TDR Targets

Basic information

Technical information

TDR Targets ID: 528258
Name: morpholine hydrochloride
MW: 123.581 | Formula: C4H10ClNO
H donors: 1 H acceptors: 0 LogP: 0.22 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: C1CNCCO1.Cl
InChi: 1S/C4H9NO.ClH/c1-3-6-4-2-5-1;/h5H,1-4H2;1H
InChiKey: JXYZHMPRERWTPM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

morpholin-4-ium chloride
hydron; morpholine; chloride
morpholine
10024-89-2
EINECS 233-029-4

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	delta tubulin, putative	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	epsilon tubulin, putative	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	alpha tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	zeta tubulin, putative	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	beta tubulin	Curated by TDR Targets	References
Leishmania major	gamma-tubulin	Curated by TDR Targets	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	epsilon tubulin	Get druggable targets OG5_130726	All targets in OG5_130726
Brugia malayi	beta-tubulin, identical	Get druggable targets OG5_126611	All targets in OG5_126611
Brugia malayi	Tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma cruzi	zeta tubulin, putative	Get druggable targets OG5_145938	All targets in OG5_145938
Leishmania mexicana	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin beta-2A chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma cruzi	tubulin delta chain	Get druggable targets OG5_143817	All targets in OG5_143817
Trypanosoma cruzi	alpha tubulin, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Entamoeba histolytica	tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Brugia malayi	tubulin alpha chain - mouse	Get druggable targets OG5_126605	All targets in OG5_126605
Babesia bovis	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Cryptosporidium parvum	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	BEN-1 protein	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania braziliensis	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Epsilon tubulin	Get druggable targets OG5_130726	All targets in OG5_130726
Trichomonas vaginalis	tubulin gamma chain, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei gambiense	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium berghei	alpha tubulin 1	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma congolense	zeta tubulin	Get druggable targets OG5_145938	All targets in OG5_145938
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin beta-4 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium falciparum	tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Brugia malayi	tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Cryptosporidium hominis	beta-catenin-like repeat protein	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma cruzi	epsilon tubulin, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Theileria parva	Tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium vivax	tubulin gamma chain, putative	Get druggable targets OG5_127652	All targets in OG5_127652
Neospora caninum	tubulin epsilon chain, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Plasmodium vivax	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin, putative	Get druggable targets OG5_127652	All targets in OG5_127652
Trypanosoma brucei gambiense	epsilon tubulin	Get druggable targets OG5_130726	All targets in OG5_130726
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Theileria parva	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	ko:K07375 tubulin beta, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Brugia malayi	Tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania donovani	epsilon tubulin, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Leishmania infantum	delta tubulin, putative	Get druggable targets OG5_143817	All targets in OG5_143817
Giardia lamblia	Beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	tubulin delta chain	Get druggable targets OG5_143817	All targets in OG5_143817
Echinococcus granulosus	tubulin subunit TubB	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium yoelii	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium berghei	alpha tubulin 2	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin gamma chain, putative	Get druggable targets OG5_127652	All targets in OG5_127652
Leishmania infantum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Cryptosporidium parvum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei gambiense	delta tubulin, putative	Get druggable targets OG5_143817	All targets in OG5_143817
Toxoplasma gondii	beta-tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	zeta tubulin	Get druggable targets OG5_145938	All targets in OG5_145938
Schistosoma japonicum	Tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	epsilon tubulin, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Brugia malayi	Tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	delta tubulin, putative	Get druggable targets OG5_143817	All targets in OG5_143817
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Toxoplasma gondii	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium knowlesi	alpha-tubulin II, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	alpha-tubulin I, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-7 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma cruzi	beta tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin alpha-3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei gambiense	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium falciparum	alpha tubulin 2	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	gamma-tubulin	Get druggable targets OG5_127652	All targets in OG5_127652
Echinococcus granulosus	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin subunit TubB	Get druggable targets OG5_126605	All targets in OG5_126605
Neospora caninum	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma congolense	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	alpha tubulin TUBA1	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin epsilon chain	Get druggable targets OG5_130726	All targets in OG5_130726
Loa Loa (eye worm)	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Babesia bovis	tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Neospora caninum	hypothetical protein	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium falciparum	tubulin epsilon chain, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Entamoeba histolytica	tubulin family protein	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium vivax	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Gamma tubulin	Get druggable targets OG5_127652	All targets in OG5_127652
Echinococcus multilocularis	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma congolense	epsilon tubulin	Get druggable targets OG5_130726	All targets in OG5_130726
Schistosoma japonicum	ko:K10389 tubulin gamma, putative	Get druggable targets OG5_127652	All targets in OG5_127652
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Candida albicans	gamma tubulin-like protein	Get druggable targets OG5_127652	All targets in OG5_127652
Plasmodium berghei	tubulin gamma chain, putative	Get druggable targets OG5_127652	All targets in OG5_127652
Loa Loa (eye worm)	BEN-1 protein	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium yoelii	tubulin beta chain	Get druggable targets OG5_130726	All targets in OG5_130726
Echinococcus multilocularis	tubulin, beta 4A class IVa	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium falciparum	alpha tubulin 1	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium yoelii	tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania braziliensis	gamma-tubulin	Get druggable targets OG5_127652	All targets in OG5_127652
