Detailed information for compound 459183

Basic information

Technical information
  • TDR Targets ID: 459183
  • Name: 6,7-dichloro-2-methylsulfonyl-3-pyrrolidin-1- ylquinoxaline
  • MW: 346.232 | Formula: C13H13Cl2N3O2S
  • H donors: 0 H acceptors: 4 LogP: 2.98 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc2nc(c(nc2cc1Cl)N1CCCC1)S(=O)(=O)C
  • InChi: 1S/C13H13Cl2N3O2S/c1-21(19,20)13-12(18-4-2-3-5-18)16-10-6-8(14)9(15)7-11(10)17-13/h6-7H,2-5H2,1H3
  • InChiKey: SESXEYFLMZWESX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6,7-dichloro-2-methylsulfonyl-3-pyrrolidin-1-yl-quinoxaline
  • 6,7-dichloro-2-methylsulfonyl-3-(1-pyrrolidinyl)quinoxaline
  • 6,7-dichloro-2-mesyl-3-pyrrolidino-quinoxaline
  • 6,7-dichloro-2-methylsulfonyl-3-1-pyrrolidinylquinoxaline
  • 6,7-dichloro-2-mesyl-3-pyrrolidin-1-yl-quinoxaline

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0207 0.0393 0.0388
Toxoplasma gondii IMP dehydrogenas 0.1582 0.344 1
Echinococcus granulosus somatostatin receptor 0.0207 0.0393 0.0388
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Trypanosoma cruzi GMP reductase 0.1582 0.344 1
Schistosoma mansoni hypothetical protein 0.0041 0.0027 0.0019
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0157 0.0283 0.0281
Onchocerca volvulus 0.0207 0.0393 0.195
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0207 0.0393 0.195
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4544 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0011 0.0011
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.4438 0.9764 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0157 0.0283 0.0281
Brugia malayi GnHR receptor homolog 0.0207 0.0393 0.0394
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0207 0.0393 0.0394
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) chloride channel protein 7 0.0094 0.0144 0.0147
Echinococcus granulosus H:Cl exchange transporter 4 0.0094 0.0144 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0011 0.0002
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0207 0.0393 0.0394
Echinococcus granulosus g protein coupled receptor 0.0207 0.0393 0.0388
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0157 0.0283 0.0281
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0207 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus granulosus neuropeptides capa receptor 0.0207 0.0393 0.0388
Onchocerca volvulus 0.0207 0.0393 0.195
Onchocerca volvulus 0.0207 0.0393 0.195
Schistosoma mansoni alpha-1 adrenergic receptor 0.0207 0.0393 0.0394
Schistosoma mansoni opsin-like receptor 0.0207 0.0393 0.0394
Leishmania major chloride channel protein, putative 0.0094 0.0144 0.0175
Onchocerca volvulus 0.0207 0.0393 0.195
Mycobacterium tuberculosis Conserved protein 0.0094 0.0144 0.0175
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus granulosus neuropeptide receptor 0.0207 0.0393 0.0388
Loa Loa (eye worm) intermediate filament protein 0.0052 0.005 0.0051
Echinococcus granulosus biogenic amine 5HT receptor 0.2214 0.4838 0.4835
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.1582 0.344 0.3518
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.0088 0.0082
Loa Loa (eye worm) TYRA-2 protein 0.0207 0.0393 0.0403
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0011 0.0005
Echinococcus multilocularis musashi 0.0052 0.005 0.0042
Leishmania major CBS domain protein, conserved 0.0094 0.0144 0.0175
Echinococcus granulosus neuropeptides capa receptor 0.0207 0.0393 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0011 0.0002
Schistosoma mansoni hypothetical protein 0.0207 0.0393 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0011 0.0002
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Plasmodium falciparum amino acid transporter, putative 0.0157 0.0283 0.0451
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0207 0.0393 0.0403
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0157 0.0283 0.08
Brugia malayi Dopamine receptor protein 1 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.0513 0.0507
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0207 0.0393 0.0394
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.1488 0.3232 1
Brugia malayi RE15519p 0.0207 0.0393 0.0394
Trichomonas vaginalis set domain proteins, putative 0.0261 0.0514 0.5
Schistosoma mansoni amine GPCR 0.0207 0.0393 0.0394
Schistosoma mansoni hypothetical protein 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0924 0.1981 0.2022
Leishmania major chloride channel protein, putative 0.0094 0.0144 0.0175
Onchocerca volvulus 0.0207 0.0393 0.195
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0079 0.0073
Toxoplasma gondii CBS domain-containing protein 0.0094 0.0144 0.0394
Loa Loa (eye worm) norepinephrine transporter 0.0924 0.1981 0.2029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0207 0.0393 0.0385
