Detailed information for compound 57697

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 255.272 | Formula: C14H13N3O2
  • H donors: 1 H acceptors: 2 LogP: 1.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)OC)c1nc2c(n1)cc[nH]c2
  • InChi: 1S/C14H13N3O2/c1-18-9-3-4-10(13(7-9)19-2)14-16-11-5-6-15-8-12(11)17-14/h3-8,15H,1-2H3
  • InChiKey: MITJCPOOGYAMDG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.1486 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0498 0.0489
Brugia malayi jmjC domain containing protein 0.0015 0.0055 0.0029
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0355 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0049 0.0565 0.0556
Onchocerca volvulus 0.0035 0.0355 0.0543
Loa Loa (eye worm) cysteine protease 0.0016 0.0071 0.0098
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0174 0.0216
Schistosoma mansoni protein kinase 0.0034 0.0333 0.0279
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0222 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0565 0.0836
Toxoplasma gondii cathepsin CPL 0.0016 0.0071 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0174 0.0163
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0055 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0498 0.0772
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Brugia malayi hypothetical protein 0.0016 0.0058 0.0033
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0339 0.4363
Brugia malayi Steroid receptor seven-up type 2 0.0049 0.0565 0.0836
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0055 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0565 0.0556
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0265 0.036
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0498 0.073
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0323 0.0269
Brugia malayi jmjC domain containing protein 0.0015 0.0055 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0535 0.0788
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0405 0.4934
Schistosoma mansoni zinc finger protein 0.0023 0.0174 0.0119
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0594
Leishmania major glucose transporter, lmgt3 0.0034 0.0339 0.4363
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0058 0.0627
Plasmodium vivax sugar transporter, putative 0.0016 0.0058 0.0004
Brugia malayi Cytochrome P450 family protein 0.0022 0.0157 0.0191
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0139 1
Trypanosoma brucei glucose transporter 1E 0.0034 0.0339 0.4007
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0196 0.2456
Schistosoma mansoni protein kinase 0.0034 0.0333 0.0279
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0049 0.0565 0.0556
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0222 0.0336
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0058 0.0006
Brugia malayi nuclear hormone receptor 0.0049 0.0565 0.0836
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0056 0.0046
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0071 0.0095
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0691 0.0682
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0056 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0196 0.2456
Brugia malayi Protein kinase domain containing protein 0.0031 0.0296 0.0411
Schistosoma mansoni intermediate filament proteins 0.0026 0.0222 0.0167
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0058 0.0002
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.3311 0.3304
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0405 0.0784
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0333 0.3915
Echinococcus multilocularis solute carrier family 22 0.0016 0.0058 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Loa Loa (eye worm) hypothetical protein 0.0435 0.6355 1
Leishmania major glucose transporter, lmgt1 0.0034 0.0339 0.4363
Brugia malayi nuclear receptor NHR-67 0.0023 0.0174 0.0216
Brugia malayi Death domain containing protein 0.0029 0.0265 0.036
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0071 0.0016
Schistosoma mansoni microtubule-associated protein tau 0.0678 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0498 0.0446
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Echinococcus multilocularis geminin 0.0166 0.2323 0.2315
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0071 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0339 0.223
Loa Loa (eye worm) hypothetical protein 0.0025 0.0196 0.0295
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Onchocerca volvulus 0.0016 0.0071 0.0095
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0323 1
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0195 0.0185
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0333 0.0407
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Schistosoma mansoni thyroid hormone receptor 0.0049 0.0565 0.0513
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0071 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0049 0.0565 0.0877
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0157 0.0235
Plasmodium vivax hexose transporter 0.0111 0.1486 0.2097
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0765 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0049 0.0565 0.0836
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0058 0.1623
Onchocerca volvulus 0.0047 0.0535 0.0827
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0174 0.0163
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.2044 0.3207
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0323 0.0452
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0071 0.0061
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0195 0.0205
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi hypothetical protein 0.0016 0.0064 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0498 0.0489
Brugia malayi nuclear hormone receptor 0.0023 0.0174 0.0216
Brugia malayi jmjC domain containing protein 0.0058 0.0691 0.1035
Schistosoma mansoni protein kinase 0.0034 0.0333 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0049 0.0565 0.0836
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0071 0.0098
