Detailed information for compound 563530

Basic information

Technical information
  • TDR Targets ID: 563530
  • Name: 4-[(6-amino-1-ethyl-quinolin-1-ium-4-yl)amino ]-N-[4-[(1-ethylpyridin-1-ium-4-yl)amino]phen yl]benzamide dibromide
  • MW: 664.433 | Formula: C31H32Br2N6O
  • H donors: 4 H acceptors: 1 LogP: 7.16 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[n+]1ccc(cc1)Nc1ccc(cc1)NC(=O)c1ccc(cc1)Nc1cc[n+](c2c1cc(N)cc2)CC.[Br-].[Br-]
  • InChi: 1S/C31H30N6O.2BrH/c1-3-36-18-15-27(16-19-36)33-24-10-12-26(13-11-24)35-31(38)22-5-8-25(9-6-22)34-29-17-20-37(4-2)30-14-7-23(32)21-28(29)30;;/h5-21H,3-4,32H2,1-2H3,(H,35,38);2*1H
  • InChiKey: OIPLMVLJMKFSDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(6-amino-1-ethyl-4-quinolin-1-iumyl)amino]-N-[4-[(1-ethyl-4-pyridin-1-iumyl)amino]phenyl]benzamide dibromide
  • 4-[(6-azanyl-1-ethyl-quinolin-1-ium-4-yl)amino]-N-[4-[(1-ethylpyridin-1-ium-4-yl)amino]phenyl]benzamide dibromide
  • 4-[(6-amino-1-ethylquinolin-1-ium-4-yl)amino]-N-[4-[(1-ethylpyridin-1-ium-4-yl)amino]phenyl]benzamide dibromide
  • Cain quinolinium
  • 42013-69-4
  • NSC 113089
  • Quinolinium, 6-amino-1-ethyl-4-(p-((p-((1-ethylpyridinium-4-yl)amino)phenyl)carbamoyl)anilino)-, dibromide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0888 0.087
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0315 0.3841 0.3829
Onchocerca volvulus Glucosylceramidase homolog 0.0333 0.4064 1
Onchocerca volvulus 0.0033 0.0338 0.0726
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.6236 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0047 0.0027
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0047 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0299 0.0279
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Schistosoma mansoni nAChR subunit 0.0315 0.3841 0.3829
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0033 0.0338 0.0319
Onchocerca volvulus 0.0145 0.1729 0.4188
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0047 0.0041
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Entamoeba histolytica hypothetical protein 0.017 0.2033 0.5
Brugia malayi hypothetical protein 0.0145 0.1729 0.2632
Schistosoma mansoni coup transcription factor 0.001 0.0047 0.0027
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0145 0.1729 0.1713
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0047 0.0041
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0315 0.3841 0.5883
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0315 0.3841 0.5883
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0042 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0168 0.201 0.3064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0047 0.0041
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2861 0.4588
Onchocerca volvulus 0.0033 0.0338 0.0726
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0299 0.0279
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0047 0.0027
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0033 0.0338 0.5
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0145 0.1729 0.1713
Schistosoma mansoni hypothetical protein 0.0078 0.0888 0.087
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0041
Schistosoma mansoni mucolipin 0.006 0.0671 0.0653
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0047 0.0041
Schistosoma mansoni acetylcholine receptor-related 0.0145 0.1729 0.1713
Schistosoma mansoni hypothetical protein 0.0396 0.4859 0.4849
Loa Loa (eye worm) hypothetical protein 0.0168 0.201 0.3064
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Brugia malayi Coelomocyte uptake defective protein 5 0.0066 0.074 0.1109
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0047 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0047 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0299 0.0279
Brugia malayi Pre-SET motif family protein 0.0207 0.2505 0.3827
Loa Loa (eye worm) hypothetical protein 0.017 0.2033 0.31
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0315 0.3841 0.5883
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0047 0.0027
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.147 0.2233
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0042 0.0023
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0033 0.0338 0.049
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0315 0.3841 0.3829
Loa Loa (eye worm) hypothetical protein 0.017 0.2033 0.31
Loa Loa (eye worm) hypothetical protein 0.017 0.2033 0.31
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0182 0.2193 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0315 0.3841 0.5883
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0047 0.0041
Brugia malayi TAR-binding protein 0.0124 0.147 0.2233
Schistosoma mansoni choline o-acyltransferase 0.0033 0.0338 0.0319
Echinococcus multilocularis cpg binding protein 0.0029 0.0288 0.0269
Loa Loa (eye worm) hypothetical protein 0.017 0.2033 0.31
Echinococcus granulosus glycine receptor subunit alpha 1 0.0315 0.3841 0.3829
Echinococcus multilocularis microtubule associated protein 2 0.0809 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.4064 0.6518
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.017 0.2033 0.2017
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0315 0.3841 0.3829
Onchocerca volvulus 0.0145 0.1729 0.4188
Brugia malayi nuclear receptor NHR-88 0.001 0.0047 0.0041
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0315 0.3841 0.5883
Schistosoma mansoni neurotransmitter gated ion channel 0.0145 0.1729 0.1713
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0529 0.6515 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0315 0.3841 0.3829
