Detailed information for compound 459185

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.553 | Formula: C27H30N4O
  • H donors: 2 H acceptors: 2 LogP: 5.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)nc(cc2C)N[C@H]1CCC[C@@H](C1)NCc1cncc2c1cccc2
  • InChi: 1S/C27H30N4O/c1-18-12-27(31-26-14-23(32-2)10-11-24(18)26)30-22-8-5-7-21(13-22)29-17-20-16-28-15-19-6-3-4-9-25(19)20/h3-4,6,9-12,14-16,21-22,29H,5,7-8,13,17H2,1-2H3,(H,30,31)/t21-,22-/m0/s1
  • InChiKey: JMJVAROAWXUCQG-VXKWHMMOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein coupled receptor 0.0231 0.0382 0.0425
Echinococcus granulosus G protein coupled receptor 139 0.0231 0.0382 0.0427
Schistosoma mansoni biogenic amine (5HT) receptor 0.2557 0.4821 0.4817
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.1377 0.257 0.2908
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0231 0.0382 0.0425
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0077 0.0081
Brugia malayi hypothetical protein 0.0185 0.0296 0.0288
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.4656 0.8825 1
Trypanosoma cruzi chloride channel protein, putative 0.0082 0.0098 0.0381
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0231 0.0382 0.0427
Brugia malayi G-protein coupled receptor 0.0231 0.0382 0.0375
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.1377 0.257 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0071 0.0071
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0185 0.0296 0.0288
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.1295 0.2414 1
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0231 0.0382 0.0382
Echinococcus granulosus dro:myosuppressin receptor 0.0231 0.0382 0.0427
Onchocerca volvulus Neuropeptide F receptor homolog 0.0231 0.0382 0.1854
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.006 0.006
Brugia malayi GMP reductase 0.0572 0.1034 0.1027
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0185 0.0296 0.0327
Schistosoma mansoni coup transcription factor 0.0036 0.001 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0185 0.0296 0.0288
Loa Loa (eye worm) melatonin receptor type 1A 0.0231 0.0382 0.0382
Entamoeba histolytica hypothetical protein 0.0072 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni hypothetical protein 0.0231 0.0382 0.0375
Brugia malayi neuropeptide F receptor 0.0231 0.0382 0.0375
Trypanosoma cruzi GMP reductase 0.1377 0.257 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0008 0.0008
Echinococcus multilocularis geminin 0.0196 0.0315 0.0349
Echinococcus granulosus intermediate filament protein 0.0054 0.0045 0.0045
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0082 0.0098 0.0352
Echinococcus multilocularis G-protein coupled receptor, putative 0.0231 0.0382 0.0425
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.001 0.0002
Onchocerca volvulus 0.0231 0.0382 0.1854
Trypanosoma cruzi GMP reductase 0.1377 0.257 1
Echinococcus granulosus neuropeptide Y receptor 0.0231 0.0382 0.0427
Onchocerca volvulus 0.0054 0.0045 0.0186
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni protein kinase subunit gamma 0.0082 0.0098 0.009
Schistosoma mansoni neuropeptide receptor 0.0231 0.0382 0.0375
Leishmania major inosine-5-monophosphate dehydrogenase 0.1377 0.257 1
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0082 0.0098 0.0085
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0231 0.0382 0.0425
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Echinococcus granulosus allatostatin A receptor 0.0231 0.0382 0.0427
Mycobacterium tuberculosis Conserved protein 0.0082 0.0098 0.0085
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0231 0.0382 0.0382
Echinococcus granulosus neuropeptide Y receptor 0.0231 0.0382 0.0427
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Echinococcus granulosus serotonin transporter 0.1093 0.2026 0.2292
Leishmania major CBS domain protein, conserved 0.0082 0.0098 0.0085
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0045 0.0038
Onchocerca volvulus 0.0056 0.0048 0.0201
Schistosoma mansoni biogenic amine receptor 0.0231 0.0382 0.0375
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0185 0.0296 0.0329
Brugia malayi chloride channel protein 7 0.0082 0.0098 0.009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.001 0.0005
Loa Loa (eye worm) IMP dehydrogenase 1 0.1377 0.257 0.257
Brugia malayi Pre-SET motif family protein 0.024 0.04 0.0393
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Loa Loa (eye worm) loechrig isoform VII 0.0082 0.0098 0.0098
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0071 0.0075
Loa Loa (eye worm) hypothetical protein 0.0082 0.0098 0.0098
Schistosoma mansoni opsin-like receptor 0.0231 0.0382 0.0375
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0654 0.119 0.4465
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0231 0.0382 0.0375
