Detailed information for compound 594360

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 704.571 | Formula: C29H28F8N8O4
  • H donors: 4 H acceptors: 6 LogP: 2.46 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.O=C(Nc1cc(ccc1F)C(F)(F)F)Nc1ccc(cc1F)c1nn(c2c1cnc(n2)NCCCN1CCOCC1)C
  • InChi: 1S/C27H27F5N8O2.C2HF3O2/c1-39-24-18(15-34-25(37-24)33-7-2-8-40-9-11-42-12-10-40)23(38-39)16-3-6-21(20(29)13-16)35-26(41)36-22-14-17(27(30,31)32)4-5-19(22)28;3-2(4,5)1(6)7/h3-6,13-15H,2,7-12H2,1H3,(H,33,34,37)(H2,35,36,41);(H,6,7)
  • InChiKey: DECLEGHIYFTRBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi pyruvate kinase 2, putative 0.0101 0.1013 1
Leishmania major lysyl-tRNA synthetase, putative 0.0049 0.0449 0.4423
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0067 0.0647 0.2619
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.033 0.1431
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0053 0.0107
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0034 0.031
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0034 0.0074
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0053 0.0501
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.033 0.3245
Loa Loa (eye worm) hypothetical protein 0.0101 0.1013 0.411
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Toxoplasma gondii pyruvate kinase PyKII 0.0052 0.0481 0.0722
Entamoeba histolytica protein kinase, putative 0.0067 0.0647 0.9476
Loa Loa (eye worm) pyruvate kinase 0.0101 0.1013 0.411
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0219 0.2294 0.4624
Echinococcus multilocularis solute carrier family 22 0.0031 0.0253 0.051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0895 0.3628
Echinococcus granulosus pyruvate kinase 0.0052 0.0481 0.0969
Brugia malayi Inositol-1 0.0038 0.033 0.1334
Onchocerca volvulus 0.0031 0.0253 0.2483
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0656 0.2852
Leishmania major glucose transporter, lmgt3 0.0068 0.0656 0.6465
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0185 0.1807
Schistosoma mansoni pyruvate kinase 0.0101 0.1013 0.2229
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0714 0.1425
Echinococcus multilocularis lysyl tRNA synthetase 0.0049 0.0449 0.0906
Schistosoma mansoni protein kinase 0.0067 0.0647 0.1423
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1039 0.4215
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0049 0.0449 0.4223
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0253 0.1095
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2294 0.4624
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0127
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0253 0.1095
Toxoplasma gondii ABC1 family protein 0.0073 0.0714 0.1075
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0034 0.0127
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0714 0.6938
Brugia malayi hypothetical protein 0.0024 0.0185 0.0743
Echinococcus multilocularis GPCR, family 2 0.0033 0.0274 0.0552
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.033 0.3243
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0714 0.3107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.1303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0034 0.0127
Loa Loa (eye worm) hypothetical protein 0.0066 0.0632 0.256
Echinococcus granulosus synaptojanin 1 0.0008 0.0002 0.0005
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0053 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0656 0.2852
Brugia malayi lysyl-tRNA synthetase 0.0049 0.0449 0.1818
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.6465
Schistosoma mansoni cpg binding protein 0.0032 0.0263 0.0578
Echinococcus granulosus pyruvate kinase 0.0101 0.1013 0.2042
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.037 0.0735
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0287 0.256
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0253 0.0379
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0053 0.0159
Schistosoma mansoni hypothetical protein 0.0334 0.3546 0.7803
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0895 0.1803
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0656 0.6465
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0037 0.0153
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.1303
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0053 0.0076
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0221
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0714 0.1572
Giardia lamblia Sugar-proton symporter 0.0031 0.0253 0.2483
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.033 0.0495
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0034 0.031
Entamoeba histolytica protein kinase, putative 0.0067 0.0647 0.9476
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.0206
Brugia malayi Sugar transporter family protein 0.0031 0.0253 0.102
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0608 0.1338
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0449 0.0989
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0253 0.1095
Schistosoma mansoni hypothetical protein 0.0033 0.0274 0.0602
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.1103
Echinococcus multilocularis traf and tnf receptor associated protein 0.0008 0.0002 0.0005
Mycobacterium ulcerans sugar transporter 0.0031 0.0253 0.2212
