Detailed information for compound 584575

Basic information

Technical information
  • TDR Targets ID: 584575
  • Name: (2S,3R,4R,5R,6R)-6-(hydroxymethyl)-2-propoxy- 3,4-di(tetradecoxy)tetrahydropyran-3,4,5-trio l
  • MW: 646.979 | Formula: C37H74O8
  • H donors: 4 H acceptors: 4 LogP: 11.71 Rotable bonds: 32
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCO[C@]1(O)[C@H](O)[C@@H](CO)O[C@@H]([C@@]1(O)OCCCCCCCCCCCCCC)OCCC
  • InChi: 1S/C37H74O8/c1-4-7-9-11-13-15-17-19-21-23-25-27-30-43-36(40)34(39)33(32-38)45-35(42-29-6-3)37(36,41)44-31-28-26-24-22-20-18-16-14-12-10-8-5-2/h33-35,38-41H,4-32H2,1-3H3/t33-,34-,35+,36-,37-/m1/s1
  • InChiKey: SWXKOMYMFNSOFZ-KHKVHWIZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3R,4R,5R,6R)-6-(hydroxymethyl)-2-propoxy-3,4-di(tetradecoxy)oxane-3,4,5-triol
  • (2S,3R,4R,5R,6R)-6-methylol-3,4-dimyristyloxy-2-propoxy-tetrahydropyran-3,4,5-triol
  • 1,2-di-O-tetradecyl-3-O-(glucopyranosyl)glycerol
  • 81281-22-3
  • 1,2-Tdgg
  • alpha-D-Glucopyranoside, 2,3-bis(tetradecyloxy)propyl-, (R)-
  • alpha-Dtgl

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0319 0.0591
Schistosoma mansoni ap endonuclease 0.0018 0.003 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0305 0.0569
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0116 0.0162
Schistosoma mansoni survival motor neuron protein 0.0048 0.0454 0.0435
Loa Loa (eye worm) hypothetical protein 0.0024 0.0116 0.0181
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0318 0.0599
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.0366 1
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0305 0.0385
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0305 0.4001
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0319 0.0601
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0319 0.0301
Brugia malayi MH2 domain containing protein 0.0024 0.0115 0.0214
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0305 0.0535
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0116 0.0191
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0032 0.0023
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0319 0.866
Schistosoma mansoni inositol monophosphatase 0.0038 0.0318 0.03
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0116 0.0191
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0319 0.0301
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0126 0.3559
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0115 0.0096
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0116 0.0191
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.003 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0305 0.0562
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0116 0.0162
Toxoplasma gondii ABC1 family protein 0.0037 0.0305 0.9539
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.0366 0.0694
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.003 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0319 0.0301
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0116 0.0217
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0305 0.0569
Onchocerca volvulus 0.0024 0.0116 0.198
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0042 0.0366 0.063
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0535
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0019 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0305 0.0286
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0115 0.0179
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0063 0.0044
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0305 0.0569
Brugia malayi MH2 domain containing protein 0.0354 0.4813 0.8985
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0116 0.1253
Schistosoma mansoni smad 0.0024 0.0115 0.0096
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0126 0.021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0454 0.0847
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0116 0.0162
Echinococcus multilocularis tumor protein p63 0.0353 0.4807 0.4797
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0374 0.5096 0.5086
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0116 0.0162
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0042 0.0366 0.063
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0366 0.051
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0116 0.0217
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.003 0.0021
Leishmania major cathepsin L-like protease 0.0066 0.0717 0.1397
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.0116 0.3234
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0318 1
Onchocerca volvulus 0.0037 0.0305 0.584
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.0116 0.0191
Schistosoma mansoni loxhd1 0.0021 0.0063 0.0044
Schistosoma mansoni Smad4 0.0024 0.0115 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.003 0.1009
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0319 0.0301
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0319 0.0591
Brugia malayi beta-lactamase family protein 0.0037 0.0305 0.0569
Schistosoma mansoni inositol monophosphatase 0.0038 0.0318 0.03
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.0116 0.0097
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.3181 0.6331
Mycobacterium leprae Probable lipase LipE 0.0037 0.0305 0.0385
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0104 0.014
Schistosoma mansoni hypothetical protein 0.0036 0.028 0.0261
Onchocerca volvulus 0.0052 0.0508 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0366 0.063
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0366 0.063
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.003 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0635 0.1212
Onchocerca volvulus 0.0024 0.0116 0.198
Mycobacterium tuberculosis Conserved protein 0.0037 0.0305 0.0569
Brugia malayi hypothetical protein 0.0235 0.3117 0.5819
Brugia malayi Doublecortin family protein 0.0021 0.0063 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0366 0.0682
Toxoplasma gondii propionate-CoA ligase 0.0024 0.0116 0.3234
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0305 0.0286
Echinococcus granulosus RUN 0.0021 0.0063 0.0044
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0374 0.5096 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0116 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0366 0.0649
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0366 0.063
Loa Loa (eye worm) hypothetical protein 0.0042 0.0366 0.0649
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0535
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.0116 0.9086
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0116 0.0194
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0717 0.1374