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.001 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0185 0.0296 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.001 0.0002
Mycobacterium ulcerans hypothetical protein 0.0082 0.0098 0.0085
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.001
Plasmodium falciparum amino acid transporter, putative 0.0185 0.0296 0.0854
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4656 0.8825 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0185 0.0296 0.0288
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0231 0.0382 0.0427
Echinococcus granulosus H:Cl exchange transporter 7 0.0082 0.0098 0.0105
Toxoplasma gondii hypothetical protein 0.0185 0.0296 0.1124
Echinococcus multilocularis serotonin transporter 0.1093 0.2026 0.229
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0231 0.0382 0.0382
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0082 0.0098 0.0105
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Loa Loa (eye worm) chloride channel protein 7 0.0082 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni histamine h1 receptor 0.0231 0.0382 0.0375
Onchocerca volvulus 0.0082 0.0098 0.0447
Echinococcus granulosus g-protein coupled receptor 0.0231 0.0382 0.0427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0231 0.0382 0.0375
Echinococcus granulosus lamin 0.0054 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Brugia malayi Dopamine receptor protein 1 0.0231 0.0382 0.0375
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.001 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0231 0.0382 0.0382
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.001 0.001
Echinococcus granulosus neuropeptide receptor A26 0.0231 0.0382 0.0427
Brugia malayi Melatonin receptor type 1A 0.0231 0.0382 0.0375
Echinococcus multilocularis lamin dm0 0.0054 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Onchocerca volvulus 0.0231 0.0382 0.1854
Loa Loa (eye worm) hypothetical protein 0.0082 0.0098 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.001 0.0002
Trypanosoma cruzi chloride channel protein, putative 0.0082 0.0098 0.0381
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.001
Brugia malayi CBS domain containing protein 0.0082 0.0098 0.009
Echinococcus granulosus orexin receptor type 2 0.0231 0.0382 0.0427
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0185 0.0296 0.0288
Loa Loa (eye worm) hypothetical protein 0.2557 0.4821 0.4821
Loa Loa (eye worm) hypothetical protein 0.1093 0.2026 0.2026
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0082 0.0098 0.0105
Toxoplasma gondii CBS domain-containing protein 0.0082 0.0098 0.0352
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.1377 0.257 1
Echinococcus multilocularis g protein coupled receptor 0.0231 0.0382 0.0425
Schistosoma mansoni myosin xvIII 0.0231 0.0382 0.0375
Loa Loa (eye worm) hypothetical protein 0.0185 0.0296 0.0296
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.008 0.0072
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0085 0.0104 0.0109
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0082 0.0098 0.0085
Schistosoma mansoni neuropeptide receptor 0.0231 0.0382 0.0375
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0082 0.0098 0.0085
Mycobacterium ulcerans transcriptional regulator 0.0082 0.0098 0.0085
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0231 0.0382 0.0425
Schistosoma mansoni nuclear hormone receptor 0.0036 0.001 0.0002
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0082 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Echinococcus multilocularis musashi 0.0054 0.0045 0.0043
Onchocerca volvulus 0.0231 0.0382 0.1854
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0082 0.0098 0.009
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0071 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.001 0.001
Brugia malayi putative neuropeptide receptor NPR1 0.0231 0.0382 0.0375
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0082 0.0098 0.0102
Loa Loa (eye worm) hypothetical protein 0.0053 0.0043 0.0043
Onchocerca volvulus 0.0231 0.0382 0.1854
Echinococcus granulosus rhodopsin orphan GPCR 0.0231 0.0382 0.0427
Echinococcus multilocularis sex peptide receptor 0.0231 0.0382 0.0425
Schistosoma mansoni amine GPCR 0.0231 0.0382 0.0375
Schistosoma mansoni chloride channel protein 0.0082 0.0098 0.009
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0082 0.0098 0.0085
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0045 0.0045
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0231 0.0382 0.0425
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Mycobacterium ulcerans cystathionine beta-synthase 0.0082 0.0098 0.0085
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0654 0.119 0.4418
Trypanosoma cruzi chloride channel protein, putative 0.0082 0.0098 0.0381
