Detailed information for compound 519179

Basic information

Technical information
  • TDR Targets ID: 519179
  • Name: N-(2-hydroxy-5-phenylphenyl)acetamide
  • MW: 227.259 | Formula: C14H13NO2
  • H donors: 2 H acceptors: 2 LogP: 2.37 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1cc(ccc1O)c1ccccc1
  • InChi: 1S/C14H13NO2/c1-10(16)15-13-9-12(7-8-14(13)17)11-5-3-2-4-6-11/h2-9,17H,1H3,(H,15,16)
  • InChiKey: ODBZGVNPNRYIIU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(2-hydroxy-5-phenyl-phenyl)acetamide
  • N-(2-hydroxy-5-phenyl-phenyl)ethanamide
  • 5409-54-1
  • BAS 01900756
  • Oprea1_622722
  • Acetamide, N-(4-hydroxy(1,1'-biphenyl)-3-yl)-
  • Acetanilide, 2'-hydroxy-5'-phenyl-
  • NSC12483
  • N-(4-Hydroxy(1,1'-biphenyl)-3-yl)acetamide
  • Oprea1_102141
  • MLS000030849
  • N-(4-Hydroxy-biphenyl-3-yl)-acetamide
  • SMR000010843
  • Acetanilide, 2'-hydroxy-5'-phenyl- (8CI)
  • ZINC00319638
  • EINECS 226-480-3
  • NSC 12483

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens APOBEC3A and APOBEC3B deletion hybrid Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens histone deacetylase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.177 0.5549 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0059 0.0055 0.0099
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0059 0.0055 0.0055
Echinococcus multilocularis histone deacetylase 1 0.0077 0.0114 0.0114
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0258 0.0695 0.1252
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0258 0.0695 1
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.0527 0.0474
Toxoplasma gondii target of rapamycin (TOR), putative 0.0059 0.0055 0.0794
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0059 0.0055 0.0099
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.058 0.1727 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0258 0.0695 0.0775
Loa Loa (eye worm) hypothetical protein 0.0059 0.0055 0.0062
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.058 0.1727 0.3113
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0059 0.0055 0.0794
Loa Loa (eye worm) phosphatidylinositol 3 0.0059 0.0055 0.0062
Leishmania major N-myristoyl transferase, putative 0.018 0.0444 0.6385
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.018 0.0444 0.6385
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.0527 0.3049
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0109 0.0197
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.018 0.0444 0.0707
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.058 0.1727 0.3043
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.177 0.5549 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1387 0.4318 0.7782
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0059 0.0055 0.032
Echinococcus granulosus serine protein kinase ATM 0.0059 0.0055 0.0055
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0059 0.0055 0.0794
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0258 0.0695 0.1165
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0059 0.0055 0.0055
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0059 0.0055 0.0055
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.058 0.1727 0.1681
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0258 0.0695 0.1252
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.0527 0.0527
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.058 0.1727 0.3043
Treponema pallidum phosphoglycerate kinase 0.0206 0.0527 0.5
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.0527 0.7578
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.0527 0.5
Leishmania major histone deacetylase, putative 0.0077 0.0114 0.1637
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0095 0.0095
Loa Loa (eye worm) histone deacetylase 3 0.0077 0.0114 0.0127
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.0527 0.7578
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0059 0.0055 0.0794
Loa Loa (eye worm) hypothetical protein 0.0365 0.1038 0.1158
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0258 0.0695 0.0695
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0059 0.0055 0.0099
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0095 0.0095
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0114 0.0107
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0114 0.0107
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.018 0.0444 0.0444
Brugia malayi hypothetical protein 0.0365 0.1038 0.1871
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.0527 0.3049
Loa Loa (eye worm) hypothetical protein 0.0049 0.0025 0.0028
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0258 0.0695 0.0643
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0059 0.0055 0.0099
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0109 0.0197
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.0114 0.0205
Plasmodium vivax histone deacetylase 1, putative 0.0077 0.0114 0.1637
Loa Loa (eye worm) phosphatidylinositol 3 0.0059 0.0055 0.0062
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.018 0.0444 0.0444
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0059 0.0055 0.032
Echinococcus multilocularis serine protein kinase ATM 0.0059 0.0055 0.0055
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0258 0.0695 0.0695
Echinococcus granulosus histone deacetylase 3 0.0077 0.0114 0.0114
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0102 0.0047
Loa Loa (eye worm) phosphatidylinositol 3 0.2836 0.8968 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0258 0.0695 0.0695
Leishmania major phosphatidylinositol 4-kinase, putative 0.0059 0.0055 0.0794
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0059 0.0055 0.0794
Toxoplasma gondii FATC domain-containing protein 0.0059 0.0055 0.0794
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0059 0.0055 0.032
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0258 0.0695 0.0643
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.0527 0.0474
Loa Loa (eye worm) hypothetical protein 0.0206 0.0527 0.0587
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0059 0.0055 0.032
Trypanosoma cruzi N-myristoyl transferase, putative 0.018 0.0444 0.08
Loa Loa (eye worm) hypothetical protein 0.0052 0.0032 0.0036