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0339 0.223
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0058 0.032
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0111 0.1486 0.1477
Plasmodium falciparum protein kinase 6 0.047 0.6879 1
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0195 0.5182
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0001
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0055 0.0594
Brugia malayi major facilitator superfamily protein 0.0016 0.0058 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Leishmania major hypothetical protein, conserved 0.0025 0.0196 0.2456
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0691 0.0682
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.001 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0326 0.0458
Plasmodium vivax vivapain-2 0.0016 0.0071 0.0023
Echinococcus granulosus Ankyrin 0.003 0.0268 0.0258
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0058 0.0047
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Onchocerca volvulus 0.0016 0.0071 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0565 0.0556
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0037 0.0045
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0042 0.0421
Onchocerca volvulus 0.0016 0.0058 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0196 0.0206
Loa Loa (eye worm) runx1 0.0055 0.0643 0.1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0196 0.1979
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.0294
Onchocerca volvulus 0.0016 0.0058 0.0075
Brugia malayi jmjC domain containing protein 0.0058 0.0691 0.1035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0174 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0339 0.223
Echinococcus multilocularis lamin 0.0026 0.0222 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0049 0.0565 0.0877
Brugia malayi hypothetical protein 0.0023 0.0174 0.0216
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0229 0.0347
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0339 0.4363
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0174 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi hypothetical protein 0.0023 0.0174 0.0216
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0354 0.0301
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Echinococcus multilocularis netrin receptor unc 5 0.0029 0.0265 0.0255
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.6643 0.664
Onchocerca volvulus 0.0435 0.6355 1
Schistosoma mansoni single-minded 0.0048 0.0541 0.0489
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Toxoplasma gondii sugar transporter ST3 0.0016 0.0058 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0071 0.0061
Brugia malayi ecdysone receptor 0.0023 0.0174 0.0216
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0058 0.0077
Brugia malayi Sugar transporter family protein 0.0016 0.0058 0.0033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Schistosoma mansoni hypothetical protein 0.0111 0.1486 0.1439
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0216 0.0205
Onchocerca volvulus 0.0023 0.0174 0.0257
Echinococcus granulosus solute carrier family 22 0.0016 0.0058 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni lozenge 0.0055 0.0643 0.0591
Brugia malayi Sugar transporter family protein 0.0016 0.0058 0.0033
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0339 0.4007
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0565 0.0836
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0049 0.0565 0.0556
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0354 0.0344
Echinococcus multilocularis musashi 0.0026 0.0222 0.0211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0559 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Brugia malayi hypothetical protein 0.0016 0.0058 0.0033
Schistosoma mansoni coup transcription factor 0.0049 0.0565 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0049 0.0565 0.0836
Brugia malayi steroid hormone receptor 0.0049 0.0565 0.0836
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0049 0.0565 0.0513
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0058 0.0627
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0565 0.0513
Schistosoma mansoni retinoic acid receptor RXR 0.0049 0.0565 0.0513
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0216 0.0326
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0058 0.1623
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0339 0.4007
Onchocerca volvulus 0.0016 0.0071 0.0095
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0049 0.0565 0.0513
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.0265 0.0255
Leishmania major protein kinase, putative 0.0034 0.0333 0.4277
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0174 0.0163
Onchocerca volvulus 0.0016 0.0058 0.0075
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0056 0.0046
Schistosoma mansoni sugar transporter 0.0016 0.0058 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni sugar transporter 0.0016 0.0058 0.0002
Echinococcus granulosus General substrate transporter 0.0095 0.1252 0.1243
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0563 0.7331
Echinococcus granulosus intermediate filament protein 0.0026 0.0222 0.0211
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0405 0.5236
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Schistosoma mansoni glucose transport protein 0.0111 0.1486 0.1439
Echinococcus multilocularis FTZ F1 alpha 0.0049 0.0565 0.0556
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0049 0.0565 0.0513
Onchocerca volvulus 0.0016 0.0058 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0339 0.223
Echinococcus granulosus single minded 2 0.0035 0.0355 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Onchocerca volvulus 0.0023 0.0174 0.0257
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0301 0.0291
Brugia malayi major facilitator superfamily protein 0.0016 0.0058 0.0033
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0049 0.0565 0.0877
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0323 1
Echinococcus granulosus solute carrier family 22 0.0016 0.0058 0.0047