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.001 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.001 0.0002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0382 0.0382
Schistosoma mansoni hypothetical protein 0.0196 0.0315 0.0308
Brugia malayi steroid hormone receptor 0.0036 0.001 0.0002
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0231 0.0382 0.0375
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0052 0.0044
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.1377 0.257 1
Onchocerca volvulus 0.0231 0.0382 0.1854
Brugia malayi sulfakinin receptor protein 0.0231 0.0382 0.0375
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0082 0.0098 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0231 0.0382 0.0427
Brugia malayi G protein-coupled receptor 0.0231 0.0382 0.0375
Schistosoma mansoni sodium/chloride dependent transporter 0.0185 0.0296 0.0288
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0185 0.0296 0.0329
Echinococcus granulosus rhodopsin orphan GPCR 0.0231 0.0382 0.0427
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0231 0.0382 0.0382
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0231 0.0382 0.0375
Echinococcus multilocularis somatostatin receptor 0.0231 0.0382 0.0425
Schistosoma mansoni opsin-like receptor 0.0231 0.0382 0.0375
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Loa Loa (eye worm) neuropeptide F receptor 0.0231 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.1295 0.2414 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.001 0.0002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1093 0.2026 0.202
Schistosoma mansoni survival motor neuron protein 0.0056 0.0048 0.0041
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0185 0.0296 0.0296
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.001 0.0002
Onchocerca volvulus 0.0231 0.0382 0.1854
Plasmodium falciparum transporter, putative 0.0185 0.0296 0.0854
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.0463 0.0516
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0048 0.0041
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.001 0.0005
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0723 0.1322 0.4951
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.001 0.001
Onchocerca volvulus 0.0231 0.0382 0.1854
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.001 0.0002
Brugia malayi AKH receptor 0.0231 0.0382 0.0375
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni chloride channel protein 0.0082 0.0098 0.009
Loa Loa (eye worm) hypothetical protein 0.1093 0.2026 0.2026
Echinococcus granulosus neuropeptide receptor 0.0231 0.0382 0.0427
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0231 0.0382 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.001 0.0002
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.1377 0.257 0.2564
Schistosoma mansoni neuropeptide receptor 0.0231 0.0382 0.0375
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.0231 0.0382 0.0425
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.001 0.0002
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0572 0.1034 0.1027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0231 0.0382 0.0425
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0231 0.0382 0.0375
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Echinococcus granulosus tm gpcr rhodopsin 0.0231 0.0382 0.0427
Echinococcus granulosus serotonin receptor 0.0231 0.0382 0.0427
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.001
Echinococcus granulosus biogenic amine 5HT receptor 0.2557 0.4821 0.546
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.001 0.0002
Leishmania major chloride channel protein, putative 0.0082 0.0098 0.0085
Brugia malayi RE15519p 0.0231 0.0382 0.0375
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0008 0.0003
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0572 0.1034 0.1027
Schistosoma mansoni biogenic amine (5HT) receptor 0.2242 0.422 0.4215
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0231 0.0382 0.0425
Schistosoma mansoni opsin-like receptor 0.0231 0.0382 0.0375
Trypanosoma cruzi chloride channel protein, putative 0.0082 0.0098 0.0381
Loa Loa (eye worm) TYRA-2 protein 0.0231 0.0382 0.0382
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0231 0.0382 0.0425
Brugia malayi neuropeptide F receptor 0.0231 0.0382 0.0375
Onchocerca volvulus 0.0231 0.0382 0.1854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.001 0.001
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Echinococcus multilocularis neuropeptides capa receptor 0.0231 0.0382 0.0425
Echinococcus granulosus fmrfamide receptor 0.0231 0.0382 0.0427
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0185 0.0296 0.0288
Schistosoma mansoni hypothetical protein 0.0056 0.0048 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0231 0.0382 0.0427
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0071 0.0072
