Detailed information for compound 553822

Basic information

Technical information
  • TDR Targets ID: 553822
  • Name: (2S,3R)-2-[(E)-non-1-en-3,5,7-triynyl]tetrahy dropyran-3-ol
  • MW: 214.26 | Formula: C14H14O2
  • H donors: 1 H acceptors: 1 LogP: 2.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC#CC#CC#C/C=C/[C@@H]1OCCC[C@H]1O
  • InChi: 1S/C14H14O2/c1-2-3-4-5-6-7-8-11-14-13(15)10-9-12-16-14/h8,11,13-15H,9-10,12H2,1H3/b11-8+/t13-,14+/m1/s1
  • InChiKey: WFJPISZWZQHNLX-GELOPOQCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3R)-2-[(E)-non-1-en-3,5,7-triynyl]-3-tetrahydropyranol
  • (2S,3R)-2-[(E)-non-1-en-3,5,7-triynyl]oxan-3-ol
  • 2H-Pyran-3-ol, tetrahydro-2-(1-nonene-3,5,7-triynyl)-, (2S-(2alpha(E),3beta))-
  • ichthyothereol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0107 0.255
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0041 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0045 0.1253
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0461 0.1003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0045 0.0097
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0045 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0005 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0107 0.0304
Loa Loa (eye worm) hypothetical protein 0.0308 0.1232 0.2679
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0041 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0107 0.9708
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0308 0.1232 0.2679
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0045 1
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0041 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0107 0.255
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0045 0.0051
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0045 0.0098
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0107 0.0121
Trypanosoma brucei ISWI complex protein 0.0015 0.0022 0.0788
Echinococcus granulosus fatty acid binding protein, adipocyte 0.0132 0.0505 0.0575
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0107 0.0304
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0107 0.0304
Trypanosoma cruzi ISWI complex protein 0.0015 0.0022 0.1938
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0111 0.2626
Brugia malayi nuclear receptor NHR-88 0.002 0.0045 0.0097
Leishmania major UDP-galactopyranose mutase 0.0021 0.0045 0.1603
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0045 0.0097
Schistosoma mansoni amine oxidase 0.0021 0.0045 0.0051
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0111 0.042 0.042
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0032 0.007
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0015 0.1248
Schistosoma mansoni DNA helicase recq1 0.002 0.0041 0.0047
Echinococcus multilocularis geminin 0.0167 0.0651 0.0651
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0026
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0204 0.0204
Echinococcus multilocularis fatty acid binding protein FABP2 0.0301 0.1205 0.1205
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0005 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0203 0.1405
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0624 0.0624
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0111 0.0585
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0097 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Echinococcus granulosus FTZ F1 alpha 0.002 0.0045 0.0051
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0041 0.0089
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0045 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0308 0.1232 0.2679
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0045 0.1253
Schistosoma mansoni DNA helicase recq5 0.002 0.0041 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.035 0.035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0417 0.0417
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0107 0.0233
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0021 0.0045 0.1253
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.001
Schistosoma mansoni hypothetical protein 0.0167 0.0651 0.074
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0417 0.0474
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0111 0.0111
Schistosoma mansoni amine oxidase 0.0021 0.0045 0.0051
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0045 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0045 0.0097
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0044 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0117 0.0253
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0045 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.035 0.0398
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0107 0.4928
Schistosoma mansoni alpha glucosidase 0.0036 0.0107 0.0122
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0045 0.0146
Brugia malayi Pre-SET motif family protein 0.0094 0.035 0.0761
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0098
Schistosoma mansoni inositol monophosphatase 0.0036 0.0111 0.0126
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0203 0.1405
Schistosoma mansoni hypothetical protein 0.002 0.0044 0.005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0045 0.0097
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0203 0.152
Entamoeba histolytica hypothetical protein 0.0111 0.0417 1
Onchocerca volvulus 0.002 0.0045 0.0146
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0045 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0045 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0045 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0343 0.039
Brugia malayi PHD-finger family protein 0.0025 0.0062 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0098
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0045 0.3999
Schistosoma mansoni zinc finger protein 0.0019 0.004 0.0045
Echinococcus granulosus zinc finger protein 0.0019 0.004 0.0045
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0111 0.0126
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0107 0.3041
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0097 0.0363 0.0412
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0097 0.0363 0.0788
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.042 0.0477
Schistosoma mansoni hypothetical protein 0.021 0.083 0.0944
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0045 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0045 0.0097
Brugia malayi steroid hormone receptor 0.002 0.0045 0.0097
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0045 0.0045
Brugia malayi nuclear receptor RXR 0.0011 0.0005 0.001
