TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 312.406 | Formula: C19H24N2O2
H donors: 2 H acceptors: 1 LogP: 3.37 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1c[nH]cc1)NC[C@@H]1CC[C@@H](CC1)COc1ccccc1
InChi: 1S/C19H24N2O2/c22-19(17-10-11-20-13-17)21-12-15-6-8-16(9-7-15)14-23-18-4-2-1-3-5-18/h1-5,10-11,13,15-16,20H,6-9,12,14H2,(H,21,22)/t15-,16+
InChiKey: UFDWLAUWNXEFBP-IYBDPMFKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Glutamate [NMDA] receptor subunit epsilon 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	glutamate NMDA receptor subunit	Get druggable targets OG5_129290	All targets in OG5_129290
Schistosoma mansoni	glutamate receptor NMDA	Get druggable targets OG5_129290	All targets in OG5_129290
Schistosoma japonicum	ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative	Get druggable targets OG5_129290	All targets in OG5_129290
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	Get druggable targets OG5_129290	All targets in OG5_129290

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0032	0.0008	0.0002
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0986	0.1622	0.4582
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Schistosoma mansoni	hypothetical protein	0.0275	0.0419	0.0413
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0275	0.0419	0.0419
Echinococcus granulosus	neuropeptide receptor	0.0275	0.0419	0.0435
Brugia malayi	ancient conserved domain protein 2	0.0123	0.0162	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0248	0.0373	0.0373
Schistosoma mansoni	biogenic amine receptor	0.0275	0.0419	0.0413
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0207	0.0304	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0032	0.0008	0.0002
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0014	0.0008
Schistosoma mansoni	amine GPCR	0.0275	0.0419	0.0413
Mycobacterium ulcerans	hypothetical protein	0.0123	0.0162	0.0293
Echinococcus granulosus	biogenic amine 5HT receptor	0.2994	0.5022	0.5261
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0275	0.0419	0.0433
Echinococcus granulosus	orexin receptor type 2	0.0275	0.0419	0.0435
Loa Loa (eye worm)	G-protein coupled receptor	0.0275	0.0419	0.0419
Trypanosoma cruzi	GMP reductase	0.2076	0.3468	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Loa Loa (eye worm)	IMP dehydrogenase 1	0.2076	0.3468	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0162	0.0162
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0275	0.0419	0.0433
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0207	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Plasmodium vivax	hypothetical protein, conserved	0.0207	0.0304	0.0915
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.2076	0.3468	1
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0064	0.0062	0.0056
Echinococcus granulosus	tm gpcr rhodopsin	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0207	0.0304	0.0298
Onchocerca volvulus		0.0275	0.0419	0.2052
Schistosoma mansoni	hypothetical protein	0.0275	0.0419	0.0413
Brugia malayi	CLC chloride channel protein	0.0123	0.0162	0.0156
Loa Loa (eye worm)	hypothetical protein	0.122	0.2019	0.2019
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0008	0.0004
Schistosoma mansoni	retinoic acid receptor RXR	0.0032	0.0008	0.0002
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0275	0.0419	0.0435
Echinococcus granulosus	neuropeptide receptor A26	0.0275	0.0419	0.0435
Brugia malayi	ancient conserved domain protein 4	0.0123	0.0162	0.0156
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0207	0.0304	0.0312
Echinococcus granulosus	tm gpcr rhodopsin	0.0275	0.0419	0.0435
Schistosoma mansoni	lamin	0.0049	0.0036	0.003
Onchocerca volvulus	Protein ultraspiracle homolog	0.0032	0.0008	0.0008
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0032	0.0008	0.0004
Schistosoma mansoni	sodium/chloride dependent transporter	0.0207	0.0304	0.0298
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0032	0.0008	0.0002
Toxoplasma gondii	hypothetical protein	0.0207	0.0304	0.086
Schistosoma mansoni	hypothetical protein	0.0094	0.0113	0.0107
Echinococcus multilocularis	g protein coupled receptor	0.0275	0.0419	0.0433
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.2076	0.3468	0.3464
Loa Loa (eye worm)	GMP reductase	0.0863	0.1414	0.1414
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0275	0.0419	0.0433
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0275	0.0419	0.0433
Schistosoma mansoni	amine GPCR	0.0275	0.0419	0.0413
