Detailed information for compound 589015

Basic information

Technical information
  • TDR Targets ID: 589015
  • Name: (2S)-2-[[(2S)-1-[(2S)-1-[2-[[(2S)-2-[[(2S)-2- [[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-5-gu anidino-pentanoyl]amino]-5-guanidino-pentanoy l]amino]hexanoyl]amino]propanoyl]amino]-3-hyd roxy-propanoyl]amino]acetyl]pyrrolidine-2-car bonyl]pyrrolidine-2-carbonyl]amino]-3-methyl- butanoic acid
  • MW: 967.127 | Formula: C41H74N16O11
  • H donors: 14 H acceptors: 11 LogP: -7.54 Rotable bonds: 37
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C)CO)C)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)N)CCCN=C(N)N
  • InChi: 1S/C41H74N16O11/c1-22(2)31(39(67)68)55-37(65)28-13-8-19-57(28)38(66)29-14-9-18-56(29)30(59)20-50-34(62)27(21-58)54-32(60)23(3)51-35(63)25(11-4-5-15-42)53-36(64)26(12-7-17-49-41(46)47)52-33(61)24(43)10-6-16-48-40(44)45/h22-29,31,58H,4-21,42-43H2,1-3H3,(H,50,62)(H,51,63)(H,52,61)(H,53,64)(H,54,60)(H,55,65)(H,67,68)(H4,44,45,48)(H4,46,47,49)/t23-,24-,25-,26-,27-,28-,29-,31-/m0/s1
  • InChiKey: AYCGGOLGQXQAQT-QJSOSHDRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[[(2S)-1-[[(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-5-guanidino-1-oxopentyl]amino]-5-guanidino-1-oxopentyl]amino]-1-oxohexyl]amino]-1-oxopropyl]amino]-3-hydroxy-1-oxopropyl]amino]-1-oxoethyl]-2-pyrrolidinyl]-oxomethyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-methylbutanoic acid
  • (2S)-2-[[(2S)-1-[(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-azanyl-2-[[(2S)-2-[[(2S)-2-azanyl-5-[bis(azanyl)methylideneamino]pentanoyl]amino]-5-[bis(azanyl)methylideneamino]pentanoyl]amino]hexanoyl]amino]propanoyl]amino]-3-hydroxy-propanoyl]amino]ethanoyl]pyrrolidin-2-yl]carbonylpyrrolidin-2-yl]carbonylamino]-3-methyl-butanoic acid
  • (2S)-2-[[(2S)-1-[(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]propanoyl]amino]-3-hydroxy-propanoyl]amino]acetyl]prolyl]prolyl]amino]-3-methyl-butyric acid
  • (2S)-2-[[(2S)-1-[(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoic acid
  • arginyl-arginyl-lysyl-alanyl-seryl-glycyl-prolyl-prolyl-valine
  • (2S)-2-[[(2S)-1-[(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]propanoyl]amino]-3-hydroxy-propanoyl]amino]acetyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-methyl-butyric acid
  • (2S)-2-[[(2S)-1-[(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]propanoyl]amino]-3-hydroxy-propanoyl]amino]ethanoyl]pyrrolidin-2-yl]carbonylpyrrolidin-2-yl]carbonylamino]-3-methyl-butanoic acid
  • 93511-94-5
  • Aalasgppv
  • Arg-arg-lys-ala-ser-gly-pro-pro-val
  • L-Valine, N-(1-(1-(N-(N-(N-(N2-(N2-L-arginyl-L-arginyl)-L-lysyl)-L-alanyl)-L-seryl)glycyl)-L-prolyl)-L-prolyl)-, (3beta)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0759 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0408 0.0386
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.0721 0.9392
Loa Loa (eye worm) hypothetical protein 0.0107 0.0759 0.0738
Echinococcus granulosus tar DNA binding protein 0.0062 0.0408 0.0752
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0235 0.2842
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0029 0.0002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0408 0.0386
Mycobacterium ulcerans lipase LipD 0.0107 0.0759 0.6341
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.015 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0408 0.0752
Loa Loa (eye worm) hypothetical protein 0.004 0.0234 0.0212
Loa Loa (eye worm) transcription factor SMAD2 0.0193 0.1438 0.1419
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.0721 0.1319
Toxoplasma gondii thioredoxin reductase 0.004 0.0235 0.2842
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0759 0.1392
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0322 0.0322
Echinococcus granulosus intermediate filament protein 0.0029 0.015 0.0248
Brugia malayi beta-lactamase family protein 0.0107 0.0759 0.0759
Mycobacterium leprae Probable lipase LipE 0.0107 0.0759 1
Brugia malayi RNA binding protein 0.0062 0.0408 0.0408
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0029 0.0013
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0029 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0759 0.1437
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0266 0.0266
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0759 1
Entamoeba histolytica hypothetical protein 0.0035 0.0197 0.7515
Mycobacterium tuberculosis Conserved protein 0.0107 0.0759 0.1392
Plasmodium falciparum thioredoxin reductase 0.0014 0.0029 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0029 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0266 0.0474
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.2315 0.2294
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0759 0.1392
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0408 0.0386
Echinococcus granulosus expressed protein 0.0026 0.0125 0.0198
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0197 0.0283
Schistosoma mansoni hypothetical protein 0.0123 0.0888 0.1688
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.1894 0.304
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.1894 0.3653
Echinococcus granulosus lamin 0.0029 0.015 0.0248
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0408 0.0752
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0759 1
Loa Loa (eye worm) hypothetical protein 0.1279 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0029 0.0002
Schistosoma mansoni lamin 0.0029 0.015 0.0248
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0029 0.0156
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0125 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0197 0.034
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0029 0.0003
Toxoplasma gondii ABC1 family protein 0.0107 0.0759 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0029 0.0021
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0029 0.0067
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1279 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0008
Echinococcus multilocularis musashi 0.0029 0.015 0.0206
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0759 0.6341
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0284 0.3501
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0029 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0029 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0266 0.0395
