Detailed information for compound 502933

Basic information

Technical information
  • TDR Targets ID: 502933
  • Name: 2-[(4-naphthalen-2-ylpiperazine-1-carbonyl)am ino]benzoic acid
  • MW: 375.42 | Formula: C22H21N3O3
  • H donors: 2 H acceptors: 3 LogP: 4.03 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)c1ccc2c(c1)cccc2)Nc1ccccc1C(=O)O
  • InChi: 1S/C22H21N3O3/c26-21(27)19-7-3-4-8-20(19)23-22(28)25-13-11-24(12-14-25)18-10-9-16-5-1-2-6-17(16)15-18/h1-10,15H,11-14H2,(H,23,28)(H,26,27)
  • InChiKey: HIIXCRLGHAWJQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-(2-naphthyl)piperazine-1-carbonyl]amino]benzoic acid
  • 2-[[[4-(2-naphthalenyl)-1-piperazinyl]-oxomethyl]amino]benzoic acid
  • 2-[(4-naphthalen-2-ylpiperazin-1-yl)carbonylamino]benzoic acid
  • 2-[[[4-(2-naphthyl)-1-piperazinyl]-oxomethyl]amino]benzoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxycarboxylic acid receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis G-protein coupled receptor, putative hydroxycarboxylic acid receptor 2 363 aa 294 aa 20.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0041 0.0552 0.0597
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0496 0.0546
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0134
Loa Loa (eye worm) hypothetical protein 0.0036 0.0448 0.0448
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0063 0.0075
Treponema pallidum fructose-bisphosphate aldolase 0.0298 0.5918 1
Echinococcus multilocularis cpg binding protein 0.0061 0.0959 0.1141
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0552 0.2447
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0448 0.1986
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0134
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0537 0.0861
Toxoplasma gondii exonuclease III APE 0.004 0.0537 0.2646
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0448 0.0741
Echinococcus granulosus lamin dm0 0.0027 0.0267 0.0318
Loa Loa (eye worm) hypothetical protein 0.0041 0.0552 0.0552
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0041 0.0552 0.2447
Echinococcus multilocularis lamin 0.0027 0.0267 0.0318
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0041 0.0552 0.0523
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.2255 0.2684
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.4517 0.4941
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.089 0.089
Echinococcus granulosus jun protein 0.0187 0.3609 0.4295
Schistosoma mansoni cpg binding protein 0.0057 0.089 0.089
Echinococcus multilocularis peregrin 0.0028 0.0288 0.0342
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0267 0.0294
Echinococcus granulosus geminin 0.0173 0.3302 0.3929
Loa Loa (eye worm) hypothetical protein 0.0056 0.0868 0.0868
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.001 0.0011
Onchocerca volvulus 0.0147 0.2768 0.3037
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0041 0.0552 0.2447
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0385 0.0651
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0024 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0045 0.0198
Echinococcus granulosus dnaJ subfamily B 0.0416 0.8404 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0537 0.7986
Echinococcus granulosus para nitrobenzyl esterase 0.0064 0.1029 0.1225
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0385 0.0603
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.2255 1
Schistosoma mansoni cpg binding protein 0.0061 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0041 0.0552 0.0552
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0448 0.1986
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0385 0.0635
Loa Loa (eye worm) hypothetical protein 0.0064 0.1029 0.1029
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0545 0.0905
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0065 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0468 0.0775
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0385 0.5624
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0385 0.0635
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0468 0.2077
Leishmania major hypothetical protein, conserved 0.0041 0.0552 0.2447
Brugia malayi intermediate filament protein 0.0027 0.0267 0.0294
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1913 0.2093
Trichomonas vaginalis esterase, putative 0.0036 0.0448 0.0741
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0868 0.0955
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.3534 0.4205
Leishmania major hypothetical protein, conserved 0.0041 0.0552 0.2447
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.003 0.0134
Loa Loa (eye worm) hypothetical protein 0.0064 0.1029 0.1029
Loa Loa (eye worm) hypothetical protein 0.0064 0.1029 0.1029
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0041 0.0552 0.0657
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0545 0.2689
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.2255 0.3801
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.2255 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0267 0.0267
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0045 0.0642 0.1039
Loa Loa (eye worm) hypothetical protein 0.0064 0.1029 0.1029
Loa Loa (eye worm) hypothetical protein 0.0449 0.9091 0.9091
Brugia malayi PHD-finger family protein 0.0028 0.0288 0.0316
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.2255 0.378
Loa Loa (eye worm) hypothetical protein 0.0049 0.0713 0.0713
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0134
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.014 0.0153
Onchocerca volvulus 0.0036 0.0448 0.0482