Brugia malayi	Serotonin receptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	serotonin transporter b	0.122	0.2019	0.2019
Schistosoma mansoni	chloride channel protein	0.0123	0.0162	0.0156
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0304	0.0304
Loa Loa (eye worm)	chloride channel protein 7	0.0123	0.0162	0.0162
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0275	0.0419	0.0419
Echinococcus granulosus	somatostatin receptor	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0032	0.0008	0.0002
Echinococcus granulosus	neuropeptide FF receptor 2	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0008	0.0008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0275	0.0419	0.0433
Schistosoma mansoni	transcription factor LCR-F1	0.0066	0.0064	0.0058
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0123	0.0162	0.0163
Schistosoma mansoni	jumonji domain containing protein	0.0062	0.0058	0.0051
Echinococcus multilocularis	sex peptide receptor	0.0275	0.0419	0.0433
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0008	0.0002
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.109	0.1798	0.5099
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0032	0.0008	0.0004
Brugia malayi	Voltage gated chloride channel family protein	0.0123	0.0162	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Brugia malayi	CBS domain containing protein	0.0123	0.0162	0.0156
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0207	0.0304	0.0298
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0275	0.0419	0.0413
Brugia malayi	neuropeptide F receptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	norepinephrine transporter	0.122	0.2019	0.2019
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0032	0.0008	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0275	0.0419	0.0435
Leishmania major	inosine-5-monophosphate dehydrogenase	0.2076	0.3468	1
Echinococcus multilocularis	neuropeptide receptor	0.0275	0.0419	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus multilocularis	serotonin receptor	0.2994	0.5022	0.526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0275	0.0419	0.0413
Brugia malayi	photoreceptor-specific nuclear receptor	0.0032	0.0008	0.0002
Echinococcus granulosus	lamin	0.0049	0.0036	0.0034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0275	0.0419	0.0433
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0275	0.0419	0.0433
Onchocerca volvulus		0.0275	0.0419	0.2052
Onchocerca volvulus		0.0275	0.0419	0.2052
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0008	0.0002
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0863	0.1414	0.1408
Echinococcus multilocularis	musashi	0.0049	0.0036	0.0032
Brugia malayi	nuclear hormone receptor	0.0032	0.0008	0.0002
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0207	0.0304	0.086
Onchocerca volvulus		0.0275	0.0419	0.2052
Schistosoma mansoni	neuropeptide receptor	0.0275	0.0419	0.0413
Brugia malayi	putative neuropeptide receptor	0.0275	0.0419	0.0413
Schistosoma mansoni	hypothetical protein	0.0066	0.0064	0.0058
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0275	0.0419	0.0413
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0275	0.0419	0.0435
Loa Loa (eye worm)	loechrig isoform VII	0.0123	0.0162	0.0162
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Brugia malayi	follicle stimulating hormone receptor	0.0275	0.0419	0.0413
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.2076	0.3468	1
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0304	0.0304
Onchocerca volvulus	Bile acid receptor homolog	0.0032	0.0008	0.0008
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0032	0.0008	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0008	0.0008
Toxoplasma gondii	CBS domain-containing protein	0.0123	0.0162	0.045
Schistosoma mansoni	intermediate filament proteins	0.0049	0.0036	0.003
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0064	0.0062	0.0058
Loa Loa (eye worm)	G-protein coupled receptor	0.0275	0.0419	0.0419
Echinococcus multilocularis	neuropeptide receptor A26	0.0275	0.0419	0.0433
Schistosoma mansoni	hypothetical protein	0.0178	0.0254	0.0248
Schistosoma mansoni	hypothetical protein	0.0036	0.0014	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Brugia malayi	G-protein coupled receptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	intermediate filament protein	0.0049	0.0036	0.0036
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0008	0.0002
