-[(1S)-1-phenyl-2-[[4-(trifluoromethoxy)phenyl]amino]ethyl]butyramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0047 0.2392 0.2392
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.2913 0.7005
Loa Loa (eye worm) variant SH3 domain-containing protein 0.011 0.7127 0.7127
Onchocerca volvulus 0.0036 0.1565 0.4689
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0044 0.2167 0.2167
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Brugia malayi Cathepsin L-like precursor 0.0036 0.1565 0.1565
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0016 0.0039 0.0039
Plasmodium vivax vivapain-1 0.0028 0.0936 0.1973
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0068 0.3998 1
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus granulosus cathepsin L 0.0028 0.0936 0.098
Echinococcus multilocularis RUN 0.002 0.0375 0.0375
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0018 0.0184 0.0184
Brugia malayi TAZ zinc finger family protein 0.0106 0.6819 0.6819
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.2214 0.2317
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0068 0.3998 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0936 0.0936
Onchocerca volvulus 0.0054 0.2913 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Onchocerca volvulus 0.0054 0.2913 1
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0936 0.2267
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Echinococcus granulosus RUN 0.002 0.0375 0.0393
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.2913 0.7005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus multilocularis CREB binding protein 0.0017 0.01 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.1565 0.2807
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.1565 0.2054
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.2913 0.726
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.3998 1
Echinococcus granulosus cathepsin l1 0.0054 0.2913 0.3049
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.3998 0.3998
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0024 0.0619 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0936 0.0947
Toxoplasma gondii cathepsin CPL 0.0054 0.2913 0.726
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.2913 0.6792
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0035 0.1482 0.1482
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.2913 0.2913
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.3998 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0036 0.1551 0.1623
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0106 0.6819 0.6819
Loa Loa (eye worm) cysteine protease 0.0054 0.2913 0.2913
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0068 0.3998 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0048 0.2457 0.2457
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0184 0.0367
Loa Loa (eye worm) doublecortin family protein 0.002 0.0375 0.0375
Plasmodium vivax unspecified product 0.0028 0.0936 0.1973
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0936 0.2267
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0936 0.098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.0036 0.1565 0.1565
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.2913 0.2913
Loa Loa (eye worm) ctsf protein 0.0054 0.2913 0.2913
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0021 0.0435 0.0435
Plasmodium vivax vivapain-2 0.0054 0.2913 0.7156
Loa Loa (eye worm) hypothetical protein 0.0033 0.1351 0.1351
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.2913 0.3049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Onchocerca volvulus Cathepsin L homolog 0.0054 0.2913 1
Brugia malayi phospholipase C homolog 0.0026 0.0826 0.0826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0936 0.0936
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.2913 0.7005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0936 0.0936
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0047 0.2392 0.5566
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.3998 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.2215 0.5497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0936 0.0947
Loa Loa (eye worm) hypothetical protein 0.0018 0.0184 0.0184
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0375 0.0375
Brugia malayi hypothetical protein 0.002 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0018 0.0184 0.0184
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.2218 0.4737
Brugia malayi Cathepsin L-like precursor 0.0036 0.1565 0.1565
Loa Loa (eye worm) hypothetical protein 0.0036 0.1551 0.1551
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.3998 0.3998
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.3998 0.3998
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0036 0.1551 0.1551
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0024 0.0619 0.5
Onchocerca volvulus 0.0054 0.2913 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2515 0.2515
Echinococcus multilocularis cathepsin L 0.0028 0.0936 0.0936
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0375 0.0502
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.3998 1
Loa Loa (eye worm) CBP-B 0.0074 0.4463 0.4463
Echinococcus multilocularis CREB binding protein 0.0017 0.01 0.01
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.2214 0.4726
Echinococcus multilocularis CREB binding protein 0.0017 0.01 0.01
Onchocerca volvulus 0.0054 0.2913 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Toxoplasma gondii hypothetical protein 0.0047 0.2392 0.5943
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0435 0.1002
Onchocerca volvulus 0.0036 0.1551 0.4632
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Schistosoma mansoni lipoxygenase 0.0122 0.8045 0.8045
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0047 0.2399 0.2399
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0036 0.1565 0.3856
Schistosoma mansoni CREB-binding protein 2 0.0106 0.6819 0.6819
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0936 0.2267
Plasmodium vivax vivapain-2 0.0054 0.2913 0.7156
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0375 0.0375
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.2913 0.726
Echinococcus multilocularis cysteine protease 0.0054 0.2913 0.2913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0068 0.3998 0.5
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0068 0.3998 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0375 0.0375
Schistosoma mansoni rab6-interacting 0.002 0.0375 0.0375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Brugia malayi hypothetical protein 0.002 0.0375 0.0375
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0026 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0936 0.2267
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.9556 1
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.2913 0.726
Schistosoma mansoni hypothetical protein 0.002 0.0375 0.0375
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0068 0.3998 0.5
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0936 0.0936
Onchocerca volvulus 0.0054 0.2913 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Onchocerca volvulus 0.0054 0.2913 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2515 0.2515
Onchocerca volvulus 0.0036 0.1551 0.4632
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0375 0.0375
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0045 0.2215 0.5497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.2913 0.726
