Detailed information for compound 581522

Basic information

Technical information
  • TDR Targets ID: 581522
  • Name: 10-hydroxycoronaridine
  • MW: 354.443 | Formula: C21H26N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@H]1C[C@H]2CN3[C@@H]1[C@](C2)(C(=O)OC)c1[nH]c2c(c1CC3)cc(cc2)O
  • InChi: 1S/C21H26N2O3/c1-3-13-8-12-10-21(20(25)26-2)18-15(6-7-23(11-12)19(13)21)16-9-14(24)4-5-17(16)22-18/h4-5,9,12-13,19,22,24H,3,6-8,10-11H2,1-2H3/t12-,13+,19+,21-/m1/s1
  • InChiKey: TUZCJNZERFWZAS-YDBSYXHISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 76129-67-4
  • Ibogamine-18-carboxylic acid, 12-hydroxy-, methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.01 0.0058 0.0058
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.01 0.0058 0.0032
Echinococcus granulosus neutral alpha glucosidase AB 0.1468 0.1548 0.1657
Brugia malayi hypothetical protein 0.0048 0.0001 0.0001
Schistosoma mansoni bile acid beta-glucosidase-related 0.7545 0.8162 0.8788
Echinococcus granulosus smoothened 0.0173 0.0137 0.0137
Brugia malayi hypothetical protein 0.0136 0.0097 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.005 0.0043
Loa Loa (eye worm) hypothetical protein 0.0136 0.0097 0.0097
Brugia malayi intermediate filament protein 0.0056 0.001 0.001
Echinococcus granulosus non lysosomal glucosylceramidase 0.7545 0.8162 0.8788
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0058 0.0052
Trichomonas vaginalis glycoside hydrolases, putative 0.0186 0.0152 0.0126
Loa Loa (eye worm) hypothetical protein 0.0133 0.0094 0.0094
Leishmania major alpha glucosidase II subunit, putative 0.1468 0.1548 1
Schistosoma mansoni hypothetical protein 0.0232 0.0202 0.0207
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0123 0.0083 0.0083
Echinococcus multilocularis ceramide glucosyltransferase 0.8578 0.9287 1
Trichomonas vaginalis glucosylceramidase, putative 0.6384 0.6899 0.6891
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0058 0.0052
Echinococcus multilocularis lysosomal alpha glucosidase 0.8174 0.8847 0.9526
Onchocerca volvulus Glucosylceramidase homolog 0.6058 0.6544 0.7043
Trichomonas vaginalis alpha-glucosidase, putative 0.1468 0.1548 0.1525
Trichomonas vaginalis glucosylceramidase, putative 0.9233 1 1
Echinococcus granulosus glycogen debranching enzyme 0.0207 0.0175 0.0178
Loa Loa (eye worm) hypothetical protein 0.0054 0.0008 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0796 0.0816 0.0791
Loa Loa (eye worm) hypothetical protein 0.0169 0.0133 0.0133
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0058 0.0052
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.1468 0.1548 0.1525
Entamoeba histolytica glycogen debranching enzyme, putative 0.0207 0.0175 0.0628
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.005 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.6058 0.6544 0.6535
Trichomonas vaginalis beta-glucosidase, putative 0.0186 0.0152 0.0126
Trichomonas vaginalis glucosylceramidase, putative 0.6058 0.6544 0.6535
Echinococcus granulosus bile acid beta glucosidase 0.7545 0.8162 0.8788
Trichomonas vaginalis glucosylceramidase, putative 0.9233 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.1468 0.1548 0.1548
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.9233 1 1
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.8578 0.9287 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0796 0.0816 0.0791
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.005 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.9233 1 1
Trichomonas vaginalis beta-mannosidase, putative 0.0102 0.0061 0.0034
Loa Loa (eye worm) hypothetical protein 0.0136 0.0097 0.0097
Onchocerca volvulus 0.0136 0.0097 0.0093
Brugia malayi hypothetical protein 0.0133 0.0094 0.0094
Schistosoma mansoni ceramide glucosyltransferase 0.8578 0.9287 1
Schistosoma mansoni hypothetical protein 0.015 0.0112 0.011
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0058 0.0052
Echinococcus multilocularis lysosomal alpha glucosidase 0.8174 0.8847 0.9526
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0796 0.0816 0.0791
Trichomonas vaginalis beta-galactosidase, putative 0.0315 0.0293 0.0267
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0058 0.0052
Onchocerca volvulus 0.0136 0.0097 0.0093
Onchocerca volvulus Huntingtin homolog 0.0133 0.0094 0.009
