Detailed information for compound 58481

Basic information

Technical information
  • TDR Targets ID: 58481
  • Name: 6-bromo-2-phenyl-2H-pyrano[2,3-b]pyridine
  • MW: 288.139 | Formula: C14H10BrNO
  • H donors: 0 H acceptors: 1 LogP: 3.9 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cnc2c(c1)C=CC(O2)c1ccccc1
  • InChi: 1S/C14H10BrNO/c15-12-8-11-6-7-13(17-14(11)16-9-12)10-4-2-1-3-5-10/h1-9,13H
  • InChiKey: HAWPOVRQHFBASB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 102830-81-9
  • AIDS-190904
  • AIDS190904
  • 2H-Pyrano(2,3-b)pyridine, 6-bromo-2-phenyl-
  • 2H-Pyrano[2,3-b]pyridine, 6-bromo-2-phenyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei uracil-DNA glycosylase, putative 0.0063 0.0444 0.0711
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0449 0.0449
Loa Loa (eye worm) tubulin alpha 2 0.039 0.2907 0.4995
Trichomonas vaginalis conserved hypothetical protein 0.018 0.1319 0.2243
Loa Loa (eye worm) hypothetical protein 0.0302 0.2244 0.3856
Leishmania major beta tubulin 0.0777 0.582 1
Echinococcus multilocularis tubulin subunit TubB 0.057 0.426 0.7309
Leishmania major beta tubulin 0.0777 0.582 1
Leishmania major alpha tubulin 0.057 0.426 0.7305
Loa Loa (eye worm) tubulin alpha-3 chain 0.0336 0.2497 0.4291
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0091 0.0118
Echinococcus granulosus Tubulin alpha 1 chain 0.057 0.426 0.7309
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0362 0.0621
Loa Loa (eye worm) hypothetical protein 0.0336 0.2497 0.4291
Loa Loa (eye worm) hypothetical protein 0.0131 0.0953 0.1638
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0362 0.0568
Plasmodium vivax tubulin beta chain, putative 0.0777 0.582 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0091 0.0101
Schistosoma mansoni cpg binding protein 0.0032 0.0207 0.0207
Entamoeba histolytica tubulin family protein 0.0777 0.582 1
Echinococcus granulosus peroxisome assembly protein 26 0.057 0.426 0.7309
Brugia malayi tubulin alpha chain - mouse 0.057 0.426 0.7305
Loa Loa (eye worm) tubulin alpha 2 0.0156 0.1144 0.1966
Schistosoma mansoni tubulin subunit beta 0.0777 0.582 0.582
Schistosoma mansoni polyadenylate binding protein 0.0009 0.0033 0.0033
Brugia malayi Tubulin alpha-2 chain 0.057 0.426 0.7305
Brugia malayi alpha-tubulin 0.057 0.426 0.7305
Echinococcus multilocularis muscleblind protein 0.0302 0.2244 0.3832
Leishmania major beta tubulin 0.0777 0.582 1
Schistosoma mansoni alpha tubulin 0.057 0.426 0.426
Trichomonas vaginalis tubulin epsilon chain, putative 0.0777 0.582 1
Echinococcus granulosus Tubulin beta 2C chain 0.0777 0.582 1
Leishmania major alpha tubulin 0.057 0.426 0.7305
Echinococcus granulosus Tubulin beta 2C chain 0.0777 0.582 1
Echinococcus granulosus tubulin alpha 1C chain 0.057 0.426 0.7309
Trichomonas vaginalis tubulin, putative 0.0777 0.582 1
Echinococcus multilocularis tubulin delta chain 0.018 0.1319 0.2236
Schistosoma mansoni uracil-DNA glycosylase 0.0063 0.0444 0.0444
Echinococcus multilocularis tubulin alpha chain 0.057 0.426 0.7309
Loa Loa (eye worm) alpha-tubulin 0.057 0.426 0.732
Brugia malayi Uracil-DNA glycosylase 0.0063 0.0444 0.0711
Trichomonas vaginalis tubulin beta chain, putative 0.0234 0.1729 0.295
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0024
Schistosoma mansoni tubulin subunit beta 0.0777 0.582 0.582
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0091
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0414 0.3082 0.5269
Schistosoma mansoni polyadenylate binding protein 0.0009 0.0033 0.0033
Echinococcus granulosus tubulin alpha 1C chain 0.057 0.426 0.7309