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Echinococcus granulosus netrin receptor unc 5 0.0029 0.0265 0.0255
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0001
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0323 0.2116
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0174 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0691 0.0682
Echinococcus granulosus FTZ F1 alpha 0.0049 0.0565 0.0556
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0073
Echinococcus granulosus solute carrier family 22 0.0016 0.0058 0.0047
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0058 0.032
Echinococcus multilocularis ecdysone induced protein 78C 0.0049 0.0565 0.0556
Schistosoma mansoni nuclear receptor 0.0023 0.0174 0.0119
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0049 0.0565 0.0877
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni nuclear receptor 0.0023 0.0174 0.0119
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0058 0.0047
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0174 0.0163
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0405 0.5236
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0071 0.0061
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0196 0.0206
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0333 0.0323
Echinococcus granulosus death domain containing protein 0.0029 0.0265 0.0255
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0174 0.0216
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0195 0.5493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi nuclear receptor RXR 0.0023 0.0174 0.0216
Schistosoma mansoni thyroid hormone receptor 0.0049 0.0565 0.0513
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0565 0.0836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.2486 0.3902
Brugia malayi Uncoordinated protein 44 0.0029 0.0265 0.036
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0179 0.251 0.3597
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0016 0.0005
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0333 0.0407
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0049 0.0565 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Echinococcus multilocularis Ankyrin 0.003 0.0268 0.0258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0498 0.0489
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0174 0.0216
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0049 0.0565 0.0513
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Brugia malayi tailless protein 0.0023 0.0174 0.0216
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0071 0.0802
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0049 0.0565 0.0836
Schistosoma mansoni hypothetical protein 0.0029 0.0265 0.0211
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0336
Echinococcus granulosus cathepsin l1 0.0016 0.0071 0.0061
Toxoplasma gondii protein kinase, putative 0.0313 0.4521 1
Leishmania major cathepsin L-like protease 0.0063 0.0765 1
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0174 0.0119
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0333 0.0407
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0174 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Schistosoma mansoni RAR-like nuclear receptor 0.0049 0.0565 0.0513
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0174 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0174 0.0119
Onchocerca volvulus 0.0049 0.0565 0.0875
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.3311 0.3304
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0323 0.0269
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Brugia malayi nuclear receptor NHR-88 0.0023 0.0174 0.0216
Brugia malayi hypoxia-induced factor 1 0.0148 0.2044 0.3177
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Onchocerca volvulus 0.0016 0.0071 0.0095
Plasmodium vivax vivapain-2 0.0016 0.0071 0.0023
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0405 0.5236
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0056 0.0046
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0323 0.0452
Echinococcus multilocularis cysteine protease 0.0016 0.0071 0.0061
Plasmodium falciparum protein kinase 7 0.0313 0.4521 0.6544
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0196 0.0206
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0333 0.0468
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0174 0.0163
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0222 0.0292
Mycobacterium ulcerans sugar transporter 0.0016 0.0058 0.1623
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Entamoeba histolytica protein kinase, putative 0.0034 0.0333 0.9241
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0216 0.0205
Onchocerca volvulus 0.0016 0.0058 0.0075
Plasmodium falciparum mitogen-activated protein kinase 2 0.0179 0.251 0.3597
Loa Loa (eye worm) hypothetical protein 0.0435 0.6355 1
Brugia malayi hypothetical protein 0.0026 0.0216 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0195 0.5493
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0055 0.0045
Schistosoma mansoni netrin receptor unc5 0.0029 0.0265 0.0211
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.0265 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0195 0.2447
Schistosoma mansoni steroid hormone receptor ad4bp 0.0049 0.0565 0.0513
Brugia malayi hypothetical protein 0.0035 0.0354 0.0502
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0073
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0195 0.0141
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0174 0.026
Onchocerca volvulus 0.0016 0.0058 0.0075
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0055 0.0073
Loa Loa (eye worm) hypothetical protein 0.0029 0.0265 0.0403
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0174 0.0257
Loa Loa (eye worm) steroid hormone receptor 0.0049 0.0565 0.0877
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0049 0.0565 0.0556
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0055 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0049 0.0565 0.0513
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0071 0.0098