Schistosoma mansoni loxhd1 0.002 0.0375 0.0375
Plasmodium vivax ubiquitin activating enzyme, putative 0.0047 0.2392 0.5789
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0016 0.0039 0.0039
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.2215 0.1855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0435 0.1002
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.0054 0.2913 0.2913
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Echinococcus multilocularis CREB binding protein 0.0074 0.4395 0.4395
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.2215 0.5497
Schistosoma mansoni hypothetical protein 0.0033 0.1351 0.1351
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.2218 0.2218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0184 0.0367
Echinococcus granulosus CREB binding protein 0.0066 0.3863 0.4043
Brugia malayi Cathepsin L-like precursor 0.0018 0.0184 0.0184
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.3998 0.4184
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.8045 0.8419
Loa Loa (eye worm) Plcb4 protein 0.0035 0.1482 0.1482
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0047 0.2392 0.2503
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.3998 0.4184
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0375 0.0393
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.2913 0.2913
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0047 0.2392 0.2392
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1351 0.1351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Entamoeba histolytica cysteine protease, putative 0.0054 0.2913 0.6457
Brugia malayi Variant SH3 domain containing protein 0.011 0.7127 0.7127
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.1809 0.2851
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.2218 0.2218
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0184 0.0184
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0068 0.3998 0.5
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0936 0.2267
Schistosoma mansoni phospholipase C beta 0.0035 0.1482 0.1482
Brugia malayi Doublecortin family protein 0.002 0.0375 0.0375
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0068 0.3998 0.3998
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0375 0.0393
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.2214 0.4726
Loa Loa (eye worm) fibroinase 0.0054 0.2913 0.2913
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.2913 0.3049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0936 0.2267
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0184 0.0184
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.3998 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0375 0.0375
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.1809 0.3958
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.2218 0.2321
Onchocerca volvulus 0.0054 0.2913 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0068 0.3998 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.2218 0.4737
Onchocerca volvulus Cathepsin F homolog 0.0054 0.2913 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.2913 0.2913
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.1565 0.1565
Schistosoma mansoni rab6-interacting 0.002 0.0375 0.0375
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0435 0.1002
Echinococcus granulosus cathepsin l1 0.0036 0.1565 0.1638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0375 0.0393
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0021 0.0435 0.1002
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Echinococcus multilocularis cysteine protease 0.0054 0.2913 0.2913
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.3998 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1565 0.1565
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0435 0.1002
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0936 0.1548
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.2913 0.6792
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2515 0.2515
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0047 0.2392 0.2392
Schistosoma mansoni polycystin 1-related 0.002 0.0375 0.0375
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.3998 0.3998
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0047 0.2399 0.2399
Echinococcus granulosus cysteine protease 0.0028 0.0936 0.098
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.3998 1
Echinococcus granulosus CREB binding protein 0.0106 0.6819 0.7136
Brugia malayi ThiF family protein 0.0047 0.2392 0.2392
Brugia malayi cathepsin L-like precursor 0.0036 0.1565 0.1565
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.2913 0.6457
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.1565 0.1565
Schistosoma mansoni lipoxygenase 0.0085 0.5274 0.5274
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0068 0.3998 0.3998
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.1565 0.2807
Plasmodium vivax vivapain-3 0.0028 0.0936 0.1973
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.8045 0.8045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.2913 0.2913
Loa Loa (eye worm) hypothetical protein 0.0036 0.1551 0.1551
Loa Loa (eye worm) hypothetical protein 0.0036 0.1565 0.1565
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.2215 0.5497
Loa Loa (eye worm) hypothetical protein 0.0045 0.2218 0.2218
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.2214 0.5495
Leishmania major cathepsin L-like protease 0.0054 0.2913 0.726
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.2214 0.5324
Loa Loa (eye worm) acetyltransferase 0.0148 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.2913 0.2913
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.2214 0.5495
Onchocerca volvulus Cathepsin L homolog 0.0054 0.2913 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.2218 0.2218
Leishmania major cysteine peptidase A (CPA) 0.0054 0.2913 0.726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0936 0.2267
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0024 0.0616 0.0616
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0068 0.3998 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0068 0.3998 1
Echinococcus granulosus CREB binding protein 0.0017 0.01 0.0105
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.2913 0.2913
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.2913 0.6457
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.2913 0.6792
Schistosoma mansoni cathepsin s 0.0018 0.0184 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.2913 0.6792
Echinococcus granulosus CREB binding protein 0.0017 0.01 0.0105
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.2913 0.726
Brugia malayi Cathepsin L-like precursor 0.0054 0.2913 0.2913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.2913 0.726
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0068 0.3998 0.3998

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.261 uM Inhibition of cathepsin S ChEMBL. 17382545
Ki (binding) = 0.261 uM Inhibition of cathepsin S ChEMBL. 17382545
Ki (binding) = 10.54 uM Inhibition of cathepsin K ChEMBL. 17382545
Ki (binding) = 10.54 uM Inhibition of cathepsin K ChEMBL. 17382545
Ki (binding) = 48.37 uM Inhibition of cathepsin L ChEMBL. 17382545
Ki (binding) = 48.37 uM Inhibition of cathepsin L ChEMBL. 17382545

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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