Echinococcus multilocularis peroxisome assembly protein 26 0.057 0.426 0.7309
Echinococcus multilocularis tubulin alpha chain 0.057 0.426 0.7309
Loa Loa (eye worm) tubulin beta chain 0.018 0.1319 0.2267
Brugia malayi Tubulin alpha-2 chain 0.057 0.426 0.7305
Leishmania major beta tubulin 0.0777 0.582 1
Echinococcus granulosus tubulin alpha 0.0414 0.3082 0.5277
Echinococcus multilocularis hypothetical protein 0.057 0.426 0.7309
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0301 0.048
Echinococcus granulosus tubulin gamma 1 chain 0.0414 0.3082 0.5277
Leishmania major alpha tubulin 0.057 0.426 0.7305
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0037 0.0063
Plasmodium falciparum tubulin gamma chain 0.0414 0.3082 0.5269
Loa Loa (eye worm) alpha-tubulin isotype 2 0.039 0.2907 0.4995
Echinococcus multilocularis uracil DNA glycosylase 0.0063 0.0444 0.0727
Trypanosoma cruzi tubulin gamma chain 0.0414 0.3082 0.5269
Echinococcus multilocularis cpg binding protein 0.0032 0.0207 0.0318
Echinococcus granulosus tubulin subunit TubB 0.057 0.426 0.7309
Brugia malayi RNA binding protein 0.0131 0.0953 0.159
Leishmania major alpha tubulin 0.057 0.426 0.7305
Chlamydia trachomatis uracil DNA glycosylase 0.0063 0.0444 0.5
Schistosoma mansoni tubulin subunit beta 0.0777 0.582 0.582
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0091 0.0101
Entamoeba histolytica tubulin gamma chain 0.0414 0.3082 0.4907
Brugia malayi tubulin alpha-2 chain 0.057 0.426 0.7305
Echinococcus multilocularis tubulin epsilon chain 0.0414 0.3082 0.5277
Plasmodium vivax tubulin epsilon chain, putative 0.0414 0.3082 0.5269
Leishmania major beta tubulin 0.0777 0.582 1
Trypanosoma brucei epsilon tubulin 0.0414 0.3082 0.5269
Schistosoma mansoni G/t mismatch-specific thymine DNA glycosylase 0.0063 0.0444 0.0444
Entamoeba histolytica tubulin alpha chain, putative 0.057 0.426 0.7098
Trypanosoma brucei beta tubulin 0.0777 0.582 1
Echinococcus multilocularis tubulin alpha chain 0.057 0.426 0.7309
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0024
Echinococcus multilocularis polyadenylate binding protein 0.0009 0.0033 0.0017
Trichomonas vaginalis tubulin beta chain, putative 0.057 0.426 0.7312
Echinococcus multilocularis tubulin alpha 1C chain 0.057 0.426 0.7309
Schistosoma mansoni polyadenylate binding protein 0.0009 0.0033 0.0033
Echinococcus multilocularis Tubulin beta 2C chain 0.0777 0.582 1
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0131 0.0953 0.0953
Schistosoma mansoni tubulin subunit beta 0.0777 0.582 0.582
Trypanosoma cruzi alpha tubulin, putative 0.057 0.426 0.7305
Echinococcus granulosus tubulin alpha 3 chain 0.057 0.426 0.7309
Leishmania major beta tubulin 0.0777 0.582 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0033 0.0057
Loa Loa (eye worm) BEN-1 protein 0.0777 0.582 1
Trypanosoma brucei beta tubulin 0.0777 0.582 1
Echinococcus granulosus uracil DNA glycosylase 0.0063 0.0444 0.0727
Echinococcus granulosus tubulin alpha chain 0.057 0.426 0.7309
Echinococcus multilocularis tubulin subunit beta 0.0777 0.582 1
Echinococcus granulosus GPCR family 2 0.0017 0.0091 0.0118
Echinococcus multilocularis tubulin alpha chain 0.057 0.426 0.7309
Trypanosoma cruzi epsilon tubulin, putative 0.0414 0.3082 0.5269
Leishmania major alpha tubulin 0.057 0.426 0.7305
Onchocerca volvulus 0.0234 0.1729 1
Leishmania major beta tubulin 0.0777 0.582 1
Toxoplasma gondii beta-1 tubulin, putative 0.0777 0.582 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0242 0.1791 0.1791
Brugia malayi Cell division protein ftsZ 0.018 0.1319 0.2223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0301 0.048