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0275	0.0419	0.0433
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0275	0.0419	0.0433
Schistosoma mansoni	protein kinase subunit gamma	0.0123	0.0162	0.0156
Echinococcus multilocularis	orexin receptor type 2	0.0275	0.0419	0.0433
Onchocerca volvulus	Putative GMP reductase	0.0863	0.1414	0.6993
Plasmodium falciparum	transporter, putative	0.0207	0.0304	0.0458
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0863	0.1414	0.1408
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0275	0.0419	0.0413
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0275	0.0419	0.0433
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0275	0.0419	0.0413
Echinococcus granulosus	intermediate filament protein	0.0049	0.0036	0.0034
Toxoplasma gondii	hypothetical protein	0.0207	0.0304	0.086
Loa Loa (eye worm)	solute carrier family 6 member 4	0.122	0.2019	0.2019
Mycobacterium tuberculosis	Hypoxic response protein 1 Hrp1	0.0123	0.0162	0.0293
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0008	0.0002
Onchocerca volvulus		0.0207	0.0304	0.1479
Echinococcus multilocularis	neuropeptide Y receptor	0.0275	0.0419	0.0433
Echinococcus multilocularis	fmrfamide receptor	0.0275	0.0419	0.0433
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0275	0.0419	0.0413
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Schistosoma mansoni	adenoreceptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0035	0.0035
Toxoplasma gondii	chloride transporter, chloride channel (ClC) family protein	0.0123	0.0162	0.045
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0008	0.0008
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0123	0.0162	0.0466
Echinococcus multilocularis	H(+):Cl() exchange transporter 4	0.0123	0.0162	0.0163
Brugia malayi	Dopamine receptor protein 1	0.0275	0.0419	0.0413
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0008	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0123	0.0162	0.0293
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0032	0.0008	0.0004
Schistosoma mansoni	hypothetical protein	0.0275	0.0419	0.0413
Echinococcus granulosus	g protein coupled receptor	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0008	0.0008
Loa Loa (eye worm)	steroid hormone receptor	0.0032	0.0008	0.0008
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.122	0.2019	0.2014
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0008	0.0002
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0275	0.0419	0.0413
Echinococcus multilocularis	neuropeptides capa receptor	0.0275	0.0419	0.0433
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0207	0.0304	0.0298
Entamoeba histolytica	hypothetical protein	0.0066	0.0064	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0275	0.0419	0.0413
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0275	0.0419	0.0433
Schistosoma mansoni	amine GPCR	0.0275	0.0419	0.0413
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0032	0.0008	0.0002
Echinococcus multilocularis	g protein coupled receptor	0.0275	0.0419	0.0433
Schistosoma mansoni	glutamate receptor NMDA	0.0076	0.0081	0.0075
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0275	0.0419	0.0435
Onchocerca volvulus		0.0051	0.0039	0.0162
Onchocerca volvulus		0.0275	0.0419	0.2052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0275	0.0419	0.0435
Trypanosoma brucei	GMP reductase	0.2076	0.3468	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0062	0.0058	0.0056
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0275	0.0419	0.0435
Mycobacterium tuberculosis	Conserved protein	0.0123	0.0162	0.0293
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0066	0.0064	0.0061
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0275	0.0419	0.0435
Echinococcus granulosus	neuropeptides capa receptor	0.0275	0.0419	0.0435
Echinococcus granulosus	neuropeptide Y receptor	0.0275	0.0419	0.0435
Brugia malayi	steroid hormone receptor	0.0032	0.0008	0.0002
Echinococcus granulosus	g protein coupled receptor	0.0275	0.0419	0.0435
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0207	0.0304	0.0298
Onchocerca volvulus		0.0275	0.0419	0.2052
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0218	0.0323	0.0323
Echinococcus multilocularis	neuropeptides capa receptor	0.0275	0.0419	0.0433
Brugia malayi	Melatonin receptor type 1A	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.2994	0.5022	0.5022
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0207	0.0304	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0006	0.0006
