Detailed information for compound 456259

Basic information

Technical information
  • TDR Targets ID: 456259
  • Name: 3-(2,3-dichlorophenyl)-4-[(2-methoxyphenyl)me thyl]-1,2,4-triazole
  • MW: 334.2 | Formula: C16H13Cl2N3O
  • H donors: 0 H acceptors: 2 LogP: 3.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1Cn1cnnc1c1cccc(c1Cl)Cl
  • InChi: 1S/C16H13Cl2N3O/c1-22-14-8-3-2-5-11(14)9-21-10-19-20-16(21)12-6-4-7-13(17)15(12)18/h2-8,10H,9H2,1H3
  • InChiKey: WXZGZVKTKDRMPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2,3-dichlorophenyl)-4-o-anisyl-1,2,4-triazole
  • 3-(2,3-dichlorophenyl)-4-(2-methoxybenzyl)-1,2,4-triazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 7 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0405 0.043
Brugia malayi p70 ribosomal S6 kinase beta 0.0056 0.0505 0.0524
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.1533
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0052 0.045 0.0477
Entamoeba histolytica protein kinase, putative 0.0034 0.0221 0.148
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0221 0.1539
Brugia malayi Protein kinase domain containing protein 0.0048 0.0393 0.0405
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0518 0.0549
Schistosoma mansoni protein kinase 0.0034 0.0221 0.0234
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0242 0.0715
Entamoeba histolytica protein kinase, putative 0.0026 0.0116 0.0735
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0018 0.0013 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0442 0.5491 0.5823
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0549 0.6868 0.81
Echinococcus multilocularis serine:threonine protein kinase 0.0048 0.0393 0.0382
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0058 0.0526 0.0558
Schistosoma mansoni P2X receptor subunit 0.0082 0.0836 0.0886
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0026 0.0116 0.0105
Echinococcus multilocularis cyclin dependent kinase 1 0.0058 0.0526 0.0516
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0221 0.0248
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0242 0.0273
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0542 0.1682
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0221 0.1539
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0038 0.0266 0.0282
Echinococcus granulosus microtubule associated protein 2 0.0673 0.8477 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0232 0.0684
Echinococcus multilocularis musashi 0.0026 0.0117 0.0106
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0078 0.0779 0.0769
Schistosoma mansoni tyrosine kinase 0.0024 0.0086 0.0091
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0232 0.0097
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1831 0.1822
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0058 0.0526 0.6917
Onchocerca volvulus 0.0026 0.0117 0.0462
Trichomonas vaginalis STE family protein kinase 0.0127 0.1416 0.4372
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0024 0.0086 0.0089
Schistosoma mansoni hypothetical protein 0.003 0.0163 0.0172
Echinococcus multilocularis lamin 0.0026 0.0117 0.0106
Loa Loa (eye worm) hypothetical protein 0.0043 0.0328 0.0347
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0076 0.0446
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.004 0.0289 0.0306
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0188 0.0199
Echinococcus granulosus serine:threonine protein kinase 0.0048 0.0393 0.0451
Echinococcus granulosus p2X purinoceptor 4 0.0082 0.0836 0.0975
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0032 0.0191 0.018
Schistosoma mansoni adapter molecule crk 0.0018 0.0011 0.0011
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0242 0.0752
Echinococcus multilocularis casein kinase I alpha 0.0052 0.045 0.044
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0091 0.0096
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0727 0.5091
Loa Loa (eye worm) hypothetical protein 0.004 0.0289 0.0307
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0403 0.0416
Loa Loa (eye worm) hypothetical protein 0.003 0.0163 0.0173
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0074 0.0727 0.5091
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.1533
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0222 0.2644 0.2803
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0266 0.0282
Echinococcus granulosus NDR protein kinase 0.0024 0.0091 0.0094
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0518 0.0508