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0145 0.1729 0.2632
Loa Loa (eye worm) hypothetical protein 0.0033 0.0338 0.049
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0047 0.0027
Schistosoma mansoni nAChR subunit 0.0315 0.3841 0.3829
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1363 0.2068
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0041 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0124 0.147 0.1453
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0047 0.0027
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0315 0.3841 0.5883
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0047 0.0027
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0315 0.3841 0.5883
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0047 0.0027
Onchocerca volvulus 0.0033 0.0338 0.0726
Brugia malayi MH2 domain containing protein 0.0116 0.1363 0.2068
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0145 0.1729 0.2632
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0021 0.0002
Echinococcus granulosus glycine receptor subunit beta 0.0315 0.3841 0.3829
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1363 0.2068
Loa Loa (eye worm) choline O-acetyltransferase 0.0033 0.0338 0.049
Loa Loa (eye worm) LGC-31 protein 0.0315 0.3841 0.5883
Onchocerca volvulus 0.0315 0.3841 0.9443
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0182 0.2193 0.2178
Brugia malayi Cation transporter family protein 0.0315 0.3841 0.5883
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0033 0.0338 0.5
Schistosoma mansoni nuclear hormone receptor 0.001 0.0047 0.0027
Loa Loa (eye worm) GABA receptor subunit 0.017 0.2033 0.31
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0041
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) RNA binding protein 0.0124 0.147 0.2233
Schistosoma mansoni microtubule-associated protein tau 0.0809 1 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Schistosoma mansoni neurotransmitter gated ion channel 0.017 0.2033 0.2017
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0299 0.0279
Echinococcus granulosus nAChR subunit 0.017 0.2033 0.2017
Loa Loa (eye worm) TAR-binding protein 0.0124 0.147 0.2233
Echinococcus granulosus FTZ F1 alpha 0.001 0.0047 0.0027
Brugia malayi Choline O-acetyltransferase 0.0033 0.0338 0.049
Loa Loa (eye worm) hypothetical protein 0.017 0.2033 0.31
Schistosoma mansoni nAChR subunit 0.0315 0.3841 0.3829
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Loa Loa (eye worm) hypothetical protein 0.0529 0.6515 1
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.6236 1
Echinococcus granulosus geminin 0.0164 0.1967 0.1951
Loa Loa (eye worm) hypothetical protein 0.0078 0.0888 0.1337
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0315 0.3841 0.5883
Loa Loa (eye worm) histone methyltransferase 0.001 0.0042 0.0035
Brugia malayi Cation transporter family protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0047 0.0041
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.017 0.2033 0.2017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.2828 0.4324
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0315 0.3841 0.3829
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0315 0.3841 0.3829
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0315 0.3841 0.3829
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0351 0.4288 0.6876
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.4064 0.6518
Schistosoma mansoni neurotransmitter gated ion channel 0.0145 0.1729 0.1713
Schistosoma mansoni nAChR subunit 0.0145 0.1729 0.1713
Echinococcus multilocularis nAChR subunit 0.017 0.2033 0.2017
Schistosoma mansoni tar DNA-binding protein 0.0124 0.147 0.1453
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0888 0.087
Echinococcus multilocularis GPCR, family 2 0.0078 0.0888 0.087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0047 0.0027
Brugia malayi Choline O-acetyltransferase 0.0033 0.0338 0.049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.067 0.0652
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0315 0.3841 0.3829
Brugia malayi RNA binding protein 0.0124 0.147 0.2233
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0047 0.0027
Schistosoma mansoni nAChR subunit 0.0145 0.1729 0.1713
Loa Loa (eye worm) hypothetical protein 0.0397 0.4862 0.7455
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0229 0.2774 0.2759
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0047 0.0027
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Onchocerca volvulus 0.0315 0.3841 0.9443
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0047 0.0027
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0145 0.1729 0.2632
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0047 0.0027
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0182 0.2193 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0315 0.3841 0.5883
Echinococcus multilocularis tar DNA binding protein 0.0124 0.147 0.1453
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Schistosoma mansoni hypothetical protein 0.0168 0.201 0.1994
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0315 0.3841 0.3829
Loa Loa (eye worm) ACC-1 protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0047 0.0027
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0033 0.0338 0.0319
Echinococcus multilocularis geminin 0.0164 0.1967 0.1951
Echinococcus multilocularis nAChR subunit 0.0315 0.3841 0.3829
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0033 0.0338 0.049
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.017 0.2033 0.31
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0268 0.0383
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.017 0.2033 0.31