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0059 0.0055 0.0099
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0258 0.0695 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0059 0.0055 0.0099
Leishmania major phosphatidylinositol kinase, putative 0.0059 0.0055 0.0794
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1277 0.3966 0.7119
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0131 0.0287 0.4133
Leishmania major hypothetical protein, conserved 0.0059 0.0055 0.0794
Leishmania major hypothetical protein, unknown function 0.0059 0.0055 0.0794
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.3157 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0059 0.0055 0.0099
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.0527 0.0949
Leishmania major phosphatidylinositol 3-kinase, putative 0.0059 0.0055 0.0794
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.0114 0.0107
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.058 0.1727 0.3043
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0114 0.0107
Loa Loa (eye worm) hypothetical protein 0.0059 0.0055 0.0062
Brugia malayi histone deacetylase 1 (HD1) 0.0077 0.0114 0.0205
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0258 0.0695 0.1165
Brugia malayi jmjC domain containing protein 0.0071 0.0095 0.0171
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.0114 0.0205
Leishmania major phosphatidylinositol 3-kinase, putative 0.0258 0.0695 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0059 0.0055 0.0794
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0059 0.0055 0.0055
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0059 0.0055 0.032
Trichomonas vaginalis N-myristoyl transferase, putative 0.0118 0.0246 0.0347
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0059 0.0055 0.0055
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0059 0.0055 0.0055
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0059 0.0055 0.0055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0059 0.0055 0.0099
Trypanosoma cruzi target of rapamycin kinase 3 0.0059 0.0055 0.0099
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0258 0.0695 0.1252
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0258 0.0695 1
Giardia lamblia Histone deacetylase 0.0077 0.0114 0.0203
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0131 0.0287 0.0518
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0059 0.0055 0.032
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0059 0.0055 0.0099
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0006 0.0006
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.0527 0.1701
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0059 0.0055 0.0099
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0059 0.0055 0.0055
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0059 0.0055 0.0055
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0114 0.0107
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.1073 0.331 0.331
Schistosoma mansoni N-myristoyltransferase 0.018 0.0444 0.0391
Brugia malayi Bromodomain containing protein 0.0091 0.0158 0.0284
Giardia lamblia CDC72 0.018 0.0444 0.135
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.0114 0.0107
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0109 0.0197
Loa Loa (eye worm) hypothetical protein 0.1073 0.331 0.3691
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1449 0.4517 0.8121
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.0527 0.0858
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0131 0.0287 0.0287
Plasmodium falciparum histone deacetylase 1 0.0077 0.0114 0.1637
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0109 0.0632
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0055 0.0794
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0521 0.1539 0.2773
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.038 0.1087 0.3585
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0098 0.0098
Entamoeba histolytica hypothetical protein 0.1449 0.4517 0.8121
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0956 0.2934 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0059 0.0055 0.0055
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0114 0.0107
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0098 0.0098
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0131 0.0287 0.0518
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0102 0.0102
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0059 0.0055 0.0099
Loa Loa (eye worm) hypothetical protein 0.0698 0.2106 0.2349
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.058 0.1727 0.3113
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0059 0.0055 0.0794
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0059 0.0055 0.032
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0095 0.004
Loa Loa (eye worm) phosphatidylinositol 3 0.0059 0.0055 0.0062
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0059 0.0055 0.0794
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0059 0.0055 0.0099
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.0527 0.1701
Brugia malayi N-myristoyltransferase 2 0.018 0.0444 0.08
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0131 0.0287 0.0518
Loa Loa (eye worm) phosphatidylinositol 3 0.0521 0.1539 0.1716
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.177 0.5549 1
Trypanosoma brucei N-myristoyltransferase 0.018 0.0444 0.2569
Onchocerca volvulus 0.0365 0.1038 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0059 0.0055 0.0099
Mycobacterium leprae PROBABLE NAPHTHOATE SYNTHASE MENB (DIHYDROXYNAPHTHOIC ACID SYNTHETASE) (DHNA SYNTHETASE) 0.0922 0.2828 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0109 0.1571
Loa Loa (eye worm) phosphatidylinositol 3 0.0059 0.0055 0.0062
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0059 0.0055 0.0099
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0131 0.0287 0.0287
Schistosoma mansoni bromodomain containing protein 0.0076 0.0112 0.0057
Loa Loa (eye worm) phosphatidylinositol 3 0.0059 0.0055 0.0062
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0059 0.0055 0.0794
Brugia malayi histone deacetylase 3 (HD3) 0.0077 0.0114 0.0205
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.0527 0.7578