Trypanosoma brucei rac serine-threonine kinase, putative 0.0056 0.0505 0.5611
Entamoeba histolytica protein kinase 2, putative 0.004 0.0294 0.2001
Loa Loa (eye worm) SRC-1 0.0024 0.0086 0.0092
Echinococcus multilocularis serine:threonine protein kinase 0.0048 0.0393 0.0382
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0221 0.1539
Schistosoma mansoni protein kinase 0.0018 0.0013 0.0013
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.004 0.0294 0.2049
Schistosoma mansoni alpha-glucosidase 0.0137 0.1545 0.1638
Loa Loa (eye worm) hypothetical protein 0.0024 0.0091 0.0097
Trypanosoma cruzi cdc2-related kinase 1 0.0058 0.0526 0.594
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0266 0.0282
Echinococcus granulosus serine threonine protein kinase nrc 0.004 0.0294 0.0334
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0091 0.0243
Loa Loa (eye worm) hypothetical protein 0.0062 0.0582 0.0617
Schistosoma mansoni cell adhesion molecule 0.0043 0.0328 0.0347
Trypanosoma cruzi cdc2-related kinase 3 0.0058 0.0526 0.594
Echinococcus granulosus calcium dependent protein kinase 0.0026 0.0118 0.0126
Entamoeba histolytica protein kinase, putative 0.0024 0.0091 0.0556
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0058 0.0526 0.0558
Trypanosoma cruzi Protein kinase B 0.004 0.0294 0.124
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0221 0.0234
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0076 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0266 0.0282
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0221 0.1539
Schistosoma mansoni serine/threonine protein kinase 0.0747 0.943 1
Echinococcus multilocularis casein kinase I delta 0.0052 0.045 0.044
Brugia malayi Protein kinase domain containing protein 0.0747 0.943 1
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0091 0.0096
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.1533
Echinococcus multilocularis roundabout 2 0.0045 0.0358 0.0347
Echinococcus granulosus c src tyrosine kinase 0.0024 0.0086 0.0089
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0221 0.021
Schistosoma mansoni hypothetical protein 0.0165 0.1913 0.2028
Echinococcus granulosus twitchin 0.005 0.0422 0.0486
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0258 0.3111 0.3104
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0526 0.16
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0076 0.0234
Plasmodium falciparum protein kinase 5 0.0058 0.0526 0.367
Plasmodium falciparum NIMA related kinase 1 0.0128 0.1434 1
Echinococcus granulosus casein kinase I delta 0.0052 0.045 0.0519
Schistosoma mansoni serine/threonine-protein kinase 0.004 0.0294 0.0311
Echinococcus granulosus p2X purinoceptor 4 0.0082 0.0836 0.0975
Brugia malayi serine/threonine kinase 12 0.0074 0.0727 0.0761
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0128 0.1434 1
Echinococcus multilocularis p2X purinoceptor 4 0.0082 0.0836 0.0826
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0727 0.2226
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0542 0.0627
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0026 0.0116 0.0105
Brugia malayi Protein kinase domain containing protein 0.0024 0.0091 0.0085
Schistosoma mansoni protein kinase 0.0034 0.0221 0.0234
Echinococcus multilocularis p2X purinoceptor 4 0.0082 0.0836 0.0826
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0076 0.0234
Schistosoma mansoni inositol monophosphatase 0.0036 0.0242 0.0257
Giardia lamblia Kinase, AGC PKA 0.004 0.0294 0.1348
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0221 0.1539
Brugia malayi casein kinase 1, delta 0.0052 0.045 0.0466
Loa Loa (eye worm) hypothetical protein 0.004 0.0289 0.0307
Entamoeba histolytica p21-activated kinase 0.0026 0.0116 0.0735
Entamoeba histolytica casein kinase 1, putative 0.0052 0.045 0.3114
Giardia lamblia Kinase, CMGC CDK 0.0058 0.0526 0.3113
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0526 0.0558
Entamoeba histolytica PH domain containing protein kinase, putative 0.004 0.0294 0.2001
Echinococcus granulosus nervana 2 0.0032 0.0191 0.0212
Mycobacterium ulcerans hypothetical protein 0.0023 0.0076 0.0234
Entamoeba histolytica protein kinase, putative 0.0074 0.0727 0.5091
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0086 0.0075
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0024 0.0091 0.0097
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.1831 0.1941
Brugia malayi glutaminase DH11.1 0.0267 0.3223 0.341
