Detailed information for compound 588596

Basic information

Technical information
  • TDR Targets ID: 588596
  • Name: SUN 2071
  • MW: 530.607 | Formula: C29H38O9
  • H donors: 3 H acceptors: 6 LogP: 2.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCC(=CC(=O)O[C@H]1C(=O)O[C@H]2[C@]34[C@@H]1C(=C)[C@@H](O)[C@@]([C@@H]4[C@@]1([C@@H](C2)C(=CC(=O)[C@H]1O)C)C)(OC3)O)C
  • InChi: 1S/C29H38O9/c1-6-7-8-9-14(2)10-20(31)38-22-21-16(4)23(32)29(35)26-27(5)17(15(3)11-18(30)24(27)33)12-19(37-25(22)34)28(21,26)13-36-29/h10-11,17,19,21-24,26,32-33,35H,4,6-9,12-13H2,1-3,5H3/b14-10+/t17-,19+,21+,22+,23+,24+,26+,27+,28-,29-/m0/s1
  • InChiKey: XOCICDFNNMOAKJ-OLGFVZGESA-N  


Substructure search Similarity search

Network

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Synonyms

  • 92211-45-5
  • 11,20-Epoxy-1,11,12-trihydroxy-15-(3-methyl-2-octenoyl)oxypicras-3,13(21)-diene-2,16-dione
  • Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-15-((3-methyl-1-oxo-2-octenyl)oxy)-, (1beta,11beta,12alpha,15beta(E))-
  • Sun-2071