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0207 0.0393 0.0394
Brugia malayi Voltage gated chloride channel family protein 0.0094 0.0144 0.0139
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0011 0.0005
Loa Loa (eye worm) hypothetical protein 0.0261 0.0513 0.0525
Loa Loa (eye worm) hypothetical protein 0.3909 0.8593 0.88
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0157 0.0283 1
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Schistosoma mansoni amine GPCR 0.0207 0.0393 0.0394
Mycobacterium ulcerans hypothetical protein 0.0094 0.0144 0.0175
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0157 0.0283 0.0275
Echinococcus granulosus rhodopsin orphan GPCR 0.0207 0.0393 0.0388
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.1582 0.344 0.3435
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0011 0.0002
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0094 0.0144 0.5
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0157 0.0283 0.029
Schistosoma mansoni hypothetical protein 0.0069 0.0088 0.0082
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0207 0.0393 0.0403
Onchocerca volvulus 0.0207 0.0393 0.195
Echinococcus granulosus hypothetical protein 0.3095 0.6789 0.6788
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus multilocularis rhodopsin orphan GPCR 0.0207 0.0393 0.0385
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0157 0.0283 0.0281
Echinococcus granulosus G protein coupled receptor 139 0.0207 0.0393 0.0388
Schistosoma mansoni protein kinase subunit gamma 0.0094 0.0144 0.0139
Onchocerca volvulus 0.0261 0.0514 0.2563
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0157 0.0283 0.0281
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0207 0.0393 0.0388
Onchocerca volvulus 0.0207 0.0393 0.195
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Echinococcus granulosus tm gpcr rhodopsin 0.0207 0.0393 0.0388
Echinococcus granulosus sodium and chloride dependent glycine 0.0157 0.0283 0.0277
Echinococcus multilocularis conserved hypothetical protein 0.2888 0.6332 0.6329
Echinococcus granulosus H:Cl exchange transporter 7 0.0094 0.0144 0.0138
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0011 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0207 0.0393 0.0388
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0157 0.0283 0.0275
Brugia malayi putative neuropeptide receptor NPR1 0.0207 0.0393 0.0394
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0011 0.0002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0207 0.0393 0.0388
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0011 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0027 0.0019
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0207 0.0393 0.0388
Brugia malayi G protein-coupled receptor 0.0207 0.0393 0.0394
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0207 0.0393 0.0394
Echinococcus multilocularis neuropeptide Y receptor 0.0207 0.0393 0.0385
Brugia malayi hypothetical protein 0.0157 0.0283 0.0281
Schistosoma mansoni lamin 0.0052 0.005 0.0043
Leishmania major guanosine monophosphate reductase 0.1582 0.344 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.1582 0.344 0.3436
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0011 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0069 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0207 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Schistosoma mansoni neuropeptide receptor 0.0207 0.0393 0.0394
Schistosoma mansoni opsin-like receptor 0.0207 0.0393 0.0394
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0094 0.0144 0.0147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.0088 0.0083
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0011 0.0005
Brugia malayi AKH receptor 0.0207 0.0393 0.0394
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Schistosoma mansoni neuropeptide receptor 0.0207 0.0393 0.0394
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0094 0.0144 0.0139
Echinococcus granulosus neuropeptide s receptor 0.0207 0.0393 0.0388
Echinococcus granulosus tm gpcr rhodopsin 0.0207 0.0393 0.0388
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0157 0.0283 0.029
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0011 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0011 0.0005
Loa Loa (eye worm) serotonin transporter b 0.0924 0.1981 0.2029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0207 0.0393 0.0385
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.005 0.0051
Toxoplasma gondii hypothetical protein 0.0157 0.0283 0.08
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0207 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0207 0.0393 0.0394
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Brugia malayi ecdysteroid receptor 0.0034 0.0011 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0079 0.0081
