Detailed information for compound 544463

Basic information

Technical information
  • TDR Targets ID: 544463
  • Name: (1E)-1-[amino-[(6-ethoxy-4-methyl-quinazolin- 2-yl)amino]methylene]-3-(3-methoxyphenyl)thio urea
  • MW: 410.493 | Formula: C20H22N6O2S
  • H donors: 2 H acceptors: 2 LogP: 3.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc2c(c1)c(C)nc(n2)N=C(N=C(Nc1cccc(c1)OC)S)N
  • InChi: 1S/C20H22N6O2S/c1-4-28-15-8-9-17-16(11-15)12(2)22-19(24-17)25-18(21)26-20(29)23-13-6-5-7-14(10-13)27-3/h5-11H,4H2,1-3H3,(H4,21,22,23,24,25,26,29)
  • InChiKey: ZVQFHESFSLLHPK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • (1E)-1-[amino-[(6-ethoxy-4-methyl-2-quinazolinyl)amino]methylene]-3-(3-methoxyphenyl)thiourea
  • (1E)-1-[azanyl-[(6-ethoxy-4-methyl-quinazolin-2-yl)amino]methylidene]-3-(3-methoxyphenyl)thiourea
  • (1E)-1-[amino-[(6-ethoxy-4-methylquinazolin-2-yl)amino]methylidene]-3-(3-methoxyphenyl)thiourea
  • 1-[amino-[(6-ethoxy-4-methylquinazolin-2-yl)amino]methylidene]-3-(3-methoxyphenyl)thiourea
  • 1-[amino-[(6-ethoxy-4-methyl-quinazolin-2-yl)amino]methylene]-3-(3-methoxyphenyl)thiourea
  • 1-[amino-[(6-ethoxy-4-methyl-2-quinazolinyl)amino]methylene]-3-(3-methoxyphenyl)thiourea
  • 1-[azanyl-[(6-ethoxy-4-methyl-quinazolin-2-yl)amino]methylidene]-3-(3-methoxyphenyl)thiourea
  • 1-[amino-[(6-ethoxy-4-methyl-quinazolin-2-yl)amino]methylidene]-3-(3-methoxyphenyl)thiourea
  • (1E)-1-[amino-[(6-ethoxy-4-methyl-quinazolin-2-yl)amino]methylidene]-3-(3-methoxyphenyl)thiourea
  • STK131761
  • MLS000332288
  • SMR000435004