Loa Loa (eye worm) hypothetical protein 0.0149 0.0111 0.0111
Onchocerca volvulus 0.0136 0.0097 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.6058 0.6544 0.6535
Loa Loa (eye worm) hypothetical protein 0.0136 0.0097 0.0097
Loa Loa (eye worm) TRE-1 protein 0.0136 0.0097 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.005 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.6058 0.6544 0.6535
Loa Loa (eye worm) hypothetical protein 0.0207 0.0175 0.0175
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.1468 0.1548 1
Echinococcus multilocularis geminin 0.0169 0.0133 0.0132
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0008 0.0008
Trichomonas vaginalis glycoside hydrolase, putative 0.0437 0.0425 0.0399
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0796 0.0816 0.0791
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.1468 0.1548 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0796 0.0816 0.0791
Echinococcus multilocularis bile acid beta glucosidase 0.7545 0.8162 0.8788
Schistosoma mansoni beta-mannosidase 0.0102 0.0061 0.0054
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.8174 0.8847 0.8847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.005 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.1468 0.1548 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.1468 0.1548 0.1525
Trichomonas vaginalis glucosylceramidase, putative 0.9233 1 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0058 0.0052
Trichomonas vaginalis maltase-glucoamylase, putative 0.0796 0.0816 0.0791
Loa Loa (eye worm) hypothetical protein 0.5093 0.5493 0.5493
Schistosoma mansoni alpha-amylase 0.0123 0.0083 0.0078
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.1468 0.1548 0.1547
Echinococcus multilocularis non lysosomal glucosylceramidase 0.7545 0.8162 0.8788
Schistosoma mansoni bile acid beta-glucosidase-related 0.7545 0.8162 0.8788
Brugia malayi Trehalase family protein 0.0136 0.0097 0.0097
Onchocerca volvulus Huntingtin homolog 0.0133 0.0094 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.9233 1 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.0058 0.0052
Loa Loa (eye worm) hypothetical protein 0.0067 0.0023 0.0022
Mycobacterium leprae Putative uncharacterized protein ML2045 0.0123 0.0083 0.5
Onchocerca volvulus Trehalase homolog 0.0136 0.0097 0.0093
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0796 0.0816 0.5004
Trichomonas vaginalis alpha-glucosidase, putative 0.0796 0.0816 0.0791
Trichomonas vaginalis sucrase-isomaltase, putative 0.1468 0.1548 0.1525
Schistosoma mansoni alpha glucosidase 0.1468 0.1548 0.1657
Schistosoma mansoni hypothetical protein 0.0169 0.0133 0.0132
Brugia malayi Glycosyl hydrolases family 31 protein 0.8174 0.8847 0.8847
Trichomonas vaginalis glucosylceramidase, putative 0.9233 1 1
Schistosoma mansoni hypothetical protein 0.0169 0.0133 0.0132
Loa Loa (eye worm) alpha amylase 0.0123 0.0083 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0056 0.001 0.001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.1468 0.1548 0.1525
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0207 0.0175 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0065 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.6058 0.6544 0.6535
Loa Loa (eye worm) hypothetical protein 0.0136 0.0097 0.0097
Mycobacterium tuberculosis Trehalose synthase TreS 0.0123 0.0083 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.1468 0.1548 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.1468 0.1548 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0796 0.0816 0.0816
Treponema pallidum hypothetical protein 0.0047 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0796 0.0816 0.0816
Giardia lamblia Ceramide glucosyltransferase 0.3889 0.4182 1
Echinococcus multilocularis alpha glucosidase 0.0123 0.0083 0.0078
Schistosoma mansoni beta-galactosidase 0.0149 0.0111 0.0109
Entamoeba histolytica beta-galactosidase, putative 0.0213 0.0181 0.067
Loa Loa (eye worm) alpha amylase 0.0123 0.0083 0.0083
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.0058 0.0052
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0178 0.0143 0.0143
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0178 0.0143 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.005 0.0043
Brugia malayi Melibiase family protein 0.01 0.0058 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.6058 0.6544 0.6535