Schistosoma mansoni cpg binding protein 0.0061 0.0959 0.0959
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0448 0.0741
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0537 0.059
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0481 0.0481
Plasmodium vivax glutathione reductase, putative 0.0047 0.0666 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0045 0.0642 0.1084
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0041 0.0552 0.0552
Schistosoma mansoni d-amino acid oxidase 0.0493 1 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0385 0.6803
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0666 0.2953
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0564 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0468 0.0775
Onchocerca volvulus 0.0106 0.1914 0.2097
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0134
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0545 0.0905
Echinococcus granulosus peregrin 0.0028 0.0288 0.0342
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0537 0.0891
Schistosoma mansoni intermediate filament proteins 0.0027 0.0267 0.0267
Trypanosoma brucei unspecified product 0.0035 0.0424 0.1881
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0666 0.0666
Echinococcus granulosus dna polymerase kappa 0.0042 0.0564 0.0671
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0184 0.3534 0.3534
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0041 0.0552 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0352 0.1562
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.001 0.0046
Brugia malayi Bromodomain containing protein 0.0028 0.0288 0.0316
Loa Loa (eye worm) hypothetical protein 0.0064 0.1029 0.1029
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0468 0.0468
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0564 0.0938
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0537 0.0907
Giardia lamblia Fructose-bisphosphate aldolase 0.0298 0.5918 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1641 0.1953
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0065 0.0077
Echinococcus multilocularis Protein lozenge 0.0056 0.0872 0.1037
Echinococcus granulosus acetylcholinesterase 0.0378 0.7603 0.9047
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0065 0.0071
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0921 0.0921
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0868 0.0955
Schistosoma mansoni hypothetical protein 0.0152 0.2876 0.2876
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0545 0.0905
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0253 0.0278
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2161 0.2364
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0134
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.1962 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0187 0.3609 0.4295
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.2734 0.2712
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0385 0.5624
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0065 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.5918 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.001 0.0046
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1241 0.1241
Echinococcus granulosus GPCR family 2 0.0018 0.0065 0.0077
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0537 0.0537
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0064 0.1029 0.1126
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0545 0.2417
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0064 0.1029 0.1029
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0545 0.0905
Brugia malayi beta-lactamase family protein 0.0036 0.0448 0.0493
Brugia malayi Muscleblind-like protein 0.0152 0.2874 0.3162
Echinococcus multilocularis acetylcholinesterase 0.0378 0.7603 0.9047
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0452 0.9141 1
Schistosoma mansoni alpha-glucosidase 0.0158 0.2999 0.2999
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0288 0.0288
Brugia malayi RE18450p 0.0041 0.0552 0.0607
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0552 0.2447
Leishmania major hypothetical protein, conserved 0.0036 0.0448 0.1986
Plasmodium falciparum glutathione reductase 0.0016 0.003 0.0092
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0448 0.049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0481 0.0481
Schistosoma mansoni hypothetical protein 0.0173 0.3302 0.3302
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0024 0.0026
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.003 0.0134
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0041 0.0552 0.0657
Loa Loa (eye worm) runx1 0.0056 0.0872 0.0872
Loa Loa (eye worm) hypothetical protein 0.0032 0.0352 0.0352
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2161 0.2364
Brugia malayi hypothetical protein 0.0449 0.9091 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0448 0.0741
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0385 0.1863
Onchocerca volvulus 0.0027 0.0267 0.0283
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0385 0.1863
Loa Loa (eye worm) hypothetical protein 0.0027 0.0267 0.0267
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0041 0.0552 0.0552
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Mycobacterium ulcerans hypothetical protein 0.0036 0.0448 0.0419
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0545 0.0905
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0024 0.0024
Plasmodium falciparum thioredoxin reductase 0.0047 0.0666 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.003 0.003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0537 0.238
