TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 683.664 | Formula: C33H21N3O10S2--
H donors: 3 H acceptors: 9 LogP: 3.66 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: O=C(c1cc(NC(=O)c2ccco2)cc(c1)C(=O)Nc1cccc2c1ccc(c2)S(=O)(=O)[O-])Nc1cccc2c1ccc(c2)S(=O)(=O)[O-]
InChi: 1S/C33H23N3O10S2/c37-31(35-28-6-1-4-19-17-24(47(40,41)42)9-11-26(19)28)21-14-22(16-23(15-21)34-33(39)30-8-3-13-46-30)32(38)36-29-7-2-5-20-18-25(48(43,44)45)10-12-27(20)29/h1-18H,(H,34,39)(H,35,37)(H,36,38)(H,40,41,42)(H,43,44,45)/p-2
InChiKey: GFTSGGTXPHFCMQ-UHFFFAOYSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	hypothetical protein	0.0159	0.5126	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0012	0.0096	0.0145
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0012	0.0096	0.0145
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0071
Echinococcus granulosus	centrosomal protein of 41 kDa	0.001	0.0032	0.0045
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Brugia malayi	G-protein coupled receptor	0.0015	0.0223	0.0566
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0208	0.0527
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.1556	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0301	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0538	0.1357
Brugia malayi	Nuclear hormone receptor-like 1	0.0013	0.0143	0.0363
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0071
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0015	0.0223	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0143	0.0354
Brugia malayi	Nuclear hormone receptor-like 1	0.0013	0.0143	0.0363
Onchocerca volvulus		0.0015	0.0223	0.0489
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0024	0.0538	0.0845
Onchocerca volvulus		0.0077	0.2335	0.5892
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Echinococcus granulosus	death domain containing protein	0.0015	0.0208	0.0322
Loa Loa (eye worm)	DR-78	0.0012	0.0096	0.0233
Echinococcus granulosus	somatostatin receptor	0.0015	0.0223	0.0347
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0015	0.0223	0.0193
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0024	0.0538	0.0512
Brugia malayi	mbt repeat family protein	0.0049	0.1382	0.3507
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0096	0.0064
Schistosoma mansoni	amine GPCR	0.0015	0.0223	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Onchocerca volvulus	Netrin receptor homolog	0.0015	0.0208	0.0449
Brugia malayi	RE15519p	0.0015	0.0223	0.0566
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0024	0.0538	0.0845
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0124	0.394	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0015	0.0223	0.0347
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0301	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0024	0.0538	0.1357
Schistosoma mansoni	RAR-like nuclear receptor	0.0024	0.0538	0.0512
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0024	0.0538	0.0845
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Schistosoma mansoni	adenoreceptor	0.0015	0.0223	0.0193
Schistosoma mansoni	retinoic acid receptor RXR	0.0024	0.0538	0.0512
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0024	0.0538	0.0845
Brugia malayi	AKH receptor	0.0015	0.0223	0.0566
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Schistosoma mansoni	thyroid hormone receptor	0.0024	0.0538	0.0512
Brugia malayi	Rhodanese-like domain containing protein	0.001	0.0032	0.0081
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0015	0.0223	0.0193
Plasmodium vivax	mitogen-activated protein kinase phosphatase 1, putative	0.001	0.0032	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0013	0.0143	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3609	0.9159
Echinococcus granulosus	ecdysone induced protein 78C	0.0024	0.0538	0.0845
Brugia malayi	Thiosulfate sulfurtransferase D2023.5	0.001	0.0032	0.0081
Echinococcus granulosus	jun protein	0.0098	0.3055	0.4827
Brugia malayi	Rhodanese-like domain containing protein	0.0124	0.394	1
Toxoplasma gondii	hypothetical protein	0.0049	0.1362	0.8725
Echinococcus granulosus	neuropeptide receptor A26	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0143	0.0354
Schistosoma mansoni	nuclear receptor	0.0012	0.0096	0.0064
Onchocerca volvulus		0.0015	0.0223	0.0489
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0142	0.4575	0.4558
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus multilocularis	ecdysone induced protein 78C	0.0024	0.0538	0.0845
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0015	0.0223	0.0347
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0056	0.1615	0.2548
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.1149	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.4575	0.4558
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0015	0.0223	0.0347
Mycobacterium leprae	Conserved hypothetical protein	0.001	0.0032	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0015	0.0223	0.0347
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0223	0.0347
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0124	0.394	1
Brugia malayi	Rhodanese-like domain containing protein	0.0124	0.394	1
Entamoeba histolytica	rodhanase-like domain containing protein	0.0124	0.394	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0015	0.0223	0.0193