Neospora caninum	hypothetical protein	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Theileria parva	tubulin gamma chain, putative	Get druggable targets OG5_127652	All targets in OG5_127652
Echinococcus granulosus	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium falciparum	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Cryptosporidium parvum	gamma tubulin	Get druggable targets OG5_127652	All targets in OG5_127652
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	zeta tubulin, putative	Get druggable targets OG5_145938	All targets in OG5_145938
Schistosoma mansoni	tubulin subunit epsilon	Get druggable targets OG5_130726	All targets in OG5_130726
Trypanosoma cruzi	tubulin delta chain	Get druggable targets OG5_143817	All targets in OG5_143817
Entamoeba histolytica	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	peroxisome assembly protein 26	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	alpha-tubulin isotype 2	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma congolense	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei gambiense	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania mexicana		Get druggable targets OG5_126611	All targets in OG5_126611
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	Get druggable targets OG5_143817	All targets in OG5_143817
Leishmania infantum	gamma-tubulin	Get druggable targets OG5_127652	All targets in OG5_127652
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	tubulin, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	epsilon tubulin, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Leishmania donovani	tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Echinococcus granulosus	tubulin beta 4A class IVa	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma congolense	tubulin delta chain	Get druggable targets OG5_143817	All targets in OG5_143817
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin beta-4 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin gamma 1 chain	Get druggable targets OG5_127652	All targets in OG5_127652
Brugia malayi	Tubulin beta-1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma cruzi	epsilon tubulin, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Candida albicans	gamma tubulin-like protein	Get druggable targets OG5_127652	All targets in OG5_127652
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	ko:K10391 tubulin epsilon, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	gamma-tubulin	Get druggable targets OG5_127652	All targets in OG5_127652
Neospora caninum	Beta-tubulin, related	Get druggable targets OG5_127652	All targets in OG5_127652
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania donovani	zeta tubulin, putative	Get druggable targets OG5_145938	All targets in OG5_145938
Theileria parva	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Neospora caninum	hypothetical protein	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-1 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin beta-1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	delta tubulin, putative	Get druggable targets OG5_143817	All targets in OG5_143817
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	zeta tubulin, putative	Get druggable targets OG5_145938	All targets in OG5_145938
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	Get druggable targets OG5_130726	All targets in OG5_130726
Cryptosporidium hominis	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania donovani	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	zeta tubulin, putative	Get druggable targets OG5_145938	All targets in OG5_145938
Schistosoma japonicum	ko:K07375 tubulin beta, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Cryptosporidium hominis	gamma-tubulin	Get druggable targets OG5_127652	All targets in OG5_127652
Plasmodium yoelii	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin alpha-2/alpha-4 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania infantum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma cruzi	tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	peroxisome assembly protein 26	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin gamma 1 chain	Get druggable targets OG5_127652	All targets in OG5_127652
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium vivax	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-1C chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium berghei	tubulin epsilon chain, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Trypanosoma brucei gambiense	gamma tubulin	Get druggable targets OG5_127652	All targets in OG5_127652
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin alpha chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium vivax	tubulin epsilon chain, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Trypanosoma brucei	epsilon tubulin	Get druggable targets OG5_130726	All targets in OG5_130726
Babesia bovis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Candida albicans	cytoskeletal structural protein	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	zeta tubulin, putative	Get druggable targets OG5_145938	All targets in OG5_145938
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin beta 1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Neospora caninum	tubulin delta chain, putative	Get druggable targets OG5_143817	All targets in OG5_143817
Trichomonas vaginalis	tubulin gamma chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium yoelii	Tubulin/FtsZ family, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium knowlesi	tubulin epsilon chain, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	beta-1 tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania donovani	tubulin delta chain	Get druggable targets OG5_143817	All targets in OG5_143817
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit gamma	Get druggable targets OG5_127652	All targets in OG5_127652
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Entamoeba histolytica	tubulin family protein	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	zeta tubulin, putative	Get druggable targets OG5_145938	All targets in OG5_145938
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma cruzi	zeta tubulin, putative	Get druggable targets OG5_145938	All targets in OG5_145938
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium knowlesi	alpha tubulin, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium berghei	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma congolense	tubulin gamma chain	Get druggable targets OG5_127652	All targets in OG5_127652
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Babesia bovis	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin beta-1 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	epsilon tubulin, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Echinococcus granulosus	tubulin epsilon chain	Get druggable targets OG5_130726	All targets in OG5_130726
Leishmania braziliensis	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	epsilon tubulin, putative	Get druggable targets OG5_130726	All targets in OG5_130726
Entamoeba histolytica	tubulin alpha-1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin beta 1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei gambiense	zeta tubulin	Get druggable targets OG5_145938	All targets in OG5_145938
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Brugia malayi	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium knowlesi	tubulin gamma chain, putative	Get druggable targets OG5_127652	All targets in OG5_127652