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0029 0.0156
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0721 0.1319
Plasmodium falciparum glutathione reductase 0.0014 0.0029 0.0067
Loa Loa (eye worm) hypothetical protein 0.0107 0.0759 0.0738
Brugia malayi Thioredoxin reductase 0.004 0.0235 0.0235
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0759 0.6341
Plasmodium falciparum thioredoxin reductase 0.004 0.0235 0.9208
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0125 0.0843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0266 0.0474
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0266 0.0474
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0759 1
Leishmania major trypanothione reductase 0.004 0.0235 0.0208
Schistosoma mansoni apoferritin-2 0.0026 0.0125 0.0198
Leishmania major hypothetical protein, conserved 0.0107 0.0759 0.0734
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0284 0.3501
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0043 0.002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0759 0.0759
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.064 0.8125
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0759 1
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0759 0.0734
Trypanosoma brucei trypanothione reductase 0.004 0.0235 0.0208
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0029 0.0002
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.2315 0.2294
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.2315 0.2294
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0256 0.0229
Loa Loa (eye worm) hypothetical protein 0.0029 0.015 0.0127
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.0721 0.1319
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0125 1
Schistosoma mansoni ferritin light chain 0.0026 0.0125 0.0198
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0031 0.0015
Echinococcus granulosus geminin 0.0123 0.0888 0.1688
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.024 0.0423
Schistosoma mansoni hypothetical protein 0.0035 0.0197 0.034
Schistosoma mansoni hypothetical protein 0.0123 0.0888 0.1688
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0253 1
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0759 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.1894 0.1875
Schistosoma mansoni ferritin 0.0026 0.0125 0.0198
Brugia malayi hypothetical protein 0.0035 0.0197 0.0197
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.1053 0.1028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.064 0.1166
Echinococcus multilocularis vesicular acetylcholine transporter 0.049 0.378 0.6105
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0284 0.3501
Onchocerca volvulus 0.0107 0.0759 0.1678
Trichomonas vaginalis ferritin, putative 0.0026 0.0125 0.1329
Mycobacterium tuberculosis Conserved protein 0.0107 0.0759 0.1392
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0125 0.0843
Echinococcus multilocularis lamin 0.0029 0.015 0.0206
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0759 0.1392
Echinococcus multilocularis ferritin 0.0026 0.0125 0.0165
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0125 0.0185
Schistosoma mansoni ferritin 0.0026 0.0125 0.0198
Echinococcus granulosus vesicular acetylcholine transporter 0.049 0.378 0.7334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0266 0.0395
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0029 0.0067
Brugia malayi TAR-binding protein 0.0062 0.0408 0.0408
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0759 0.1392
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1053 0.1028
Plasmodium falciparum glutathione reductase 0.004 0.0235 0.9208
Loa Loa (eye worm) beta-lactamase 0.0107 0.0759 0.0738
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0031 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0266 0.0243
Mycobacterium ulcerans hypothetical protein 0.016 0.1181 1
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0759 0.0734
Schistosoma mansoni ferritin 0.0026 0.0125 0.0198
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.6177 1
Brugia malayi MH2 domain containing protein 0.0193 0.1438 0.1438
Entamoeba histolytica hypothetical protein 0.0035 0.0197 0.7515
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0029 0.0013
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.1158 0.2215
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0235 0.0213
Mycobacterium tuberculosis Conserved protein 0.0107 0.0759 0.1392
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0029 0.5
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0029 0.0021
Echinococcus granulosus lamin dm0 0.0029 0.015 0.0248
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0759 0.1196
Schistosoma mansoni ferritin light chain 0.0026 0.0125 0.0198
Loa Loa (eye worm) MH2 domain-containing protein 0.0193 0.1438 0.1419
Loa Loa (eye worm) hypothetical protein 0.0107 0.0759 0.0738
Onchocerca volvulus 0.0107 0.0759 0.1678
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0235 0.0208
Treponema pallidum NADH oxidase 0.0014 0.0029 0.0156
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0029 0.0012
Loa Loa (eye worm) hypothetical protein 0.0654 0.5072 0.506
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0284 0.0509
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.0028 0.0009
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0235 0.0396
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0253 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0408 0.0752
Echinococcus multilocularis lamin dm0 0.0029 0.015 0.0206
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0029 0.0002
Schistosoma mansoni lamin 0.0029 0.015 0.0248
Onchocerca volvulus 0.0051 0.0322 0.0475
Mycobacterium tuberculosis Probable reductase 0.0091 0.064 0.1166
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0256 0.0229
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0408 0.0752
Entamoeba histolytica hypothetical protein 0.0035 0.0197 0.7515
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0029 0.0021
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0029 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.033 0.0303
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0284 0.3501