Onchocerca volvulus 0.0207 0.0393 0.195
Echinococcus granulosus alpha 1A adrenergic receptor 0.0207 0.0393 0.0388
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus multilocularis sex peptide receptor 0.0207 0.0393 0.0385
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0011 0.0002
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0079 0.0072
Plasmodium vivax amine transporter, putative 0.0157 0.0283 0.0851
Echinococcus multilocularis serotonin transporter 0.0924 0.1981 0.1974
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.1582 0.344 1
Schistosoma mansoni biogenic amine receptor 0.0207 0.0393 0.0394
Echinococcus multilocularis g protein coupled receptor 0.0207 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Mycobacterium ulcerans cystathionine beta-synthase 0.0094 0.0144 0.0175
Entamoeba histolytica hypothetical protein 0.0069 0.0088 0.5
Loa Loa (eye worm) hypothetical protein 0.4438 0.9764 1
Trypanosoma cruzi chloride channel protein, putative 0.0094 0.0144 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0011 0.0002
Echinococcus granulosus g-protein coupled receptor 0.0207 0.0393 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.0207 0.0393 0.0385
Echinococcus multilocularis orexin receptor type 2 0.0207 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.0157 0.0283 0.029
Schistosoma mansoni biogenic amine (5HT) receptor 0.2178 0.476 0.487
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0011 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0207 0.0393 0.0388
Onchocerca volvulus 0.0207 0.0393 0.195
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0011 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0157 0.0283 0.0851
Loa Loa (eye worm) hypothetical protein 0.0157 0.0283 0.029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0207 0.0393 0.0385
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0051
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0157 0.0283 0.0277
Brugia malayi ORL1-like opioid receptor 0.0207 0.0393 0.0394
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0157 0.0283 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0207 0.0393 0.0394
Leishmania major hypothetical protein, conserved 0.0094 0.0144 0.0175
Loa Loa (eye worm) hypothetical protein 0.0094 0.0144 0.0147
Schistosoma mansoni hypothetical protein 0.0187 0.0349 0.0349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0011 0.0011
Echinococcus granulosus lamin 0.0052 0.005 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0011 0.0002
Schistosoma mansoni lamin 0.0052 0.005 0.0043
Brugia malayi loechrig isoform VII 0.0094 0.0144 0.0139
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0085 0.0077
Echinococcus multilocularis neuropeptide receptor 0.0207 0.0393 0.0385
Schistosoma mansoni sodium/chloride dependent transporter 0.0157 0.0283 0.0281
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0079 0.0072
Schistosoma mansoni chloride channel protein 0.0094 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus multilocularis allatostatin A receptor 0.0207 0.0393 0.0385
Echinococcus granulosus serotonin transporter 0.0924 0.1981 0.1977
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0207 0.0393 0.0394
Brugia malayi Melatonin receptor type 1A 0.0207 0.0393 0.0394
Echinococcus granulosus H:Cl exchange transporter 3 0.0094 0.0144 0.0138
Echinococcus granulosus intermediate filament protein 0.0052 0.005 0.0044
Schistosoma mansoni neuropeptide receptor 0.0207 0.0393 0.0394
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0094 0.0144 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0207 0.0393 0.0385
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0207 0.0393 0.0394
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0094 0.0144 0.0175
Brugia malayi jmjC domain containing protein 0.0065 0.0079 0.0072
Echinococcus multilocularis fmrfamide receptor 0.0207 0.0393 0.0385
Schistosoma mansoni amine GPCR 0.0207 0.0393 0.0394
Echinococcus multilocularis geminin 0.0187 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0011 0.0011
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1582 0.344 1
Brugia malayi hypothetical protein 0.0069 0.0088 0.0082
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0094 0.0144 0.0138
Echinococcus granulosus g protein coupled receptor 0.0207 0.0393 0.0388
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0157 0.0283 0.0281
Schistosoma mansoni sodium/chloride dependent transporter 0.0157 0.0283 0.0281
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0011 0.0002
Trypanosoma cruzi chloride channel protein, putative 0.0094 0.0144 0.0417
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0157 0.0283 0.0281
Echinococcus granulosus sodium and chloride dependent glycine 0.0157 0.0283 0.0277
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.1582 0.344 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0157 0.0283 0.0275
