Detailed information for compound 564205

Basic information

Technical information
  • TDR Targets ID: 564205
  • Name: Aurintricarboxylic Acid
  • MW: 1777.47 | Formula: C92H64O38
  • H donors: 25 H acceptors: 38 LogP: 15.91 Rotable bonds: 29
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC(=O)C1=C/C(=C(\c2ccc(c(c2)C(=O)O)O)/c2cc(Cc3cc(cc(c3O)C(=O)O)C(c3cc(Cc4cc(C(=O)O)c(c(c4)C(c4cc(cc(c4O)C(=O)O)Cc4cc(cc(c4O)C(=O)O)C(c4ccc(c(c4)C(=O)O)O)(c4ccc(c(c4)C(=O)O)O)O)c4ccc(c(c4)C(=O)O)O)O)cc(c3O)C(=O)O)(c3cc(C)c(c(c3)C(=O)O)O)O)c(c(c2)C(=O)O)O)/C=CC1=O
  • InChi: 1S/C92H64O38/c1-34-12-47(31-61(72(34)98)88(123)124)92(130,49-24-44(75(101)63(33-49)90(127)128)22-43-21-41(28-60(74(43)100)87(121)122)70(38-2-7-65(93)50(25-38)79(105)106)39-3-8-66(94)51(26-39)80(107)108)64-20-36(18-59(78(64)104)86(119)120)13-35-15-55(76(102)57(17-35)84(115)116)71(40-4-9-67(95)52(27-40)81(109)110)56-16-37(19-58(77(56)103)85(117)118)14-42-23-48(32-62(73(42)99)89(125)126)91(129,45-5-10-68(96)53(29-45)82(111)112)46-6-11-69(97)54(30-46)83(113)114/h2-12,15-21,23-33,71,93,95-104,129-130H,13-14,22H2,1H3,(H,105,106)(H,107,108)(H,109,110)(H,111,112)(H,113,114)(H,115,116)(H,117,118)(H,119,120)(H,121,122)(H,123,124)(H,125,126)(H,127,128)/b70-39-
  • InChiKey: CKSWBAVXNIPRQG-FOUYNJCBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NSC4056
  • 1,4-Cyclohexadiene-1-carboxylic acid, 3-[bis(3-carboxy-4-hydroxyphenyl)methylene]-6-oxo-
  • Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.1202 0.1467
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0209 0.0452
Brugia malayi intermediate filament protein 0.0056 0.0401 0.0622
Echinococcus multilocularis peregrin 0.0057 0.0404 0.0493
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0771 0.094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0129
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1202 0.286
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1034 0.2451
Echinococcus granulosus chromobox protein 1 0.0068 0.0522 0.0637
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0022 0.0291
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.1202 0.1467
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0191 0.6578
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0214 0.0465
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0208 0.0088
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0638 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0091 0.0093
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0295 0.2907 0.6992
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0209 0.7179
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0196 0.1866 0.2894
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0186 0.6377
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0191 0.0233
Mycobacterium tuberculosis Conserved protein 0.0413 0.4148 1
Schistosoma mansoni jumonji domain containing protein 0.0148 0.1361 0.1661
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0038 0.0948
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0214 0.0261
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0238 0.0294
Trypanosoma brucei glucosidase, putative 0.0037 0.0191 0.6578
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0217 0.0337
Brugia malayi Thioredoxin family protein 0.0413 0.4148 0.6434
Mycobacterium tuberculosis Conserved protein 0.0039 0.0214 0.0465
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0209 0.0255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0603 0.6153 0.8352
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0295 0.2907 0.6992
Echinococcus granulosus chromobox protein 1 0.0068 0.0522 0.0637
Loa Loa (eye worm) jmjC domain-containing protein 0.0117 0.104 0.1614
Schistosoma mansoni lamin 0.0056 0.0401 0.049
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0002 0.0084
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0401 0.0622
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0058 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0771 0.094
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1202 0.1467
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0459 0.0711
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0191 0.023
Mycobacterium ulcerans hypothetical protein 0.0413 0.4148 1
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0209 0.7179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.18 0.2196
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0214 0.0261
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.1092 0.1332
Loa Loa (eye worm) hypothetical protein 0.0039 0.0214 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Loa Loa (eye worm) hypothetical protein 0.0039 0.0214 0.0332
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0022 0.0035
Echinococcus multilocularis chromobox protein 1 0.0068 0.0522 0.0637
Echinococcus multilocularis chromobox protein 1 0.0068 0.0522 0.0637
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.0188
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0209 0.7179
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0214 0.0332
Brugia malayi jmjC domain containing protein 0.0072 0.0564 0.0874
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.013 0.1079
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0209 0.0254
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0214 0.0465
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0209 0.0452
Schistosoma mansoni chromobox protein 0.0068 0.0522 0.0637
Loa Loa (eye worm) glutathione reductase 0.0046 0.0291 0.0451
Onchocerca volvulus 0.0056 0.0401 0.0283
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.013 0.0158
Onchocerca volvulus 0.0056 0.0401 0.0283
Onchocerca volvulus 0.0107 0.0933 0.0822
