Detailed information for compound 510994

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 226.189 | Formula: C8H10N4O4
  • H donors: 6 H acceptors: 4 LogP: -1.05 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: ONC(=O)Nc1ccc(cc1)NC(=O)NO
  • InChi: 1S/C8H10N4O4/c13-7(11-15)9-5-1-2-6(4-3-5)10-8(14)12-16/h1-4,15-16H,(H2,9,11,13)(H2,10,12,14)
  • InChiKey: AAGCROWGMVRBQK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0296 0.0642
Brugia malayi 6-phosphofructokinase 0.0114 0.1362 0.2141
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0109 0.129 0.1553
Schistosoma mansoni cathepsin D (A01 family) 0.0019 0.0009 0.0009
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0634 0.0634
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.051 0.1229
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.051 0.0806
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0183 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0296 0.0704
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0009 0.0009
Toxoplasma gondii exonuclease III APE 0.002 0.0026 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4089 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0094 0.0162
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1868 0.2263
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0138 0.1694 0.2677
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0982 0.0982
Schistosoma mansoni memapsin-2 (A01 family) 0.0462 0.627 0.627
Treponema pallidum licC protein (licC) 0.0109 0.129 0.3112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4089 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0281 0.0281
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0183 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0727 0.1667
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0087 0.0977 0.0977
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.1362 0.1362
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0284 0.0674
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0727 0.0727
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0649 0.0649
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0008 0.0008
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.4234 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.038 0.0601
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0026 0.0026
Brugia malayi Thioredoxin reductase 0.004 0.0309 0.0475
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0316 0.0316
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0183 0.0386
Echinococcus multilocularis bloom syndrome protein 0.0043 0.0358 0.0358
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.051 0.051
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0982 0.0982
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0172 0.0172
Trypanosoma brucei protein kinase, putative 0.0054 0.051 0.1151
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.051 0.051
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0026 0.0028
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.021 0.0438
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0309 0.0347
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0183 0.0386
Schistosoma mansoni zinc finger protein 0.0021 0.0037 0.0037
Toxoplasma gondii thioredoxin reductase 0.004 0.0309 0.2341
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0183 0.136
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0172 0.0258
Leishmania major trypanothione reductase 0.004 0.0309 0.0672
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0183 0.136
Schistosoma mansoni DNA helicase recq1 0.003 0.0172 0.0172
Schistosoma mansoni alpha-glucosidase 0.0147 0.183 0.183
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0094 0.0167
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0103 0.0735
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0014
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.187 0.4383
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0649 0.1025
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1362 0.2152
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0087 0.0977 0.0977
Echinococcus granulosus transcription factor Dp 1 0.004 0.0314 0.0314
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0094 0.0667
Loa Loa (eye worm) hypothetical protein 0.0087 0.0977 0.1544
Schistosoma mansoni vav2 0.0019 0.0018 0.0018
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.1029 0.1232
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.051 0.1151
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0009 0.0009
Echinococcus granulosus myotubularin protein 13 0.0019 0.0018 0.0018
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0019 0.0009 0.0014
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0596 0.8166 1
Trichomonas vaginalis DNA helicase recq, putative 0.0033 0.021 0.0495
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.211 0.2561
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0026 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0378 0.0835
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0094 0.0084
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0284 0.2147
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0123 0.1481 0.234
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.2167 0.3425
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.1362 0.157
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0009 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0183 0.0427
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0109 0.129 1
Loa Loa (eye worm) glutathione reductase 0.004 0.0309 0.0488
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0309 0.0672
Entamoeba histolytica recQ family helicase, putative 0.0033 0.021 0.0454
Loa Loa (eye worm) aspartyl protease 6 0.0019 0.0009 0.0014
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.051 0.1151
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0087 0.0977 0.0977
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0026 0.0561
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0296 0.0642
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.4089 1
Brugia malayi Bromodomain containing protein 0.004 0.0316 0.0486
Brugia malayi C1-like domain containing protein 0.0138 0.1694 0.2667
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0014
Schistosoma mansoni hypothetical protein 0.0022 0.0053 0.0053
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.051 0.051
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.1029 0.1232
Plasmodium falciparum thioredoxin reductase 0.004 0.0309 0.9647
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0727 0.1726
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.0272
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0284 0.0674
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0019 0.0009 0.0014
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.2167 0.2167
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0284 0.0674
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.4089 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0727 0.0727
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0309 1
Echinococcus granulosus zinc finger protein 0.0021 0.0037 0.0037
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0183 0.0427
Loa Loa (eye worm) hypothetical protein 0.0157 0.1966 0.3107
Echinococcus multilocularis zinc finger protein 0.0021 0.0037 0.0037
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.051 0.1151
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.051 0.051
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.051 0.1151