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.0077 0.0069
Toxoplasma gondii hypothetical protein 0.0185 0.0296 0.1124
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0723 0.1322 0.4993
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.1093 0.2026 0.2026
Echinococcus multilocularis neuropeptide receptor 0.0231 0.0382 0.0425
Echinococcus granulosus g protein coupled receptor 0.0231 0.0382 0.0427
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Echinococcus multilocularis serotonin receptor 0.2557 0.4821 0.5459
Schistosoma mansoni adenoreceptor 0.0231 0.0382 0.0375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0231 0.0382 0.0375
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.04 0.04
Echinococcus multilocularis allatostatin A receptor 0.0231 0.0382 0.0425
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0185 0.0296 0.1124
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0071 0.0064
Mycobacterium tuberculosis Conserved protein 0.0082 0.0098 0.0085
Echinococcus granulosus neuropeptides capa receptor 0.0231 0.0382 0.0427
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.001 0.0002
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.001 0.0002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0231 0.0382 0.0425
Echinococcus multilocularis neuropeptide Y receptor 0.0231 0.0382 0.0425
Onchocerca volvulus 0.0036 0.001 0.001
Echinococcus granulosus biogenic amine 5HT receptor 0.2242 0.422 0.4778
Mycobacterium ulcerans hypothetical protein 0.0082 0.0098 0.0085
Schistosoma mansoni amine GPCR 0.0231 0.0382 0.0375
Onchocerca volvulus Putative GMP reductase 0.0572 0.1034 0.5083
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.008 0.0084
Brugia malayi Serotonin receptor 0.2689 0.5073 0.5069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.001 0.0002
Brugia malayi Voltage gated chloride channel family protein 0.0082 0.0098 0.009
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1377 0.257 1
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0231 0.0382 0.0425
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.001 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0231 0.0382 0.0427
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0231 0.0382 0.0375
Onchocerca volvulus 0.0231 0.0382 0.1854
Loa Loa (eye worm) GMP reductase 0.0572 0.1034 0.1034
Echinococcus granulosus rhodopsin orphan GPCR 0.0231 0.0382 0.0427
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1093 0.2026 0.202
Brugia malayi hypothetical protein 0.0072 0.008 0.0072
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0185 0.0296 0.0329
Brugia malayi jmjC domain containing protein 0.0068 0.0071 0.0064
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0231 0.0382 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0231 0.0382 0.0425
Brugia malayi Tachykinin-like peptides receptor 99D 0.0231 0.0382 0.0375
Loa Loa (eye worm) G-protein coupled receptor 0.0231 0.0382 0.0382
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0082 0.0098 0.0381
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.008 0.0082
Loa Loa (eye worm) hypothetical protein 0.5271 1 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0098 0.0098
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0231 0.0382 0.0375
Echinococcus granulosus g protein coupled receptor 0.0231 0.0382 0.0427
Toxoplasma gondii IMP dehydrogenas 0.1377 0.257 1
Loa Loa (eye worm) norepinephrine transporter 0.1093 0.2026 0.2026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0231 0.0382 0.0375
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0054 0.0045 0.0045
Schistosoma mansoni neuropeptide F-like receptor 0.0231 0.0382 0.0375
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0185 0.0296 0.1124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.001 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.001 0.0005
Schistosoma mansoni sodium/chloride dependent transporter 0.1093 0.2026 0.202
Echinococcus granulosus alpha 1A adrenergic receptor 0.0231 0.0382 0.0427
Echinococcus multilocularis rhodopsin orphan GPCR 0.0231 0.0382 0.0425
Brugia malayi G protein-coupled receptor F59B2.13 0.0231 0.0382 0.0375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.001 0.001
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0071 0.0072
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0017 0.0009
Echinococcus granulosus 7tm_1 domain containing protein 0.0231 0.0382 0.0427
Schistosoma mansoni sodium-dependent amino acid transporter 0.0185 0.0296 0.0288
Onchocerca volvulus 0.0231 0.0382 0.1854
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.001 0.0002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0045 0.0045
Echinococcus granulosus nuclear factor of activated T cells 5 0.0085 0.0104 0.0112
Schistosoma mansoni hypothetical protein 0.0196 0.0315 0.0308
Onchocerca volvulus 0.0185 0.0296 0.1427