Onchocerca volvulus Alhambra homolog 0.0028 0.0288 0.0305
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0065 0.0077
Plasmodium falciparum thioredoxin reductase 0.0016 0.003 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0448 0.0741
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2161 0.1793
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0468 0.0557
Loa Loa (eye worm) hypothetical protein 0.0449 0.9091 0.9091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0448 0.0448
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0545 0.0905
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0564 0.2502
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.2255 0.3812
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0666 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1913 0.1534
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0065
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0064 0.1029 0.1029
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0448 0.049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.5918 1
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0041 0.0552 0.0597
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0041 0.0552 0.2447
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0537 0.0587
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0564 0.0671
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0545 0.06
Onchocerca volvulus 0.0064 0.1029 0.1122
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0468 0.0557
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.2255 0.2255
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0041 0.0552 0.0552
Brugia malayi polk-prov protein 0.0032 0.0352 0.0388
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.8404 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1029 0.1029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0134
Onchocerca volvulus 0.0449 0.9091 1
Schistosoma mansoni gliotactin 0.0064 0.1029 0.1029
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0537 0.0639
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0468 0.0515
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0064 0.1029 0.1725
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0552 0.2447
Onchocerca volvulus 0.0036 0.0448 0.0482
Onchocerca volvulus 0.0064 0.1029 0.1122
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0024 0.0107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0029
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1124 0.1098
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0552 0.2447
Plasmodium falciparum phd finger protein, putative 0.0028 0.0288 0.4105
Echinococcus multilocularis jun protein 0.0187 0.3609 0.4295
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.003 0.0092
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1913 0.2093
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0545 0.0545
Schistosoma mansoni neuroligin 3 (S09 family) 0.0064 0.1029 0.1029
Brugia malayi jmjC domain containing protein 0.0093 0.1641 0.1805
Onchocerca volvulus 0.0027 0.0267 0.0283
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0448 0.049
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0041 0.0552 0.0523
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0552 0.8223
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.2255 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0385 0.5624
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0552 0.2447
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.2255 0.3801
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0288 0.0288
Echinococcus multilocularis geminin 0.0173 0.3302 0.3929
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.2255 0.3812
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.003 0.0134
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0537 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.3534 0.4205
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0063 0.0075
Schistosoma mansoni alpha-glucosidase 0.0158 0.2999 0.2999
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0537 0.238
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.2255 0.3801
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0024 0.0029
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0123 0.2255 0.1892
Loa Loa (eye worm) hypothetical protein 0.0036 0.0448 0.0448
Trypanosoma brucei trypanothione reductase 0.0047 0.0666 0.2953
Brugia malayi Carboxylesterase family protein 0.0064 0.1029 0.1132
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0448 0.0493
Schistosoma mansoni alpha glucosidase 0.0041 0.0545 0.0545
Echinococcus granulosus acetylcholinesterase 0.0378 0.7603 0.9047
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0041 0.0552 0.2447
Mycobacterium ulcerans lipase LipD 0.0036 0.0448 0.0419
Loa Loa (eye worm) acetylcholinesterase 1 0.0378 0.7603 0.7603
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0385 0.0635
Echinococcus multilocularis para nitrobenzyl esterase 0.0064 0.1029 0.1225
Echinococcus granulosus BC026374 protein S09 family 0.0064 0.1029 0.1225
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0024 0.0027
Schistosoma mansoni hypothetical protein 0.0018 0.0065 0.0065
Leishmania major DNA polymerase kappa, putative 0.0021 0.014 0.0621
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0552 0.8223
Schistosoma mansoni hypothetical protein 0.0173 0.3302 0.3302
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1124 0.1124
Brugia malayi jmjC domain containing protein 0.0038 0.0481 0.0529