Echinococcus granulosus aurora kinase A 0.0074 0.0727 0.0846
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0518 0.0599
Entamoeba histolytica PH domain containing protein kinase, putative 0.004 0.0294 0.2001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0405 0.0418
Loa Loa (eye worm) hypothetical protein 0.005 0.0423 0.0449
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0221 0.021
Brugia malayi Protein kinase domain containing protein 0.0058 0.0526 0.0547
Echinococcus multilocularis protein kinase c epsilon type 0.0024 0.0091 0.008
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0221 0.021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0221 0.0234
Echinococcus granulosus intermediate filament protein 0.0026 0.0117 0.0125
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0018 0.0013 0.0002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0086 0.0075
Brugia malayi Tyrosine-protein kinase abl-1 0.0149 0.1707 0.18
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0076 0.0234
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0076 0.0234
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.004 0.0294 0.0334
Echinococcus granulosus nervana 2 0.0032 0.0191 0.0212
Brugia malayi Hr1 repeat family protein 0.0024 0.0091 0.0085
Trichomonas vaginalis STE family protein kinase 0.0026 0.0116 0.0321
Trichomonas vaginalis CK1 family protein kinase 0.0052 0.045 0.1362
Trypanosoma cruzi rac serine-threonine kinase, putative 0.004 0.0294 0.124
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0242 0.2558
Echinococcus multilocularis Immunoglobulin 0.004 0.0289 0.0278
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0086 0.0089
Schistosoma mansoni Neurotrimin precursor (hNT) 0.004 0.0289 0.0306
Trichomonas vaginalis STE family protein kinase 0.0026 0.0116 0.0321
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0242 0.0232
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.004 0.0294 0.2049
Plasmodium falciparum protein kinase, putative 0.0127 0.1416 0.9875
Loa Loa (eye worm) AUR protein kinase 0.0074 0.0727 0.0771
Echinococcus granulosus tyrosine protein kinase Src42A 0.0024 0.0086 0.0089
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0405 0.0418
Echinococcus multilocularis cyclin dependent kinase 0.0058 0.0526 0.0516
Echinococcus granulosus cyclin dependent kinase 1 0.0058 0.0526 0.0609
Echinococcus granulosus protein kinase c iota type 0.0024 0.0091 0.0094
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0232 0.1564
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0091 0.0243
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0024 0.0086 0.0075
Echinococcus multilocularis basement membrane specific heparan sulfate 0.004 0.0289 0.0278
Trypanosoma cruzi casein kinase, putative 0.0052 0.045 0.4396
Entamoeba histolytica protein kinase, putative 0.0026 0.0116 0.0735
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0032 0.0191 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0091 0.0096
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.1533
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0011 0.0011
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0518 0.0508
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0018 0.0013 0.0014
Brugia malayi cell division control protein 2 homolog 0.0058 0.0526 0.0547
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.1533
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0232 0.0684
Echinococcus multilocularis p2X purinoceptor 4 0.0082 0.0836 0.0826
Schistosoma mansoni hypothetical protein 0.0033 0.0206 0.0218
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0117
Echinococcus granulosus tyrosine protein kinase Lyn 0.0032 0.019 0.0211
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0221 0.1539
Echinococcus multilocularis cyclin dependent kinase 5 0.0058 0.0526 0.0516
Schistosoma mansoni hypothetical protein 0.003 0.0163 0.0172
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0018 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0117 0.0124
Onchocerca volvulus 0.0052 0.045 0.4212
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0204 0.2407 0.2399
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0232 0.0684
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0221 0.0248
Trichomonas vaginalis STE family protein kinase 0.0128 0.1434 0.4428
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0074 0.0727 0.5091
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0074 0.0727 0.0846