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0195 0.0214
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0487 0.0448
Loa Loa (eye worm) carboxylesterase 0.0066 0.207 0.2276
Echinococcus granulosus cpg binding protein 0.0031 0.0872 0.2672
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0166 0.0183
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.207 0.2276
Brugia malayi hypothetical protein 0.0016 0.0356 0.0392
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1408 0.4316
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0356 0.0392
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0063 0.0192
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0195 0.0598
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0016 0.0356 0.0268
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0166 0.0509
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0166 0.0509
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0166 0.0509
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0063 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0166 0.0509
Schistosoma mansoni cpg binding protein 0.0029 0.0815 0.0896
Echinococcus granulosus carboxylesterase 5A 0.0066 0.207 0.6343
Loa Loa (eye worm) carboxylesterase 0.0011 0.0195 0.0214
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0016 0.0356 0.0268
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0016 0.0356 0.0392
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Echinococcus multilocularis neuroligin 0.0011 0.0195 0.0598
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0195 0.0214
Onchocerca volvulus 0.0011 0.0195 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0195 0.0214
Echinococcus granulosus ectonucleotide 0.0084 0.272 0.8337
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0487 0.249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0166 0.0183
Schistosoma mansoni hypothetical protein 0.0216 0.7258 0.7982
Onchocerca volvulus 0.0216 0.7258 1
Trypanosoma brucei unspecified product 0.002 0.0487 0.249
Onchocerca volvulus 0.0011 0.0195 0.0041
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0166 0.0183
Treponema pallidum fructose-bisphosphate aldolase 0.0296 1 0.5
Echinococcus multilocularis Endonuclease G 0.006 0.1886 0.578
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0084 0.272 0.8337
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.479 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0166 0.0183
Schistosoma mansoni nuclear hormone receptor 0.001 0.0166 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0166 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0166 0.0183
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.479 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0166 0.0183
Echinococcus multilocularis transferase 0.0016 0.0356 0.1092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 1 1
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0016 0.0356 0.0268
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0124 0.0136
Schistosoma mansoni acetylcholinesterase 0.0011 0.0195 0.0214
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0124 0.0379
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0487 0.0511
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0487 0.0535
Onchocerca volvulus 0.0011 0.0195 0.0041
Trypanosoma brucei endonuclease G, putative 0.006 0.1886 1
Onchocerca volvulus 0.0011 0.0195 0.0041
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0166 0.0509
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0487 0.0535
Trypanosoma cruzi endonuclease G, putative 0.006 0.1886 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0166 0.0183
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.006 0.1886 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0166 0.0183
Schistosoma mansoni DNA polymerase eta 0.002 0.0487 0.0535
Schistosoma mansoni hypothetical protein 0.0016 0.0356 0.0392
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0166 0.0509
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0487 0.249
Echinococcus granulosus dna polymerase kappa 0.002 0.0487 0.1491
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1408 0.4316
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Brugia malayi ecdysteroid receptor 0.001 0.0166 0.0183
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.006 0.1886 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0195 0.0598
Brugia malayi polk-prov protein 0.0006 0.0023 0.0025
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Trypanosoma brucei unspecified product 0.0013 0.0278 0.1369
Schistosoma mansoni hypothetical protein 0.0016 0.0356 0.0392
Loa Loa (eye worm) hypothetical protein 0.001 0.0166 0.0183
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0166 0.0509
Brugia malayi nuclear receptor NHR-88 0.001 0.0166 0.0183
Trypanosoma brucei endonuclease G, putative 0.006 0.1886 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0487 0.0465
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0487 0.249
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0016 0.0356 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0166 0.0183
Trypanosoma brucei endonuclease G, putative 0.006 0.1886 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.207 0.2276
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0487 0.249
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0016 0.0356 0.1092
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0195 0.0598
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0487 0.249
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0084 0.272 0.8337
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0016 0.0356 0.1791
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0166 0.0183
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0487 0.0448
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0487 0.249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0166 0.0183
Loa Loa (eye worm) hypothetical protein 0.0011 0.0195 0.0214
Loa Loa (eye worm) hypothetical protein 0.0084 0.272 0.2991
Echinococcus granulosus neuroligin 0.0011 0.0195 0.0598
Leishmania major ethanolamine phosphotransferase, putative 0.0016 0.0356 0.1791
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0166 0.0509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1408 0.1548
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0166 0.0509
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0016 0.0356 0.0268
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.006 0.1886 1
Brugia malayi Carboxylesterase family protein 0.0011 0.0195 0.0214
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0016 0.0356 0.1092
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0487 0.0634
Loa Loa (eye worm) hypothetical protein 0.001 0.0166 0.0183
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0166 0.0183
Brugia malayi hypothetical protein 0.0016 0.0356 0.0392
Echinococcus multilocularis dna polymerase eta 0.002 0.0487 0.1491
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0195 0.019
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0016 0.0356 0.0334
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0016 0.0356 0.0268
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0023 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0487 0.0535
Echinococcus granulosus dna polymerase eta 0.002 0.0487 0.1491
Loa Loa (eye worm) hypothetical protein 0.01 0.3263 0.3588
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0487 0.1491
Echinococcus granulosus FTZ F1 alpha 0.001 0.0166 0.0509
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0016 0.0356 0.1092
Loa Loa (eye worm) hypothetical protein 0.01 0.3263 0.3588
Brugia malayi Carboxylesterase family protein 0.0011 0.0195 0.0214
Mycobacterium ulcerans glutaminase 0.027 0.9094 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0487 0.0535
Trypanosoma brucei unspecified product 0.0013 0.0278 0.1369
Loa Loa (eye worm) glutaminase 2 0.027 0.9094 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0815 0.0896
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0487 0.249
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.01 0.3263 0.3588
Echinococcus multilocularis acetylcholinesterase 0.0066 0.207 0.6343
Schistosoma mansoni coup transcription factor 0.001 0.0166 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0278 0.1369
Schistosoma mansoni gliotactin 0.0011 0.0195 0.0214
Trichomonas vaginalis glutaminase, putative 0.027 0.9094 0.909
Loa Loa (eye worm) hypothetical protein 0.0006 0.0023 0.0025
Echinococcus multilocularis dna polymerase kappa 0.002 0.0487 0.1491
Brugia malayi hypothetical protein 0.0011 0.0195 0.0214