Trypanosoma brucei tubulin gamma chain 0.0414 0.3082 0.5269
Toxoplasma gondii alpha-tubulin I, putative 0.057 0.426 0.7305
Loa Loa (eye worm) tubulin beta-2A chain 0.0777 0.582 1
Leishmania major beta tubulin 0.0777 0.582 1
Plasmodium falciparum uracil-DNA glycosylase 0.0063 0.0444 0.0711
Echinococcus granulosus tubulin alpha 3 chain 0.057 0.426 0.7309
Giardia lamblia Gamma tubulin 0.0414 0.3082 0.3917
Brugia malayi CXXC zinc finger family protein 0.003 0.0194 0.0278
Echinococcus granulosus tubulin delta chain 0.018 0.1319 0.2236
Echinococcus granulosus tubulin beta 1 chain 0.0777 0.582 1
Echinococcus granulosus polyadenylate binding protein 0.0009 0.0033 0.0017
Mycobacterium leprae cell division protein FtsZ 0.018 0.1319 1
Echinococcus multilocularis tubulin alpha chain 0.057 0.426 0.7309
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.039 0.2907 0.498
Leishmania major beta tubulin 0.0777 0.582 1
Trypanosoma brucei beta tubulin 0.0777 0.582 1
Trypanosoma cruzi epsilon tubulin, putative 0.0414 0.3082 0.5269
Loa Loa (eye worm) tubulin alpha 2 0.039 0.2907 0.4995
Trichomonas vaginalis tubulin gamma chain, putative 0.018 0.1319 0.2243
Schistosoma mansoni hypothetical protein 0.0431 0.321 0.321
Echinococcus multilocularis Tubulin alpha 1 chain 0.057 0.426 0.7309
Echinococcus granulosus Tubulin alpha 1 chain 0.057 0.426 0.7309
Echinococcus multilocularis muscleblind protein 1 0.0302 0.2244 0.3832
Trypanosoma brucei alpha tubulin 0.057 0.426 0.7305
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0091 0.0118
Toxoplasma gondii beta tubulin 0.0777 0.582 1
Echinococcus multilocularis tubulin alpha 1C chain 0.057 0.426 0.7309
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0091
Brugia malayi Muscleblind-like protein 0.0302 0.2244 0.3821
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0301 0.0463
Schistosoma mansoni tubulin subunit alpha 0.018 0.1319 0.1319
Schistosoma mansoni tubulin subunit beta 0.0777 0.582 0.582
Trypanosoma cruzi tubulin delta chain 0.018 0.1319 0.2223
Trypanosoma brucei alpha tubulin, putative 0.0234 0.1729 0.2931
Giardia lamblia Alpha-tubulin 0.057 0.426 0.6534
Plasmodium vivax tubulin alpha chain, putative 0.057 0.426 0.7305
Trichomonas vaginalis tubulin beta chain, putative 0.0777 0.582 1
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0237 0.0352
Giardia lamblia Beta tubulin 0.0777 0.582 1
Echinococcus granulosus Tubulin alpha 1 chain 0.057 0.426 0.7309
Echinococcus granulosus tubulin alpha chain 0.057 0.426 0.7309
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0036 0.0005
Echinococcus multilocularis tubulin beta 1 chain 0.0777 0.582 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0777 0.582 1
Brugia malayi Tubulin beta chain 0.0234 0.1729 0.2931
Mycobacterium ulcerans cell division protein FtsZ 0.018 0.1319 1
Trypanosoma brucei epsilon tubulin 0.0414 0.3082 0.5269
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0131 0.0953 0.0953
Brugia malayi Tubulin alpha chain 0.057 0.426 0.7305
Trichomonas vaginalis tubulin beta-1 chain, putative 0.018 0.1319 0.2243
Leishmania major beta tubulin 0.0777 0.582 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0091 0.0157
Echinococcus multilocularis tubulin alpha 0.0414 0.3082 0.5277
Leishmania major beta tubulin 0.0777 0.582 1
Plasmodium vivax tubulin alpha chain, putative 0.057 0.426 0.7305
Trypanosoma cruzi zeta tubulin, putative 0.018 0.1319 0.2223
Echinococcus granulosus tubulin beta 4A class IVa 0.0777 0.582 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0301 0.0301