Onchocerca volvulus 0.0207 0.0393 0.195
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.0085 0.0079
Loa Loa (eye worm) hypothetical protein 0.2214 0.4838 0.4955
Loa Loa (eye worm) G-protein coupled receptor 0.0207 0.0393 0.0403
Brugia malayi G-protein coupled receptor 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus granulosus neuropeptide FF receptor 2 0.0207 0.0393 0.0388
Loa Loa (eye worm) solute carrier family 6 member 4 0.0924 0.1981 0.2029
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0094 0.0144 0.5
Plasmodium falciparum transporter, putative 0.0157 0.0283 0.0451
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0099 0.0155 0.015
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0157 0.0283 0.0277
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.0513 0.0505
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0094 0.0144 0.0139
Echinococcus granulosus rhodopsin orphan GPCR 0.0207 0.0393 0.0388
Toxoplasma gondii CBS domain-containing protein 0.0094 0.0144 0.0394
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0011 0.0002
Onchocerca volvulus 0.0034 0.0011 0.0011
Brugia malayi chloride channel protein 7 0.0094 0.0144 0.0139
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0094 0.0144 0.0175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0011 0.0002
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0207 0.0393 0.0385
Toxoplasma gondii CBS family protein 0.0094 0.0144 0.0394
Echinococcus multilocularis neuropeptides capa receptor 0.0207 0.0393 0.0385
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0207 0.0393 0.0394
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0207 0.0393 0.0388
Echinococcus granulosus neuropeptide receptor 0.0207 0.0393 0.0388
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0157 0.0283 0.029
Echinococcus granulosus fmrfamide receptor 0.0207 0.0393 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0011 0.0002
Loa Loa (eye worm) melatonin receptor type 1A 0.0207 0.0393 0.0403
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0207 0.0393 0.0403
Onchocerca volvulus 0.0207 0.0393 0.195
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0069 0.0062
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0069 0.0062
Onchocerca volvulus 0.0157 0.0283 0.1391
Brugia malayi intermediate filament protein 0.0052 0.005 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.0207 0.0393 0.0388
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0207 0.0393 0.0385
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0094 0.0144 0.0138
Onchocerca volvulus 0.0052 0.005 0.0211
Echinococcus granulosus geminin 0.0187 0.0349 0.0344
Echinococcus multilocularis G-protein coupled receptor, putative 0.0207 0.0393 0.0385
Schistosoma mansoni opsin-like receptor 0.0207 0.0393 0.0394
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0752 0.16 0.4418
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0094 0.0144 0.0175
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0011 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0011 0.0002
Mycobacterium ulcerans transcriptional regulator 0.0094 0.0144 0.0175
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Mycobacterium ulcerans hypothetical protein 0.0094 0.0144 0.0175
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.005 0.0043
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Schistosoma mansoni neuropeptide f receptor 76f 0.0207 0.0393 0.0394
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0094 0.0144 0.0175
Schistosoma mansoni biogenic amine receptor 0.0207 0.0393 0.0394
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0094 0.0144 0.0135
Loa Loa (eye worm) hypothetical protein 0.0051 0.0048 0.0049
Echinococcus granulosus allatostatin A receptor 0.0207 0.0393 0.0388
Brugia malayi jmjC domain containing protein 0.0065 0.0079 0.0072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0011 0.0005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0157 0.0283 0.0281
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0157 0.0283 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0011 0.0011
Echinococcus granulosus orexin receptor type 2 0.0207 0.0393 0.0388
Schistosoma mansoni survival motor neuron protein 0.0053 0.0053 0.0046
Brugia malayi Tachykinin-like peptides receptor 99D 0.0207 0.0393 0.0394
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0094 0.0144 0.0138
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Schistosoma mansoni sodium/chloride dependent transporter 0.0924 0.1981 0.2022
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Schistosoma mansoni amine GPCR 0.0207 0.0393 0.0394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0011 0.0011
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0831 0.1776 0.5039
Brugia malayi hypothetical protein 0.0261 0.0513 0.0517
