Detailed information for compound 570123

Basic information

Technical information
  • TDR Targets ID: 570123
  • Name: 6-hydroxy-4-(3-hydroxyphenyl)-1-methyl-5-(thi ophene-2-carbonyl)-6-(trifluoromethyl)hexahyd ropyrimidin-2-one
  • MW: 400.372 | Formula: C17H15F3N2O4S
  • H donors: 3 H acceptors: 4 LogP: 2.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)C1NC(=O)N(C(C1C(=O)c1cccs1)(O)C(F)(F)F)C
  • InChi: 1S/C17H15F3N2O4S/c1-22-15(25)21-13(9-4-2-5-10(23)8-9)12(16(22,26)17(18,19)20)14(24)11-6-3-7-27-11/h2-8,12-13,23,26H,1H3,(H,21,25)
  • InChiKey: KLAHXTAKGDOFHY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-hydroxy-4-(3-hydroxyphenyl)-1-methyl-5-[oxo(2-thienyl)methyl]-6-(trifluoromethyl)-2-hexahydropyrimidinone
  • 6-hydroxy-4-(3-hydroxyphenyl)-1-methyl-5-thiophen-2-ylcarbonyl-6-(trifluoromethyl)-1,3-diazinan-2-one
  • 6-hydroxy-4-(3-hydroxyphenyl)-1-methyl-5-(2-thenoyl)-6-(trifluoromethyl)hexahydropyrimidin-2-one
  • 6-hydroxy-4-(3-hydroxyphenyl)-1-methyl-5-(thiophene-2-carbonyl)-6-(trifluoromethyl)-1,3-diazinan-2-one
  • 6-hydroxy-4-(3-hydroxyphenyl)-1-methyl-5-[oxo-(2-thienyl)methyl]-6-(trifluoromethyl)-2-hexahydropyrimidinone
  • 6-hydroxy-4-(3-hydroxyphenyl)-1-methyl-5-(thien-2-ylcarbonyl)-6-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one
  • EU-0012052
  • MLS000090128
  • SMR000024746

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1202 0.2401
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0119 0.0171
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0452 0.0597
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0119 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0517 0.1192
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Entamoeba histolytica hypothetical protein 0.0096 0.1598 0.2721
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0153 0.1269
Brugia malayi hypothetical protein 0.0014 0.0153 0.0352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Echinococcus granulosus solute carrier family 22 0.0014 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0517 0.1192
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0021 0.0021
Brugia malayi Dopamine receptor 0.0012 0.0119 0.0274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0119 0.0171
Schistosoma mansoni sugar transporter 0.0014 0.0153 0.022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Brugia malayi beta-lactamase family protein 0.0035 0.0517 0.1192
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0441 0.0441
Leishmania major glucose transporter, lmgt1 0.0032 0.0459 0.3818
Loa Loa (eye worm) hypothetical protein 0.0097 0.1621 0.3739
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0119 0.0171
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0119 0.0274
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.018 0.0237
Mycobacterium ulcerans hypothetical protein 0.0035 0.0517 0.4299
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Schistosoma mansoni glucose transport protein 0.0102 0.1707 0.2464
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0023
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0711 1
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0119 0.0119
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.018 0.1495
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0452 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0023
Echinococcus granulosus neuropeptide receptor A26 0.0568 1 1
Echinococcus granulosus dnaJ subfamily B 0.0395 0.6927 0.6927
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1752 0.4549
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.1707 0.3937
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0153 0.2146
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1752 0.4549
Echinococcus multilocularis cpg binding protein 0.0029 0.042 0.042
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0051 0.0117
Onchocerca volvulus 0.0014 0.0153 0.0126
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.281 0.6481
Echinococcus granulosus cpg binding protein 0.0029 0.042 0.042
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0459 0.646
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0531 0.4414
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1707 0.1707
Echinococcus granulosus geminin 0.0164 0.281 0.281
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0153 0.0352
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.018 0.253
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0119 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0881 0.0881
Echinococcus multilocularis solute carrier family 22 0.0014 0.0153 0.0153
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0119 0.0119
Toxoplasma gondii thioredoxin reductase 0.0046 0.0711 0.1419
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Schistosoma mansoni hypothetical protein 0.0012 0.0119 0.0171
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1621 0.3739
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.018 0.1495
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2967 0.6842
Brugia malayi neuropeptide F receptor 0.0012 0.0119 0.0274
Schistosoma mansoni hypothetical protein 0.0066 0.1076 0.1554
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0153 0.0352
Schistosoma mansoni hypothetical protein 0.0164 0.281 0.4057
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Toxoplasma gondii sugar transporter ST1 0.0014 0.0153 0.0305
Mycobacterium leprae Probable lipase LipE 0.0035 0.0517 0.2639
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0443 0.0443
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0302 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0459 0.1059
Schistosoma mansoni biogenic amine receptor 0.0012 0.0119 0.0171
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0153 0.0153
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0443 0.0443
Plasmodium falciparum thioredoxin reductase 0.0016 0.018 0.0237
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.018 0.0415
Echinococcus multilocularis serotonin receptor 0.0012 0.0119 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.018 0.253
Echinococcus granulosus g protein coupled receptor 0.0012 0.0119 0.0119
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.018 0.253
Loa Loa (eye worm) beta-lactamase 0.0035 0.0517 0.1192
Mycobacterium tuberculosis Probable reductase 0.0104 0.1752 0.4549
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0531 0.4414
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.6927 0.6927
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1752 0.4549
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0119 0.0274
Onchocerca volvulus 0.0014 0.0153 0.0126
Onchocerca volvulus 0.0014 0.0153 0.0126