Trichomonas vaginalis alpha-glucosidase, putative 0.0796 0.0816 0.0791
Loa Loa (eye worm) trehalase 0.0136 0.0097 0.0097
Echinococcus granulosus alpha glucosidase 0.0123 0.0083 0.0078
Echinococcus granulosus beta galactosidase 0.0149 0.0111 0.0109
Schistosoma mansoni alpha-amylase 0.0123 0.0083 0.0078
Loa Loa (eye worm) hypothetical protein 0.0055 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0315 0.0293 0.0267
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0123 0.0083 0.0083
Trichomonas vaginalis alpha-glucosidase, putative 0.1468 0.1548 0.1525
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.005 0.0049
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0796 0.0816 0.0868
Echinococcus granulosus lysosomal alpha glucosidase 0.8174 0.8847 0.9526
Schistosoma mansoni alpha-amylase 0.0123 0.0083 0.0078
Trypanosoma brucei glucosidase, putative 0.1468 0.1548 1
Loa Loa (eye worm) trehalase 0.0136 0.0097 0.0097
Trichomonas vaginalis trehalase, putative 0.0136 0.0097 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.005 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.6384 0.6899 0.6891
Loa Loa (eye worm) trehalase 0.0136 0.0097 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.6058 0.6544 0.6535
Schistosoma mansoni alpha-glucosidase 0.7501 0.8115 0.8737
Brugia malayi Beta-glucuronidase precursor 0.017 0.0134 0.0134
Loa Loa (eye worm) ceramide glucosyltransferase 0.8578 0.9287 0.9287
Echinococcus granulosus geminin 0.0169 0.0133 0.0132
Loa Loa (eye worm) TRE-2 protein 0.0136 0.0097 0.0097
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0207 0.0175 0.0149
Loa Loa (eye worm) hypothetical protein 0.0089 0.0046 0.0045
Echinococcus multilocularis smoothened 0.0173 0.0137 0.0137
Brugia malayi Ceramide glucosyltransferase 0.8578 0.9287 0.9287
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0207 0.0175 0.0175
Trichomonas vaginalis alpha-glucosidase, putative 0.1468 0.1548 0.1525
Schistosoma mansoni alpha-amylase 0.0123 0.0083 0.0078
Onchocerca volvulus 0.0136 0.0097 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0008 0.0008
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0449 0.0438 0.0437
Mycobacterium tuberculosis Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas 0.0123 0.0083 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.001 0.001
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.0071 0.0027 0.0018
Echinococcus multilocularis neutral alpha glucosidase AB 0.1468 0.1548 0.1657
Loa Loa (eye worm) hypothetical protein 0.0136 0.0097 0.0097
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.001 0.001
Echinococcus multilocularis beta galactosidase 0.0149 0.0111 0.0109
Schistosoma mansoni ceramide glucosyltransferase 0.8578 0.9287 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.0094 0.0094
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0101 0.0059 0.0059
Brugia malayi Trehalase family protein 0.0136 0.0097 0.0097
Brugia malayi manba-prov protein 0.0102 0.0061 0.0061
Onchocerca volvulus 0.533 0.5751 0.6188
Schistosoma mansoni alpha-amylase 0.0123 0.0083 0.0078
Brugia malayi Trehalase family protein 0.0136 0.0097 0.0097
Onchocerca volvulus 0.0136 0.0097 0.0093
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0207 0.0175 0.0149
Trichomonas vaginalis alpha-glucosidase, putative 0.1468 0.1548 0.1525
Schistosoma mansoni hypothetical protein 0.0267 0.024 0.0247
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.0058 0.0052
Mycobacterium ulcerans trehalose synthase TreS 0.0123 0.0083 0.5
Schistosoma mansoni alpha-glucosidase 0.7501 0.8115 0.8737
Brugia malayi Trehalase family protein 0.0136 0.0097 0.0097
Echinococcus multilocularis glycogen debranching enzyme 0.0207 0.0175 0.0178
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0008 0.0008
Echinococcus granulosus beta hexosaminidase subunit alpha 0.0071 0.0027 0.0018
Echinococcus granulosus ceramide glucosyltransferase 0.8578 0.9287 1
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0097 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.005 0.0043
Trichomonas vaginalis alpha-glucosidase, putative 0.1468 0.1548 0.1525
Loa Loa (eye worm) beta-glucuronidase 0.017 0.0134 0.0134

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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