Echinococcus granulosus dnaJ subfamily B 0.0431 0.321 0.5498
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0091 0.0118
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0091
Leishmania major alpha tubulin 0.057 0.426 0.7305
Giardia lamblia Beta tubulin 0.0777 0.582 1
Echinococcus granulosus tubulin alpha chain 0.057 0.426 0.7309
Trypanosoma cruzi beta tubulin, putative 0.0777 0.582 1
Leishmania major gamma-tubulin 0.0414 0.3082 0.5269
Trypanosoma brucei zeta tubulin 0.018 0.1319 0.2223
Trypanosoma cruzi tubulin delta chain 0.018 0.1319 0.2223
Echinococcus multilocularis tubulin gamma 1 chain 0.0414 0.3082 0.5277
Schistosoma mansoni tubulin subunit epsilon 0.0414 0.3082 0.3082
Echinococcus granulosus Tubulin beta 2C chain 0.0777 0.582 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.018 0.1319 0.2223
Plasmodium vivax delta tubulin, putative 0.018 0.1319 0.2223
Loa Loa (eye worm) alpha-tubulin 0.057 0.426 0.732
Leishmania major beta tubulin 0.0777 0.582 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0777 0.582 1
Treponema pallidum cell division protein FtsZ 0.018 0.1319 1
Echinococcus multilocularis tubulin alpha 3 chain 0.057 0.426 0.7309
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0194 0.0333
Echinococcus granulosus tubulin epsilon chain 0.0414 0.3082 0.5277
Mycobacterium tuberculosis Cell division protein FtsZ 0.018 0.1319 1
Echinococcus multilocularis beta tubulin 0.0777 0.582 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0777 0.582 1
Leishmania major alpha tubulin 0.057 0.426 0.7305
Trichomonas vaginalis tubulin epsilon chain, putative 0.057 0.426 0.7312
Loa Loa (eye worm) BEN-1 protein 0.0777 0.582 1
Trichomonas vaginalis uracil DNA glycosylase, putative 0.0063 0.0444 0.0735
Brugia malayi Tubulin beta-1 chain 0.0777 0.582 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0301 0.048
Loa Loa (eye worm) tubulin beta-4 chain 0.0777 0.582 1
Trichomonas vaginalis tubulin, putative 0.0234 0.1729 0.295
Schistosoma mansoni tubulin subunit alpha 0.057 0.426 0.426
Echinococcus granulosus tubulin alpha chain 0.057 0.426 0.7309
Entamoeba histolytica tubulin alpha-1 chain 0.057 0.426 0.7098
Loa Loa (eye worm) tubulin gamma chain 0.0414 0.3082 0.5296
Echinococcus granulosus Tubulin beta 2C chain 0.0777 0.582 1
Plasmodium falciparum tubulin delta chain, putative 0.018 0.1319 0.2223
Leishmania major uracil-DNA-glycosylase, putative 0.0063 0.0444 0.0711
Echinococcus granulosus Tubulin beta 2C chain 0.0777 0.582 1
Schistosoma mansoni hypothetical protein 0.0036 0.0237 0.0237
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0131 0.0953 0.0953
Loa Loa (eye worm) tubulin alpha chain 0.057 0.426 0.732
Leishmania major alpha tubulin 0.057 0.426 0.7305
Trichomonas vaginalis tubulin alpha chain, putative 0.0234 0.1729 0.295
Echinococcus multilocularis beta tubulin 0.0777 0.582 1
Loa Loa (eye worm) hypothetical protein 0.057 0.426 0.732
Trypanosoma brucei beta tubulin 0.0777 0.582 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.057 0.426 0.7309
Echinococcus multilocularis GPCR, family 2 0.0017 0.0091 0.0118
Trichomonas vaginalis tubulin, putative 0.018 0.1319 0.2243
Trichomonas vaginalis tubulin epsilon chain, putative 0.018 0.1319 0.2243
Leishmania major beta tubulin 0.0777 0.582 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.018 0.1319 1
Trypanosoma brucei epsilon tubulin 0.0414 0.3082 0.5269
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0023 0.0023
Leishmania major alpha tubulin 0.057 0.426 0.7305
Giardia lamblia Beta tubulin 0.0777 0.582 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0234 0.1729 0.295