Onchocerca volvulus 0.0053 0.0053 0.0227
Echinococcus multilocularis neuropeptide receptor 0.0207 0.0393 0.0385
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0157 0.0283 0.08
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0207 0.0393 0.0394
Schistosoma mansoni hypothetical protein 0.0207 0.0393 0.0394
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Loa Loa (eye worm) loechrig isoform VII 0.0094 0.0144 0.0147
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0207 0.0393 0.0388
Echinococcus multilocularis g protein coupled receptor 0.0207 0.0393 0.0385
Onchocerca volvulus 0.0207 0.0393 0.195
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0157 0.0283 0.0277
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0066 0.0068
Echinococcus multilocularis G protein coupled receptor 139 0.0207 0.0393 0.0385
Leishmania major inosine-5-monophosphate dehydrogenase 0.1582 0.344 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0207 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Onchocerca volvulus Neuropeptide F receptor homolog 0.0207 0.0393 0.195
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0011 0.0002
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1488 0.3232 0.938
Loa Loa (eye worm) hypothetical protein 0.0924 0.1981 0.2029
Echinococcus multilocularis neuropeptide s receptor 0.0207 0.0393 0.0385
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0207 0.0393 0.0394
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Schistosoma mansoni histamine h1 receptor 0.0207 0.0393 0.0394
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0207 0.0393 0.0394
Echinococcus granulosus neuropeptide Y receptor 0.0207 0.0393 0.0388
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0011 0.0002
Brugia malayi nuclear hormone receptor 0.0034 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus multilocularis neuropeptide Y receptor 0.0207 0.0393 0.0385
Echinococcus granulosus biogenic amine 5HT receptor 0.2178 0.476 0.4757
Brugia malayi neuropeptide F receptor 0.0207 0.0393 0.0394
Onchocerca volvulus 0.0207 0.0393 0.195
Brugia malayi G protein-coupled receptor F59B2.13 0.0207 0.0393 0.0394
Loa Loa (eye worm) chloride channel 3 0.0094 0.0144 0.0147
Loa Loa (eye worm) hypothetical protein 0.0157 0.0283 0.029
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0831 0.1776 0.4951
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0053 0.0046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0207 0.0393 0.0394
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0085 0.0079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0079 0.0072
Brugia malayi neuropeptide F receptor 0.0207 0.0393 0.0394
Schistosoma mansoni neuropeptide receptor 0.0207 0.0393 0.0394
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0157 0.0283 0.0281
Onchocerca volvulus Putative GMP reductase 0.0658 0.1392 0.7013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0207 0.0393 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0011 0.0011
Echinococcus granulosus serotonin receptor 0.0207 0.0393 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0011 0.0002
Onchocerca volvulus 0.0207 0.0393 0.195
Onchocerca volvulus 0.0207 0.0393 0.195
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0011 0.0005
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1582 0.344 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0008 0.0003
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0658 0.1392 0.1418
Schistosoma mansoni biogenic amine (5HT) receptor 0.2214 0.4838 0.4951
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0011 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0094 0.0144 0.0147
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0011 0.0002
Brugia malayi G-protein coupled receptor 0.0207 0.0393 0.0394
Echinococcus multilocularis neuropeptides capa receptor 0.0207 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Schistosoma mansoni adenoreceptor 0.0207 0.0393 0.0394
Schistosoma mansoni myosin xvIII 0.0207 0.0393 0.0394
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0011 0.0011
Echinococcus multilocularis biogenic amine (5HT) receptor 0.2178 0.476 0.4755
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0094 0.0144 0.0394
Echinococcus granulosus neuropeptide receptor A26 0.0207 0.0393 0.0388
Brugia malayi GMP reductase 0.0658 0.1392 0.1418
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0207 0.0393 0.0385
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Schistosoma mansoni neuropeptide F-like receptor 0.0207 0.0393 0.0394
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0658 0.1392 0.1418
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0207 0.0393 0.0403
Echinococcus granulosus peptide allatostatin:somatostatin 0.0207 0.0393 0.0388
Loa Loa (eye worm) hypothetical protein 0.0924 0.1981 0.2029