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0119 0.0119
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0021 0.0021
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0119 0.0171
Echinococcus granulosus somatostatin receptor 0.0012 0.0119 0.0119
Schistosoma mansoni amine GPCR 0.0012 0.0119 0.0171
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0452 0.0452
Schistosoma mansoni neuropeptide receptor 0.0012 0.0119 0.0171
Brugia malayi GnHR receptor homolog 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Trypanosoma brucei glucose transporter, putative 0.0032 0.0459 0.646
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0302 0.0514
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0119 0.0274
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0452 0.1043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.1707 0.1707
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0459 0.646
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0153 0.0352
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0452 0.0597
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1707 0.1707
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0302 0.0436
Schistosoma mansoni biogenic amine receptor 0.0012 0.0119 0.0171
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.2821 0.5632
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1707 0.1707
Brugia malayi major facilitator superfamily protein 0.0014 0.0153 0.0352
Brugia malayi beta-lactamase family protein 0.0035 0.0517 0.1192
Loa Loa (eye worm) hypothetical protein 0.0035 0.0517 0.1192
Plasmodium falciparum glutathione reductase 0.0016 0.018 0.0237
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0418 0.0418
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1202 0.1202
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0452 0.0597
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0531 0.7468
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1621 0.3739
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.018 0.5955
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0452 0.0653
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1958 0.5086
Leishmania major glucose transporter, lmgt2 0.0032 0.0459 0.3818
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0452 0.0903
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0119 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.281 0.6481
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.018 0.253
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0153 0.8484
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0517 0.1342
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0119 0.0171
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.009 0.5
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.018 0.0237
Onchocerca volvulus 0.0035 0.0517 0.148
Schistosoma mansoni opsin-like receptor 0.0012 0.0119 0.0171
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0119 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0031 0.0443 0.064
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0459 0.1059
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0711 0.1639
Schistosoma mansoni cpg binding protein 0.0028 0.0392 0.0566
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0441 0.0751
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1707 0.1707
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.018 0.253
Loa Loa (eye worm) hypothetical protein 0.0035 0.0517 0.1192
Loa Loa (eye worm) hypothetical protein 0.0031 0.0443 0.1023
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0517 0.1342
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Onchocerca volvulus 0.0035 0.0517 0.148
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0119 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4336 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1202 0.3123
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.018 0.0306
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0153 0.0352
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0119 0.0274
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0119 0.0119
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0452 0.0452
Trypanosoma brucei glucose transporter, putative 0.0032 0.0459 0.646
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0119 0.0119
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0241 0.0626
Brugia malayi glutathione reductase 0.0046 0.0711 0.1639
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0119 0.0119
Echinococcus multilocularis solute carrier family 22 0.0014 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Schistosoma mansoni hypothetical protein 0.0012 0.0119 0.0171
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.018 0.1495
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0153 0.0352
Echinococcus granulosus neuropeptide receptor 0.0012 0.0119 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.018 0.253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0023
Entamoeba histolytica protein kinase, putative 0.0031 0.0452 0.077
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0021 0.0021
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0021 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1958 0.5086
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0119 0.0119
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0153 0.0305
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Entamoeba histolytica protein kinase, putative 0.0031 0.0452 0.077
Leishmania major glucose transporter, lmgt3 0.0032 0.0459 0.3818
Echinococcus multilocularis neuropeptide receptor A26 0.0568 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.001 0.0023
Treponema pallidum NADH oxidase 0.0016 0.018 1
Echinococcus multilocularis sex peptide receptor 0.0012 0.0119 0.0119
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.009 0.2978
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus granulosus g protein coupled receptor 0.0012 0.0119 0.0119
Echinococcus granulosus orexin receptor type 2 0.0012 0.0119 0.0119
Onchocerca volvulus 0.0014 0.0153 0.0126
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0119 0.0171
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.001 0.0023
Trypanosoma brucei glucose transporter, putative 0.0032 0.0459 0.646
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0302 0.0696
Echinococcus granulosus hypothetical protein 0.0012 0.0119 0.0119
Brugia malayi RE15519p 0.0012 0.0119 0.0274
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0119 0.0171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Giardia lamblia Hexose transporter 0.0014 0.0153 0.026
Echinococcus granulosus serotonin receptor 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0035 0.0517 0.1192