Brugia malayi	putative neuropeptide receptor NPR1	0.0275	0.0419	0.0413
Echinococcus granulosus	nmda type glutamate receptor	0.0032	0.0007	0.0003
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0207	0.0304	0.0304
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0123	0.0162	0.0466
Echinococcus granulosus	7tm_1 domain containing protein	0.0275	0.0419	0.0435
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0207	0.0304	0.0312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0275	0.0419	0.0413
Onchocerca volvulus		0.0049	0.0036	0.015
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0032	0.0008	0.0002
Brugia malayi	Serotonin receptor	0.3269	0.5488	0.5485
Trypanosoma cruzi	chloride channel protein, putative	0.0123	0.0162	0.0466
Brugia malayi	Pre-SET motif family protein	0.0218	0.0323	0.0317
Echinococcus granulosus	neuropeptides capa receptor	0.0275	0.0419	0.0435
Schistosoma mansoni	histamine h1 receptor	0.0275	0.0419	0.0413
Schistosoma mansoni	opsin-like receptor	0.0275	0.0419	0.0413
Echinococcus granulosus	serotonin receptor	0.0275	0.0419	0.0435
Echinococcus granulosus	rhodopsin orphan GPCR	0.0275	0.0419	0.0435
Echinococcus granulosus	7TM GPCR rhodopsin	0.0275	0.0419	0.0435
Brugia malayi	chloride channel protein 7	0.0123	0.0162	0.0156
Brugia malayi	hypothetical protein	0.0207	0.0304	0.0298
Brugia malayi	jmjC domain containing protein	0.0062	0.0058	0.0051
Giardia lamblia	Manganese-dependent inorganic pyrophosphatase, putative	0.0123	0.0162	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0275	0.0419	0.0413
Echinococcus granulosus	SNF4:AMP activated protein kinase gamma subunit	0.0123	0.0162	0.0165
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0207	0.0304	0.0298
Echinococcus granulosus	H:Cl exchange transporter 3	0.0123	0.0162	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0123	0.0162	0.0156
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0275	0.0419	0.0413
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0275	0.0419	0.0413
Onchocerca volvulus		0.0032	0.0008	0.0008
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0275	0.0419	0.0433
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0207	0.0304	0.0298
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0275	0.0419	0.0419
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0076	0.0081	0.0081
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0275	0.0419	0.0435
Echinococcus granulosus	rhodopsin orphan GPCR	0.0275	0.0419	0.0435
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0008	0.0002
Echinococcus multilocularis	fmrfamide receptor	0.0275	0.0419	0.0433
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.5664	0.9543	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0275	0.0419	0.0419
Mycobacterium tuberculosis	Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450)	0.0123	0.0162	0.0293
Echinococcus granulosus	hypothetical protein	0.3961	0.6659	0.6977
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0162	0.0162
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.2076	0.3468	0.3631
Onchocerca volvulus		0.0275	0.0419	0.2052
Echinococcus multilocularis	neuropeptide receptor	0.0275	0.0419	0.0433
Schistosoma mansoni	RAR-like nuclear receptor	0.0032	0.0008	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0032	0.0008	0.0002
Echinococcus granulosus	allatostatin A receptor	0.0275	0.0419	0.0435
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0207	0.0304	0.086
Echinococcus multilocularis	G protein coupled receptor 139	0.0275	0.0419	0.0433
Onchocerca volvulus		0.0249	0.0374	0.1828
Mycobacterium ulcerans	cystathionine beta-synthase	0.0123	0.0162	0.0293
Brugia malayi	G-protein coupled receptor	0.0275	0.0419	0.0413
Onchocerca volvulus		0.0275	0.0419	0.2052
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0008	0.0002
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0275	0.0419	0.0413
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.1953	0.3259	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0207	0.0304	0.0312
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0207	0.0304	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus granulosus	serotonin transporter	0.122	0.2019	0.2112
Echinococcus granulosus	neuropeptide Y receptor	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus granulosus	sodium and chloride dependent glycine	0.0207	0.0304	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0062	0.0058	0.0054