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0082 0.0098 0.009
Plasmodium vivax hypothetical protein, conserved 0.0185 0.0296 0.1197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0231 0.0382 0.0375
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0231 0.0382 0.0427
Echinococcus granulosus H:Cl exchange transporter 3 0.0082 0.0098 0.0105
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0071 0.0064
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0185 0.0296 0.0288
Schistosoma mansoni thyroid hormone receptor 0.0036 0.001 0.0002
Echinococcus granulosus H:Cl exchange transporter 4 0.0082 0.0098 0.0105
Schistosoma mansoni lamin 0.0054 0.0045 0.0038
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0077 0.0078
Brugia malayi Dopamine receptor protein 2 0.0231 0.0382 0.0375
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0185 0.0296 0.0288
Echinococcus multilocularis biogenic amine (5HT) receptor 0.2242 0.422 0.4777
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.001 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.0231 0.0382 0.0425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.001 0.001
Schistosoma mansoni lamin 0.0054 0.0045 0.0038
Loa Loa (eye worm) hypothetical protein 0.0185 0.0296 0.0296
Brugia malayi ORL1-like opioid receptor 0.0231 0.0382 0.0375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.001 0.001
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0185 0.0296 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0231 0.0382 0.0425
Schistosoma mansoni neuropeptide F-like receptor 0.0231 0.0382 0.0375
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.1377 0.257 0.2564
Entamoeba histolytica hypothetical protein 0.0072 0.008 0.5
Schistosoma mansoni thyroid hormone receptor 0.0036 0.001 0.0002
Echinococcus granulosus FTZ F1 alpha 0.0036 0.001 0.0005
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0082 0.0098 0.009
Onchocerca volvulus 0.0185 0.0296 0.1427
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0185 0.0296 0.0296
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0082 0.0098 0.0381
Echinococcus multilocularis neuropeptide s receptor 0.0231 0.0382 0.0425
Loa Loa (eye worm) hypothetical protein 0.0185 0.0296 0.0296
Echinococcus granulosus neuropeptide s receptor 0.0231 0.0382 0.0427
Echinococcus multilocularis lamin 0.0054 0.0045 0.0043
Schistosoma mansoni amine GPCR 0.0231 0.0382 0.0375
Loa Loa (eye worm) solute carrier family 6 member 4 0.1093 0.2026 0.2026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0231 0.0382 0.0375
Brugia malayi ancient conserved domain protein 4 0.0082 0.0098 0.009
Brugia malayi Dopamine receptor 0.0231 0.0382 0.0375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0231 0.0382 0.0375
Echinococcus granulosus geminin 0.0196 0.0315 0.0352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0231 0.0382 0.0375
Brugia malayi ancient conserved domain protein 2 0.0082 0.0098 0.009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0231 0.0382 0.0375
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0071 0.0075
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0082 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0231 0.0382 0.1854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0231 0.0382 0.0425
Onchocerca volvulus 0.0231 0.0382 0.1854
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0185 0.0296 0.0288
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0082 0.0098 0.0102
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni neuropeptide receptor 0.0231 0.0382 0.0375
Brugia malayi ecdysteroid receptor 0.0036 0.001 0.0002
Brugia malayi CLC chloride channel protein 0.0082 0.0098 0.009
Loa Loa (eye worm) hypothetical protein 0.0082 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.001
Onchocerca volvulus 0.0231 0.0382 0.1854
Schistosoma mansoni intermediate filament proteins 0.0054 0.0045 0.0038
Loa Loa (eye worm) hypothetical protein 0.0185 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0058 0.0052 0.0052
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0231 0.0382 0.0425
Echinococcus granulosus somatostatin receptor 0.0231 0.0382 0.0427
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0052 0.0044
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Onchocerca volvulus 0.1093 0.2026 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0231 0.0382 0.0427
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.0077 0.0069
Echinococcus multilocularis serotonin receptor 0.2557 0.4821 0.5459
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0231 0.0382 0.0375
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Echinococcus granulosus rhodopsin orphan GPCR 0.0231 0.0382 0.0427
Echinococcus multilocularis fmrfamide receptor 0.0231 0.0382 0.0425
Echinococcus granulosus sodium and chloride dependent glycine 0.0185 0.0296 0.0329