Loa Loa (eye worm) glutaminase 0.0267 0.3223 0.3418
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0024 0.0086 0.0075
Entamoeba histolytica cell division protein kinase 2, putative 0.0058 0.0526 0.3659
Brugia malayi hypothetical protein 0.004 0.0289 0.0295
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0043 0.0328 0.0374
Echinococcus multilocularis calcium dependent protein kinase 0.0026 0.0118 0.0107
Loa Loa (eye worm) AUR protein kinase 0.0074 0.0727 0.0771
Echinococcus granulosus geminin 0.0165 0.1913 0.2247
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0727 0.2226
Trichomonas vaginalis AGC family protein kinase 0.0128 0.1434 0.4428
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0242 0.5
Schistosoma mansoni tyrosine kinase 0.0024 0.0088 0.0093
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0024 0.0086 0.0075
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0747 0.943 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0393 0.0416
Plasmodium vivax casein kinase 1, putative 0.0052 0.045 0.3138
Echinococcus granulosus serine/threonine protein kinase 0.004 0.0294 0.0334
Echinococcus multilocularis cyclin dependent kinase 1 0.0058 0.0526 0.0516
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0091 0.0096
Brugia malayi Cam kinase protein 1 0.0034 0.0221 0.0223
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0221 0.1539
Brugia malayi jmjC domain containing protein 0.0057 0.0518 0.0538
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0242 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0076 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0091 0.0096
Brugia malayi protein kinase C II. 0.0024 0.0091 0.0085
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0074 0.0727 0.5091
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0542 0.0575
Trypanosoma brucei cdc2-related kinase 3 0.0058 0.0526 0.6034
Echinococcus granulosus casein kinase I alpha 0.0052 0.045 0.0519
Schistosoma mansoni serine/threonine kinase 0.0024 0.0091 0.0096
Schistosoma mansoni alpha glucosidase 0.0035 0.0232 0.0246
Echinococcus granulosus Immunoglobulin 0.004 0.0289 0.0328
Schistosoma mansoni protein kinase 0.0074 0.0727 0.0771
Giardia lamblia Kinase, NEK 0.0128 0.1434 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0076 0.0446
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0086 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0012
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0221 0.021
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0024 0.0086 0.0075
Brugia malayi Protein kinase domain containing protein 0.0024 0.0091 0.0085
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0086 0.0089
Brugia malayi Inositol-1 0.0036 0.0242 0.0246
Echinococcus multilocularis serine:threonine protein kinase N2 0.0024 0.0091 0.008
Plasmodium falciparum serine/threonine protein kinase, putative 0.0074 0.0727 0.5072
Echinococcus multilocularis nervana 2 0.0032 0.0191 0.018
Loa Loa (eye worm) AGC/PKN protein kinase 0.0024 0.0091 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0266 0.0789
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0221 0.1539
Brugia malayi intermediate filament protein 0.0026 0.0117 0.0112
Schistosoma mansoni protein kinase 0.0034 0.0221 0.0234
Onchocerca volvulus 0.0044 0.0347 0.3052
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0024 0.0091 0.008
Echinococcus granulosus protein kinase C gamma type 0.0024 0.0091 0.0094
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0232 0.2407
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0194 0.3569
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0221 0.0223
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0393 0.1183
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.1533
Echinococcus multilocularis c src tyrosine kinase 0.0024 0.0086 0.0075
Brugia malayi P21-Rho-binding domain containing protein 0.0018 0.0013 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0232 0.0684
Schistosoma mansoni serine/threonine-protein kinase 0.004 0.0294 0.0311
Toxoplasma gondii casein kinase I 0.0052 0.045 0.189
Trypanosoma cruzi casein kinase, putative 0.0052 0.045 0.4396
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0518 0.0599
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0232 0.0222
Echinococcus granulosus tyrosine protein kinase ABL1 0.0258 0.3111 0.3662
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0076 0.0068
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0013