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Brugia malayi larval opioid receptor 0.0012 0.0119 0.0274
Trichomonas vaginalis helicase, putative 0.0006 0.001 0.0023
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0517 0.1192
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0517 0.1192
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.3851 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0452 0.0452
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0096 0.1598 0.2721
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.281 1
Schistosoma mansoni neuropeptide receptor 0.0012 0.0119 0.0171
Entamoeba histolytica hypothetical protein 0.0023 0.0302 0.0514
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0119 0.0171
Onchocerca volvulus 0.0035 0.0517 0.148
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.018 0.1495
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0119 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.281 0.6481
Trypanosoma brucei glucose transporter 1E 0.0032 0.0459 0.646
Brugia malayi neuropeptide F receptor 0.0012 0.0119 0.0274
Mycobacterium ulcerans sugar transporter 0.0014 0.0153 0.1269
Mycobacterium tuberculosis Conserved protein 0.0035 0.0517 0.1342
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.018 0.0237
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.281 0.6481
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0119 0.0119
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0119 0.0171
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0241 0.0626
Leishmania major hypothetical protein, conserved 0.0035 0.0517 0.4299
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0443 0.1023
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0119 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0881 0.1272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0119 0.0171
Onchocerca volvulus 0.0014 0.0153 0.0126
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0119 0.0274
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0302 0.0399
Schistosoma mansoni histamine h1 receptor 0.0012 0.0119 0.0171
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0119 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1958 0.5086
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1202 0.1202
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0302 0.2511
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4336 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0517 0.1342
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0441 0.0636
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0119 0.0119
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0119 0.0119
Onchocerca volvulus 0.0014 0.0153 0.0126
Echinococcus granulosus allatostatin A receptor 0.0012 0.0119 0.0119
Echinococcus granulosus fmrfamide receptor 0.0012 0.0119 0.0119
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0517 0.1342
Brugia malayi Cam kinase protein 1 0.0031 0.0452 0.1043
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0153 0.1269
Giardia lamblia Sugar-proton symporter 0.0014 0.0153 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Brugia malayi sulfakinin receptor protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0452 0.1043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0119 0.0171
Schistosoma mansoni hypothetical protein 0.0395 0.6927 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0881 0.1272
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1202 0.1736
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Plasmodium falciparum hexose transporter 0.0102 0.1707 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0119 0.0119
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0452 0.0597
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0517 0.1342
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.018 0.253
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.018 0.0415
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0119 0.0119
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.018 0.0467
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0051
Schistosoma mansoni protein kinase 0.0031 0.0452 0.0653
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.2821 0.3724
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0452 0.0597
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0452 0.0597
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0119 0.0171
Onchocerca volvulus 0.0014 0.0153 0.0126
Schistosoma mansoni hypothetical protein 0.0102 0.1707 0.2464
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0119 0.0119
Echinococcus multilocularis serotonin receptor 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0021 0.003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0392 0.0903
Echinococcus granulosus GPCR family 2 0.0031 0.0443 0.0443
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0119 0.0171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Plasmodium falciparum protein kinase 7 0.0287 0.5008 0.6612
Brugia malayi Thioredoxin reductase 0.0046 0.0711 0.1639
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0119 0.0119
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0119 0.0119
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0119 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.1707 0.3408
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0023
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0302 0.4248
Brugia malayi ORL1-like opioid receptor 0.0012 0.0119 0.0274
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0119 0.0171
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.018 0.1495
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1707 0.1707
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0119 0.0119
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0153 0.0201
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Onchocerca volvulus 0.0014 0.0153 0.0126
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0119 0.0274
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0459 0.3818
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0531 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0119 0.0171
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0881 0.2031
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0711 0.1846
Onchocerca volvulus Putative transporter 0.0014 0.0153 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.018 0.253
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0153 0.0153
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0459 0.646
Brugia malayi G-protein coupled receptor 0.0012 0.0119 0.0274
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0153 0.022