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0159	0.5126	1
Brugia malayi	RIKEN cDNA 4930451A13	0.001	0.0032	0.0081
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0538	0.1357
Echinococcus multilocularis	jun protein	0.0098	0.3055	0.4827
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0012	0.0096	0.0064
Schistosoma mansoni	thyroid hormone receptor	0.0024	0.0538	0.0512
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0538	0.1365
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0223	0.0193
Echinococcus multilocularis	somatostatin receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0024	0.0538	0.1357
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0015	0.0223	0.0347
Schistosoma mansoni	nuclear receptor nhr-48	0.0012	0.0096	0.0064
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0013	0.0143	0.0112
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0538	0.1365
Schistosoma mansoni	amine GPCR	0.0015	0.0223	0.0193
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Onchocerca volvulus		0.0015	0.0223	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0223	0.0347
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0538	0.1365
Loa Loa (eye worm)	melatonin receptor type 1A	0.0015	0.0223	0.0557
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0223	0.0347
Brugia malayi	bZIP transcription factor family protein	0.0098	0.3055	0.7753
Brugia malayi	sulfakinin receptor protein	0.0015	0.0223	0.0566
Onchocerca volvulus		0.0012	0.0096	0.0163
Echinococcus multilocularis	FTZ F1 alpha	0.0024	0.0538	0.0845
Brugia malayi	mbt repeat family protein	0.0049	0.1382	0.3507
Echinococcus granulosus	sex peptide receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.0223	0.0193
Brugia malayi	putative neuropeptide receptor NPR1	0.0015	0.0223	0.0566
Schistosoma mansoni	nuclear receptor	0.0012	0.0096	0.0064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0223	0.0347
Onchocerca volvulus	Bile acid receptor homolog	0.0024	0.0538	0.1294
Echinococcus multilocularis	netrin receptor unc 5	0.0015	0.0208	0.0322
Onchocerca volvulus		0.0124	0.394	1
Brugia malayi	nuclear receptor RXR	0.0013	0.0143	0.0363
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0015	0.0223	0.0347
Schistosoma mansoni	coup transcription factor	0.0024	0.0538	0.0512
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Schistosoma mansoni	hypothetical protein	0.0015	0.0223	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Brugia malayi	nuclear receptor NHR-67	0.0012	0.0096	0.0243
Echinococcus granulosus	histone acetyltransferase MYST2	0.0056	0.1615	0.2548
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.0223	0.0347
Echinococcus granulosus	neuropeptide FF receptor 2	0.0015	0.0223	0.0347
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Entamoeba histolytica	rodhanase-like domain containing protein	0.0124	0.394	1
Loa Loa (eye worm)	MBCTL1	0.0056	0.1615	0.4092
Brugia malayi	Death domain containing protein	0.0015	0.0208	0.0527
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0071
Echinococcus granulosus	m phase inducer phosphatasecdc25	0.0124	0.394	0.6227
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0223	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0134	0.0332
Onchocerca volvulus		0.0015	0.0223	0.0489
Echinococcus multilocularis	g-protein coupled receptor	0.0015	0.0223	0.0347
Plasmodium falciparum	mitogen-activated protein kinase phosphatase 1, putative	0.001	0.0032	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Onchocerca volvulus		0.0015	0.0223	0.0489
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0223	0.0193
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0012	0.0096	0.0233
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0012	0.0096	0.0145
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0223	0.0557
Brugia malayi	G protein-coupled receptor	0.0015	0.0223	0.0566
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0049	0.1382	0.3454
Brugia malayi	hypothetical protein	0.0077	0.2335	0.5925
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus multilocularis	nuclear receptor nhr 48	0.0012	0.0096	0.0145
Schistosoma mansoni	opsin-like receptor	0.0015	0.0223	0.0193
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0015	0.0223	0.0566
Echinococcus granulosus	thyroid hormone receptor alpha	0.0012	0.0096	0.0145
Echinococcus granulosus	dro:myosuppressin receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0015	0.0223	0.0557
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0012	0.0096	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Echinococcus granulosus	Ankyrin	0.0015	0.0212	0.0329
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0134	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0024	0.0538	0.1365
Trichomonas vaginalis	cdc25b, putative	0.0124	0.394	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0223	0.0193
Mycobacterium leprae	PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRAN	0.001	0.0032	0.5
Brugia malayi	CXXC zinc finger family protein	0.0029	0.068	0.1726
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.068	0.1718
Echinococcus multilocularis	neuropeptide s receptor	0.0015	0.0223	0.0347
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0015	0.0223	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0024	0.0538	0.1365
Loa Loa (eye worm)	steroid hormone receptor	0.0024	0.0538	0.1357