Onchocerca volvulus		0.0275	0.0419	0.2052
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0207	0.0304	0.0298
Loa Loa (eye worm)	hypothetical protein	0.5227	0.8802	0.8802
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0008	0.0008
Echinococcus granulosus	AMP activated protein kinase gamma regulatory	0.0123	0.0162	0.0165
Giardia lamblia	Hypothetical protein	0.0123	0.0162	0.5
Onchocerca volvulus		0.0275	0.0419	0.2052
Echinococcus granulosus	ecdysone induced protein 78C	0.0032	0.0008	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0304	0.0304
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0275	0.0419	0.0433
Echinococcus multilocularis	H(+):Cl() exchange transporter 7	0.0123	0.0162	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0042	0.0042
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0032	0.0008	0.0004
Loa Loa (eye worm)	hypothetical protein	0.2994	0.5022	0.5022
Mycobacterium ulcerans	hypothetical protein	0.0123	0.0162	0.0293
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0042	0.0036
Echinococcus multilocularis	nmda type glutamate receptor	0.0032	0.0007	0.0001
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.2076	0.3468	0.363
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0275	0.0419	0.0433
Brugia malayi	Intermediate filament tail domain containing protein	0.0049	0.0036	0.003
Schistosoma mansoni	sodium/chloride dependent transporter	0.0207	0.0304	0.0298
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0207	0.0304	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0008	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0032	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus granulosus	5' AMP activated protein kinase subunit gamma	0.0123	0.0162	0.0165
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0008	0.0002
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0207	0.0304	0.0298
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.2076	0.3468	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0207	0.0304	0.0312
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0207	0.0304	0.0314
Mycobacterium tuberculosis	Conserved protein	0.0123	0.0162	0.0293
Schistosoma mansoni	hypothetical protein	0.0275	0.0419	0.0413
Echinococcus granulosus	g-protein coupled receptor	0.0275	0.0419	0.0435
Echinococcus multilocularis	survival motor neuron protein 1	0.0248	0.0373	0.0385
Loa Loa (eye worm)	TYRA-2 protein	0.0275	0.0419	0.0419
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.1953	0.3259	1
Trypanosoma cruzi	chloride channel protein, putative	0.0123	0.0162	0.0466
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0275	0.0419	0.2052
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0275	0.0419	0.0413
Echinococcus granulosus	geminin	0.0178	0.0254	0.0262
Plasmodium vivax	amine transporter, putative	0.0207	0.0304	0.0915
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0032	0.0008	0.0002
Treponema pallidum	sodium- and chloride- dependent transporter	0.122	0.2019	1
Brugia malayi	Dopamine receptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0032	0.0008	0.0002
Toxoplasma gondii	CBS family protein	0.0123	0.0162	0.045
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0275	0.0419	0.0413
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Schistosoma mansoni	hypothetical protein	0.0051	0.0039	0.0033
Schistosoma mansoni	neuropeptide receptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0032	0.0008	0.0008
Echinococcus multilocularis	allatostatin A receptor	0.0275	0.0419	0.0433
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0077	0.0084	0.0082
Brugia malayi	AKH receptor	0.0275	0.0419	0.0413
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0066	0.0064	0.0063
Echinococcus granulosus	fmrfamide receptor	0.0275	0.0419	0.0435
Trypanosoma cruzi	chloride channel protein, putative	0.0123	0.0162	0.0466
Brugia malayi	ORL1-like opioid receptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.5934	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0008	0.0002
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.1953	0.3259	0.9387
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0275	0.0419	0.0433
Echinococcus granulosus	g protein coupled receptor	0.0275	0.0419	0.0435
Echinococcus granulosus	tm gpcr rhodopsin	0.5664	0.9543	1
Onchocerca volvulus		0.0207	0.0304	0.1479
Echinococcus granulosus	rhodopsin orphan GPCR	0.0275	0.0419	0.0435
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0032	0.0008	0.0008