Echinococcus multilocularis lamin dm0 0.0056 0.0401 0.049
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0214 0.0465
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0214 0.0332
Mycobacterium tuberculosis Conserved hypothetical protein 0.0413 0.4148 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1538 0.2386
Brugia malayi AF-10 protein 0.0019 0.0002 0.0004
Onchocerca volvulus Alhambra homolog 0.0057 0.0404 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0084 0.2894
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0459 0.0711
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0209 0.0324
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0404 0.0493
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0058 0.0048
Schistosoma mansoni hypothetical protein 0.0062 0.0459 0.056
Giardia lamblia Transglutaminase/protease, putative 0.0413 0.4148 0.673
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0209 0.0304
Loa Loa (eye worm) hypothetical protein 0.0092 0.0771 0.1195
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.013 0.4461
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0184 0.0224
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0564 0.0688
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0209 0.7179
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0291 0.0355
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0038 0.0498
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0176 0.0215
Brugia malayi hypothetical protein 0.0035 0.0176 0.0273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.18 0.2196
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.013 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0103 0.0888 0.1083
Toxoplasma gondii thioredoxin reductase 0.0046 0.0291 0.242
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.18 0.2792
Trichomonas vaginalis esterase, putative 0.0039 0.0214 0.0261
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0094 0.0115
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0459 0.0711
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.013 0.0158
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0058 0.0048
Echinococcus granulosus survival motor neuron protein 1 0.0525 0.5328 0.6499
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0638 0.0779
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0771 0.094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.18 0.2196
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0603 0.6153 0.8352
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0186 0.0288
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0058 0.0048
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0186 0.0226
Echinococcus multilocularis lamin 0.0056 0.0401 0.049
Schistosoma mansoni alpha-glucosidase 0.0142 0.1297 0.1583
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0002 0.002
Brugia malayi Isocitrate dehydrogenase 0.0031 0.013 0.0201
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0058 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Onchocerca volvulus 0.0039 0.0214 0.0094
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.013 0.1079
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.018 0.1704 0.2643
Echinococcus granulosus dna polymerase kappa 0.0038 0.0209 0.0255
Schistosoma mansoni hypothetical protein 0.0798 0.8198 1
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.1215 0.1884
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0058 0.0048
Onchocerca volvulus 0.0039 0.0214 0.0094
Schistosoma mansoni cpg binding protein 0.0056 0.0396 0.0483
Leishmania major DNA polymerase eta, putative 0.0038 0.0209 0.1737
Toxoplasma gondii exonuclease III APE 0.002 0.0022 0.0186
Mycobacterium ulcerans transglutaminase family protein 0.0413 0.4148 1
Brugia malayi beta-lactamase family protein 0.0039 0.0214 0.0332
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0291 1
Echinococcus multilocularis tumor protein p63 0.0333 0.3306 0.4033
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0084 0.2894
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0191 0.023
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1034 0.2083
Echinococcus multilocularis GPCR, family 2 0.0062 0.0459 0.056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0214 0.0332
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0291 0.0451
Schistosoma mansoni cpg binding protein 0.0059 0.043 0.0524
Brugia malayi beta-lactamase family protein 0.0039 0.0214 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Toxoplasma gondii ABC1 family protein 0.0039 0.0214 0.1781
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0209 0.7179
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0125 0.0195
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0056 0.0401 0.0622
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0911 0.2153
Brugia malayi chromobox protein homolog 3 0.0038 0.0208 0.0322
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0209 0.0324
Brugia malayi Pre-SET motif family protein 0.0631 0.6448 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0771 0.6411
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0186 0.0226
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0459 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Schistosoma mansoni hypothetical protein 0.0062 0.0459 0.056
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0771 0.094
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0564 0.0874
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0209 0.1737
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0209 0.0255
Brugia malayi Bromodomain containing protein 0.0057 0.0404 0.0627
Schistosoma mansoni chromobox protein 0.0068 0.0522 0.0637