Schistosoma mansoni cpg binding protein 0.0032 0.0207 0.0207
Plasmodium falciparum alpha tubulin 1 0.057 0.426 0.7305
Plasmodium falciparum alpha tubulin 2 0.057 0.426 0.7305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0301 0.048
Schistosoma mansoni tubulin subunit gamma 0.0414 0.3082 0.3082
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0131 0.0953 0.1605
Leishmania major beta tubulin 0.0777 0.582 1
Loa Loa (eye worm) beta-tubulin 0.0777 0.582 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0234 0.1729 0.295
Trichomonas vaginalis tubulin beta chain, putative 0.057 0.426 0.7312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0301 0.0301
Trichomonas vaginalis tubulin gamma chain, putative 0.0414 0.3082 0.5281
Schistosoma mansoni tubulin subunit beta 0.0777 0.582 0.582
Trichomonas vaginalis tubulin epsilon chain, putative 0.057 0.426 0.7312
Schistosoma mansoni tubulin subunit beta 0.018 0.1319 0.1319
Loa Loa (eye worm) tubulin alpha-2 chain 0.057 0.426 0.732
Echinococcus granulosus beta tubulin 0.0777 0.582 1
Echinococcus granulosus muscleblind protein 0.0302 0.2244 0.3832
Trichomonas vaginalis tubulin epsilon chain, putative 0.0777 0.582 1
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0091
Trypanosoma brucei alpha tubulin 0.057 0.426 0.7305
Echinococcus multilocularis Tubulin beta 2C chain 0.0777 0.582 1
Toxoplasma gondii alpha tubulin TUBA1 0.057 0.426 0.7305
Loa Loa (eye worm) tubulin alpha chain 0.057 0.426 0.732
Loa Loa (eye worm) hypothetical protein 0.039 0.2907 0.4995
Echinococcus multilocularis Tubulin alpha 1 chain 0.057 0.426 0.7309
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0131 0.0953 0.1605
Loa Loa (eye worm) hypothetical protein 0.0052 0.0362 0.0621
Leishmania major zeta tubulin, putative 0.018 0.1319 0.2223
Trichomonas vaginalis tubulin beta chain, putative 0.057 0.426 0.7312
Trichomonas vaginalis tubulin alpha chain, putative 0.0414 0.3082 0.5281
Trypanosoma brucei alpha tubulin 0.057 0.426 0.7305
Trichomonas vaginalis tubulin beta chain, putative 0.057 0.426 0.7312
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0301 0.0517
Trichomonas vaginalis tubulin gamma chain, putative 0.0414 0.3082 0.5281
Brugia malayi Tubulin gamma chain 0.0414 0.3082 0.5269
Trichomonas vaginalis conserved hypothetical protein 0.018 0.1319 0.2243
Entamoeba histolytica tubulin family protein 0.0777 0.582 1
Echinococcus granulosus cpg binding protein 0.0032 0.0207 0.0318
Trypanosoma brucei tubulin delta chain 0.018 0.1319 0.2223
Schistosoma mansoni tubulin subunit alpha 0.057 0.426 0.426
Echinococcus granulosus beta tubulin 0.0777 0.582 1
Echinococcus granulosus tubulin alpha chain 0.057 0.426 0.7309
Schistosoma mansoni alpha tubulin 0.057 0.426 0.426
Leishmania major beta tubulin 0.0777 0.582 1
Plasmodium falciparum tubulin beta chain 0.0777 0.582 1
Leishmania major beta tubulin 0.0777 0.582 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0777 0.582 1
Leishmania major epsilon tubulin, putative 0.0414 0.3082 0.5269
Brugia malayi Tubulin beta chain 0.018 0.1319 0.2223
Leishmania major alpha tubulin 0.057 0.426 0.7305
Trypanosoma brucei alpha tubulin 0.057 0.426 0.7305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0301 0.0301
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0336 0.2497 0.4273
Trypanosoma cruzi uracil-DNA glycosylase 0.0063 0.0444 0.0711
Loa Loa (eye worm) tubulin beta chain 0.0777 0.582 1
Leishmania major alpha tubulin 0.057 0.426 0.7305
Toxoplasma gondii uracil-DNA glycosylase 0.0063 0.0444 0.0711
Leishmania major delta tubulin, putative 0.018 0.1319 0.2223