Schistosoma mansoni	myosin xvIII	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Onchocerca volvulus		0.0275	0.0419	0.2052
Loa Loa (eye worm)	neuropeptide F receptor	0.0275	0.0419	0.0419
Onchocerca volvulus		0.0275	0.0419	0.2052
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus multilocularis	geminin	0.0178	0.0254	0.026
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0032	0.0008	0.0008
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.109	0.1798	0.4951
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0032	0.0008	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0032	0.0008	0.0008
Leishmania major	CBS domain protein, conserved	0.0123	0.0162	0.0293
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0049	0.0036	0.0036
Leishmania major	chloride channel protein, putative	0.0123	0.0162	0.0293
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0275	0.0419	0.0433
Echinococcus multilocularis	conserved hypothetical protein	0.3686	0.6193	0.6487
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0123	0.0162	0.0293
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0275	0.0419	0.0435
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.2725	0.4566	0.4782
Loa Loa (eye worm)	hypothetical protein	0.122	0.2019	0.2019
Schistosoma mansoni	amine GPCR	0.0275	0.0419	0.0413
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.5934	1	1
Schistosoma mansoni	neuropeptide receptor	0.0275	0.0419	0.0413
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0058	0.0051
Toxoplasma gondii	CBS domain-containing protein	0.0123	0.0162	0.045
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0032	0.0008	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus granulosus	G protein coupled receptor 139	0.0275	0.0419	0.0435
Echinococcus multilocularis	ecdysone induced protein 78C	0.0032	0.0008	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0275	0.0419	0.0413
Echinococcus multilocularis	SNF4:AMP activated protein kinase gamma subunit	0.0123	0.0162	0.0163
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0275	0.0419	0.0433
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0032	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0275	0.0419	0.0419
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.122	0.2019	0.2014
Brugia malayi	neuropeptide F receptor	0.0275	0.0419	0.0413
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0008	0.0002
Brugia malayi	RE15519p	0.0275	0.0419	0.0413
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0123	0.0162	0.0156
Schistosoma mansoni	chloride channel protein	0.0123	0.0162	0.0156
Brugia malayi	GnHR receptor homolog	0.0275	0.0419	0.0413
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0275	0.0419	0.0413
Echinococcus multilocularis	serotonin receptor	0.2994	0.5022	0.526
Entamoeba histolytica	hypothetical protein	0.0066	0.0064	0.5
Schistosoma mansoni	coup transcription factor	0.0032	0.0008	0.0002
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0123	0.0162	0.0293
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0032	0.0008	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0162	0.0162
Giardia lamblia	5-AMP-activated protein kinase, gamma-1 subunit	0.0123	0.0162	0.5
Brugia malayi	ecdysteroid receptor	0.0032	0.0008	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0008	0.0002
Brugia malayi	Steroid receptor seven-up type 2	0.0032	0.0008	0.0002
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0207	0.0304	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0032	0.0008	0.0008
Echinococcus granulosus	lysine specific demethylase 5A	0.0062	0.0058	0.0056
Echinococcus multilocularis	dro:myosuppressin receptor	0.0275	0.0419	0.0433
Schistosoma mansoni	opsin-like receptor	0.0275	0.0419	0.0413
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0032	0.0008	0.0002
Echinococcus multilocularis	lamin dm0	0.0049	0.0036	0.0032
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0275	0.0419	0.0413
Brugia malayi	nuclear receptor NHR-88	0.0032	0.0008	0.0002
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.0374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0076	0.0081	0.0079
Toxoplasma gondii	IMP dehydrogenas	0.2076	0.3468	1
Brugia malayi	intermediate filament protein	0.0049	0.0036	0.003
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus multilocularis	lamin	0.0049	0.0036	0.0032
Mycobacterium ulcerans	transcriptional regulator	0.0123	0.0162	0.0293
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0077	0.0084	0.0084
Echinococcus granulosus	dro:myosuppressin receptor	0.0275	0.0419	0.0435