Loa Loa (eye worm) hypothetical protein 0.0011 0.0195 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0278 0.1369
Onchocerca volvulus 0.0011 0.0195 0.0041
Echinococcus granulosus acetylcholinesterase 0.0066 0.207 0.6343
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0063 0.0192
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0166 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0166 0.0183
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.01 0.3263 0.3588
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 1 1
Loa Loa (eye worm) hypothetical protein 0.01 0.3263 0.3588
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1408 0.1548
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.479 0.5255
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.01 0.3263 0.3588
Onchocerca volvulus 0.01 0.3263 0.4366
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0016 0.0356 0.1092
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.01 0.3263 0.3588
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0195 0.0598
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0166 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0166 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 1 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0166 0.0183
Echinococcus granulosus acetylcholinesterase 0.0066 0.207 0.6343
Schistosoma mansoni glutaminase 0.027 0.9094 1
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0016 0.0356 0.1092
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0023 0.0025
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0487 0.1491
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0166 0.0183
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0487 0.249
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0166 0.0183
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0166 0.0183
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0195 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0166 0.0183
Loa Loa (eye worm) hypothetical protein 0.0011 0.0195 0.0214
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0166 0.0183
Schistosoma mansoni hypothetical protein 0.0016 0.0356 0.0392
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0063 0.0192
Loa Loa (eye worm) hypothetical protein 0.001 0.0166 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0166 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0166 0.0183
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0124 0.0379
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0166 0.0183
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.171 0.9058
Schistosoma mansoni cpg binding protein 0.0031 0.0872 0.0959
Brugia malayi AEL166Cp 0.0016 0.0356 0.0392
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0166 0.0183
Schistosoma mansoni hypothetical protein 0.0016 0.0356 0.0392
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0166 0.0183
Onchocerca volvulus 0.01 0.3263 0.4366
Echinococcus multilocularis ectonucleotide 0.0084 0.272 0.8337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0166 0.0183
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0016 0.0356 0.0392
Brugia malayi Thrombospondin type 1 domain containing protein 0.0216 0.7258 0.7982
Echinococcus granulosus transferase 0.0016 0.0356 0.1092
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0166 0.0509
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.006 0.1886 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Echinococcus granulosus Endonuclease G 0.006 0.1886 0.578
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0216 0.7258 0.7982
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0016 0.0356 0.1092
Brugia malayi Carboxylesterase family protein 0.0011 0.0195 0.0214
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0166 0.0509
Echinococcus multilocularis acetylcholinesterase 0.0066 0.207 0.6343
Brugia malayi steroid hormone receptor 0.001 0.0166 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.012 0.0132
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0166 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 1 1
Brugia malayi Carboxylesterase family protein 0.0066 0.207 0.2276
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1937 0.213
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.207 0.6343
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0487 0.249
Brugia malayi nuclear hormone receptor 0.001 0.0166 0.0183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0166 0.0509
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0166 0.0183
Leishmania major DNA polymerase eta, putative 0.002 0.0487 0.249
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0166 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0278 0.1369
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0166 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0195 0.0598
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.01 0.3263 0.3588
Echinococcus multilocularis cpg binding protein 0.0031 0.0872 0.2672
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0166 0.0183
Loa Loa (eye worm) hypothetical protein 0.0011 0.0195 0.0214
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0487 0.0511
Schistosoma mansoni endonuclease related 0.006 0.1886 0.2074
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0487 0.0634
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0016 0.0356 0.0392
Loa Loa (eye worm) carboxylesterase 0.0011 0.0195 0.0214
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0166 0.0509
Brugia malayi glutaminase DH11.1 0.027 0.9094 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0166 0.0509
Brugia malayi Carboxylesterase family protein 0.0066 0.207 0.2276
Loa Loa (eye worm) hypothetical protein 0.0011 0.0195 0.0214
Loa Loa (eye worm) hypothetical protein 0.001 0.0166 0.0183
Loa Loa (eye worm) glutaminase 0.027 0.9094 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0195 0.0155
Loa Loa (eye worm) hypothetical protein 0.0011 0.0195 0.0214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 1 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.207 0.2276
Trypanosoma cruzi endonuclease G, putative 0.006 0.1886 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0166 0.0183
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0166 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0166 0.0183
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0487 0.0535
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0487 0.0135
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0063 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0166 0.0183
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1408 0.1548
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0487 0.249
Schistosoma mansoni cpg binding protein 0.0031 0.0872 0.0959
Loa Loa (eye worm) hypothetical protein 0.0016 0.0356 0.0392
Leishmania major DNA polymerase kappa, putative 0.002 0.0487 0.249
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0487 0.0535
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0195 0.0214
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0195 0.0214
Loa Loa (eye worm) hypothetical protein 0.0066 0.207 0.2276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1408 0.1548
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.01 0.3263 1
Leishmania major endonuclease G, putative 0.006 0.1886 1
Mycobacterium ulcerans hypothetical protein 0.0016 0.0356 0.0368
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0016 0.0356 0.1092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1408 0.4316
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0815 0.0896
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0166 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0487 0.249
Brugia malayi Carboxylesterase family protein 0.0011 0.0195 0.0214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1408 0.4316
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0166 0.0183
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1408 0.1548
Onchocerca volvulus 0.0029 0.0815 0.0915
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0166 0.0183
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0166 0.0183
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0195 0.0214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0356 0.0392
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0195 0.0598
Loa Loa (eye worm) hypothetical protein 0.0016 0.0356 0.0392
Brugia malayi endonuclease G, mitochondrial precursor 0.006 0.1886 0.2074

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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