Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | propionate-CoA ligase | 0.004 | 0.0188 | 0.2679 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.0031 | 0.0055 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.0357 | 0.0655 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0166 | 0.5152 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0034 | 0.0382 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0106 | 0.0676 | 0.1203 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0188 | 0.0274 |
Brugia malayi | Smad1 | 0.0025 | 0.0075 | 0.0133 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0057 | 0.0314 | 0.0355 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0037 | 0.0159 | 0.0159 |
Mycobacterium ulcerans | hypothetical protein | 0.0106 | 0.0676 | 0.1149 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0166 | 0.5152 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0158 | 0.0158 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0057 | 0.0314 | 0.0501 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0106 | 0.0676 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0106 | 0.0676 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0106 | 0.0676 | 0.1253 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0737 | 0.5391 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0159 | 0.0159 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0075 | 0.0075 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0019 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0258 | 0.046 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0037 | 0.0159 | 0.0282 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0075 | 0.0075 |
Mycobacterium tuberculosis | Conserved protein | 0.0106 | 0.0676 | 0.1253 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0248 | 0.0441 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0372 | 0.2667 | 0.475 |
Trichomonas vaginalis | esterase, putative | 0.0106 | 0.0676 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.004 | 0.0188 | 0.0334 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.0055 | 0.0055 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0106 | 0.0676 | 0.1253 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0106 | 0.0676 | 0.1203 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0106 | 0.0676 | 0.0676 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0372 | 0.2667 | 0.475 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0218 | 0.0388 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0166 | 0.0166 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0091 | 0.0101 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.004 | 0.0188 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0676 | 0.1203 |
Brugia malayi | beta-lactamase family protein | 0.0106 | 0.0676 | 0.1203 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0009 | 0.0016 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0158 | 0.0158 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0034 | 0.0048 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0158 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0188 | 0.0334 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0357 | 0.0646 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.004 | 0.0188 | 0.5859 |
Onchocerca volvulus | 0.0095 | 0.0594 | 0.8772 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0159 | 0.0282 |
Echinococcus granulosus | smad | 0.0025 | 0.0075 | 0.0075 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0027 | 0.0091 | 0.3194 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0133 | 0.0237 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0025 | 0.0075 | 0.0133 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0166 | 0.0166 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0034 | 0.0061 |
Loa Loa (eye worm) | Smad1 | 0.0025 | 0.0075 | 0.0133 |
Schistosoma mansoni | lipoxygenase | 0.0055 | 0.0293 | 0.0293 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0057 | 0.0314 | 0.0575 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.004 | 0.0188 | 0.0274 |
Onchocerca volvulus | 0.0019 | 0.0031 | 0.0329 | |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.0159 | 0.0278 |
Mycobacterium leprae | POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) | 0.004 | 0.0188 | 0.0112 |
Brugia malayi | AMP-binding enzyme family protein | 0.004 | 0.0188 | 0.0334 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0009 | 0.0009 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0159 | 0.0159 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0159 | 0.2243 |
Schistosoma mansoni | FFA transport protein | 0.0737 | 0.5391 | 0.5391 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0009 | 0.0016 |
Brugia malayi | AMP-binding enzyme family protein | 0.0057 | 0.0314 | 0.0559 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0158 | 0.2238 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0158 | 0.4894 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0265 | 0.0471 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0075 | 0.0133 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.0055 | 0.0055 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0465 | 0.3358 | 0.3358 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.004 | 0.0188 | 0.0334 |
Onchocerca volvulus | 0.0106 | 0.0676 | 1 | |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0767 | 0.5615 | 1 |
Mycobacterium tuberculosis | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.003 | 0.0108 | 0.0183 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1354 | 1 | 1 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0737 | 0.5391 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0158 | 0.0158 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0034 | 0.0382 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0027 | 0.0091 | 0.1225 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.004 | 0.0188 | 0.0188 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0106 | 0.0676 | 0.1149 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0009 | 0.0016 |
Onchocerca volvulus | 0.004 | 0.0188 | 0.2679 | |