Brugia malayi glutathione reductase 0.0047 0.0666 0.0733
Echinococcus granulosus jumonji domain containing protein 0.004 0.0521 0.062
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0424 0.1881
Loa Loa (eye worm) hypothetical protein 0.0038 0.0496 0.0496
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1913 0.2093
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.003 0.0034
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.003 0.0134
Echinococcus multilocularis musashi 0.0027 0.0267 0.0318
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.2255 0.2255
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.003 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0134
Schistosoma mansoni hypothetical protein 0.0416 0.8404 0.8404
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0666 0.0729
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0468 0.0468
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0468 0.0468
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0041 0.0552 0.0933
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0537 0.7986
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0493 1 1
Schistosoma mansoni jun-related protein 0.0152 0.2876 0.2876
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0064 0.1029 0.1126
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.014 0.0621
Schistosoma mansoni lamin 0.0027 0.0267 0.0267
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.003 0.0034
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0448 0.049
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1124 0.1338
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0187 0.3609 0.4295
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.2255 0.3801
Echinococcus granulosus cpg binding protein 0.0061 0.0959 0.1141
Echinococcus granulosus lysosomal alpha glucosidase 0.0184 0.3534 0.4205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.5918 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0024 0.0107
Schistosoma mansoni hypothetical protein 0.0018 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0378 0.7603 0.7603
Onchocerca volvulus 0.0036 0.0448 0.0482
Brugia malayi cDNA sequence BC016226 0.0041 0.0552 0.0607
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0448 0.1986
Loa Loa (eye worm) carboxylesterase 0.0378 0.7603 0.7603
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0468 0.0557
Mycobacterium tuberculosis Carboxylesterase LipT 0.0064 0.1029 0.1126
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0041 0.0552 0.2447
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1124 0.1098
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0564 0.2502
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0493 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1641 0.1953
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.001 0.0046
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.2255 0.2467
Echinococcus multilocularis BC026374 protein (S09 family) 0.0064 0.1029 0.1225
Brugia malayi hypothetical protein 0.0064 0.1029 0.1132
Echinococcus multilocularis lamin dm0 0.0027 0.0267 0.0318
Loa Loa (eye worm) hypothetical protein 0.0036 0.0448 0.0448
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1124 0.1338
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0537 0.0861
Brugia malayi Thioredoxin reductase 0.0047 0.0666 0.0733
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.001 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.5918 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0378 0.7603 0.7603
Leishmania major glycosyl hydrolase-like protein 0.0015 0.001 0.0046
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0481 0.0481
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0448 0.0419
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1124 0.1124
Brugia malayi Carboxylesterase family protein 0.0064 0.1029 0.1132
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.003 0.0031
Brugia malayi Glycosyl hydrolases family 31 protein 0.0184 0.3534 0.3887
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0552 0.2447
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0448 0.049
Onchocerca volvulus 0.0064 0.1029 0.1122
Schistosoma mansoni acetylcholinesterase 0.0064 0.1029 0.1029
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0041 0.0552 0.2724
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.003 0.0134
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0064 0.1029 0.1029
Schistosoma mansoni lamin 0.0027 0.0267 0.0267
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0537 0.0639
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0666 0.0793
Trypanosoma brucei glucosidase, putative 0.0041 0.0545 0.2417
Leishmania major trypanothione reductase 0.0047 0.0666 0.2953
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0448 0.0533
Echinococcus multilocularis muscleblind protein 1 0.0152 0.2874 0.342
Brugia malayi 6-phosphofructokinase 0.0123 0.2255 0.2481
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0545 0.0649
Echinococcus granulosus neuroligin 0.0064 0.1029 0.1225
Brugia malayi isocitrate dehydrogenase 0.0016 0.0024 0.0027
Brugia malayi Carboxylesterase family protein 0.0378 0.7603 0.8363
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.003 0.0134
Onchocerca volvulus 0.0057 0.089 0.0969
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0385 0.0635
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0385 0.5624
Loa Loa (eye worm) hypothetical protein 0.0378 0.7603 0.7603
Brugia malayi Carboxylesterase family protein 0.0378 0.7603 0.8363
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0545 0.0649