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0015	0.0208	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Brugia malayi	nuclear receptor NHR-88	0.0024	0.0538	0.1365
Plasmodium vivax	rhodanese like protein, putative	0.001	0.0032	0.5
Brugia malayi	ecdysteroid receptor	0.0024	0.0538	0.1365
Echinococcus multilocularis	serotonin receptor	0.0015	0.0223	0.0347
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0024	0.0538	0.0845
Loa Loa (eye worm)	mbt repeat family protein	0.0049	0.1382	0.3501
Echinococcus multilocularis	cpg binding protein	0.003	0.0736	0.1158
Onchocerca volvulus		0.0015	0.0223	0.0489
Brugia malayi	Nuclear hormone receptor E75	0.0012	0.0096	0.0243
Onchocerca volvulus		0.0124	0.394	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0212	0.0528
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0024	0.0538	0.1357
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0071
Onchocerca volvulus		0.0124	0.394	1
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0223	0.0347
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1382	0.3501
Brugia malayi	G-protein coupled receptor	0.0015	0.0223	0.0566
Onchocerca volvulus		0.0029	0.068	0.1659
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0024	0.0538	0.0845
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.1466	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus granulosus	5'partial\|tRNA 2 selenouridine synthase	0.001	0.0032	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Brugia malayi	ORL1-like opioid receptor	0.0015	0.0223	0.0566
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0024	0.0538	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0124	0.394	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0015	0.0223	0.0566
Brugia malayi	nuclear receptor RXR	0.0012	0.0096	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Echinococcus granulosus	fmrfamide receptor	0.0015	0.0223	0.0347
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0024	0.0538	0.0845
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0134	0.0341
Brugia malayi	hypothetical protein	0.0012	0.0096	0.0243
Onchocerca volvulus		0.0015	0.0223	0.0489
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0223	0.0193
Echinococcus granulosus	SAM and MBT domain containing protein	0.0049	0.1382	0.218
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0056	0.1615	0.2548
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.0223	0.0193
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0024	0.0538	0.1365
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0015	0.0223	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0009	0.001	0.0015
Schistosoma mansoni	amine GPCR	0.0015	0.0223	0.0193
Echinococcus granulosus	G protein coupled receptor 139	0.0015	0.0223	0.0347
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0012	0.0096	0.0145
Onchocerca volvulus		0.0015	0.0223	0.0489
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0015	0.0223	0.0347
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.0223	0.0347
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Schistosoma mansoni	hypothetical protein	0.0015	0.0223	0.0193
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0015	0.0223	0.0347
Echinococcus multilocularis	Rhodanese	0.001	0.0032	0.0045
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0049	0.1382	0.218
Onchocerca volvulus		0.0015	0.0223	0.0489
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0024	0.0538	0.0512
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0134	0.0332
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0223	0.0347
Brugia malayi	Steroid receptor seven-up type 2	0.0024	0.0538	0.1365
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0538	0.1365
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0015	0.0223	0.0566
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0013	0.0143	0.0112
Echinococcus multilocularis	neuropeptide receptor A26	0.0015	0.0223	0.0347
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0015	0.0223	0.0193
Brugia malayi	follicle stimulating hormone receptor	0.0015	0.0223	0.0566
Onchocerca volvulus		0.0015	0.0223	0.0489
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0223	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Trichomonas vaginalis	cdc25b, putative	0.0124	0.394	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0012	0.0096	0.0145
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0223	0.0193
Brugia malayi	photoreceptor-specific nuclear receptor	0.0024	0.0538	0.1365
Brugia malayi	neuropeptide F receptor	0.0015	0.0223	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0538	0.1357
Entamoeba histolytica	rodhanase-like domain containing protein	0.0124	0.394	1
Brugia malayi	nuclear hormone receptor	0.0024	0.0538	0.1365
Schistosoma mansoni	hypothetical protein	0.0015	0.0208	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Brugia malayi	Uncoordinated protein 44	0.0015	0.0208	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0143	0.0354
Echinococcus granulosus	nuclear receptor nhr 48	0.0012	0.0096	0.0145
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0223	0.0193
Schistosoma mansoni	cpg binding protein	0.003	0.0736	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0538	0.1357
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0015	0.0223	0.0193