Echinococcus granulosus	biogenic amine 5HT receptor	0.2725	0.4566	0.4783
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0275	0.0419	0.0433
Trypanosoma cruzi	chloride channel protein, putative	0.0123	0.0162	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0162	0.0162
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0008	0.0002
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0039	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0304	0.0304
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.2076	0.3468	0.3464
Onchocerca volvulus		0.0275	0.0419	0.2052
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.0048	0.0048
Schistosoma mansoni	biogenic amine receptor	0.0275	0.0419	0.0413
Leishmania major	guanosine monophosphate reductase	0.2076	0.3468	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.5934	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0008	0.0002
Loa Loa (eye worm)	melatonin receptor type 1A	0.0275	0.0419	0.0419
Echinococcus granulosus	sex peptide receptor	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0275	0.0419	0.0433
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0064	0.0062	0.0056
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0039	0.0033
Echinococcus granulosus	H:Cl exchange transporter 7	0.0123	0.0162	0.0165
Schistosoma mansoni	neuropeptide receptor	0.0275	0.0419	0.0413
Mycobacterium tuberculosis	Conserved protein	0.0123	0.0162	0.0293
Brugia malayi	jmjC domain containing protein	0.0062	0.0058	0.0051
Brugia malayi	loechrig isoform VII	0.0123	0.0162	0.0156
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.2076	0.3468	1
Echinococcus multilocularis	neuropeptide s receptor	0.0275	0.0419	0.0433
Onchocerca volvulus		0.0275	0.0419	0.2052
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus granulosus	neuropeptide receptor	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Schistosoma mansoni	biogenic amine receptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0304	0.0304
Echinococcus granulosus	H:Cl exchange transporter 4	0.0123	0.0162	0.0165
Echinococcus multilocularis	serotonin transporter	0.122	0.2019	0.2111
Onchocerca volvulus		0.0123	0.0162	0.0773
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0123	0.0162	0.0156
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0275	0.0419	0.0413
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0275	0.0419	0.0413
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0275	0.0419	0.0413
Trypanosoma cruzi	GMP reductase	0.2076	0.3468	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0275	0.0419	0.0413
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0275	0.0419	0.0433
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0032	0.0008	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0304	0.0304
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0207	0.0304	0.0314
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0275	0.0419	0.0419
Onchocerca volvulus		0.0275	0.0419	0.2052
Plasmodium falciparum	amino acid transporter, putative	0.0207	0.0304	0.0458
Echinococcus multilocularis	somatostatin receptor	0.0275	0.0419	0.0433
Onchocerca volvulus		0.0275	0.0419	0.2052
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0032	0.0008	0.0002
Brugia malayi	G protein-coupled receptor	0.0275	0.0419	0.0413
Onchocerca volvulus		0.122	0.2019	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0275	0.0419	0.0413
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0275	0.0419	0.0413
Entamoeba histolytica	hypothetical protein	0.0066	0.0064	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0064	0.0062	0.006
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.2076	0.3468	1
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.2076	0.3468	1
Echinococcus multilocularis	g-protein coupled receptor	0.0275	0.0419	0.0433
Onchocerca volvulus		0.0049	0.0036	0.015
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0042	0.0036
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0058	0.0051
Echinococcus multilocularis	lysine specific demethylase 5A	0.0062	0.0058	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0032	0.0008	0.0002
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0032	0.0007	0.0001
Schistosoma mansoni	hypothetical protein	0.0178	0.0254	0.0248
Echinococcus multilocularis	neuropeptide Y receptor	0.0275	0.0419	0.0433
Schistosoma mansoni	neuropeptide f receptor 76f	0.0275	0.0419	0.0413