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0759 0.1392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0266 0.0474
Entamoeba histolytica hypothetical protein 0.0035 0.0197 0.7515
Loa Loa (eye worm) hypothetical protein 0.0107 0.0759 0.0738
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.1158 0.1158
Loa Loa (eye worm) hypothetical protein 0.0107 0.0759 0.0738
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0197 0.034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0759 0.1437
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0759 0.1392
Trypanosoma brucei C-8 sterol isomerase, putative 0.1279 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0029 0.0002
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0284 0.3501
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0029 0.0002
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.049 0.378 0.3766
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0408 0.0752
Echinococcus multilocularis geminin 0.0123 0.0888 0.1405
Brugia malayi glutathione reductase 0.004 0.0235 0.0235
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0759 0.1437
Loa Loa (eye worm) glutathione reductase 0.004 0.0235 0.0213
Schistosoma mansoni ap endonuclease 0.0014 0.0028 0.0009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.064 0.1166
Echinococcus granulosus ferritin 0.0026 0.0125 0.0198
Schistosoma mansoni apoferritin-2 0.0026 0.0125 0.0198
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0759 1
Schistosoma mansoni vesicular acetylcholine transporter 0.049 0.378 0.7334
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0029 0.0002
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0256 0.0229
Schistosoma mansoni microtubule-associated protein tau 0.0663 0.5146 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0029 0.0002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0029 0.001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.024 0.0352
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.1158 0.1844
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0408 0.0626
Toxoplasma gondii hypothetical protein 0.0049 0.0306 0.3806
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0029 0.0012
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.064 0.1166
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.2315 0.2294
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0759 0.0738
Schistosoma mansoni cellular tumor antigen P53 0.004 0.0234 0.0413
Loa Loa (eye worm) hypothetical protein 0.0107 0.0759 0.0738
Plasmodium vivax glutathione reductase, putative 0.004 0.0235 0.2842
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.1123 0.2147
Brugia malayi beta-lactamase family protein 0.0107 0.0759 0.0759
Brugia malayi vesicular acetylcholine transporter unc-17 0.049 0.378 0.378
Trichomonas vaginalis esterase, putative 0.0107 0.0759 1
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.0028 0.0028
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0029 0.0002
Echinococcus multilocularis expressed protein 0.0026 0.0125 0.0165
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0681 0.5283 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.1181 0.2195
Brugia malayi MH1 domain containing protein 0.0013 0.0023 0.0023
Brugia malayi MH2 domain containing protein 0.0013 0.0023 0.0023
Echinococcus granulosus microtubule associated protein 2 0.0663 0.5146 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0043 0.0043
Echinococcus multilocularis tumor protein p63 0.0273 0.2071 0.3327
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0029 0.0021
Brugia malayi hypothetical protein 0.0251 0.1894 0.1894
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0759 0.1392
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0253 1
Onchocerca volvulus 0.0107 0.0759 0.1678
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.064 0.1166
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0408 0.0408
Echinococcus multilocularis microtubule associated protein 2 0.0663 0.5146 0.8324
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.064 0.1166
Schistosoma mansoni ap endonuclease 0.0014 0.0028 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1053 0.1028
Echinococcus granulosus tumor protein p63 0.0273 0.2071 0.3997
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0256 0.0229
Onchocerca volvulus 0.004 0.0234 0.0233
Brugia malayi intermediate filament protein 0.0029 0.015 0.015
Schistosoma mansoni survival motor neuron protein 0.0051 0.0322 0.0584
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.049 0.378 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.015 0.0248
Brugia malayi MH1 domain containing protein 0.0013 0.0023 0.0023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0029 0.0002
Schistosoma mansoni ferritin 0.0026 0.0125 0.0198
Mycobacterium ulcerans beta-lactamase 0.0107 0.0759 0.6341
Brugia malayi beta-lactamase 0.0107 0.0759 0.0759
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.0028 0.0007
Loa Loa (eye worm) acetyltransferase 0.0157 0.1158 0.1137
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0029 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0029 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0029 0.0002
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0125 0.0185
Loa Loa (eye worm) intermediate filament protein 0.0029 0.015 0.0127
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0029 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.015 0.015
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0029 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0266 0.0474
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0029 0.0002
Brugia malayi Smad1 0.0013 0.0023 0.0023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.0028 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0759 0.0734
Loa Loa (eye worm) hypothetical protein 0.0029 0.0146 0.0123
Brugia malayi MH2 domain containing protein 0.0013 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0051 0.0322 0.0584
Leishmania major C-8 sterol isomerase-like protein 0.1279 1 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0029 0.0067
Mycobacterium ulcerans hypothetical protein 0.0107 0.0759 0.6341

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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