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0106 0.1264
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0355 0.0503
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0174 0.0257
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0055 0.0045
Trypanosoma brucei sugar transporter, putative 0.0016 0.0058 0.0035
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0058 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0559 0.0867
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0049 0.0565 0.0877
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Echinococcus multilocularis GPCR, family 2 0.0015 0.0056 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0333 0.0407
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0683 0.8918
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0058 0.0035
Entamoeba histolytica hypothetical protein 0.0035 0.0354 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0049 0.0565 0.0556
Loa Loa (eye worm) hypothetical protein 0.003 0.0268 0.0409
Onchocerca volvulus 0.0016 0.0058 0.0075
Schistosoma mansoni hypothetical protein 0.0166 0.2323 0.228
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0049 0.0565 0.0836
Schistosoma mansoni hypothetical protein 0.0166 0.2323 0.228
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0195 0.2447
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0195 0.0205
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0174 0.0163
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0333 0.0407
Brugia malayi ecdysteroid receptor 0.0049 0.0565 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0058 0.032
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.6643 0.664
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0333 0.0511
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0196 0.0314
Onchocerca volvulus 0.0016 0.0058 0.0075
Onchocerca volvulus 0.0026 0.0222 0.0333
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0216 0.0283
Brugia malayi PAS domain containing protein 0.0048 0.0541 0.0798
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0174 0.0119
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0174 0.026
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0333 0.0623
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0765 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0691 0.064
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0049 0.0565 0.0556
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0216 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0333 0.0407
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0042 0.0421
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0058 0.0033
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Brugia malayi hypothetical protein 0.016 0.2231 0.3472
Onchocerca volvulus 0.0016 0.0058 0.0075
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0055 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0765 1
Loa Loa (eye worm) DR-78 0.0023 0.0174 0.026
Brugia malayi hypothetical protein 0.0435 0.6355 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0174 0.0163
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0016 0.0005
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0323 0.0313
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0333 0.2186
Leishmania major protein kinase, putative 0.0015 0.0042 0.0421
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0174 0.0216
Onchocerca volvulus 0.0016 0.0058 0.0075
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0055 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0071 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0559 0.0826
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0216 0.0283
Loa Loa (eye worm) hypothetical protein 0.0049 0.0559 0.0867
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0174 0.0119
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0058 0.0033
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.0265 0.0211
Toxoplasma gondii facilitative glucose transporter GT1 0.0111 0.1486 0.3205
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0071 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0071 0.041
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0339 0.4363
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.003 0.0268 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi conserved hypotetical protein 0.0023 0.0174 0.0216
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0058 0.0627
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Schistosoma mansoni glucose transporter 0.0016 0.0058 0.0002
Echinococcus multilocularis Protein lozenge 0.0055 0.0643 0.0634
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0195 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0049 0.0565 0.0836
Brugia malayi hypothetical protein 0.0232 0.3311 0.5182
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0301 0.0291
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0056 0.0076
Onchocerca volvulus Putative transporter 0.0016 0.0058 0.0075
Onchocerca volvulus 0.0016 0.0058 0.0075
Leishmania major glucose transporter, lmgt2 0.0034 0.0339 0.4363
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0195 0.197
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0355 0.0345
Schistosoma mansoni sugar transporter 0.0016 0.0058 0.0002
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0333 0.0407
Schistosoma mansoni glucose transport protein 0.0111 0.1486 0.1439
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0058 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Loa Loa (eye worm) fibroinase 0.0016 0.0071 0.0098
Plasmodium vivax CDK-related protein kinase 6, putative 0.047 0.6879 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0.001 0.0527
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0195 0.5912
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0073
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0058 0.0004
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0058 0.032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0042 0.0421
Echinococcus multilocularis solute carrier family 22 0.0016 0.0058 0.0047