Brugia malayi | hypothetical protein | 0.0019 | 0.0031 | 0.0055 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0106 | 0.0676 | 0.0676 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0106 | 0.0676 | 0.1238 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1109 | 0.1109 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0767 | 0.5615 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Brugia malayi | AMP-binding enzyme family protein | 0.0767 | 0.5615 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0106 | 0.0676 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0106 | 0.0676 | 0.1203 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0037 | 0.0159 | 0.0159 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0031 | 0.0031 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0106 | 0.0676 | 0.1253 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0034 | 0.0034 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0009 | 0.0009 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0218 | 0.0218 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.004 | 0.0188 | 0.0332 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0248 | 0.0441 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0034 | 0.0836 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.004 | 0.0188 | 0.2679 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0037 | 0.0159 | 0.0282 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0037 | 0.0159 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0357 | 0.0646 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0159 | 0.0159 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0034 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0031 | 0.0055 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.004 | 0.0188 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0031 | 0.0031 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0055 | 0.0293 | 0.0293 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0158 | 0.0282 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0009 | 0.0009 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0248 | 0.0441 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0218 | 0.0218 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1109 | 0.1109 |
Schistosoma mansoni | survival motor neuron protein | 0.0095 | 0.0594 | 0.0594 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.004 | 0.0188 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0676 | 0.1203 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.0357 | 0.0655 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0009 | 0.0016 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.004 | 0.0188 | 0.0332 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0009 | 0.0016 |
Brugia malayi | AMP-binding enzyme family protein | 0.0057 | 0.0314 | 0.0559 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0314 | 0.0559 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0031 | 0.0031 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0055 | 0.0055 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0218 | 0.0218 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0.0031 | 0.0859 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0063 | 0.0357 | 0.0646 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0034 | 0.0996 |
Brugia malayi | AMP-binding enzyme family protein | 0.0057 | 0.0314 | 0.0559 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0106 | 0.0676 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0031 | 0.0055 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0133 | 0.0237 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0075 | 0.0133 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0057 | 0.0314 | 0.0501 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.005 | 0.0256 | 0.0458 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.013 | 0.0223 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0158 | 0.0282 |
Mycobacterium ulcerans | beta-lactamase | 0.0106 | 0.0676 | 0.1149 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0158 | 0.2238 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0034 | 0.0034 |
Mycobacterium leprae | Probable lipase LipE | 0.0106 | 0.0676 | 0.1053 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0106 | 0.0676 | 0.1253 |
Echinococcus granulosus | long chain fatty acid transport protein 4 | 0.0737 | 0.5391 | 0.5391 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.004 | 0.0188 | 0.2679 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.004 | 0.0188 | 0.2679 |
Brugia malayi | hypothetical protein | 0.0465 | 0.3358 | 0.5981 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0166 | 0.5152 |
Toxoplasma gondii | ABC1 family protein | 0.0106 | 0.0676 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.004 | 0.0188 | 0.2679 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0158 | 0.193 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 0.3358 | 0.5981 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.0265 | 0.359 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0009 | 0.0016 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0075 | 0.0133 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0009 | 0.0009 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.004 | 0.0188 | 0.2679 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0218 | 0.0218 |
Onchocerca volvulus | 0.0019 | 0.0031 | 0.0329 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.0265 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0106 | 0.0676 | 0.1253 |
Onchocerca volvulus | 0.005 | 0.0258 | 0.3736 | |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.004 | 0.0188 | 0.0332 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.0159 | 0.2243 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0009 | 0.0009 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0106 | 0.0676 | 0.1238 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0031 | 0.0031 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0106 | 0.0676 | 0.0676 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0075 | 0.0075 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0034 | 0.0382 |
Mycobacterium leprae | POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.004 | 0.0188 | 0.0112 |
Onchocerca volvulus | 0.0106 | 0.0676 | 1 | |