Entamoeba histolytica hypothetical protein 0.0025 0.0094 0.0167
Mycobacterium ulcerans hypothetical protein 0.0109 0.129 0.1553
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0183 0.581
Schistosoma mansoni apoptosis regulator bax 0.0087 0.0977 0.0977
Onchocerca volvulus 0.0087 0.0982 0.154
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0026 0.0581
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0026 0.0043
Mycobacterium tuberculosis Conserved hypothetical protein 0.0109 0.129 0.1553
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.051 0.1192
Trichomonas vaginalis DNA helicase recq1, putative 0.0043 0.0358 0.0857
Loa Loa (eye worm) phosphofructokinase 0.0114 0.1362 0.2152
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.032 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.1172 0.1408
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0014
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.187 0.4383
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0087 0.0977 0.0977
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4089 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0026 0.0043
Brugia malayi Muscleblind-like protein 0.0157 0.1966 0.3098
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1868 0.2198
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.1172 0.1408
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0172 0.1274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4089 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0094 0.0667
Echinococcus granulosus bloom syndrome protein 0.0043 0.0358 0.0358
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0982 0.154
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0026 0.0026
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0596 0.8166 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0596 0.8166 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0183 0.5605
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0649 0.0649
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.4089 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0296 0.0704
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0284 0.0448
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.062 0.062
Brugia malayi glutathione reductase 0.004 0.0309 0.0475
Schistosoma mansoni DNA helicase recq5 0.003 0.0172 0.0172
Brugia malayi Bromodomain containing protein 0.0079 0.0861 0.1349
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0296 0.0296
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.4234 1
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0296 0.0296
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.1029 0.1232
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1362 0.3316
Loa Loa (eye worm) hypothetical protein 0.0122 0.1467 0.2319
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0284 0.0674
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.051 0.3913
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0009 0.0009
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.1172 0.1335
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0183 0.0427
Schistosoma mansoni alpha-glucosidase 0.0147 0.183 0.183
Loa Loa (eye worm) hypothetical protein 0.0466 0.6328 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0183 0.0427
Echinococcus multilocularis muscleblind protein 0.0157 0.1966 0.1966
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0141 0.0141
Echinococcus multilocularis muscleblind protein 1 0.0157 0.1966 0.1966
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0296 0.0642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4089 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.051 0.1151
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0727 0.1667
Brugia malayi 6-phosphofructokinase 0.0114 0.1362 0.2141
Brugia malayi PHD-finger family protein 0.0026 0.0117 0.0171
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.051 0.1229
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.021 0.0438
Loa Loa (eye worm) hypothetical protein 0.0087 0.0982 0.1552
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0296 0.0296
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1362 0.1362
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0094 0.0084
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0087 0.0977 0.0977
Schistosoma mansoni bromodomain containing protein 0.0067 0.0687 0.0687
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0172 0.5252
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0094 0.0162
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0284 0.0612
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1362 0.1362
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0284 0.0674
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0284 0.0634
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0378 0.0835
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Schistosoma mansoni hypothetical protein 0.0087 0.0977 0.0977
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4089 1
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1362 0.3316
Loa Loa (eye worm) hypothetical protein 0.0039 0.0296 0.0468
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0172 0.0359
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.051 0.1229
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.4234 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0109 0.129 0.1553
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0378 0.0835
Loa Loa (eye worm) hypothetical protein 0.0141 0.1739 0.2748
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0183 0.136
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0111 0.3415
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0596 0.8166 1
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1362 0.3316
Schistosoma mansoni hypothetical protein 0.0087 0.0977 0.0977
Schistosoma mansoni ap endonuclease 0.002 0.0026 0.0026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0137 0.1681 0.2656
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0296 0.0704
Onchocerca volvulus 0.0099 0.1147 0.1801
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0009 0.0009
Brugia malayi Pleckstrin Homology Domain 0.0019 0.0018 0.0015
Echinococcus multilocularis Protein lozenge 0.0058 0.0572 0.0572
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.2167 0.2167
Brugia malayi MAP kinase sur-1 0.0054 0.051 0.0794
Onchocerca volvulus 0.0141 0.1739 0.2738
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.1362 0.3174
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0281 0.0281
Brugia malayi phosphofructokinase 0.0114 0.1362 0.2141
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4089 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0296 0.0296
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0284 0.0674
Loa Loa (eye worm) hypothetical protein 0.004 0.0317 0.0501
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0183 0.5605
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0634 0.0634
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0284 0.0674
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0082 0.0082
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.1362 0.1641
Onchocerca volvulus 0.0466 0.6328 1
Loa Loa (eye worm) RecQ helicase 0.0043 0.0358 0.0566
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0284 0.0674
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0009 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0284 0.0612
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.051 0.1151
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0309 0.0488