Brugia malayi Protein kinase domain containing protein 0.0414 0.5132 0.5437
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0044 0.0347 0.2312
Echinococcus multilocularis nervana 2 0.0032 0.0191 0.018
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0018 0.0014 0.0008
Brugia malayi MH2 domain containing protein 0.0116 0.1282 0.1349
Trypanosoma cruzi rac serine-threonine kinase, putative 0.004 0.0294 0.124
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0242 0.0715
Trypanosoma cruzi aurora B kinase, putative 0.0074 0.0727 1
Giardia lamblia Kinase, CMGC CDK 0.0058 0.0526 0.3113
Toxoplasma gondii AGC kinase 0.0056 0.0505 0.2343
Echinococcus granulosus PAK box P21 Rho binding 0.0018 0.0013 0.0002
Schistosoma mansoni nck2/grb4 0.0018 0.0011 0.0011
Echinococcus multilocularis tyrosine protein kinase Abl 0.0116 0.1281 0.1272
Trypanosoma cruzi cdc2-related kinase 3 0.0058 0.0526 0.594
Echinococcus granulosus neuroglian 0.0042 0.0319 0.0364
Brugia malayi serine/threonine-protein kinase PAK 7 0.0222 0.2644 0.2795
Echinococcus multilocularis PAK box P21 Rho binding 0.0018 0.0013 0.0002
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0048 0.0403 0.0427
Echinococcus granulosus tyrosine protein kinase Src64B 0.0024 0.0086 0.0089
Echinococcus multilocularis protein kinase c iota type 0.0024 0.0091 0.008
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0024 0.0086 0.0091
Brugia malayi serine/threonine protein kinase 6 0.0074 0.0727 0.0761
Entamoeba histolytica protein kinase, putative 0.0127 0.1416 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0232 0.1564
Echinococcus multilocularis casein kinase i 0.0052 0.045 0.044
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0221 0.1539
Giardia lamblia Aurora kinase 0.0074 0.0727 0.4638
Brugia malayi jmjC domain containing protein 0.0057 0.0518 0.0538
Echinococcus multilocularis cyclin g associated kinase 0.0077 0.0774 0.0764
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0078 0.0779 0.0769
Giardia lamblia Kinase, CK1 Casein kinase 0.0052 0.045 0.2533
Loa Loa (eye worm) TK/ABL protein kinase 0.0258 0.3111 0.3299
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0052 0.045 0.0477
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0024 0.0086 0.0075
Echinococcus granulosus serine:threonine protein kinase 0.0048 0.0393 0.0451
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0058 0.0526 0.0609
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0242 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0779 0.0826
Echinococcus multilocularis lamin dm0 0.0026 0.0117 0.0106
Loa Loa (eye worm) AGC/NDR protein kinase 0.0024 0.0091 0.0097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.008
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0058 0.0526 0.0558
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0242 0.0199
Loa Loa (eye worm) hypothetical protein 0.0045 0.0358 0.0379
Loa Loa (eye worm) hypothetical protein 0.0049 0.0405 0.043
Echinococcus granulosus p2X purinoceptor 4 0.0082 0.0836 0.0975
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0232 0.0684
Schistosoma mansoni protein kinase 0.0052 0.045 0.0477
Echinococcus granulosus cyclin g associated kinase 0.0077 0.0774 0.0902
Trypanosoma brucei aurora B kinase 0.0074 0.0727 1
Mycobacterium ulcerans glutaminase 0.0267 0.3223 1
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0013
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0127 0.1416 0.1502
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0076 0.0068
Trypanosoma brucei casein kinase I, isoform 2 0.0052 0.045 0.4526
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0727 0.2226
Brugia malayi Protein kinase domain containing protein 0.0077 0.0774 0.0811
Trichomonas vaginalis STE family protein kinase 0.0127 0.1416 0.4372
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0024 0.0086 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1282 0.1359
Leishmania major protein kinase, putative 0.0074 0.0727 1
Entamoeba histolytica protein kinase, putative 0.0056 0.0505 0.3506
Brugia malayi Fibronectin type III domain containing protein 0.004 0.0289 0.0295
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0013
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0414 0.5132 0.5442
Echinococcus multilocularis serine:threonine protein kinase 38 0.0024 0.0091 0.008
Schistosoma mansoni protein kinase 0.0026 0.0116 0.0123
Schistosoma mansoni alpha-glucosidase 0.0137 0.1545 0.1638