Echinococcus granulosus Smad4 0.0024 0.0115 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0319 1
Onchocerca volvulus 0.0021 0.0063 0.0901
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0126 0.021
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0717 0.1374
Toxoplasma gondii exonuclease III APE 0.0018 0.003 0.0359
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0116 0.0194
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0319 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0115 0.0096
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.0116 0.339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Schistosoma mansoni lipoxygenase 0.0057 0.0589 0.0571
Brugia malayi AMP-binding enzyme family protein 0.0392 0.5357 1
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0318 0.03
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0392 0.5357 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0589 0.0571
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0305 0.0562
Leishmania major cathepsin L-like protease 0.0066 0.0717 0.1397
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0115 0.0179
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.016
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0036
Echinococcus multilocularis microtubule associated protein 2 0.0718 1 1
Echinococcus granulosus long chain fatty acid transport protein 4 0.0374 0.5096 0.5086
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0116 0.3227
Entamoeba histolytica acyl-coA synthetase, putative 0.0042 0.0366 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0023 0.0104 0.5
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0392 0.5357 1
Entamoeba histolytica hypothetical protein 0.0036 0.028 0.7533
Loa Loa (eye worm) transcription factor SMAD2 0.0354 0.4813 0.8981
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0535
Schistosoma mansoni lipoxygenase 0.0021 0.0063 0.0044
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.003 0.5
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0024 0.0116 0.2794
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0319 0.0301
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0374 0.5096 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0116 0.0191
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.0116 0.1253
Brugia malayi MH1 domain containing protein 0.0024 0.0115 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0116 0.0162
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0116 0.0191
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0116 0.0181
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0036
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0305 0.0569
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0305 0.9518
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0261 0.0296
Schistosoma mansoni ap endonuclease 0.0018 0.003 0.0011
Brugia malayi hypothetical protein 0.0021 0.0063 0.0118
Schistosoma mansoni smad1 5 8 and 0.0024 0.0115 0.0096
Schistosoma mansoni rab6-interacting 0.0021 0.0063 0.0044
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.0116 0.0097
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0104 0.0168
Schistosoma mansoni hypothetical protein 0.0021 0.0063 0.0044
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0115 0.0096
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0318 0.0542
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0305 0.0569
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0318 0.4202
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.0116 0.3234
Entamoeba histolytica hypothetical protein 0.0036 0.028 0.7533
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.003 0.0022
Echinococcus granulosus smad 0.0024 0.0115 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.0116 0.0191
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0305 0.9518
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0368 0.5012 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0305 0.0516
Brugia malayi MH1 domain containing protein 0.0024 0.0115 0.0214
Loa Loa (eye worm) inositol-1 0.0038 0.0318 0.0561
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0116 0.0162
Entamoeba histolytica hypothetical protein 0.0036 0.028 0.7533
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0305 0.0516
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0063 0.0044
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0318 0.9978
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0305 0.0569
Brugia malayi Inositol-1 0.0038 0.0318 0.0595
Echinococcus multilocularis RUN 0.0021 0.0063 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.028 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Loa Loa (eye worm) Smad1 0.0024 0.0115 0.0179
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.003 0.0358
Leishmania major hypothetical protein, conserved 0.0025 0.0126 0.0213
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0535
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0368 0.5012 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0717 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0319 0.0301
Loa Loa (eye worm) MH2 domain-containing protein 0.0354 0.4813 0.8981
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0063 0.0044
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0319 0.0562
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0318 0.9978
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0717 0.1374
Loa Loa (eye worm) hypothetical protein 0.0042 0.0366 0.0649
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0036
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0036
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0116 0.0191
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0116 0.0162
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0126 1
Leishmania major fatty acid transporter protein-like protein 0.0368 0.5012 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0083
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0319 1
Echinococcus multilocularis smad 0.0024 0.0115 0.0096
Mycobacterium ulcerans acetyl-CoA synthetase 0.0024 0.0116 0.0162
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0126 0.1395
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0126 0.3731
Brugia malayi hypothetical protein 0.0021 0.0063 0.0118
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0063 0.1543
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0366 0.0682
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0116 0.0191
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0126 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0305 0.9518
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.016
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0116 0.0191
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0318 0.059