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0058 0.0077
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0323 0.8878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0498 0.0446
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0149 0.0941
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0056 0.0046
Onchocerca volvulus Protein ultraspiracle homolog 0.0049 0.0565 0.0875
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0001
Onchocerca volvulus 0.0016 0.0058 0.0075
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0179 0.251 0.5498
Echinococcus multilocularis thyroid hormone receptor alpha 0.0049 0.0565 0.0556
Loa Loa (eye worm) hypothetical protein 0.0033 0.0326 0.0501
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0055 0.0073
Leishmania major cathepsin L-like protease 0.0063 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.016 0.2231 0.3501
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0071 0.041
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0405 0.0513
Echinococcus granulosus geminin 0.0166 0.2323 0.2315
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Schistosoma mansoni lamin 0.0026 0.0222 0.0167
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0071 0.0802
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0565 0.0836
Loa Loa (eye worm) hypothetical protein 0.0033 0.0323 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0049 0.0565 0.0836
Schistosoma mansoni hypothetical protein 0.0035 0.0354 0.0301
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0339 0.223
Leishmania major hypothetical protein, conserved 0.0016 0.0058 0.0627
Echinococcus multilocularis solute carrier family 22 0.0016 0.0058 0.0047
Schistosoma mansoni survival motor neuron protein 0.0047 0.0535 0.0483
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0333 0.0407
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0565 0.0836
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Leishmania major cathepsin L-like protease 0.0063 0.0765 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0333 0.0407
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0174 0.0163
Echinococcus granulosus lamin dm0 0.0026 0.0222 0.0211
Onchocerca volvulus 0.0016 0.0058 0.0075
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0691 0.064
Loa Loa (eye worm) hypothetical protein 0.0232 0.3311 0.5203
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0049 0.0565 0.0875
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Entamoeba histolytica hypothetical protein 0.0035 0.0354 1
Onchocerca volvulus 0.0016 0.0071 0.0095
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0565 0.0556
Onchocerca volvulus Netrin receptor homolog 0.0029 0.0265 0.0401
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0405 0.0513
Echinococcus multilocularis solute carrier family 22 0.0016 0.0058 0.0047
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0056 0.0031
Loa Loa (eye worm) hypothetical protein 0.0034 0.0333 0.0511
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0339 0.4007
Onchocerca volvulus 0.0026 0.0222 0.0333
Leishmania major protein kinase, putative 0.0018 0.01 0.1183
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi intermediate filament protein 0.0026 0.0222 0.0292
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0174 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0077
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0055 0.0045
Echinococcus multilocularis General substrate transporter 0.0095 0.1252 0.1243
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0042 0.0421
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0498 0.0489
Onchocerca volvulus 0.0016 0.0058 0.0075
Loa Loa (eye worm) hypothetical protein 0.0033 0.0323 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0058 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0055 0.0073
Schistosoma mansoni hypothetical protein 0.0033 0.0326 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0498 0.0446
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0333 0.0511
Loa Loa (eye worm) ctsf protein 0.0016 0.0071 0.0098
Plasmodium falciparum hexose transporter 0.0111 0.1486 0.2097
Loa Loa (eye worm) hypothetical protein 0.0177 0.2486 0.3903
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0055 0.0594
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0691 0.0682
Trypanosoma brucei glucose transporter 2A 0.0034 0.0339 0.4007
Brugia malayi Cam kinase protein 1 0.0034 0.0333 0.0468
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0541 0.0489
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0195 0.1251
Schistosoma mansoni hypothetical protein 0.0047 0.0535 0.0483
Onchocerca volvulus 0.0016 0.0058 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0049 0.0565 0.0877
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0339 0.4363
Entamoeba histolytica hypothetical protein 0.0035 0.0354 1
Schistosoma mansoni glucose transport protein 0.0111 0.1486 0.1439
Trypanosoma cruzi hexose transporter 0.0034 0.0339 0.4363
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Brugia malayi Sugar transporter family protein 0.0111 0.1486 0.2294
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0071 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Echinococcus multilocularis lamin dm0 0.0026 0.0222 0.0211
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Onchocerca volvulus 0.0016 0.0058 0.0075
Echinococcus granulosus lamin 0.0026 0.0222 0.0211
Brugia malayi hypothetical protein 0.0026 0.0216 0.0283
Loa Loa (eye worm) sugar transporter 0.0016 0.0058 0.0077
Echinococcus granulosus nuclear factor of activated T cells 5 0.015 0.2081 0.2073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Schistosoma mansoni sugar transporter 0.0016 0.0058 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0049 0.0565 0.0877
Brugia malayi Cathepsin L-like precursor 0.0016 0.0071 0.0054
Echinococcus granulosus phd:f box containing protein 0.0015 0.0055 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0565 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0049 0.0565 0.0836
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0174 0.026