Schistosoma mansoni ap endonuclease 0.004 0.0537 0.0537
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0288 0.4105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0134
Loa Loa (eye worm) glutathione reductase 0.0047 0.0666 0.0666
Mycobacterium ulcerans beta-lactamase 0.0036 0.0448 0.0419
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.5918 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0868 0.0868
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0064 0.1029 0.1225
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0041 0.0552 0.0607
Echinococcus multilocularis GPCR, family 2 0.0018 0.0065 0.0077
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0288 0.0288
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0448 0.0533
Mycobacterium tuberculosis Probable reductase 0.0106 0.1913 0.2093
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0666 0.0793
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0552 0.0523
Trichomonas vaginalis spcc417.12 protein, putative 0.0064 0.1029 0.1725
Brugia malayi beta-lactamase 0.0036 0.0448 0.0493
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0545 0.0921
Schistosoma mansoni fad oxidoreductase 0.0041 0.0552 0.0552
Brugia malayi beta-lactamase family protein 0.0036 0.0448 0.0493
Schistosoma mansoni lozenge 0.0056 0.0872 0.0872
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0385 0.6803
Brugia malayi bZIP transcription factor family protein 0.0187 0.3609 0.397
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0448 0.049
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0045 0.0198
Brugia malayi hypothetical protein 0.0147 0.2768 0.3045
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1124 0.123
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0448 0.0741
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0468 0.2077
Chlamydia trachomatis D-amino acid dehydrogenase 0.0041 0.0552 1
Schistosoma mansoni fad oxidoreductase 0.0041 0.0552 0.0552
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.003 0.0134
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0288 0.0342
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0545 0.2417
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0065 0.0065
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0468 0.0557
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0029
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.2734 0.2991
Loa Loa (eye worm) hypothetical protein 0.0182 0.3502 0.3502
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0545 0.0921
Loa Loa (eye worm) hypothetical protein 0.0152 0.2874 0.2874
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0385 0.0603
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0552 0.0604
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.003 0.0092
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0385 0.0635
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.5918 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0545 0.0905
Loa Loa (eye worm) hypothetical protein 0.0152 0.2874 0.2874
Loa Loa (eye worm) beta-lactamase 0.0036 0.0448 0.0448
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0029
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0288 0.136
Echinococcus multilocularis carboxylesterase 5A 0.0378 0.7603 0.9047
Giardia lamblia DINP protein human, muc B family 0.0021 0.014 0.0187
Mycobacterium tuberculosis Conserved protein 0.0036 0.0448 0.049
Schistosoma mansoni hypothetical protein 0.0038 0.0496 0.0496
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0041 0.0552 0.0552
Brugia malayi CXXC zinc finger family protein 0.0057 0.089 0.0979
Loa Loa (eye worm) carboxylesterase 0.0064 0.1029 0.1029
Onchocerca volvulus 0.0064 0.1029 0.1122
Schistosoma mansoni BC026374 protein (S09 family) 0.0064 0.1029 0.1029
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.2255 0.3812
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.2734 0.2393
Giardia lamblia PHD finger protein 15 0.0028 0.0288 0.0437
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.5918 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.003 0.0134
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.003 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0385 0.0635
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0041 0.0552 0.0657
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2161 0.2364
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.5918 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0385 0.1863
Mycobacterium tuberculosis Conserved protein 0.0036 0.0448 0.049
Echinococcus granulosus lamin 0.0027 0.0267 0.0318
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.003 0.0092
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0045 0.0198
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0564 0.0536
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.003 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0267 0.0267
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0041 0.0552 0.0657
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0521 0.062
Echinococcus multilocularis acetylcholinesterase 0.0378 0.7603 0.9047
Brugia malayi Carboxylesterase family protein 0.0064 0.1029 0.1132
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.2255 0.2232
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.2255 0.2255
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0537 0.238
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.003 0.0036
Onchocerca volvulus 0.0064 0.1029 0.1122
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1124 0.5678
Toxoplasma gondii thioredoxin reductase 0.0047 0.0666 0.3313