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.018 0.1319 0.2223
Giardia lamblia Alpha-tubulin 0.057 0.426 0.6534
Trypanosoma brucei beta tubulin 0.0414 0.3082 0.5269
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.321 0.5498
Echinococcus multilocularis Tubulin beta 2C chain 0.0777 0.582 1
Echinococcus granulosus alpha tubulin 0.057 0.426 0.7309
Leishmania major beta tubulin 0.0777 0.582 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0234 0.1729 0.295
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0362 0.0568
Leishmania major beta tubulin 0.0777 0.582 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.057 0.426 0.7312
Schistosoma mansoni tubulin subunit alpha 0.057 0.426 0.426
Loa Loa (eye worm) hypothetical protein 0.0302 0.2244 0.3856
Schistosoma mansoni alpha tubulin 0.057 0.426 0.426
Trichomonas vaginalis tubulin alpha chain, putative 0.0777 0.582 1
Brugia malayi beta-tubulin, identical 0.0777 0.582 1
Loa Loa (eye worm) uracil-DNA glycosylase 0.0063 0.0444 0.0763
Plasmodium falciparum tubulin epsilon chain, putative 0.0414 0.3082 0.5269
Echinococcus multilocularis Tubulin beta 2C chain 0.0777 0.582 1
Schistosoma mansoni cpg binding protein 0.003 0.0194 0.0194
Echinococcus granulosus tubulin subunit beta 0.0777 0.582 1
Schistosoma mansoni tubulin subunit delta 0.018 0.1319 0.1319
Plasmodium vivax uracil-DNA glycosylase, putative 0.0063 0.0444 0.0711
Trichomonas vaginalis tubulin, putative 0.0234 0.1729 0.295
Plasmodium vivax tubulin gamma chain, putative 0.0414 0.3082 0.5269
Toxoplasma gondii beta-tubulin, putative 0.0777 0.582 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0398 0.063
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0091 0.0118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0237 0.0406
Leishmania major alpha tubulin 0.057 0.426 0.7305
Echinococcus multilocularis tubulin alpha 3 chain 0.057 0.426 0.7309
Trypanosoma brucei zeta tubulin, putative 0.018 0.1319 0.2223
Trypanosoma cruzi zeta tubulin, putative 0.018 0.1319 0.2223
Trichomonas vaginalis tubulin beta chain, putative 0.057 0.426 0.7312
Trichomonas vaginalis tubulin beta chain, putative 0.057 0.426 0.7312
Brugia malayi Tubulin alpha chain 0.018 0.1319 0.2223

Activities

Activity type Activity value Assay description Source Reference
CGI (functional) 0 uM Lowest concentration at which the effect on HeLa cell colony formation became apparent; d denotes Not tested ChEMBL. 3018241
ID50 (functional) = 1.49 uM Concentration required to reduce Rhino virus type 1A induced plaque formation in HeLa cell culture to 50% of control ChEMBL. 3018241
ID50 (functional) > 3.47 uM Concentration required to reduce Rhino virus type 9 induced plaque formation in HeLa cell culture to 50% of control; The highest concentration tested failed to provide 50% protection . ChEMBL. 3018241
ID50 (functional) > 3.47 uM Concentration required to reduce Rhino virus type 64 induced plaque formation in HeLa cell culture to 50% of control; The highest concentration tested failed to provide 50% protection . ChEMBL. 3018241
ID50 (functional) > 3.47 uM Concentration required to reduce Rhino virus type 9 induced plaque formation in HeLa cell culture to 50% of control; The highest concentration tested failed to provide 50% protection . ChEMBL. 3018241
ID50 (functional) > 3.47 uM Concentration required to reduce Rhino virus type 64 induced plaque formation in HeLa cell culture to 50% of control; The highest concentration tested failed to provide 50% protection . ChEMBL. 3018241

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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