Schistosoma mansoni | smad | 0.0025 | 0.0075 | 0.0075 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0158 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0057 | 0.0314 | 0.0501 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.0357 | 0.0655 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0057 | 0.0314 | 0.0501 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0057 | 0.0314 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0075 | 0.0133 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.004 | 0.0188 | 0.0274 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0057 | 0.0314 | 0.057 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.0159 | 0.1935 |
Mycobacterium tuberculosis | Conserved protein | 0.0106 | 0.0676 | 0.1253 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0095 | 0.0594 | 0.1057 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0158 | 0.0277 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0009 | 0.0016 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.0265 | 0.3835 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.004 | 0.0188 | 0.0332 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0158 | 0.0158 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0034 | 0.0043 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0106 | 0.0676 | 0.1253 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.004 | 0.0188 | 0.0332 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.0265 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0265 | 0.0475 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0075 | 0.0075 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0075 | 0.0075 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0188 | 0.0274 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.004 | 0.0188 | 0.0274 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1354 | 1 | 1 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.004 | 0.0188 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.0159 | 0.2243 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0034 | 0.0047 |
Echinococcus granulosus | tumor protein p63 | 0.0341 | 0.2432 | 0.2432 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0091 | 0.0161 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0166 | 0.5152 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0075 | 0.0075 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0159 | 0.0159 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0009 | 0.0009 |
Echinococcus multilocularis | tumor protein p63 | 0.0341 | 0.2432 | 0.2432 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0676 | 0.1203 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0106 | 0.0676 | 0.1253 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0158 | 0.0222 |
Echinococcus multilocularis | long chain fatty acid transport protein 4 | 0.0737 | 0.5391 | 0.5391 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.004 | 0.0188 | 0.0337 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0265 | 0.0471 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0465 | 0.3358 | 0.3358 |
Schistosoma mansoni | polycystin 1-related | 0.0019 | 0.0031 | 0.0031 |
Brugia malayi | MH2 domain containing protein | 0.0372 | 0.2667 | 0.475 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0027 | 0.0091 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.0265 | 0.0482 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0034 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0676 | 0.1203 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.004 | 0.0188 | 0.0334 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.004 | 0.0188 | 0.0332 |
Onchocerca volvulus | 0.004 | 0.0188 | 0.2679 | |
Echinococcus granulosus | geminin | 0.0164 | 0.1109 | 0.1109 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0031 | 0.0031 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.004 | 0.0188 | 0.2388 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0188 | 0.0274 |
Onchocerca volvulus | 0.004 | 0.0188 | 0.2679 | |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0676 | 0.1203 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.004 | 0.0188 | 0.2388 |
Schistosoma mansoni | loxhd1 | 0.0019 | 0.0031 | 0.0031 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0091 | 0.0161 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0057 | 0.0314 | 0.0501 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0091 | 0.0161 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0009 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0166 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0091 | 0.0161 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0034 | 0.0034 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0188 | 0.0274 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.004 | 0.0188 | 0.0332 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0009 | 0.0016 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0218 | 0.0388 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0057 | 0.0314 | 0.057 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0009 | 0.0016 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0188 | 0.0274 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0106 | 0.0676 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0037 | 0.0159 | 0.4905 |
Schistosoma mansoni | lipoxygenase | 0.0019 | 0.0031 | 0.0031 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0357 | 0.0646 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0009 | 0.0016 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0009 | 0.0016 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0106 | 0.0676 | 0.1253 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0314 | 0.0559 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.004 | 0.0188 | 0.6987 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0037 | 0.0159 | 0.0159 |
Brugia malayi | beta-lactamase family protein | 0.0106 | 0.0676 | 0.1203 |
Echinococcus multilocularis | smad | 0.0025 | 0.0075 | 0.0075 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0075 | 0.0075 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.004 | 0.0188 | 0.0274 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.004 | 0.0188 | 0.0332 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0188 | 0.0274 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.004 | 0.0188 | 0.0332 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0057 | 0.0314 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0009 | 0.0016 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0075 | 0.0075 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0726 | 0.5312 | 1 |