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0185 0.0296 0.0296
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.1377 0.257 0.2906
Echinococcus multilocularis neuropeptides capa receptor 0.0231 0.0382 0.0425
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0082 0.0098 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.001 0.0002
Toxoplasma gondii CBS family protein 0.0082 0.0098 0.0352
Brugia malayi hypothetical protein 0.0273 0.0463 0.0456
Giardia lamblia Hypothetical protein 0.0082 0.0098 0.5
Brugia malayi nuclear hormone receptor 0.0036 0.001 0.0002
Schistosoma mansoni sodium/chloride dependent transporter 0.0185 0.0296 0.0288
Echinococcus multilocularis sodium and chloride dependent glycine 0.0185 0.0296 0.0327
Schistosoma mansoni hypothetical protein 0.0104 0.014 0.0133
Onchocerca volvulus 0.0231 0.0382 0.1854
Loa Loa (eye worm) chloride channel 3 0.0082 0.0098 0.0098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0231 0.0382 0.0375
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.001 0.0002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0185 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.5271 1 1
Brugia malayi GnHR receptor homolog 0.0231 0.0382 0.0375
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.5271 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0231 0.0382 0.0425
Schistosoma mansoni alpha-1 adrenergic receptor 0.0231 0.0382 0.0375
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0185 0.0296 0.0327
Schistosoma mansoni amine GPCR 0.0231 0.0382 0.0375
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0231 0.0382 0.0425
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.001 0.0002
Toxoplasma gondii CBS domain-containing protein 0.0082 0.0098 0.0352
Echinococcus granulosus g protein coupled receptor 0.0231 0.0382 0.0427
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.001 0.0005
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1377 0.257 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0231 0.0382 0.0425
Echinococcus multilocularis fmrfamide receptor 0.0231 0.0382 0.0425
Schistosoma mansoni hypothetical protein 0.0039 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0185 0.0296 0.0296
Trypanosoma brucei GMP reductase 0.1377 0.257 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0185 0.0296 0.0288
Schistosoma mansoni hypothetical protein 0.0231 0.0382 0.0375
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.0463 0.0519
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.001 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.001 0.0002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.001 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0231 0.0382 0.0425
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0185 0.0296 0.0329
Brugia malayi putative neuropeptide receptor 0.0231 0.0382 0.0375
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Echinococcus granulosus rhodopsin orphan GPCR 0.0231 0.0382 0.0427
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0082 0.0098 0.0105
Brugia malayi intermediate filament protein 0.0054 0.0045 0.0038
Echinococcus granulosus tachykinin peptides receptor 99D 0.0231 0.0382 0.0427
Treponema pallidum sodium- and chloride- dependent transporter 0.1093 0.2026 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Onchocerca volvulus 0.0274 0.0464 0.2261
Echinococcus granulosus peptide allatostatin:somatostatin 0.0231 0.0382 0.0427
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0231 0.0382 0.0375
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1295 0.2414 0.9374
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0231 0.0382 0.0375
Loa Loa (eye worm) neuropeptide F receptor 0.0231 0.0382 0.0382
Echinococcus multilocularis rhodopsin orphan GPCR 0.0231 0.0382 0.0425
Schistosoma mansoni hypothetical protein 0.0231 0.0382 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0231 0.0382 0.0425
Echinococcus granulosus neuropeptides capa receptor 0.0231 0.0382 0.0427
Entamoeba histolytica hypothetical protein 0.0072 0.008 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.001 0.0005
Onchocerca volvulus 0.0054 0.0045 0.0186
Loa Loa (eye worm) hypothetical protein 0.2557 0.4821 0.4821
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1377 0.257 1
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0082 0.0098 0.0102
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Echinococcus granulosus neuropeptide FF receptor 2 0.0231 0.0382 0.0427
Schistosoma mansoni neuropeptide f receptor 76f 0.0231 0.0382 0.0375
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0082 0.0098 0.0381
Echinococcus multilocularis g-protein coupled receptor 0.0231 0.0382 0.0425
Trichomonas vaginalis set domain proteins, putative 0.0274 0.0464 0.5
Mycobacterium ulcerans hypothetical protein 0.0082 0.0098 0.0085
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0382 0.0375