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0271 0.1081 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0045 0.0051
Echinococcus granulosus microtubule associated protein 2 0.2138 0.8794 1
Echinococcus multilocularis 0.0021 0.0045 0.0045
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0107 0.0107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0343 0.0745
Loa Loa (eye worm) inositol-1 0.0036 0.0111 0.024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0045 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0045 0.0097
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0015 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.035 0.0398
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0005 0.0005
Echinococcus granulosus histone lysine methyltransferase setb 0.0111 0.042 0.0477
Leishmania major hypothetical protein, conserved 0.0015 0.0022 0.0402
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0111 0.5098
Loa Loa (eye worm) RecQ helicase 0.002 0.0041 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0045 0.0097
Schistosoma mansoni nuclear hormone receptor 0.002 0.0045 0.0051
Onchocerca volvulus 0.0094 0.035 0.1146
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0041 0.0047
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0097 0.0363 0.0788
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0098
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0111 0.0315
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0045 0.0097
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0111 0.0315
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0052 0.0052
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0107 0.0304
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0045 0.1253
Brugia malayi ecdysteroid receptor 0.002 0.0045 0.0097
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0005 0.001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0097
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0045 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0045 0.0097
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.003 0.0034
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0107 0.0122
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0041 0.272
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0097 0.0363 0.0412
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0203 0.0203
Brugia malayi Bromodomain containing protein 0.0074 0.0266 0.0578
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0045 0.0051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0097 0.0363 0.0363
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0343 0.0745
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0045 0.1253
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0111 0.3133
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.042 0.0477
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.1166 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0041 0.0089
Schistosoma mansoni fatty acid binding protein 0.0301 0.1205 0.137
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0045 0.0146
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0107 0.0233
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0041 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0308 0.1232 0.2679
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0097
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0203 0.023
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0045 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0098
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0111 0.042 0.0912
Loa Loa (eye worm) hypothetical protein 0.021 0.083 0.1804
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0097
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0045 0.0045
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0045 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0343 0.039
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0203 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0045 0.0051
Loa Loa (eye worm) hypothetical protein 0.004 0.0126 0.0274
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0015 0.1248
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0107 0.0304
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0041 0.3629
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0041 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0343 0.039
Brugia malayi hypothetical protein 0.0111 0.0417 0.0907
Schistosoma mansoni hypothetical protein 0.0167 0.0651 0.074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0343 0.039
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0052 0.0059
Brugia malayi Inositol-1 0.0036 0.0111 0.024
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0045 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0045 0.0051
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0041 0.1387
Brugia malayi hypothetical protein 0.0011 0.0005 0.001
Schistosoma mansoni inositol monophosphatase 0.0036 0.0111 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0045 0.0097
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0095 0.0481
Brugia malayi hypothetical protein 0.0011 0.0005 0.001
Plasmodium vivax SET domain protein, putative 0.0094 0.035 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0107 0.0304
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0343 0.039
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0203 0.023
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0045 0.0051
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0336 0.0382
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0001 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0107 0.0107
Brugia malayi nuclear hormone receptor 0.002 0.0045 0.0097
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0097
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0111 0.5
Schistosoma mansoni fatty acid binding protein 0.0301 0.1205 0.137
Echinococcus multilocularis fatty acid binding protein FABP2 0.0132 0.0505 0.0505
Schistosoma mansoni bromodomain containing protein 0.0062 0.0218 0.0248
Schistosoma mansoni thyroid hormone receptor 0.002 0.0045 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0107 0.9708
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0045 0.3999
Brugia malayi Latrophilin receptor protein 2 0.0097 0.0363 0.0788
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0107 0.0304
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.003 0.003
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0041 0.0089
Brugia malayi MH2 domain containing protein 0.0121 0.0461 0.1003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0042 0.0134 0.0291