Brugia malayi	neuropeptide F receptor	0.0015	0.0223	0.0566
Schistosoma mansoni	netrin receptor unc5	0.0015	0.0208	0.0178
Echinococcus multilocularis	sex peptide receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0223	0.0557
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0223	0.0347
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0098	0.3055	0.4827
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0223	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0124	0.394	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0024	0.0538	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Echinococcus multilocularis	heat shock protein 67b2	0.001	0.0032	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0071
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0212	0.0182
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1778	0.1766
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0049	0.1382	0.1365
Echinococcus multilocularis	centrosomal protein of 41 kDa	0.001	0.0032	0.0045
Onchocerca volvulus		0.0012	0.0096	0.0163
Brugia malayi	conserved hypotetical protein	0.0012	0.0096	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0208	0.0517
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Echinococcus granulosus	geminin	0.0175	0.5673	0.8968
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0223	0.0347
Schistosoma mansoni	myosin xvIII	0.0015	0.0223	0.0193
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0024	0.0538	0.1365
Echinococcus granulosus	Rhodanese	0.001	0.0032	0.0045
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0012	0.0096	0.0145
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0223	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Loa Loa (eye worm)	TYRA-2 protein	0.0015	0.0223	0.0557
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	0.0124	0.394	0.3953
Onchocerca volvulus		0.0015	0.0223	0.0489
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0013	0.0143	0.022
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0096	0.0064
Onchocerca volvulus		0.0015	0.0223	0.0489
Schistosoma mansoni	neuropeptide f receptor 76f	0.0015	0.0223	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0223	0.0193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Echinococcus granulosus	7tm_1 domain containing protein	0.0015	0.0223	0.0347
Schistosoma mansoni	ankyrin 23/unc44	0.0015	0.0208	0.0178
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0024	0.0538	0.0512
Brugia malayi	Dopamine receptor	0.0015	0.0223	0.0566
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2963	0.7517
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0015	0.0223	0.0557
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0096	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0538	0.1357
Brugia malayi	steroid hormone receptor	0.0024	0.0538	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.1149	0.1121
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.1382	0.1365
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0223	0.0347
Giardia lamblia	Dual specificity phosphatase Cdc25, putative	0.001	0.0032	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0015	0.0223	0.0347
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0223	0.0347
Giardia lamblia	Hypothetical protein	0.001	0.0032	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0223	0.0347
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0223	0.0557
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0223	0.0347
Onchocerca volvulus	Protein ultraspiracle homolog	0.0024	0.0538	0.1294
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0012	0.0096	0.0145
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0015	0.0223	0.0566
Echinococcus granulosus	allatostatin A receptor	0.0015	0.0223	0.0347
Brugia malayi	Dopamine receptor protein 1	0.0015	0.0223	0.0566
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Echinococcus multilocularis	Ankyrin	0.0015	0.0212	0.0329
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0015	0.0223	0.0193
Schistosoma mansoni	growth hormone secretagogue receptor	0.0015	0.0223	0.0193
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0223	0.0347
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0301	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0223	0.0347
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0223	0.0193
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0015	0.0223	0.0347
Echinococcus multilocularis	G protein coupled receptor 139	0.0015	0.0223	0.0347
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Brugia malayi	putative neuropeptide receptor	0.0015	0.0223	0.0566
Echinococcus granulosus	FTZ F1 alpha	0.0024	0.0538	0.0845
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.0208	0.0517
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0223	0.0193
Brugia malayi	Serotonin receptor	0.0015	0.0223	0.0566
Brugia malayi	MoeZ/MoeB domain containing protein	0.001	0.0032	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Echinococcus granulosus	serotonin receptor	0.0015	0.0223	0.0347
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0223	0.0193
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Echinococcus multilocularis	dro:myosuppressin receptor	0.0015	0.0223	0.0347
Echinococcus granulosus	heat shock protein 67b2	0.001	0.0032	0.0045
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.1149	0.1121