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin epsilon chain, putative	gamma-tubulin	447 aa	479 aa	28.2 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Trypanosoma brucei	epsilon tubulin	epsilon tubulin, putative	470 aa	488 aa	68.0 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	alpha tubulin	451 aa	457 aa	30.9 %
Plasmodium falciparum	tubulin gamma chain	beta tubulin	443 aa	438 aa	33.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity	Phenotypic quality	Occurs in	Occurs at	Evidence	Observed in	Targets
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	26882
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	26953
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29919
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	25756
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29777
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	25113
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29099
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	28601
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	24472
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	21739
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	28044
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	21309
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	24440
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	20919
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	22594
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	23453
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	21545
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29554
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29031
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	23905
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	21179
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	25450
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	22205
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	27459
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	26961
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	22252
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	23996
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	23078
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	20827
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	28024
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	promastigote (BTO:0001124)	inferred from bioassay (ECO:0000094)	Leishmania donovani	28324
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	26882
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	26953
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29919
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	25756
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29777
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	25113
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29099
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	28601
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	24472
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	21739
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	28044
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	21309
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	24440
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	20919
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	22594
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	23453
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	21545
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29554
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	29031
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	23905
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	21179
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	25450
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	22205
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	27459
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	26961
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	22252
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	23996
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	23078
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	20827
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	28024
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
growth (GO:0040007)	decreased time (PATO:0000716)	single cell organism (CARO:0000064)	amastigote (BTO:0000062)	inferred from bioassay (ECO:0000094)	Leishmania donovani	28324
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	26882
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	26953
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	29919
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	25756
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	29777
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	25113
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	29099
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	28601
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	24472
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	21739
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	28044
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	21309
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	24440
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	20919
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	22594
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	23453
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	21545
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	29554
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	29031
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	23905
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	21179
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	25450
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	22205
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	27459
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	26961
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	22252
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	23996
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	23078
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	20827
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	28024
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141
microtubule polymerization (GO:0046785)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Leishmania donovani	28324
Annotator:	aaronjr@u.washington.edu	Comment:	Drug: 10228-56-5; Drug: 36317-95-0; Drug: 62409-47-6; Drug: 62745-74-8; Drug: 204634-79-7; Drug: 483279-40-9; Drug: 483279-41-0; Drug: 483279-42-1; Drug: 483279-43-2; Drug: 483279-44-3; Drug: 483279-45-4; Drug: 483279-46-5; Drug: 483279-47-6; Drug: 88-91-5; Drug: 107-10-8; Drug: 1930-72-9; Drug: 97-08-5; Drug: 97-09-6; Drug: 62443-96-3; Drug: 483279-33-0; Drug: 483279-34-1; Drug: 483279-35-2; Drug: 483279-36-3; Drug: 483279-37-4; Drug: 483279-38-5; Drug: 483279-39-6. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin; unclear as to which topoisomerase II gene/enzyme was studied		References:	12161141

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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14 literature references were collected for this gene.

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Detailed information for compound 528258