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0517 0.4299
Schistosoma mansoni sugar transporter 0.0014 0.0153 0.022
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0119 0.0274
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0119 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0119 0.0171
Schistosoma mansoni adenoreceptor 0.0012 0.0119 0.0171
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0119 0.0171
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0119 0.0119
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0119 0.0171
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Plasmodium falciparum thioredoxin reductase 0.0046 0.0711 0.0938
Loa Loa (eye worm) hypothetical protein 0.0066 0.1076 0.2482
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.2821 0.3724
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0302 0.0603
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0881 0.1272
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0459 0.1059
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1202 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0441 0.0751
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.281 0.6481
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0517 0.0682
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0241 0.1231
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0119 0.0119
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0517 0.0517
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Echinococcus granulosus sex peptide receptor 0.0012 0.0119 0.0119
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0441 0.2251
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0531 0.106
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1707 0.1707
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.4336 1
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.018 0.253
Schistosoma mansoni amine GPCR 0.0012 0.0119 0.0171
Schistosoma mansoni glucose transport protein 0.0102 0.1707 0.2464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0119 0.0274
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0833 0.1664
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0105 0.0242
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0441 0.1017
Onchocerca volvulus 0.0014 0.0153 0.0126
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4336 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0517 0.7273
Onchocerca volvulus 0.0014 0.0153 0.0126
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0418 0.0418
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0119 0.0119
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0153 0.0352
Trypanosoma brucei glucose transporter 2A 0.0032 0.0459 0.646
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0119 0.0119
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0153 0.2146
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0153 0.1269
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.281 0.6481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0119 0.0171
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0443 0.1023
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0302 0.0302
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Schistosoma mansoni hypothetical protein 0.0031 0.0443 0.064
Loa Loa (eye worm) sugar transporter 0.0014 0.0153 0.0352
Brugia malayi Dopamine receptor protein 1 0.0012 0.0119 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4336 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0452 0.0452
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0153 0.2146
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0153 0.0352
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.018 0.253
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.018 0.018
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1958 1
Schistosoma mansoni glucose transport protein 0.0102 0.1707 0.2464
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0336 0.5872 1
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4336 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.018 0.253
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0119 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1202 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0722 0.0722
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0119 0.0119
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0711 0.0938
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0119 0.0119
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0119 0.0119
Schistosoma mansoni biogenic amine receptor 0.0012 0.0119 0.0171
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0153 0.0352
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0119 0.0119
Echinococcus multilocularis solute carrier family 22 0.0014 0.0153 0.0153
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0153 0.0352
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0881 0.2031
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0302 0.0399
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0452 0.1043
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Schistosoma mansoni hypothetical protein 0.0012 0.0119 0.0171
Trypanosoma brucei glucose transporter, putative 0.0032 0.0459 0.646
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0722 0.0722
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0531 0.7468
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0153 0.0352
Onchocerca volvulus 0.0014 0.0153 0.0126
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.4336 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0302 0.0696
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2967 0.6842
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) glutathione reductase 0.0046 0.0711 0.1639
Schistosoma mansoni cpg binding protein 0.0029 0.042 0.0606
Onchocerca volvulus 0.0014 0.0153 0.0126
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0459 0.1059
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0302 0.2511
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0119 0.0171
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0443 0.1023
Mycobacterium ulcerans lipase LipD 0.0035 0.0517 0.4299
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0119 0.0274
Schistosoma mansoni hypothetical protein 0.0031 0.0443 0.064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus granulosus neuropeptide receptor 0.0012 0.0119 0.0119
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0121 0.0279
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0441 0.1017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.018 0.253
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0302 0.0696