Leishmania major	cytochrome p450-like protein	0.0013	0.0134	0.0103
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0538	0.0845
Echinococcus multilocularis	orexin receptor type 2	0.0015	0.0223	0.0347
Schistosoma mansoni	opsin-like receptor	0.0015	0.0223	0.0193
Schistosoma mansoni	hypothetical protein	0.0175	0.5673	0.5705
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.1149	0.1121
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0134	0.0332
Brugia malayi	orphan nuclear receptor NR2E1	0.0012	0.0096	0.0243
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0223	0.0347
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.0208	0.0527
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0223	0.0347
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0015	0.0223	0.0566
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.4575	0.4558
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0015	0.0223	0.0347
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0056	0.1615	0.4098
Echinococcus granulosus	hypothetical protein	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0143	0.0354
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Chlamydia trachomatis	hypothetical protein	0.001	0.0032	0.5
Schistosoma mansoni	histamine h1 receptor	0.0015	0.0223	0.0193
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.0538	0.0512
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0538	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3609	0.9159
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0096	0.0145
Schistosoma mansoni	hypothetical protein	0.008	0.2427	0.2422
Brugia malayi	Rhodanese-like domain containing protein	0.001	0.0032	0.0081
Onchocerca volvulus		0.0015	0.0223	0.0489
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0223	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0223	0.0193
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0024	0.0538	0.1365
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0015	0.0223	0.0566
Onchocerca volvulus		0.0015	0.0223	0.0489
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0223	0.0347
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0124	0.394	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0024	0.0538	0.1357
Giardia lamblia	Hypothetical protein	0.001	0.0032	0.5
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0134	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Brugia malayi	larval opioid receptor	0.0015	0.0223	0.0566
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0012	0.0096	0.0233
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0012	0.0096	0.0243
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0076	0.2296	0.3626
Echinococcus granulosus	7TM GPCR rhodopsin	0.0015	0.0223	0.0347
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0223	0.0193
Schistosoma mansoni	amine GPCR	0.0015	0.0223	0.0193
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0223	0.0347
Brugia malayi	tailless protein	0.0012	0.0096	0.0243
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0015	0.0223	0.0347
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0024	0.0538	0.0512
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0194	0.6325	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0223	0.0193
Schistosoma mansoni	amine GPCR	0.0015	0.0223	0.0193
Brugia malayi	hypothetical protein	0.0013	0.0143	0.0363
Echinococcus granulosus	orexin receptor type 2	0.0015	0.0223	0.0347
Loa Loa (eye worm)	thiosulfate sulfurtransferase	0.001	0.0032	0.0071
Brugia malayi	nuclear hormone receptor	0.0012	0.0096	0.0243
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0223	0.0347
Echinococcus multilocularis	polycomb protein SCMH1	0.0049	0.1382	0.218
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0223	0.0347
Plasmodium falciparum	rhodanese like protein, putative	0.001	0.0032	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0538	0.0845
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	0.0124	0.394	0.6227
Brugia malayi	Melatonin receptor type 1A	0.0015	0.0223	0.0566
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0013	0.0143	0.022
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0538	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0024	0.0538	0.1365
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0223	0.0347
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0056	0.1615	0.2548
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0015	0.0208	0.0322
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0056	0.1615	0.16
Brugia malayi	Nuclear hormone receptor E75	0.0012	0.0096	0.0243
Schistosoma mansoni	hypothetical protein	0.0299	0.992	1
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0124	0.394	1
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0223	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0194	0.6325	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0024	0.0538	0.0845
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0012	0.0096	0.0163
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0015	0.0223	0.0347
Echinococcus granulosus	cpg binding protein	0.003	0.0736	0.1158
Schistosoma mansoni	hypothetical protein	0.0015	0.0223	0.0193
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0538	0.0845
Wolbachia endosymbiont of Brugia malayi	sulfurtransferase	0.001	0.0032	0.5