Echinococcus granulosus peregrin 0.0057 0.0404 0.0493
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0002 0.0084
Brugia malayi glutathione reductase 0.0046 0.0291 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0186 0.0222
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0396 0.0615
Giardia lamblia PHD finger protein 15 0.0057 0.0404 0.0623
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0191 0.0276
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0022 0.0027
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1034 0.2451
Schistosoma mansoni hypothetical protein 0.0413 0.4148 0.506
Mycobacterium tuberculosis Conserved protein 0.0039 0.0214 0.0465
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0214 0.0261
Echinococcus multilocularis Transglutaminase 0.0413 0.4148 0.506
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0214 0.0465
Brugia malayi PHD-finger family protein 0.0022 0.0036 0.0056
Brugia malayi jmjC domain containing protein 0.0186 0.1763 0.2735
Echinococcus granulosus GPCR family 2 0.0062 0.0459 0.056
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0214 0.0465
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.8045 0.9814
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0186 0.0226
Entamoeba histolytica hypothetical protein 0.0035 0.0176 0.0251
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0214 0.7361
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0186 0.6377
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0933 0.1447
Brugia malayi Calcitonin receptor-like protein seb-1 0.0196 0.1866 0.2894
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0214 0.0261
Echinococcus multilocularis cpg binding protein 0.0059 0.043 0.0524
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.013 0.0158
Echinococcus multilocularis dnaJ subfamily B 0.0798 0.8198 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0238 0.0118
Loa Loa (eye worm) hypothetical protein 0.018 0.1704 0.2643
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.013 0.4461
Mycobacterium tuberculosis Long conserved protein 0.0413 0.4148 1
Giardia lamblia Hypothetical protein 0.0413 0.4148 0.673
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0022 0.0554
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0404 0.0493
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0564 0.0688
Brugia malayi CXXC zinc finger family protein 0.0056 0.0396 0.0615
Trypanosoma brucei unspecified product 0.0026 0.0084 0.2894
Schistosoma mansoni hypothetical protein 0.0062 0.0459 0.056
Loa Loa (eye worm) hypothetical protein 0.0057 0.0404 0.0627
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0958 0.7971
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0186 0.0226
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.013 0.4461
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0404 0.5248
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0911 0.177
Plasmodium falciparum thioredoxin reductase 0.0046 0.0291 0.7193
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0603 0.6153 0.8352
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0024 0.003
Plasmodium falciparum glutathione reductase 0.0046 0.0291 0.7193
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0214 0.0465
Mycobacterium leprae Conserved hypothetical protein 0.0413 0.4148 1
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0209 0.0452
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0191 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.1652 0.222
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0084 0.2894
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0146
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.1202 0.286
Treponema pallidum fructose-bisphosphate aldolase 0.0603 0.6153 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0291 0.3775
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0191 0.0297
Loa Loa (eye worm) beta-lactamase 0.0039 0.0214 0.0332
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0522 0.068
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0564 0.0688
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0214 0.0465
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0603 0.6153 0.8352
Echinococcus granulosus dna polymerase eta 0.0038 0.0209 0.0255
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0191 0.0276
Leishmania major trypanothione reductase 0.0046 0.0291 0.242
Brugia malayi isocitrate dehydrogenase 0.0031 0.013 0.0201
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0022 0.0186
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.18 0.2792
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.077
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0176 0.0215
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0911 0.2153
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0238 0.0294
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0186 0.1543
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0024 0.003
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0191 0.023
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1202 0.286
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0209 0.0254
Leishmania major DNA polymerase kappa, putative 0.0038 0.0209 0.1737
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0401 0.0622
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0291 0.0355
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.013 0.1079
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0125 0.0195
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0631 0.6448 1
Onchocerca volvulus 0.0103 0.0888 0.0776
Loa Loa (eye worm) hypothetical protein 0.0055 0.039 0.0606
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0291 0.0651