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0396
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0048 0.0143
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0039 0.0116
Brugia malayi hypothetical protein 0.0013 0.0048 0.2314
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0039 0.1878
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0039 0.1878
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 1
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0013 0.0048 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0208 0.0617
Plasmodium vivax diacylglycerol kinase, putative 0.0013 0.0048 0.3604
Echinococcus granulosus Diacylglycerol kinase zeta 0.0013 0.0048 0.0143
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0039 0.1878
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0048 0.0143
Schistosoma mansoni sphingosine kinase A B 0.0336 0.3374 1
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0013 0.0048 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0039 0.0039
Echinococcus granulosus sphingosine kinase 1 0.0336 0.3374 1
Echinococcus multilocularis ceramide kinase 0.0013 0.0048 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0039 0.0039
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0336 0.3374 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0039 0.0116
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0039 0.0116
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0039 0.0116
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0208 0.0617
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0617
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0039 0.0116
Brugia malayi nuclear hormone receptor 0.0012 0.0039 0.1878
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0039 0.0116
Leishmania major hypothetical protein, conserved 0.0013 0.0048 0.2314
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0013 0.0048 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0048 0.0143
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0039 0.0116
Loa Loa (eye worm) ceramide kinase 0.0013 0.0048 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0039 0.1878
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0039 0.1878
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0039 0.0116
Schistosoma mansoni sphingoid long chain base kinase 0.0336 0.3374 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0039 0.0039
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0013 0.0048 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0134 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0208 0.0617
Mycobacterium ulcerans diacylglycerol kinase 0.0013 0.0048 0.0143
Echinococcus granulosus ceramide kinase 0.0013 0.0048 0.0143
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0039 0.0116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0617
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0396
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0013 0.0048 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0039 0.1878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0039 0.0116
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0013 0.0048 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0039 0.1878
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0039 0.1878
Brugia malayi Eye-specific diacylglycerol kinase 0.0013 0.0048 0.2314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0039 0.0116
Plasmodium falciparum diacylglycerol kinase, putative 0.0013 0.0048 0.3604
Trypanosoma cruzi diacylglycerol kinase, putative 0.0013 0.0048 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0134 0.5
Brugia malayi diacylglycerol kinase 0.0013 0.0048 0.2314
Mycobacterium tuberculosis Diacylglycerol kinase 0.0013 0.0048 0.0143
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0208 0.0617
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0617
Brugia malayi ecdysteroid receptor 0.0012 0.0039 0.1878
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0039 0.1878
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0013 0.0048 1
Plasmodium falciparum diacylglycerol kinase, putative 0.0013 0.0048 0.3604
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0134 1
Trypanosoma cruzi Sphingosine kinase 0.0013 0.0048 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0039 0.0116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0039 0.0116
Leishmania major diacylglycerol kinase-like protein 0.0013 0.0048 0.2314
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0396
Trypanosoma brucei diacylglycerol kinase, putative 0.0013 0.0048 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0208 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0039 0.0039
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0039 0.0116
Schistosoma mansoni diacylglycerol kinase theta 0.0013 0.0048 0.0143
Trichomonas vaginalis diacylglycerol kinase, putative 0.0013 0.0048 1
Echinococcus multilocularis sphingosine kinase 1 0.0336 0.3374 0.3374
Onchocerca volvulus 0.0029 0.0208 1
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0013 0.0048 0.0143
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0013 0.0048 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0361
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0208 0.0617
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0039 0.0039
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0039 0.1878
Trichomonas vaginalis bmru protein, putative 0.0013 0.0048 1
Schistosoma mansoni coup transcription factor 0.0012 0.0039 0.0116
Loa Loa (eye worm) hypothetical protein 0.0013 0.0048 0.0143
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0208 1
Mycobacterium ulcerans hypothetical protein 0.0336 0.3374 1
Schistosoma mansoni diacylglycerol kinase theta 0.0013 0.0048 0.0143
Onchocerca volvulus 0.0013 0.0048 0.2314
Loa Loa (eye worm) diacylglycerol kinase 2 0.0013 0.0048 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0116
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0039 0.0116
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0048 0.0143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0039 0.1878
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0039 0.1878
Echinococcus multilocularis Diacylglycerol kinase theta 0.0013 0.0048 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0048 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0396
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0617
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0039 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0039 0.0116
Brugia malayi nuclear receptor NHR-88 0.0012 0.0039 0.1878
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0039 0.0116
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0013 0.0048 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0208 0.0617
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0039 0.0116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0039 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0361
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0208 0.0617
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0039 0.1878
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0039 0.1878
Brugia malayi Diacylglycerol kinase protein 2 0.0013 0.0048 0.2314
Leishmania major diacylglycerol kinase, putative 0.0013 0.0048 0.2314
Loa Loa (eye worm) hypothetical protein 0.0013 0.0048 0.0143
Trypanosoma brucei Sphingosine kinase 0.0013 0.0048 1
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0013 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0205 0.2021 0.599
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 1
Plasmodium vivax diacylglycerol kinase, putative 0.0013 0.0048 0.3604
Trichomonas vaginalis sphingosine kinase, putative 0.0013 0.0048 1
Schistosoma mansoni hypothetical protein 0.0205 0.2021 0.599
Trichomonas vaginalis diacylglycerol kinase, putative 0.0013 0.0048 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0039 0.1878
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0048 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0039 0.1878
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0039 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0039 0.1878
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0039 0.1878
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0617
Echinococcus granulosus geminin 0.0205 0.2021 0.599
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0208 0.0617
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0116
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0013 0.0048 0.0143
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0617
Leishmania major hypothetical protein, conserved 0.0013 0.0048 0.2314
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0208 0.0617
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0208 0.0617
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0013 0.0048 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0116
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0013 0.0048 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0116
Toxoplasma gondii diacylglycerol kinase, putative 0.0013 0.0048 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0039 0.0116
Onchocerca volvulus 0.0012 0.0039 0.1878
Trypanosoma cruzi diacylglycerol kinase, putative 0.0013 0.0048 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0039 0.0116
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0048 0.0143
Brugia malayi Ceramide kinase 0.0013 0.0048 0.2314
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0013 0.0048 0.0143
Trichomonas vaginalis bmru protein, putative 0.0013 0.0048 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0039 0.1878
Mycobacterium tuberculosis Conserved protein 0.0336 0.3374 1
Brugia malayi steroid hormone receptor 0.0012 0.0039 0.1878
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0134 0.0396
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0134 0.0396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 1
Trypanosoma cruzi Sphingosine kinase 0.0013 0.0048 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0116
Schistosoma mansoni hypothetical protein 0.0013 0.0048 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0039 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0361
Trichomonas vaginalis sphingosine kinase, putative 0.0013 0.0048 1
Echinococcus granulosus Diacylglycerol kinase theta 0.0013 0.0048 0.0143
Leishmania major sphingosine kinase A, B, putative 0.0013 0.0048 0.2314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0039 0.0116
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0039 0.0039
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0039 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0039 0.0116
Entamoeba histolytica hypothetical protein, conserved 0.0336 0.3374 1
Brugia malayi diacylglycerol kinase 0.0013 0.0048 0.2314
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0039 0.0116
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0039 0.0116
Onchocerca volvulus Ceramide kinase 1 homolog 0.0013 0.0048 0.2314
Echinococcus multilocularis geminin 0.0205 0.2021 0.2021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0039 0.0116

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.4921 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 11.5821 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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