Giardia lamblia	Thiosulfate sulfurtransferase	0.001	0.0032	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Trichomonas vaginalis	cdc25c, putative	0.0124	0.394	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0223	0.0193
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0134	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0143	0.0354
Echinococcus granulosus	g-protein coupled receptor	0.0015	0.0223	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Brugia malayi	nuclear hormone receptor family member odr-7	0.0012	0.0096	0.0243
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0015	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Schistosoma mansoni	opsin-like receptor	0.0015	0.0223	0.0193
Onchocerca volvulus		0.0015	0.0223	0.0489
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0012	0.0096	0.0064
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0134	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Echinococcus granulosus	netrin receptor unc 5	0.0015	0.0208	0.0322
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0024	0.0538	0.1357
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0223	0.0193
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0098	0.3055	0.4827
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0024	0.0538	0.0845
Schistosoma mansoni	zinc finger protein	0.0012	0.0096	0.0064
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0024	0.0538	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0024	0.0538	0.0845
Schistosoma mansoni	hypothetical protein	0.0015	0.0223	0.0193
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0134	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0538	0.1357
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0015	0.0223	0.0347
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0223	0.0347
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0024	0.0538	0.1357
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0015	0.0223	0.0347
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0024	0.0538	0.1294
Brugia malayi	GnHR receptor homolog	0.0015	0.0223	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Mycobacterium leprae	Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE)	0.001	0.0032	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0015	0.0223	0.0193
Echinococcus multilocularis	geminin	0.0175	0.5673	0.8968
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0538	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Echinococcus granulosus	polycomb protein SCMH1	0.0049	0.1382	0.218
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0538	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0096	0.0233
Schistosoma mansoni	hypothetical protein	0.0175	0.5673	0.5705
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0223	0.0193
Onchocerca volvulus		0.0015	0.0223	0.0489
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0538	0.1365
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0538	0.1365
Echinococcus multilocularis	serotonin receptor	0.0015	0.0223	0.0347
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0223	0.0347
Echinococcus multilocularis	tRNA 2 selenouridine synthase	0.001	0.0032	0.0045
Brugia malayi	ecdysone receptor	0.0012	0.0096	0.0243
Loa Loa (eye worm)	nuclear hormone receptor	0.0012	0.0096	0.0233
Onchocerca volvulus		0.0124	0.394	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0015	0.0223	0.0489
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0223	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Brugia malayi	hypothetical protein	0.0015	0.0223	0.0566
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0124	0.394	1
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0223	0.0347
Mycobacterium leprae	PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE)	0.001	0.0032	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0024	0.0538	0.1365
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0538	0.0845
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0096	0.0145
Onchocerca volvulus		0.0049	0.1382	0.3454
Onchocerca volvulus		0.0015	0.0223	0.0489
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0223	0.0557
Brugia malayi	hypothetical protein	0.0012	0.0096	0.0243
Schistosoma mansoni	cpg binding protein	0.003	0.0736	0.0712
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0076	0.2296	0.3626
Schistosoma mansoni	jun-related protein	0.008	0.2427	0.2422
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0015	0.0223	0.0193
Brugia malayi	hypothetical protein	0.0013	0.0143	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0223	0.0557
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.1382	0.1365
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0012	0.0096	0.0243
Schistosoma mansoni	cpg binding protein	0.0029	0.068	0.0656
Brugia malayi	Serotonin receptor	0.0015	0.0223	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1615	0.4092
Brugia malayi	Dopamine receptor protein 2	0.0015	0.0223	0.0566
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0015	0.0223	0.0347
Onchocerca volvulus		0.0024	0.0538	0.1294

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	0	Activity at Insulin receptor in mouse 3T3-L1 cells assessed as glucose uptake	ChEMBL.	18513965

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 528461

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 511394