Loa Loa (eye worm) hypothetical protein 0.0131 0.0287 0.032
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1277 0.3966 0.7119
Brugia malayi jmjC domain containing protein 0.0073 0.0102 0.0185
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.058 0.1727 0.3043
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0059 0.0055 0.0794
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.0114 0.0107
Trypanosoma brucei histone deacetylase 1 0.0077 0.0114 0.0659
Loa Loa (eye worm) hypothetical protein 0.0059 0.0055 0.0062
Echinococcus multilocularis 0.0059 0.0055 0.0055
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0059 0.0055 0.0794
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0059 0.0055 0.0794
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0258 0.0695 0.1165
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0109 0.0197
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.1073 0.331 0.331
Brugia malayi Phosphoglycerate kinase 0.0206 0.0527 0.0949
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1712 0.5361 0.9657
Trichomonas vaginalis N-myristoyl transferase, putative 0.018 0.0444 0.0707
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0059 0.0055 0.0099
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0059 0.0055 0.0055
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.177 0.5549 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0059 0.0055 0.0055
Loa Loa (eye worm) N-myristoyltransferase 2 0.018 0.0444 0.0495
Loa Loa (eye worm) phosphatidylinositol kinase 0.0059 0.0055 0.0062
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0059 0.0055 0.0794
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0059 0.0055 0.0794
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0059 0.0055 0.032
Trypanosoma cruzi N-myristoyl transferase, putative 0.018 0.0444 0.08
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0258 0.0695 0.4024
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0258 0.0695 1
Toxoplasma gondii histone deacetylase HDAC2 0.0077 0.0114 0.1637
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0114 0.0107
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0258 0.0695 1
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.0527 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0059 0.0055 0.0099
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0059 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0046 0.0016 0.0018
Loa Loa (eye worm) histone deacetylase 1 0.0077 0.0114 0.0127
Entamoeba histolytica histone deacetylase, putative 0.0077 0.0114 0.0107
Brugia malayi Bromodomain containing protein 0.0046 0.0015 0.0028
Schistosoma mansoni histone deacetylase 0.0077 0.0114 0.0059
Loa Loa (eye worm) hypothetical protein 0.0085 0.0141 0.0157
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.0527 0.0858
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0109 0.0197
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0258 0.0695 0.0695
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.018 0.0444 0.6385
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0127
Mycobacterium ulcerans naphthoate synthase 0.0922 0.2828 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0095 0.0095
Leishmania major histone deacetylase, putative 0.0077 0.0114 0.1637
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.0527 0.7578
Giardia lamblia Phosphoglycerate kinase 0.0206 0.0527 0.1638
Mycobacterium tuberculosis Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) 0.0922 0.2828 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0059 0.0055 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0102 0.0047
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.3157 1 1
Brugia malayi Histone deacetylase 1 0.0077 0.0114 0.0205
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.0527 0.7578
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0258 0.0695 0.1165
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.0527 0.0858
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.0527 0.0949
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.177 0.5549 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0059 0.0055 0.0794
Plasmodium vivax hypothetical protein 0.0059 0.0055 0.0794
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.0527 0.0527
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0109 0.0632
Schistosoma mansoni histone deacetylase 0.0077 0.0114 0.0059
Echinococcus granulosus histone deacetylase 1 0.0077 0.0114 0.0114
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0751 0.2278 0.4045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1073 0.331 0.5965
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0258 0.0695 0.1165
Echinococcus multilocularis histone deacetylase 3 0.0077 0.0114 0.0114
Toxoplasma gondii histone deacetylase HDAC3 0.0077 0.0114 0.1637
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0059 0.0055 0.032
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0102 0.0114
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.058 0.1727 0.3043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0059 0.0055 0.0099
Brugia malayi Phosphoglycerate kinase 0.0075 0.0109 0.0197
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.177 0.5549 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0059 0.0055 0.0099
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.177 0.5549 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.0527 0.7578
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0059 0.0055 0.032
Trypanosoma brucei N-myristoyl transferase, putative 0.018 0.0444 0.2569

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 1.102 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
IC50 (binding) = 4.8 uM Inhibition of HDAC1 (unknown origin) ChEMBL. 18182289
IC50 (binding) = 4.8 uM Inhibition of HDAC1 (unknown origin) ChEMBL. 18182289
IC50 (functional) = 7.17 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
IC50 (functional) = 16.5 uM PUBCHEM_BIOASSAY: Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.8115 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Potentiators of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 101.3736 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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