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0231 0.0382 0.0427
Onchocerca volvulus 0.0185 0.0296 0.1427
Echinococcus granulosus hypothetical protein 0.3118 0.5891 0.6674
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Echinococcus granulosus neuropeptide receptor 0.0231 0.0382 0.0427
Echinococcus multilocularis g protein coupled receptor 0.0231 0.0382 0.0425
Brugia malayi larval opioid receptor 0.0231 0.0382 0.0375
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0185 0.0296 0.1124
Echinococcus multilocularis conserved hypothetical protein 0.2887 0.5451 0.6174
Brugia malayi nuclear receptor NHR-88 0.0036 0.001 0.0002
Brugia malayi loechrig isoform VII 0.0082 0.0098 0.009
Onchocerca volvulus 0.0231 0.0382 0.1854
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0231 0.0382 0.0425
Onchocerca volvulus 0.0231 0.0382 0.1854
Echinococcus multilocularis sodium and chloride dependent glycine 0.0185 0.0296 0.0327
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0185 0.0296 0.0327
Schistosoma mansoni hypothetical protein 0.0231 0.0382 0.0375
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0231 0.0382 0.0375
Leishmania major hypothetical protein, conserved 0.0082 0.0098 0.0085
Brugia malayi G-protein coupled receptor 0.0231 0.0382 0.0375
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0273 0.0463 0.0463
Mycobacterium tuberculosis Conserved protein 0.0082 0.0098 0.0085
Brugia malayi jmjC domain containing protein 0.0068 0.0071 0.0064
Loa Loa (eye worm) serotonin transporter b 0.1093 0.2026 0.2026
Schistosoma mansoni chloride channel protein 0.0082 0.0098 0.009
Schistosoma mansoni amine GPCR 0.0231 0.0382 0.0375
Plasmodium vivax amine transporter, putative 0.0185 0.0296 0.1197
Schistosoma mansoni hypothetical protein 0.0072 0.008 0.0072
Echinococcus multilocularis orexin receptor type 2 0.0231 0.0382 0.0425
Leishmania major guanosine monophosphate reductase 0.1377 0.257 1
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0082 0.0098 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.4641 0.8798 0.8798
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0231 0.0382 0.0375
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0185 0.0296 0.0288
Loa Loa (eye worm) hypothetical protein 0.0231 0.0382 0.0382
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0082 0.0098 0.0085
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0185 0.0296 0.0288
Onchocerca volvulus 0.0231 0.0382 0.1854
Schistosoma mansoni biogenic amine receptor 0.0231 0.0382 0.0375
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.001 0.0002
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.1377 0.257 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0052 0.0052
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Onchocerca volvulus 0.0231 0.0382 0.1854
Schistosoma mansoni growth hormone secretagogue receptor 0.0231 0.0382 0.0375
Echinococcus multilocularis neuropeptide receptor 0.0231 0.0382 0.0425
Echinococcus granulosus sex peptide receptor 0.0231 0.0382 0.0427
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0082 0.0098 0.0102
Leishmania major chloride channel protein, putative 0.0082 0.0098 0.0085
Echinococcus multilocularis dro:myosuppressin receptor 0.0231 0.0382 0.0425
Entamoeba histolytica hypothetical protein 0.0072 0.008 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.001 0.0002
Brugia malayi Serotonin receptor 0.0231 0.0382 0.0375
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0231 0.0382 0.0427
Brugia malayi hypothetical protein 0.0231 0.0382 0.0375
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0231 0.0382 0.0375
Schistosoma mansoni biogenic amine receptor 0.0231 0.0382 0.0375
Loa Loa (eye worm) hypothetical protein 0.0039 0.0017 0.0017
Echinococcus granulosus tm gpcr rhodopsin 0.0231 0.0382 0.0427
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.001 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.001 0.0002
Echinococcus multilocularis G protein coupled receptor 139 0.0231 0.0382 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.001 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0231 0.0382 0.0375
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1377 0.257 1
Echinococcus granulosus lamin dm0 0.0054 0.0045 0.0045
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0231 0.0382 0.0375
Echinococcus granulosus sodium and chloride dependent glycine 0.0185 0.0296 0.0329

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 500 uL/min.mg Metabolic stability assessed as intrinsic clearance in human liver microsomes ChEMBL. 17532215
IC50 (binding) = 0.022 uM Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cells ChEMBL. 17532215
IC50 (binding) = 0.022 uM Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cells ChEMBL. 17532215

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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