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.017 0.2033 0.31
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0145 0.1729 0.2632
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0315 0.3841 0.3829
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0021 0.0002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0315 0.3841 0.3829
Schistosoma mansoni tar DNA-binding protein 0.0124 0.147 0.1453
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0338 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0047 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0299 0.0429
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.147 0.2233
Schistosoma mansoni cpg binding protein 0.0029 0.0288 0.0269
Onchocerca volvulus 0.017 0.2033 0.4944
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0047 0.0027
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0315 0.3841 0.5883
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.6236 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0041
Echinococcus granulosus dnaJ subfamily B 0.0396 0.4859 0.4849
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0047 0.0027
Schistosoma mansoni nAChR subunit 0.0315 0.3841 0.3829
Brugia malayi Cation transporter family protein 0.0315 0.3841 0.5883
Echinococcus multilocularis mucolipin 3 0.0066 0.074 0.0722
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0299 0.0279
Schistosoma mansoni tar DNA-binding protein 0.0124 0.147 0.1453
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0592 1
Echinococcus granulosus nAChR subunit 0.0315 0.3841 0.3829
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Loa Loa (eye worm) ACC-1 protein 0.0315 0.3841 0.5883
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0047 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0047 0.0041
Echinococcus granulosus choline O acetyltransferase 0.0033 0.0338 0.0319
Echinococcus multilocularis glycine receptor subunit beta 0.0315 0.3841 0.3829
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0033 0.0338 0.049
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Schistosoma mansoni nAChR subunit 0.0315 0.3841 0.3829
Echinococcus granulosus glycine receptor subunit alpha 1 0.0315 0.3841 0.3829
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0047 0.0041
Schistosoma mansoni mucolipin 0.0066 0.074 0.0722
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0507 0.6236 0.957
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0315 0.3841 0.5883
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0047 0.0027
Loa Loa (eye worm) hypothetical protein 0.017 0.2033 0.31
Brugia malayi excitatory GABA receptor EXP-1A 0.0315 0.3841 0.5883
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0315 0.3841 0.3829
Echinococcus granulosus glycine receptor subunit alpha 1 0.0315 0.3841 0.3829
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.6236 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0315 0.3841 0.5883
Schistosoma mansoni hypothetical protein 0.0164 0.1967 0.1951
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0047 0.0041
Brugia malayi follicle stimulating hormone receptor 0.0233 0.2828 0.4324
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.6236 1
Echinococcus granulosus mucolipin 3 0.0066 0.074 0.0722
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0182 0.2193 0.2178
Onchocerca volvulus Putative nachr subunit 0.0315 0.3841 0.9443
Schistosoma mansoni tar DNA-binding protein 0.0124 0.147 0.1453
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0047 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.4064 0.6518
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0315 0.3841 0.3829
Onchocerca volvulus 0.0236 0.2861 0.7005
Brugia malayi ecdysteroid receptor 0.001 0.0047 0.0041
Schistosoma mansoni nAChR subunit 0.0315 0.3841 0.3829
Echinococcus granulosus cpg binding protein 0.0029 0.0288 0.0269
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0033 0.0338 0.5
Schistosoma mansoni hypothetical protein 0.0078 0.0888 0.087
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2505 0.3827
Schistosoma mansoni hypothetical protein 0.0078 0.0888 0.087
Onchocerca volvulus 0.0315 0.3841 0.9443
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0315 0.3841 0.3829
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0315 0.3841 0.5883
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0033 0.0338 0.5
Schistosoma mansoni choline o-acyltransferase 0.0033 0.0338 0.0319
Schistosoma mansoni hypothetical protein 0.0164 0.1967 0.1951
Onchocerca volvulus 0.003 0.0299 0.0627
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0315 0.3841 0.5883
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0047 0.0027
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0315 0.3841 0.3829
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.6236 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0315 0.3841 0.5883
Echinococcus multilocularis choline O acetyltransferase 0.0033 0.0338 0.0319
Onchocerca volvulus 0.0033 0.0338 0.0726
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.4064 0.6518
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0041
Onchocerca volvulus 0.0028 0.0268 0.0551
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0315 0.3841 0.3829
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.4064 0.6518
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.4064 0.6518
Brugia malayi CXXC zinc finger family protein 0.0028 0.0268 0.0383
Onchocerca volvulus 0.0315 0.3841 0.9443
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0315 0.3841 0.3829
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0315 0.3841 0.3829