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0116 0.0191
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0042 0.0366 0.0691
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0305 0.9518
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0116 0.3227
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0261 0.0482
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.0366 0.0694
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.0366 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0319 0.0596
Leishmania major cathepsin L-like protease 0.0066 0.0717 0.1397
Brugia malayi hypothetical protein 0.0036 0.028 0.0523
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0116 0.0162
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.003 0.002
Schistosoma mansoni hypothetical protein 0.0048 0.0454 0.0435
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0318 0.059
Mycobacterium ulcerans lipase LipD 0.0037 0.0305 0.0516
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0319 0.0301
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0116 0.0191
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0318 0.9978
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0514 0.0975
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0116 0.0162
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0116 0.0191
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0318 0.03
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0116 0.0194
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.0116 0.0217
Brugia malayi beta-lactamase 0.0037 0.0305 0.0569
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0535
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0115 0.0096
Onchocerca volvulus 0.0042 0.0366 0.7085
Entamoeba histolytica hypothetical protein 0.0036 0.028 0.7533
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0366 0.051
Loa Loa (eye worm) hypothetical protein 0.0052 0.0508 0.0916
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.3117 0.3104
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0116 0.0191
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0063 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.016
Schistosoma mansoni smad1 5 8 and 0.0024 0.0115 0.0096
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.003 0.031
Loa Loa (eye worm) hypothetical protein 0.0235 0.3117 0.5804
Loa Loa (eye worm) oxidoreductase 0.0024 0.0116 0.0181
Schistosoma mansoni microtubule-associated protein tau 0.0718 1 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0305 1
Brugia malayi beta-lactamase family protein 0.0037 0.0305 0.0569
Loa Loa (eye worm) hypothetical protein 0.0025 0.0126 0.02
Onchocerca volvulus 0.0021 0.0063 0.0901
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0063 0.0044
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0305 0.0569
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0535
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0116 0.0162
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.003 0.0021
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0042 0.0366 0.063
Onchocerca volvulus 0.0037 0.0305 0.584
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0116 0.0162
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0116 0.0191
Brugia malayi MH2 domain containing protein 0.0024 0.0115 0.0214
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0366 0.0682
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.0366 0.0694
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0116 0.0217
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0305 0.0569
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0305 0.0286
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0063 0.4136
Trichomonas vaginalis esterase, putative 0.0037 0.0305 0.9518
Mycobacterium tuberculosis Conserved protein 0.0037 0.0305 0.0569
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0319 0.0301
Onchocerca volvulus 0.0037 0.0305 0.584
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0115 0.0096
Onchocerca volvulus 0.0024 0.0116 0.198
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0063 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0366 0.0691
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.003 0.0376
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0589 0.0571
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0083
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.0116 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0366 0.063
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0319 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0319 0.4212
Loa Loa (eye worm) hypothetical protein 0.0024 0.0116 0.0181
Mycobacterium ulcerans hypothetical protein 0.0042 0.0366 0.063
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0318 0.8641
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.028 0.0261
Leishmania major hypothetical protein, conserved 0.0037 0.0305 0.0572
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0305 0.0569
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.028 0.0261
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.003 0.0358
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0024 0.0116 0.0162
Schistosoma mansoni polycystin 1-related 0.0021 0.0063 0.0044
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0063 0.0044
Plasmodium vivax acyl-CoA synthetase, putative 0.0023 0.0104 0.2983
Schistosoma mansoni smad1 5 8 and 0.0024 0.0115 0.0096
Schistosoma mansoni rab6-interacting 0.0021 0.0063 0.0044
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0305 0.0516
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0305 0.0286
Mycobacterium ulcerans hypothetical protein 0.0037 0.0305 0.0516
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0024 0.0116 0.0162
Onchocerca volvulus 0.0048 0.0454 0.8885
Echinococcus multilocularis Smad4 0.0024 0.0115 0.0096
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0717 0.1374
Brugia malayi hypothetical protein 0.0025 0.0126 0.0235
Onchocerca volvulus 0.0024 0.0116 0.198
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0116 0.0162
Loa Loa (eye worm) beta-lactamase 0.0037 0.0305 0.0535
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0036
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0508 0.049
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.3117 0.3104
Plasmodium falciparum acyl-CoA synthetase 0.0023 0.0104 0.7996
Echinococcus granulosus tumor protein p63 0.0353 0.4807 0.4797
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0116 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0305 0.9518
Schistosoma mansoni FFA transport protein 0.0374 0.5096 0.5086
Brugia malayi Smad1 0.0024 0.0115 0.0214

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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