Schistosoma mansoni serine/threonine kinase 0.0038 0.0266 0.0282
Trichomonas vaginalis CK1 family protein kinase 0.0052 0.045 0.1362
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.008
Trichomonas vaginalis glutaminase, putative 0.0267 0.3223 1
Echinococcus granulosus cyclin dependent kinase 5 0.0058 0.0526 0.0609
Onchocerca volvulus 0.0092 0.0965 1
Echinococcus multilocularis hypothetical protein 0.003 0.0163 0.0152
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0018 0.0011 0.0011
Plasmodium vivax protein kinase Crk2 0.0058 0.0526 0.367
Loa Loa (eye worm) hypothetical protein 0.004 0.0289 0.0307
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0518 0.0549
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0091 0.0243
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0026 0.0116 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0526 0.0558
Entamoeba histolytica cell division protein kinase 2, putative 0.0058 0.0526 0.3659
Echinococcus granulosus lamin dm0 0.0026 0.0117 0.0125
Loa Loa (eye worm) hypothetical protein 0.004 0.0289 0.0307
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0024 0.0091 0.008
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0076 0.1394
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0117 0.0124
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0078 0.0779 0.0907
Toxoplasma gondii aurora kinase 0.0074 0.0727 0.4175
Schistosoma mansoni tyrosine kinase 0.0024 0.0086 0.0091
Entamoeba histolytica protein kinase, putative 0.0056 0.0505 0.3506
Brugia malayi casein kinase I 0.0052 0.045 0.0466
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0232 0.0235
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0026 0.0116 0.0124
Loa Loa (eye worm) NAK/GAK protein kinase 0.0077 0.0774 0.0821
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0014
Brugia malayi Tyrosine-protein kinase abl-1 0.0116 0.1281 0.1349
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0091 0.0096
Trypanosoma brucei cdc2-related kinase 1 0.0058 0.0526 0.6034
Trypanosoma cruzi casein kinase, putative 0.0052 0.045 0.4396
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0024 0.0086 0.0089
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0026 0.0116 0.0105
Echinococcus multilocularis aurora kinase A 0.0074 0.0727 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.045 0.0477
Giardia lamblia Kinase, NEK 0.0128 0.1434 1
Echinococcus granulosus serine threonine protein kinase 0.0127 0.1416 0.166
Loa Loa (eye worm) hypothetical protein 0.004 0.0289 0.0307
Echinococcus multilocularis casein kinase I alpha 0.0052 0.045 0.044
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0078 0.0779 0.0907
Echinococcus granulosus calcium activated potassium channel 0.0038 0.0266 0.0301
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0542 0.1682
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0086 0.0075
Loa Loa (eye worm) hypothetical protein 0.0033 0.0206 0.0219
Plasmodium falciparum casein kinase 1 0.0052 0.045 0.3138
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0727 0.2226
Loa Loa (eye worm) hypothetical protein 0.0045 0.0358 0.0379
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0221 0.0647
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0048 0.0393 0.0416
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0779 0.0826
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0018 0.0011 0.0012
Schistosoma mansoni nephrin 0.0042 0.0319 0.0338
Schistosoma mansoni tyrosine kinase 0.0024 0.0086 0.0091
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0242 0.0715
Brugia malayi Protein kinase domain containing protein 0.0056 0.0505 0.0524
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1831 0.1822
Entamoeba histolytica protein kinase, putative 0.0056 0.0505 0.3506
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.008
Brugia malayi Protein kinase domain containing protein 0.0038 0.0266 0.0271
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0018 0.0013 0.0002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0117 0.0124
Trypanosoma cruzi casein kinase, putative 0.0052 0.045 0.4396
Brugia malayi serine/threonine-protein kinase 6 0.0074 0.0727 0.0761
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0128 0.1434 1
Schistosoma mansoni P2X receptor subunit 0.0082 0.0836 0.0886
Echinococcus granulosus serine:threonine protein kinase N2 0.0024 0.0091 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1416 0.1502
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0076 0.0234