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1752 0.8944
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0459 0.1059
Plasmodium falciparum glutathione reductase 0.0046 0.0711 0.0938
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.018 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1707 0.1707
Schistosoma mansoni hypothetical protein 0.0031 0.0443 0.064
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0119 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0517 0.1192
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0517 0.0517
Plasmodium vivax hexose transporter 0.0102 0.1707 0.2253
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0441 0.0636
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0531 0.0701
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0443 0.0443
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0119 0.0171
Brugia malayi Serotonin receptor 0.0012 0.0119 0.0274
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0302 0.4248
Onchocerca volvulus 0.0014 0.0153 0.0126
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Brugia malayi Dopamine receptor protein 2 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Brugia malayi AKH receptor 0.0012 0.0119 0.0274
Brugia malayi CXXC zinc finger family protein 0.0028 0.0392 0.0903
Loa Loa (eye worm) hypothetical protein 0.0031 0.0441 0.1017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Loa Loa (eye worm) hypothetical protein 0.0025 0.0339 0.0782
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0119 0.0119
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0205 0.2882
Echinococcus granulosus g protein coupled receptor 0.0012 0.0119 0.0119
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0119 0.0119
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0153 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0119 0.0171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Brugia malayi Sugar transporter family protein 0.0014 0.0153 0.0352
Schistosoma mansoni sugar transporter 0.0014 0.0153 0.022
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis solute carrier family 22 0.0014 0.0153 0.0153
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.018 0.026
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1752 0.4549
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0452 0.0903
Schistosoma mansoni neuropeptide receptor 0.0012 0.0119 0.0171
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0119 0.0274
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.1076 0.2482
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0119 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0023
Trypanosoma brucei trypanothione reductase 0.0046 0.0711 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.018 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0153 0.0396
Trypanosoma brucei glucose transporter, putative 0.0032 0.0459 0.646
Schistosoma mansoni sugar transporter 0.0014 0.0153 0.022
Schistosoma mansoni protein kinase 0.0031 0.0452 0.0653
Loa Loa (eye worm) hypothetical protein 0.0035 0.0517 0.1192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0517 0.0746
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0881 0.0881
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0153 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0517 0.4299
Leishmania major trypanothione reductase 0.0046 0.0711 0.5911
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.009 0.0748
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0119 0.0171
Brugia malayi beta-lactamase 0.0035 0.0517 0.1192
Plasmodium vivax glutathione reductase, putative 0.0046 0.0711 0.0938
Onchocerca volvulus 0.0014 0.0153 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.018 0.0237
Toxoplasma gondii sugar transporter ST2 0.0014 0.0153 0.0305
Mycobacterium tuberculosis Conserved protein 0.0035 0.0517 0.1342
Toxoplasma gondii ABC1 family protein 0.0035 0.0517 0.1032
Echinococcus granulosus solute carrier family 22 0.0014 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0012 0.0119 0.0171
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0517 0.7273
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0119 0.0119
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0119 0.0171
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0153 0.0352
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1202 1
Brugia malayi Melatonin receptor type 1A 0.0012 0.0119 0.0274
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0119 0.0274
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0119 0.0274
Schistosoma mansoni neuropeptide receptor 0.0012 0.0119 0.0171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Echinococcus granulosus General substrate transporter 0.0087 0.1453 0.1453
Echinococcus granulosus solute carrier family 22 0.0014 0.0153 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0517 0.0746
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.018 0.1495
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0452 0.0452
Onchocerca volvulus 0.0014 0.0153 0.0126
Trypanosoma brucei sugar transporter, putative 0.0014 0.0153 0.2146
Echinococcus multilocularis somatostatin receptor 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0119 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0441 0.1017
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.018 0.1495
Brugia malayi G-protein coupled receptor 0.0012 0.0119 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Plasmodium vivax CDK-related protein kinase 6, putative 0.0432 0.7574 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.018 0.0359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0881 0.0881
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0459 0.1059
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0119 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0023
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0517 0.1342
Giardia lamblia DNA repair protein RAD52 0.0336 0.5872 1
Brugia malayi major facilitator superfamily protein 0.0014 0.0153 0.0352
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0531 0.7468
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0119 0.0274
Loa Loa (eye worm) sugar transporter 0.0102 0.1707 0.3937
Schistosoma mansoni opsin-like receptor 0.0012 0.0119 0.0171
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0119 0.0119
Echinococcus multilocularis geminin 0.0164 0.281 0.281
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0517 0.1192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Schistosoma mansoni glucose transporter 0.0014 0.0153 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0023
Mycobacterium tuberculosis Conserved protein 0.0035 0.0517 0.1342