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0005 0.001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0095 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0204 0.0231
Echinococcus multilocularis bloom syndrome protein 0.002 0.0041 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0045 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0417 0.0474
Onchocerca volvulus 0.0021 0.0045 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0045 0.0097
Echinococcus granulosus fatty acid binding protein FABP2 0.0301 0.1205 0.137
Onchocerca volvulus 0.0749 0.3054 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0111 0.0417 0.0474
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.035 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0045 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0005 0.0005
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0041 0.1137
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0624 0.0709
Brugia malayi Bromodomain containing protein 0.0038 0.0116 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0045 0.0097
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0111 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0041 0.1137
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0111 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.003 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0749 0.3054 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0045 0.0051
Echinococcus multilocularis GPCR, family 2 0.0097 0.0363 0.0363
Schistosoma mansoni hypothetical protein 0.0097 0.0363 0.0412
Schistosoma mansoni hypothetical protein 0.0097 0.0363 0.0412
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0111 0.0315
Echinococcus multilocularis fatty acid binding protein FABP2 0.0301 0.1205 0.1205
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0097
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0052 0.0059
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0045 0.1253
Entamoeba histolytica hypothetical protein 0.0111 0.0417 1
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0041 0.0086
Echinococcus granulosus GPCR family 2 0.0097 0.0363 0.0412
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0015 0.0033
Loa Loa (eye worm) hypothetical protein 0.0097 0.0363 0.0788
Echinococcus granulosus fatty acid binding protein FABP2 0.0132 0.0505 0.0575
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0461 0.1003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0111 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.1166 1
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0045 0.0146
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0097 0.0363 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0045 0.0097
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0624 0.1356
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0045 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0041 0.0041
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0203 0.1405
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0097
Schistosoma mansoni thyroid hormone receptor 0.002 0.0045 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0097
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0624 0.1356
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0045 0.0051
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0203 0.5769
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0045 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0045 0.0045
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0097
Schistosoma mansoni microtubule-associated protein tau 0.2138 0.8794 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0658 0.2678 0.5823
Schistosoma mansoni coup transcription factor 0.002 0.0045 0.0051
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0041 0.0089
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.1123 0.46 1
Schistosoma mansoni hypothetical protein 0.0097 0.0363 0.0412
Brugia malayi hypothetical protein 0.0021 0.0045 0.0098
Echinococcus granulosus fatty acid binding protein FABP2 0.0301 0.1205 0.137
Trypanosoma brucei glucosidase, putative 0.0036 0.0107 0.9666
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0033
Trypanosoma cruzi ISWI complex protein 0.0015 0.0022 0.1938
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0203 0.023
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0045 0.0051
Brugia malayi Pre-SET motif family protein 0.0658 0.2678 0.5823
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0045 0.0051
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0045 0.0051
Entamoeba histolytica hypothetical protein 0.0111 0.0417 1
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.1123 0.46 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.0531 0.0604
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0343 0.0343
Brugia malayi latrophilin 2 splice variant baaae 0.021 0.083 0.1804
Schistosoma mansoni alpha-glucosidase 0.0138 0.0531 0.0604
Echinococcus multilocularis microtubule associated protein 2 0.2138 0.8794 0.8794
Entamoeba histolytica hypothetical protein 0.0111 0.0417 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0045 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0624 0.0624
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0045 0.0051
Onchocerca volvulus 0.0093 0.0344 0.1126
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0098
Loa Loa (eye worm) hypothetical protein 0.007 0.0248 0.054
Entamoeba histolytica recQ family helicase, putative 0.002 0.0041 0.0953
Brugia malayi SWIRM domain containing protein 0.0021 0.0045 0.0098
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0005 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0045 0.0097
Echinococcus granulosus geminin 0.0167 0.0651 0.074
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0045 0.0051
Echinococcus granulosus bloom syndrome protein 0.002 0.0041 0.0047
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0089
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0045 0.0097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0045 0.0051
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0107 0.0304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0107 0.0304
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0015 0.0328
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0045 0.0097
Schistosoma mansoni zinc finger protein 0.0015 0.0022 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0045 0.0097
Echinococcus multilocularis zinc finger protein 0.0019 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0045 0.0097

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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