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0207	0.0304	0.0298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0275	0.0419	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0008	0.0008
Brugia malayi	sulfakinin receptor protein	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Brugia malayi	hypothetical protein	0.0066	0.0064	0.0058
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0275	0.0419	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0304	0.0304
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0986	0.1622	0.4418
Brugia malayi	larval opioid receptor	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Schistosoma mansoni	lamin	0.0049	0.0036	0.003
Leishmania major	chloride channel protein, putative	0.0123	0.0162	0.0293
Echinococcus granulosus	survival motor neuron protein 1	0.0248	0.0373	0.0387
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0032	0.0008	0.0002
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0032	0.0008	0.0008
Echinococcus multilocularis	H(+):Cl() exchange transporter 3	0.0123	0.0162	0.0163
Schistosoma mansoni	biogenic amine (5HT) receptor	0.2725	0.4566	0.4563
Schistosoma mansoni	chloride channel protein	0.0123	0.0162	0.0156
Echinococcus granulosus	neuropeptide s receptor	0.0275	0.0419	0.0435
Onchocerca volvulus		0.0207	0.0304	0.1479
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Loa Loa (eye worm)	chloride channel 3	0.0123	0.0162	0.0162
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0207	0.0304	0.086
Brugia malayi	hypothetical protein	0.0248	0.0373	0.0367
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0275	0.0419	0.0413
Brugia malayi	GMP reductase	0.0863	0.1414	0.1408
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0207	0.0304	0.0298
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.2076	0.3468	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0275	0.0419	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.122	0.2019	0.2019
Schistosoma mansoni	biogenic amine (5HT) receptor	0.2994	0.5022	0.5019
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Brugia malayi	Dopamine receptor protein 2	0.0275	0.0419	0.0413
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0058	0.0058
Schistosoma mansoni	sodium/chloride dependent transporter	0.122	0.2019	0.2014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0275	0.0419	0.0435
Onchocerca volvulus		0.0275	0.0419	0.2052
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0207	0.0304	0.0298
Trypanosoma cruzi	Domain of unknown function DUF21, putative	0.0123	0.0162	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Schistosoma mansoni	neuropeptide F-like receptor	0.0275	0.0419	0.0413
Schistosoma mansoni	opsin-like receptor	0.0275	0.0419	0.0413
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.2076	0.3468	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0123	0.0162	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Schistosoma mansoni	growth hormone secretagogue receptor	0.0275	0.0419	0.0413
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0275	0.0419	0.2052
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0275	0.0419	0.0433
Echinococcus multilocularis	FTZ F1 alpha	0.0032	0.0008	0.0002
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0207	0.0304	0.0312
Leishmania major	hypothetical protein, conserved	0.0123	0.0162	0.0293
Schistosoma mansoni	amine GPCR	0.0275	0.0419	0.0413
Mycobacterium tuberculosis	Probable conserved transmembrane alanine and leucine rich protein	0.0123	0.0162	0.0293
Echinococcus multilocularis	g protein coupled receptor	0.0275	0.0419	0.0433
Giardia lamblia	Manganese-dependent inorganic pyrophosphatase, putative	0.0123	0.0162	0.5
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0006	0.0002
Echinococcus granulosus	FTZ F1 alpha	0.0032	0.0008	0.0004
Brugia malayi	hypothetical protein	0.0275	0.0419	0.0413
Echinococcus granulosus	lamin dm0	0.0049	0.0036	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Echinococcus granulosus	sodium and chloride dependent glycine	0.0207	0.0304	0.0314
Entamoeba histolytica	hypothetical protein	0.0066	0.0064	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0419	0.0419
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0275	0.0419	0.0413

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 84 nM	Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane	ChEMBL.	17766107
Ki (binding)	= 84 nM	Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane	ChEMBL.	17766107

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 459178