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0119 0.0119
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0119 0.0274
Onchocerca volvulus 0.0028 0.0392 0.1015
Schistosoma mansoni hypothetical protein 0.0164 0.281 0.4057
Schistosoma mansoni opsin-like receptor 0.0012 0.0119 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0517 0.1192
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0441 0.0441
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0105 0.0242
Echinococcus multilocularis General substrate transporter 0.0087 0.1453 0.1453
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0459 0.646
Schistosoma mansoni amine GPCR 0.0012 0.0119 0.0171
Plasmodium falciparum protein kinase 6 0.0432 0.7574 1
Brugia malayi Sugar transporter family protein 0.0102 0.1707 0.3937
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0452 0.0452
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Brugia malayi putative neuropeptide receptor 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0119 0.0119
Schistosoma mansoni amine GPCR 0.0012 0.0119 0.0171
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0119 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Brugia malayi Serotonin receptor 0.0012 0.0119 0.0274
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0302 0.1542
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0302 0.2511
Brugia malayi hypothetical protein 0.0014 0.0153 0.0352
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0119 0.0171
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1202 0.1736
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.018 0.253
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0517 0.1342
Plasmodium vivax sugar transporter, putative 0.0014 0.0153 0.0201
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0452 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0153 0.0352
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0452 0.0597
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0119 0.0119
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0517 0.2639
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0153 0.0396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0023
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0302 0.0436
Onchocerca volvulus 0.0014 0.0153 0.0126
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0049 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0119 0.0171
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.001 0.0023
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1202 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0119 0.0119
Schistosoma mansoni myosin xvIII 0.0012 0.0119 0.0171
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0452 0.0597
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0459 0.1059
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0119 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4336 1
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.018 0.0359
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Trypanosoma brucei glucose transporter, putative 0.0032 0.0459 0.646
Schistosoma mansoni amine GPCR 0.0012 0.0119 0.0171
Echinococcus multilocularis neuropeptide s receptor 0.0568 1 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0252 0.0582
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0452 0.1043
Brugia malayi hypothetical protein 0.0014 0.0153 0.0352
Toxoplasma gondii protein kinase, putative 0.0287 0.5008 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0441 0.1017
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0119 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.281 0.6481
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0452 0.0903
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Schistosoma mansoni cpg binding protein 0.0029 0.042 0.0606
Leishmania major hypothetical protein, conserved 0.0014 0.0153 0.1269
Leishmania major protein kinase, putative 0.0031 0.0452 0.3759
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0153 0.0352
Trichomonas vaginalis esterase, putative 0.0035 0.0517 0.1192
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0352
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0517 0.1192
Trypanosoma cruzi hexose transporter 0.0032 0.0459 0.646
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0459 0.646
Loa Loa (eye worm) hypothetical protein 0.0035 0.0517 0.1192
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0119 0.0119
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1752 0.4549
Mycobacterium ulcerans beta-lactamase 0.0035 0.0517 0.4299
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0153 0.0352
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0153 0.2146
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.018 0.0415
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0452 0.636
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Brugia malayi hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis GPCR, family 2 0.0031 0.0443 0.0443
Trypanosoma brucei glucose transporter, putative 0.0032 0.0459 0.646
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0119 0.0119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1621 0.3739
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0051
Schistosoma mansoni protein kinase 0.0031 0.0452 0.0653
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0881 0.0881
Brugia malayi G protein-coupled receptor 0.0012 0.0119 0.0274
Trypanosoma brucei glucose transporter, putative 0.0032 0.0459 0.646
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.018 0.018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0945 0.1364
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0274
Loa Loa (eye worm) hypothetical protein 0.0031 0.0452 0.1043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0119 0.0171
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0119 0.0171
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0153 0.1269
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0459 0.646
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0119 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0517 0.7273
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0119 0.0119
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0302 0.0302
Echinococcus granulosus solute carrier family 22 0.0014 0.0153 0.0153
Brugia malayi Sugar transporter family protein 0.0014 0.0153 0.0352
Toxoplasma gondii sugar transporter ST3 0.0014 0.0153 0.0305
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0119 0.0119

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 3.937 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.5802 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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