Leishmania major | acetyl-CoA synthetase, putative | 0.004 | 0.0188 | 0.0337 |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.004 | 0.0188 | 0.0274 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0037 | 0.0159 | 0.0159 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0031 | 0.0031 |
Echinococcus granulosus | RUN | 0.0019 | 0.0031 | 0.0031 |
Leishmania major | hypothetical protein, conserved | 0.0106 | 0.0676 | 0.1257 |
Onchocerca volvulus | 0.0057 | 0.0314 | 0.4573 | |
Mycobacterium ulcerans | lipase LipD | 0.0106 | 0.0676 | 0.1149 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0034 | 0.0047 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0058 | 0.0316 | 0.057 |
Echinococcus multilocularis | geminin | 0.0164 | 0.1109 | 0.1109 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0676 | 0.4934 | 0.9286 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0075 | 0.0075 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0034 | 0.0034 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.004 | 0.0188 | 0.0188 |
Leishmania major | fatty acid transporter protein-like protein | 0.0726 | 0.5312 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.0265 | 0.3835 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.004 | 0.0188 | 0.0332 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0106 | 0.0676 | 1 |
Onchocerca volvulus | 0.004 | 0.0188 | 0.2679 | |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0.0031 | 0.0329 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0027 | 0.0091 | 0.0149 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0009 | 0.0009 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0057 | 0.0314 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0106 | 0.0676 | 0.1149 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0057 | 0.0314 | 0.0575 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0055 | 0.0293 | 0.0293 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0025 | 0.0075 | 0.0133 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.004 | 0.0188 | 0.0332 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0218 | 0.0218 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.004 | 0.0188 | 0.0188 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0057 | 0.0314 | 0.0501 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.004 | 0.0188 | 0.0332 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0158 | 0.0277 |
Brugia malayi | hypothetical protein | 0.0033 | 0.013 | 0.0232 |
Mycobacterium leprae | possible long-chain acyl-CoA synthase | 0.0726 | 0.5312 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0265 | 0.0475 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0188 | 0.0274 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.004 | 0.0188 | 0.0332 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0009 | 0.0016 |
Brugia malayi | beta-lactamase | 0.0106 | 0.0676 | 0.1203 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0248 | 0.0441 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0166 | 0.0166 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0357 | 0.5025 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.004 | 0.0188 | 0.0334 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0218 | 0.0218 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.004 | 0.0188 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0676 | 0.1203 |
Brugia malayi | AMP-binding enzyme family protein | 0.004 | 0.0188 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0091 | 0.0161 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0019 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0314 | 0.0559 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0057 | 0.0314 | 0.0355 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.0159 | 0.0278 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0218 | 0.0218 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.0031 | 0.0055 |
Plasmodium vivax | hypothetical protein, conserved | 0.0106 | 0.0676 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0057 | 0.0314 | 0.0575 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0034 | 0.5 |
Leishmania major | acetyl-CoA synthetase, putative | 0.004 | 0.0188 | 0.0337 |
Loa Loa (eye worm) | oxidoreductase | 0.004 | 0.0188 | 0.0334 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0106 | 0.0676 | 0.0676 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0057 | 0.0314 | 0.0501 |
Mycobacterium leprae | conserved hypothetical protein | 0.0106 | 0.0676 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0031 | 0.0055 |
Onchocerca volvulus | 0.0106 | 0.0676 | 1 | |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0158 | 0.2238 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0188 | 0.0334 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0258 | 0.0258 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0057 | 0.0314 | 0.0501 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.0594 | 0.0594 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0158 | 0.2238 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0166 | 0.0166 |
Echinococcus multilocularis | RUN | 0.0019 | 0.0031 | 0.0031 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0133 | 0.0133 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.004 | 0.0188 | 0.0274 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0031 | 0.0031 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.004 | 0.0188 | 0.0274 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 4.2 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.77 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 6.1 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 21 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 43 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0.72 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 21 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 43 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.95 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.12113 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.