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0404 0.3364
Loa Loa (eye worm) hypothetical protein 0.0036 0.0186 0.0288
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.013 0.0201
Echinococcus granulosus intermediate filament protein 0.0056 0.0401 0.049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0911 0.2153
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0522 0.0809
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0129
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0911 0.2153
Plasmodium vivax SET domain protein, putative 0.0092 0.0771 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.1202 1
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0209 0.0324
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.013 0.0158
Brugia malayi Thioredoxin reductase 0.0046 0.0291 0.0451
Trichomonas vaginalis set domain proteins, putative 0.0719 0.7363 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.1866 0.2894
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0603 0.6153 1
Brugia malayi MH2 domain containing protein 0.0133 0.1201 0.1862
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0522 0.068
Loa Loa (eye worm) hypothetical protein 0.0038 0.0209 0.0324
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1538 0.2386
Echinococcus multilocularis geminin 0.0678 0.6934 0.8459
Brugia malayi beta-lactamase 0.0039 0.0214 0.0332
Giardia lamblia Fructose-bisphosphate aldolase 0.0603 0.6153 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0209 0.0452
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0404 0.0493
Brugia malayi Pre-SET motif family protein 0.0092 0.0771 0.1195
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0091 0.0093
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.013 0.3208
Mycobacterium tuberculosis Conserved hypothetical protein 0.0413 0.4148 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0186 0.1763 0.2151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0771 0.094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0771 0.094
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0191 0.023
Mycobacterium ulcerans lipase LipD 0.0039 0.0214 0.0465
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0214 0.7361
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0186 0.0222
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.013 0.026
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0214 0.0261
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0058 0.0048
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0191 0.023
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0186 0.0266
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0319 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Schistosoma mansoni hypothetical protein 0.0134 0.1215 0.1482
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0603 0.6153 0.8352
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0186 0.6377
Plasmodium falciparum phd finger protein, putative 0.0057 0.0404 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0214 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0208 0.0253
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0186 0.1763 0.2151
Mycobacterium ulcerans hypothetical protein 0.0039 0.0214 0.0465
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0186 0.0266
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0404 0.0627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.18 0.2196
Schistosoma mansoni hypothetical protein 0.0057 0.0404 0.0493
Echinococcus granulosus lamin dm0 0.0056 0.0401 0.049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0459 0.056
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0214 0.0261
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0191 0.023
Trichomonas vaginalis peptide N-glycanase, putative 0.0413 0.4148 0.562
Echinococcus multilocularis dna polymerase eta 0.0038 0.0209 0.0255
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0401 0.0622
Mycobacterium tuberculosis Hypothetical protein 0.0413 0.4148 1
Mycobacterium leprae Conserved hypothetical protein 0.0413 0.4148 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0214 0.0332
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.013 0.0158
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.1202 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.013 0.4461
Loa Loa (eye worm) hypothetical protein 0.0525 0.5328 0.8263
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0002 0.002
Leishmania major hypothetical protein, conserved 0.0039 0.0214 0.1781
Mycobacterium tuberculosis Conserved protein 0.0039 0.0214 0.0465
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0191 0.023
Loa Loa (eye worm) hypothetical protein 0.0097 0.0831 0.1289
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0191 0.1592
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0024 0.0038
Entamoeba histolytica hypothetical protein 0.0035 0.0176 0.0251
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1538 0.1877
Onchocerca volvulus 0.0056 0.0396 0.0278
Onchocerca volvulus 0.0095 0.0808 0.0696
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0295 0.2907 0.6845
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0191 0.0233
Onchocerca volvulus 0.0049 0.0319 0.0201
Echinococcus granulosus tumor protein p63 0.0333 0.3306 0.4033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0459 0.056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.18 0.2196
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0022 0.0027
Echinococcus granulosus geminin 0.0678 0.6934 0.8459
Schistosoma mansoni intermediate filament proteins 0.0056 0.0401 0.049
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.053 0.0647