Entamoeba histolytica hypothetical protein 0.0069 0.0088 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0011 0.0002
Brugia malayi larval opioid receptor 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1582 0.344 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0207 0.0393 0.0385
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.0088 0.008
Brugia malayi Serotonin receptor 0.2616 0.573 0.5865
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0011 0.0011
Mycobacterium tuberculosis Conserved protein 0.0094 0.0144 0.0175
Echinococcus multilocularis serotonin receptor 0.2214 0.4838 0.4834
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0207 0.0393 0.0394
Loa Loa (eye worm) neuropeptide F receptor 0.0207 0.0393 0.0403
Schistosoma mansoni growth hormone secretagogue receptor 0.0207 0.0393 0.0394
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0011 0.0002
Onchocerca volvulus 0.0924 0.1981 1
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0079 0.0073
Schistosoma mansoni chloride channel protein 0.0094 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0011 0.0005
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.0444 0.0454
Onchocerca volvulus 0.0207 0.0393 0.195
Echinococcus multilocularis sodium and chloride dependent glycine 0.0157 0.0283 0.0275
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0207 0.0393 0.0385
Echinococcus multilocularis neuropeptide receptor A26 0.0207 0.0393 0.0385
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0157 0.0283 0.029
Echinococcus multilocularis sodium and chloride dependent glycine 0.0157 0.0283 0.0275
Schistosoma mansoni coup transcription factor 0.0034 0.0011 0.0002
Echinococcus multilocularis g-protein coupled receptor 0.0207 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.006 0.0069 0.007
Loa Loa (eye worm) GMP reductase 0.0658 0.1392 0.1425
Echinococcus granulosus 7tm_1 domain containing protein 0.0207 0.0393 0.0388
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0115 0.011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0011 0.0002
Echinococcus granulosus dro:myosuppressin receptor 0.0207 0.0393 0.0388
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0033 0.0008 0.0009
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.1582 0.344 1
Schistosoma mansoni hypothetical protein 0.0187 0.0349 0.0349
Echinococcus multilocularis lamin dm0 0.0052 0.005 0.0042
Entamoeba histolytica hypothetical protein 0.0069 0.0088 0.5
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0207 0.0393 0.0385
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.1582 0.344 0.3518
Echinococcus multilocularis g protein coupled receptor 0.0207 0.0393 0.0385
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0085 0.0079
Echinococcus multilocularis serotonin receptor 0.2214 0.4838 0.4834
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.1488 0.3232 1
Schistosoma mansoni biogenic amine receptor 0.0207 0.0393 0.0394
Brugia malayi sulfakinin receptor protein 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Trypanosoma cruzi GMP reductase 0.1582 0.344 1
Onchocerca volvulus 0.0157 0.0283 0.1391
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0079 0.0071
Trypanosoma cruzi chloride channel protein, putative 0.0094 0.0144 0.0417
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0207 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0157 0.0283 0.029
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.4438 0.9764 1
Brugia malayi Dopamine receptor 0.0207 0.0393 0.0394
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0157 0.0283 0.0281
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0094 0.0144 0.0135
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0011 0.0005
Brugia malayi CBS domain containing protein 0.0094 0.0144 0.0139
Schistosoma mansoni intermediate filament proteins 0.0052 0.005 0.0043
Schistosoma mansoni hypothetical protein 0.0053 0.0053 0.0046
Onchocerca volvulus 0.0207 0.0393 0.195
Echinococcus granulosus g protein coupled receptor 0.0207 0.0393 0.0388
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0207 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.0924 0.1981 0.2029
Schistosoma mansoni neuropeptide F-like receptor 0.0207 0.0393 0.0394
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0752 0.16 0.4516
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0079 0.0071
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0094 0.0144 0.0417
Schistosoma mansoni amine GPCR 0.0207 0.0393 0.0394
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0094 0.0144 0.0417
Trypanosoma brucei GMP reductase 0.1582 0.344 1
Brugia malayi Pre-SET motif family protein 0.0229 0.0444 0.0446
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1582 0.344 1
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0094 0.0144 0.0139