Echinococcus granulosus Protein kinase C brain isozyme 0.0024 0.0091 0.0094
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0221 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.1533
Entamoeba histolytica protein kinase, putative 0.0034 0.0221 0.148
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0024 0.0091 0.0097
Loa Loa (eye worm) AUR protein kinase 0.0074 0.0727 0.0771
Entamoeba histolytica protein kinase, putative 0.0026 0.0116 0.0735
Brugia malayi WH1 domain containing protein 0.0018 0.0013 0.0002
Leishmania major protein kinase, putative 0.0034 0.0221 0.2227
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.8477 0.8989
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0206 0.0207
Schistosoma mansoni protein kinase 0.0026 0.0116 0.0123
Schistosoma mansoni vesicular amine transporter 0.004 0.0289 0.0306
Entamoeba histolytica protein kinase, putative 0.0018 0.0014 0.0008
Brugia malayi P21-Rho-binding domain containing protein 0.0018 0.0013 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0232 0.0684
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0076 0.0068
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0011 0.0011
Echinococcus granulosus casein kinase i 0.0052 0.045 0.0519
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0024 0.0091 0.0097
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0289 0.0295
Echinococcus granulosus casein kinase I delta 0.0052 0.045 0.0519
Loa Loa (eye worm) inositol-1 0.0036 0.0242 0.0257
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0232 0.0262
Giardia lamblia Kinase, NEK 0.0128 0.1434 1
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0526 0.16
Echinococcus granulosus casein kinase I alpha 0.0052 0.045 0.0519
Schistosoma mansoni P2X receptor subunit 0.0082 0.0836 0.0886
Onchocerca volvulus 0.0026 0.0117 0.0462
Trichomonas vaginalis STE family protein kinase 0.0026 0.0116 0.0321
Entamoeba histolytica protein kinase, putative 0.0074 0.0727 0.5091
Schistosoma mansoni protein kinase 0.0026 0.0116 0.0123
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0242 0.1634
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0774 0.0821
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0542 0.0532
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0221 0.0234
Schistosoma mansoni glutaminase 0.0267 0.3223 0.3417
Loa Loa (eye worm) AGC/AKT protein kinase 0.0056 0.0505 0.0536
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0091 0.0243
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0024 0.0086 0.0075
Echinococcus granulosus protein kinase c epsilon type 0.0024 0.0091 0.0094
Echinococcus multilocularis PAK box P21 Rho binding 0.0026 0.0116 0.0105
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0024 0.0091 0.0097
Trypanosoma cruzi casein kinase, putative 0.0052 0.045 0.4396
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0542 0.7158
Echinococcus multilocularis calcium activated potassium channel 0.0038 0.0266 0.0255
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0052 0.045 0.0477
Entamoeba histolytica protein kinase, putative 0.0026 0.0116 0.0735
Entamoeba histolytica protein kinase , putative 0.0074 0.0727 0.5091
Echinococcus granulosus lamin 0.0026 0.0117 0.0125
Trypanosoma cruzi cdc2-related kinase 1 0.0058 0.0526 0.594
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.004 0.0294 0.0283
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0221 0.0248
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0058 0.0526 0.6917
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0024 0.0091 0.008
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0194 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0242 0.0426
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0026 0.0116 0.0124
Trichomonas vaginalis STE family protein kinase 0.0026 0.0116 0.0321
Echinococcus multilocularis serine threonine protein kinase 0.0127 0.1416 0.1407
Echinococcus granulosus Glutaredoxin protein 5 0.0032 0.0191 0.0212
Trichomonas vaginalis STE family protein kinase 0.0026 0.0116 0.0321
Schistosoma mansoni hypothetical protein 0.0165 0.1913 0.2028
Schistosoma mansoni tyrosine kinase 0.0248 0.2977 0.3157
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0232 0.0684
Schistosoma mansoni tyrosine kinase 0.0024 0.0086 0.0091
Echinococcus multilocularis rac serine:threonine kinase 0.004 0.0294 0.0283
Brugia malayi STAT protein, DNA binding domain containing protein 0.0136 0.1537 0.1621