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0001
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0195 0.0185
Echinococcus granulosus ecdysone induced protein 78C 0.0049 0.0565 0.0556
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Brugia malayi N-terminal motif family protein 0.0177 0.2486 0.3876
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0214 0.0324
Trypanosoma brucei glucose transporter, putative 0.0034 0.0339 0.4007
Toxoplasma gondii sugar transporter ST1 0.0016 0.0058 0.0006
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0195 0.0141
Brugia malayi nuclear receptor NHR-88 0.0049 0.0565 0.0836
Echinococcus multilocularis nuclear factor of activated T cells 5 0.015 0.2081 0.2073
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0333 0.0623
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0139 0.4121
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0405 0.5236
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0029 0.0032
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0323 0.0313
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0565 0.0513
Onchocerca volvulus Bile acid receptor homolog 0.0049 0.0565 0.0875
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0326
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0058 0.032
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0265 0.0403
Echinococcus granulosus solute carrier family 22 0.0016 0.0058 0.0047
Brugia malayi nuclear receptor RXR 0.0026 0.0216 0.0283
Schistosoma mansoni lamin 0.0026 0.0222 0.0167
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0071 0.0023
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0195 0.025
Brugia malayi jmjC domain containing protein 0.0015 0.0055 0.0029
Brugia malayi hypothetical protein 0.0025 0.0196 0.0251
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0071 0.0054
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Echinococcus granulosus GPCR family 2 0.0015 0.0056 0.0046
Echinococcus granulosus neuropeptide s receptor 0.0454 0.6643 0.664
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0055 0.0045
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Treponema pallidum prolyl-tRNA synthetase 0.0012 0 0.5
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0333 0.0623
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0565 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0339 0.223
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0058 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0691 0.064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0174 0.026
Leishmania major cathepsin L-like protease 0.0016 0.0071 0.0802
Toxoplasma gondii sugar transporter ST2 0.0016 0.0058 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0691 0.1076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0049 0.0565 0.0556
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0058 0.1623
Entamoeba histolytica protein kinase, putative 0.0034 0.0333 0.9241
Entamoeba histolytica hypothetical protein 0.0035 0.0354 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0565 0.0877
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0071 0.0061
Onchocerca volvulus 0.0016 0.0071 0.0095
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0139 1
Echinococcus multilocularis cysteine protease 0.0016 0.0071 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0071 0.041
Brugia malayi jmjC domain containing protein 0.0015 0.0055 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0565 0.0836
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0216 0.0161
Brugia malayi hypothetical protein 0.0016 0.0058 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0071 0.041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0049 0.0565 0.0556
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0071 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0076
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0058 0.0627
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0003
Loa Loa (eye worm) sugar transporter 0.0111 0.1486 0.2328
Onchocerca volvulus 0.0016 0.0071 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0765 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.6643 0.664
Echinococcus multilocularis microtubule associated protein 2 0.0678 1 1
Entamoeba histolytica hypothetical protein 0.0025 0.0195 0.4377
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0339 0.223
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0354 0.0344
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1486 0.1477
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0333 0.0323
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0195 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0333 0.0279

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -17 % Percent change in mean arterial blood pressure in anesthetized dog ChEMBL. 4009593
Change (functional) = 9 % Percent change in heart rate in anesthetized dog ChEMBL. 4009593
Control (functional) = 158 % Inotropic activity in cat papillary muscle at 10e-5 M expressed as percent of control ChEMBL. 3397997
Control (functional) = 158 % Compound tested for contractility in isolated cat papillary muscle at 10 e-5 M. ChEMBL. 4009593
Control (functional) = 172 % Compound tested for contractility in isolated cat papillary muscle at 10 e-4 M. ChEMBL. 4009593
ED50 (functional) = 0.3 mg kg-1 Tested in anesthetized dog for its inotropic activity after intravenous administration ChEMBL. 3397997
ED50 (functional) = 0.3 mg kg-1 Compound tested for contractility in anesthetized dog when administered intravenously. ChEMBL. 4009593
pA50 (functional) = 4.01 In vitro concentration required to give a 50% increase in basal contractile force in an isolated paced guinea pig papillary muscle preparation ChEMBL. 2165165
Response ratio (functional) = 0.81 Response ratio = (percent increase to drug)/(percent increase to 10 E-5 M isoproterenol) ChEMBL. 4009593
Response ratio (functional) = 1 Response ratio = (percent increase to drug)/(percent increase to 10 E-4 M isoproterenol) ChEMBL. 4009593

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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