Mycobacterium tuberculosis Conserved protein 0.0094 0.0144 0.0175
Echinococcus multilocularis neuropeptide FF receptor 2 0.0207 0.0393 0.0385
Onchocerca volvulus 0.0052 0.005 0.0211
Brugia malayi Dopamine receptor protein 2 0.0207 0.0393 0.0394
Loa Loa (eye worm) IMP dehydrogenase 1 0.1582 0.344 0.3523
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0094 0.0144 0.0175
Brugia malayi hypothetical protein 0.0207 0.0393 0.0394
Echinococcus granulosus neuropeptide Y receptor 0.0207 0.0393 0.0388
Echinococcus granulosus sex peptide receptor 0.0207 0.0393 0.0388
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0207 0.0393 0.0385
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0011 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.0207 0.0393 0.0403
Echinococcus multilocularis lamin 0.0052 0.005 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0207 0.0393 0.0385
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0094 0.0144 0.0175
Onchocerca volvulus 0.0094 0.0144 0.0686
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0207 0.0393 0.0394
Echinococcus multilocularis rhodopsin orphan GPCR 0.0207 0.0393 0.0385
Echinococcus multilocularis somatostatin receptor 0.0207 0.0393 0.0385
Brugia malayi ancient conserved domain protein 2 0.0094 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0157 0.0283 0.029
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0924 0.1981 0.2022
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0011 0.0002
Brugia malayi putative neuropeptide receptor 0.0207 0.0393 0.0394
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0094 0.0144 0.0135
Brugia malayi steroid hormone receptor 0.0034 0.0011 0.0002
Onchocerca volvulus 0.0157 0.0283 0.1391
Echinococcus multilocularis rhodopsin orphan GPCR 0.0207 0.0393 0.0385
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0011 0.0002
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0094 0.0144 0.0417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0207 0.0393 0.0394
Brugia malayi Serotonin/octopamine receptor family protein 7 0.4438 0.9764 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0157 0.0283 0.0281
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0011 0.0002
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0157 0.0283 0.0277
Brugia malayi CLC chloride channel protein 0.0094 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0094 0.0144 0.0147
Brugia malayi Serotonin receptor 0.0207 0.0393 0.0394
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0094 0.0144 0.0135
Loa Loa (eye worm) G-protein coupled receptor 0.0207 0.0393 0.0403
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0207 0.0393 0.0394
Toxoplasma gondii hypothetical protein 0.0157 0.0283 0.08
Entamoeba histolytica hypothetical protein 0.0069 0.0088 0.5
Trypanosoma cruzi chloride channel protein, putative 0.0094 0.0144 0.0417
Schistosoma mansoni chloride channel protein 0.0094 0.0144 0.0139
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.1582 0.344 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0924 0.1981 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Brugia malayi nuclear receptor NHR-88 0.0034 0.0011 0.0002
Giardia lamblia Hypothetical protein 0.0094 0.0144 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0207 0.0393 0.0385
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0094 0.0144 0.0135
Echinococcus granulosus rhodopsin orphan GPCR 0.0207 0.0393 0.0388
Brugia malayi follicle stimulating hormone receptor 0.0207 0.0393 0.0394
Echinococcus granulosus lamin dm0 0.0052 0.005 0.0044
Echinococcus multilocularis fmrfamide receptor 0.0207 0.0393 0.0385
Echinococcus granulosus rhodopsin orphan GPCR 0.0207 0.0393 0.0388
Loa Loa (eye worm) hypothetical protein 0.2214 0.4838 0.4955
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0157 0.0283 0.08
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0207 0.0393 0.0403
Brugia malayi ancient conserved domain protein 4 0.0094 0.0144 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0011 0.0002
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0115 0.0107
Mycobacterium ulcerans hypothetical protein 0.0094 0.0144 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0011 0.0002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0207 0.0393 0.0388

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.2 uM Agonist activity at human GLP1 assessed as stimulation of cAMP ChEMBL. 17827014
EC50 (functional) = 2.2 uM Agonist activity at human GLP1 assessed as stimulation of cAMP ChEMBL. 17827014
Emax (functional) = 72 % Agonist activity at human GLP1 assessed as stimulation of cAMP relative to cAMP ChEMBL. 17827014
Emax (functional) = 72 % Agonist activity at human GLP1 assessed as stimulation of cAMP relative to cAMP ChEMBL. 17827014

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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