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0019 0.0009 0.0009
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0122 0.1467 0.2319
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0172 0.0172
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.051 0.051
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0019 0.0009 0.0009
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0082 0.0082
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0053 0.0084
Brugia malayi hypothetical protein 0.0466 0.6328 1
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0649 0.0649
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.1029 0.1232
Loa Loa (eye worm) hypothetical protein 0.0466 0.6328 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0378 0.0835
Schistosoma mansoni alpha glucosidase 0.0038 0.0284 0.0284
Onchocerca volvulus 0.0122 0.1467 0.2308
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0727 0.0727
Loa Loa (eye worm) runx1 0.0058 0.0572 0.0904
Schistosoma mansoni jumonji domain containing protein 0.0062 0.062 0.062
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0284 0.0612
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1362 0.3316
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4089 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0284 0.0634
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0094 0.2848
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0087 0.0977 0.1532
Schistosoma mansoni cathepsin D (A01 family) 0.0019 0.0009 0.0009
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0296 0.0296
Trichomonas vaginalis DNA helicase recq, putative 0.0043 0.0358 0.0857
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0727 0.115
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0727 0.1667
Loa Loa (eye worm) hypothetical protein 0.0029 0.015 0.0236
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0183 0.0427
Plasmodium vivax glutathione reductase, putative 0.004 0.0309 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.187 0.4383
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0982 0.0982
Schistosoma mansoni hypothetical protein 0.0087 0.0977 0.0977
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1362 0.2152
Schistosoma mansoni protein kinase C mu 0.0138 0.1694 0.1694
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.4234 1
Mycobacterium ulcerans hypothetical protein 0.0167 0.211 0.2561
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0009 0.0009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.1172 0.1408
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.051 0.1229
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0516 0.1163
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0183 0.0386
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0296 0.0455
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0296 0.0642
Trypanosoma brucei trypanothione reductase 0.004 0.0309 0.0672
Mycobacterium ulcerans hypothetical protein 0.0109 0.129 0.1553
Loa Loa (eye worm) hypothetical protein 0.0157 0.1966 0.3107
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0183 0.0427
Echinococcus granulosus muscleblind protein 0.0157 0.1966 0.1966
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0314 0.0314
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0138 0.1694 0.2667
Mycobacterium tuberculosis Probable reductase 0.0091 0.1029 0.1232
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1362 0.3174
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1868 0.2263
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0296 0.0296
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.1362 0.3287
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0172 0.1274
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.1029 0.1232
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1362 0.3287
Loa Loa (eye worm) hypothetical protein 0.0074 0.0797 0.126
Loa Loa (eye worm) apoptosis regulator protein 0.0087 0.0977 0.1544
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0094 0.0084
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0296 0.0665
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.1029 0.1158
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0284 0.0284
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0284 0.0674
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1362 0.3287
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0008 0.0008
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0094 0.2747
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.021 0.0438
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.1362 0.1641
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0183 0.0427
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0296 0.0296
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.2167 0.2167
Brugia malayi Bloom's syndrome protein homolog 0.0043 0.0358 0.0553
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0172 0.0272
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0082 0.0082
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0316 0.0316
Echinococcus multilocularis myotubularin protein 13 0.0019 0.0018 0.0018
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.2167 0.3416
Schistosoma mansoni ap endonuclease 0.002 0.0026 0.0026
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0296 0.0665
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1362 0.3174
Onchocerca volvulus 0.0137 0.1681 0.2646
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.4089 1
Brugia malayi jmjC domain containing protein 0.0062 0.062 0.0968
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.062 0.062
Plasmodium falciparum glutathione reductase 0.004 0.0309 0.9647
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0727 0.1667
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0284 0.0435
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0172 0.0172
Schistosoma mansoni lozenge 0.0058 0.0572 0.0572
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.051 0.1151
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0727 0.1138
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.062 0.062
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0172 0.0258
Brugia malayi jmjC domain containing protein 0.0064 0.0649 0.1013
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0183 0.581
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0009 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0009 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.0725 1 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0094 0.0084
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0296 0.0296
Schistosoma mansoni microtubule-associated protein tau 0.0725 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1362 0.3287
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.1362 0.1362
Toxoplasma gondii hypothetical protein 0.0051 0.047 0.3603
Loa Loa (eye worm) hypothetical protein 0.0043 0.0352 0.0556
Trypanosoma brucei glucosidase, putative 0.0038 0.0284 0.0612

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Cytotoxicity against mouse B16 cells at 100 uM ChEMBL. 18501598
IC50 (binding) = 27 uM Inhibition of mushroom tyrosinase ChEMBL. 18501598
IC50 (binding) = 27 uM Inhibition of mushroom tyrosinase ChEMBL. 18501598
Inhibition (functional) = 66 % Inhibition of melanin production in mouse B16 cells at 100 uM ChEMBL. 18501598
Inhibition (functional) = 66 % Inhibition of melanin production in mouse B16 cells at 100 uM ChEMBL. 18501598

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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