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0145 0.1729 0.2632
Onchocerca volvulus 0.017 0.2033 0.4944
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.4859 0.4849
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0229 0.2774 0.2759
Echinococcus granulosus tar DNA binding protein 0.0124 0.147 0.1453
Schistosoma mansoni thyroid hormone receptor 0.001 0.0047 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0047 0.0041
Loa Loa (eye worm) hypothetical protein 0.017 0.2033 0.31
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0888 0.1337
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0047 0.0041
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0888 0.1337
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0047 0.0027
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.017 0.2033 0.31
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0047 0.0027
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0145 0.1729 0.1713
Loa Loa (eye worm) mucolipin 1 0.0066 0.074 0.1109
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0315 0.3841 0.5883
Echinococcus granulosus GPCR family 2 0.0078 0.0888 0.087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0047 0.0041
Schistosoma mansoni hypothetical protein 0.0078 0.0888 0.087
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0145 0.1729 0.1713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0047 0.0041
Echinococcus multilocularis glycine receptor subunit beta 0.0315 0.3841 0.3829
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0315 0.3841 0.3829
Schistosoma mansoni nAChR subunit 0.0315 0.3841 0.3829
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0047 0.0027
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0315 0.3841 0.3829
Brugia malayi Pre-SET motif family protein 0.003 0.0299 0.0429
Trichomonas vaginalis glucosylceramidase, putative 0.0351 0.4288 0.6876
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0047 0.0041
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0145 0.1729 0.2632
Onchocerca volvulus 0.0315 0.3841 0.9443
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0145 0.1729 0.2632
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.017 0.2033 0.31
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0041
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0182 0.2193 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0047 0.0041
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0145 0.1729 0.1713
Brugia malayi hypothetical protein 0.0145 0.1729 0.2632
Schistosoma mansoni acetylcholine receptor subunit beta 0.0145 0.1729 0.1713
Loa Loa (eye worm) hypothetical protein 0.017 0.2033 0.31
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0033 0.0338 0.049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0047 0.0041
Brugia malayi hypothetical protein 0.0145 0.1729 0.2632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0299 0.0279
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0145 0.1729 0.2632
Brugia malayi steroid hormone receptor 0.001 0.0047 0.0041
Schistosoma mansoni cpg binding protein 0.0029 0.0288 0.0269
Onchocerca volvulus 0.0145 0.1729 0.4188
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0315 0.3841 0.3829
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0021 0.0002
Brugia malayi nuclear hormone receptor 0.001 0.0047 0.0041
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0021 0.0002
Brugia malayi hypothetical protein 0.0145 0.1729 0.2632
Schistosoma mansoni thyroid hormone receptor 0.001 0.0047 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0299 0.0279
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0315 0.3841 0.3829
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0277 0.0258
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0047 0.0027
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0507 0.6236 0.957
Loa Loa (eye worm) hypothetical protein 0.0145 0.1729 0.2632
Schistosoma mansoni cpg binding protein 0.0028 0.0268 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.4064 0.6518
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0888 0.1337
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0315 0.3841 0.5883
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0047 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0397 0.4862 0.7455
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0047 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0047 0.0041
Loa Loa (eye worm) acetylcholine receptor protein 0.0145 0.1729 0.2632
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0047 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0047 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0047 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0245 0.2976 0.4552
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0047 0.0041
Echinococcus granulosus glycine receptor subunit beta 0.0315 0.3841 0.3829
Plasmodium vivax SET domain protein, putative 0.003 0.0299 0.5
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0315 0.3841 0.3829
Brugia malayi hypothetical protein 0.0145 0.1729 0.2632
Loa Loa (eye worm) hypothetical protein 0.0315 0.3841 0.5883
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0315 0.3841 0.3829
Brugia malayi Calcitonin receptor-like protein seb-1 0.0245 0.2976 0.4552
Onchocerca volvulus 0.0315 0.3841 0.9443

Activities

Activity type Activity value Assay description Source Reference
LD10 (ADMET) = 10 mg kg-1 Toxicity in ip dosed C3H X DBA2 F1 hybrid mouse transfected with mouse L1210 cells on day 0 and dosed once daily on days 1 to 5 measured after 50 days ChEMBL. 423193

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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