Echinococcus multilocularis musashi 0.0056 0.0401 0.049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0214 0.0261
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0214 0.0465
Schistosoma mansoni hypothetical protein 0.0678 0.6934 0.8459
Brugia malayi hypothetical protein 0.0525 0.5328 0.8263
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0214 0.7361
Schistosoma mansoni DNA polymerase eta 0.0038 0.0209 0.0255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0603 0.6153 0.8352
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.013 0.1684
Brugia malayi PHD-finger family protein 0.0057 0.0404 0.0627
Schistosoma mansoni hypothetical protein 0.0107 0.0933 0.1138
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0319 0.0495
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.2407 0.5779
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.18 0.2196
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0191 0.1592
Schistosoma mansoni hypothetical protein 0.0035 0.0176 0.0215
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0094 0.0115
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0186 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Mycobacterium ulcerans beta-lactamase 0.0039 0.0214 0.0465
Loa Loa (eye worm) hypothetical protein 0.0134 0.1215 0.1884
Schistosoma mansoni lamin 0.0056 0.0401 0.049
Loa Loa (eye worm) hypothetical protein 0.0062 0.0459 0.0711
Loa Loa (eye worm) hypothetical protein 0.0038 0.0208 0.0322
Echinococcus multilocularis survival motor neuron protein 1 0.0525 0.5328 0.6499
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1034 0.2451
Entamoeba histolytica hypothetical protein 0.0035 0.0176 0.0251
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0214 0.2778
Trypanosoma brucei trypanothione reductase 0.0046 0.0291 1
Trypanosoma brucei unspecified product 0.0038 0.0209 0.7179
Plasmodium vivax glutathione reductase, putative 0.0046 0.0291 0.3775
Schistosoma mansoni hypothetical protein 0.0062 0.0459 0.056
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0191 0.0297
Mycobacterium ulcerans hypothetical protein 0.0413 0.4148 1
Onchocerca volvulus 0.0719 0.7363 0.7331
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1202 0.1467
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0027
Echinococcus granulosus cpg binding protein 0.0059 0.043 0.0524
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0603 0.6153 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0214 0.0261
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0603 0.6153 0.8352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0196 0.1866 0.2894
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0208 0.0253
Mycobacterium ulcerans putative transglutaminase-like protein 0.0413 0.4148 1
Schistosoma mansoni alpha-glucosidase 0.0142 0.1297 0.1583
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0209 0.0255
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0191 0.6578
Loa Loa (eye worm) hypothetical protein 0.0039 0.0214 0.0332
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0058 0.0048
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0186 0.0226
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0186 0.0226
Schistosoma mansoni alpha glucosidase 0.0037 0.0191 0.0233
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.077
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0191 0.023
Echinococcus granulosus Transglutaminase 0.0413 0.4148 0.506
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0723 0.0882
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0603 0.6153 0.8352
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0209 0.0255
Trypanosoma brucei unspecified product 0.0026 0.0084 0.2894
Echinococcus granulosus lamin 0.0056 0.0401 0.049
Mycobacterium tuberculosis Probable reductase 0.0105 0.0911 0.2153
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.1201 0.1862
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0214 0.0332
Schistosoma mansoni cpg binding protein 0.0059 0.043 0.0524
Schistosoma mansoni survival motor neuron protein 0.0107 0.0933 0.1138
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0034 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.18 0.2196
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0022 0.0035
Schistosoma mansoni hypothetical protein 0.0678 0.6934 0.8459
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0214 0.0261
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0209 0.0255
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0022 0.077
Brugia malayi Heterochromatin protein 1 0.0068 0.0522 0.0809
Entamoeba histolytica hypothetical protein 0.0035 0.0176 0.0251
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1202 0.286
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0186 0.0222
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.013 0.0158
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.1201 0.1862
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0186 0.0226
Echinococcus granulosus dnaJ subfamily B 0.0798 0.8198 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0022 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1538 0.1877
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1538 0.1877
Onchocerca volvulus 0.0039 0.0214 0.0094
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0176 0.0215
Giardia lamblia DINP protein human, muc B family 0.0038 0.0209 0.0304
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0404 0.3364
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0459 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0209 0.7179
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0911 0.2153

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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