Toxoplasma gondii hypothetical protein 0.0041 0.0552 0.2724
Onchocerca volvulus Putative fad oxidoreductase 0.0041 0.0552 0.0597
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0448 0.049
Schistosoma mansoni NAD dehydrogenase 0.0041 0.0552 0.0552
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0288 0.136
Schistosoma mansoni hypothetical protein 0.0018 0.0065 0.0065
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0024 0.0029
Brugia malayi 6-phosphofructokinase 0.0123 0.2255 0.2481
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0041 0.0552 0.0523
Echinococcus granulosus muscleblind protein 0.0152 0.2874 0.342
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0288 0.0342
Loa Loa (eye worm) hypothetical protein 0.0036 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0064 0.1029 0.1029
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0024 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0545 0.2417
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0552 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0385 0.0635
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0552 0.2447
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0537 0.0508
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0537 0.238
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.2255 0.2255
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0564 0.2502
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0468 0.0557
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1124 0.1098
Loa Loa (eye worm) phosphofructokinase 0.0123 0.2255 0.2255
Plasmodium falciparum glutathione reductase 0.0047 0.0666 1
Echinococcus multilocularis muscleblind protein 0.0152 0.2874 0.342
Echinococcus multilocularis neuroligin 0.0064 0.1029 0.1225
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.5918 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0024 0.0107
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0468 0.2077
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0564 0.0938
Loa Loa (eye worm) hypothetical protein 0.0036 0.0448 0.0448
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0029
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.003 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0448 0.0448
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.2233 0.2233
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0063 0.0063
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0064 0.1029 0.1225
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0537 0.0891
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1124 0.4985
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.5918 1
Loa Loa (eye worm) carboxylesterase 0.0064 0.1029 0.1029
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0468 0.2077
Loa Loa (eye worm) hypothetical protein 0.0027 0.0257 0.0257
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0041 0.0552 0.2447
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0621
Mycobacterium tuberculosis Conserved protein 0.0036 0.0448 0.049
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0481 0.0572
Brugia malayi phosphofructokinase 0.0123 0.2255 0.2481
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.003 0.0031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0468 0.0775
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0448 0.0419
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1913 0.2093
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0545 0.0905
Schistosoma mansoni hypothetical protein 0.0028 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0036 0.0448 0.0448
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.2255 0.2684
Toxoplasma gondii ABC1 family protein 0.0036 0.0448 0.2187
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1913 0.2093
Brugia malayi Carboxylesterase family protein 0.0064 0.1029 0.1132
Mycobacterium ulcerans carboxylesterase, LipT 0.0064 0.1029 0.1002
Echinococcus granulosus intermediate filament protein 0.0027 0.0267 0.0318
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0065 0.0077
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0413 0.0491
Schistosoma mansoni hypothetical protein 0.0018 0.0065 0.0065
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0448 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0352 0.1562
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0468 0.0557
Schistosoma mansoni ap endonuclease 0.004 0.0537 0.0537
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0468 0.0744
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0468 0.0791
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0448 0.6601
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0041 0.0552 0.0607
Echinococcus granulosus carboxylesterase 5A 0.0378 0.7603 0.9047
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0545 0.0905

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 54 % Agonist activity at human GPR106A at 100 uM by [35S]GTPgammaS binding assay relative to niacin ChEMBL. 18029181
Activity (functional) = 54 % Agonist activity at human GPR106A at 100 uM by [35S]GTPgammaS binding assay relative to niacin ChEMBL. 18029181
EC50 (functional) = 13 uM Agonist activity at human GPR106A by [35S]GTPgammaS binding assay ChEMBL. 18029181
EC50 (functional) = 13 uM Agonist activity at human GPR106A by [35S]GTPgammaS binding assay ChEMBL. 18029181
IC50 (binding) = 76 uM Displacement of [3H]niacin from human GPR109A ChEMBL. 18029181
IC50 (binding) = 76 uM Displacement of [3H]niacin from human GPR109A ChEMBL. 18029181

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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