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0542 0.1682
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0056 0.0505 0.0536
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0232 0.0684
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.8477 0.8475
Echinococcus multilocularis Immunoglobulin 0.004 0.0289 0.0278
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0526 0.16
Brugia malayi Protein kinase domain 0.0026 0.0116 0.0112
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0204 0.2407 0.2831
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0024 0.0091 0.008
Echinococcus multilocularis casein kinase I alpha 0.0052 0.045 0.044
Trichomonas vaginalis CK1 family protein kinase 0.0052 0.045 0.1362
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0542 0.2649
Loa Loa (eye worm) glutaminase 2 0.0267 0.3223 0.3418
Loa Loa (eye worm) STAT protein 0.0136 0.1537 0.163
Echinococcus granulosus defective proboscis extension response 0.004 0.0289 0.0328
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0024 0.0091 0.0094
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0232 0.0246
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0058 0.0526 0.2519
Echinococcus multilocularis serine threonine protein kinase 0.0024 0.0091 0.008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0518 0.0549
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.0011 0.0012
Schistosoma mansoni atypical protein kinase C 0.0024 0.0091 0.0096
Loa Loa (eye worm) hypothetical protein 0.004 0.0289 0.0307
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0727 0.0771
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0232 0.0684
Trypanosoma brucei glucosidase, putative 0.0035 0.0232 0.0231
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0076 0.0446
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0074 0.0727 0.5072
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0024 0.0091 0.0094
Loa Loa (eye worm) hypothetical protein 0.0098 0.1047 0.111
Echinococcus granulosus casein kinase I alpha 0.0052 0.045 0.0519
Schistosoma mansoni lamin 0.0026 0.0117 0.0123
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0518 0.0549
Leishmania major casein kinase, putative 0.0052 0.045 0.5745
Echinococcus granulosus cyclin dependent kinase 0.0058 0.0526 0.0609
Schistosoma mansoni lamin 0.0026 0.0117 0.0123
Echinococcus granulosus roundabout 2 0.0045 0.0358 0.041
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.1831 0.1932
Schistosoma mansoni intermediate filament proteins 0.0026 0.0117 0.0123
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0542 1
Echinococcus multilocularis geminin 0.0165 0.1913 0.1904
Entamoeba histolytica casein kinase, putative 0.0052 0.045 0.3114
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0024 0.0086 0.0089
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0117 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0091 0.0096
Schistosoma mansoni inositol monophosphatase 0.0036 0.0242 0.0257
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1282 0.1359
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.1831 0.2149
Schistosoma mansoni P2X receptor subunit 0.0082 0.0836 0.0886
Echinococcus multilocularis serine:threonine protein kinase N2 0.0024 0.0091 0.008
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0074 0.0727 0.0717
Echinococcus multilocularis Glutaredoxin protein 5 0.0032 0.0191 0.018
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0024 0.0091 0.0094
Brugia malayi SRC-1 0.0024 0.0086 0.008
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0221 0.0234
Brugia malayi Kinase associated domain 1 family protein 0.003 0.0163 0.0161
Echinococcus multilocularis neuroglian 0.0042 0.0319 0.0309
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0076 0.1394
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0542 0.0575
Echinococcus multilocularis casein kinase I delta 0.0052 0.045 0.044
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0127 0.1416 0.9875
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0052 0.045 0.4396

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = -6.72 Antagonist activity at human recombinant P2X7 receptor ChEMBL. 17482819
IC50 (binding) = 6.72 Antagonist activity at P2X7 receptor (unknown origin) ChEMBL. 24314880
Log IC50 (functional) = 6.72 Antagonist activity at human recombinant P2X7 receptor ChEMBL. 17482819

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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