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0002 0.0005
Brugia malayi nuclear hormone receptor 0.0011 0.0034 0.0127
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0449 0.0989
Trypanosoma brucei glucose transporter 2A 0.0068 0.0656 0.6465
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0034 0.0068
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0066 0.0632 0.6092
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0034 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0895 0.1968
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0253 0.102
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0034 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Loa Loa (eye worm) pyruvate kinase 0.0101 0.1013 0.411
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0656 0.6465
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Giardia lamblia Pyruvate kinase 0.0052 0.0481 0.4733
Giardia lamblia Pyruvate kinase 0.0101 0.1013 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.1303
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0501
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0714 0.1425
Loa Loa (eye worm) pyruvate kinase 0.0021 0.015 0.06
Brugia malayi steroid hormone receptor 0.0011 0.0034 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0034 0.0074
Onchocerca volvulus 0.0073 0.0714 0.7044
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0745
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0034 0.0068
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0714 0.6938
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0053 0.0206
Echinococcus multilocularis pyruvate kinase 0.0101 0.1013 0.2042
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0002 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0185 0.1807
Trypanosoma brucei pyruvate kinase 1, putative 0.0101 0.1013 1
Plasmodium vivax pyruvate kinase, putative 0.0101 0.1013 0.1011
Leishmania major pyruvate kinase 0.0101 0.1013 1
Echinococcus granulosus neuropeptide s receptor 0.0464 0.4962 1
Toxoplasma gondii protein kinase, putative 0.0618 0.663 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0067 0.0647 0.0645
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.037 0.0735
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2294 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0067 0.0647 0.0645
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.033 0.0665
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0274 0.1103
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Schistosoma mansoni hypothetical protein 0.0219 0.2294 0.5048
Onchocerca volvulus Pyruvate kinase homolog 0.0101 0.1013 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0034 0.0127
Schistosoma mansoni cpg binding protein 0.003 0.0244 0.0537
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0714 0.1425
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0034 0.0127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0714 0.1572
Onchocerca volvulus 0.0073 0.0714 0.7044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Onchocerca volvulus 0.0031 0.0253 0.2483
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.075 0.7395
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0034 0.0127
Schistosoma mansoni glucose transport protein 0.0219 0.2294 0.5048
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Brugia malayi Pyruvate kinase, M2 isozyme 0.0101 0.1013 0.411
Plasmodium falciparum pyruvate kinase 2 0.0052 0.0481 0.0479
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0253 0.0251
Loa Loa (eye worm) hypothetical protein 0.007 0.0685 0.2775
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0219 0.2294 0.4624
Echinococcus granulosus lysyl tRNA synthetase 0.0049 0.0449 0.0906
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Plasmodium falciparum calcium-dependent protein kinase 1 0.0067 0.0647 0.0645
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.033 0.1431
Mycobacterium tuberculosis Conserved protein 0.0073 0.0714 0.1425
Trypanosoma brucei pyruvate kinase 1 0.0101 0.1013 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0656 0.6465
Echinococcus multilocularis cpg binding protein 0.0032 0.0263 0.0529
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0002 0.0005
Schistosoma mansoni ap endonuclease 0.0038 0.033 0.0726
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0034 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0274 0.0552
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0037 0.0347
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0501
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Onchocerca volvulus Pyruvate kinase homolog 0.0101 0.1013 1
Echinococcus multilocularis neuropeptide receptor A26 0.0464 0.4962 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0049 0.0449 0.4423
Schistosoma mansoni synaptojanin 0.0008 0.0002 0.0005
Onchocerca volvulus 0.0031 0.0253 0.2483
Echinococcus multilocularis solute carrier family 22 0.0031 0.0253 0.051
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0253 0.051
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0067 0.0647 0.0645
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.6465
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0053 0.0498 0.2016
Echinococcus granulosus neuropeptide receptor A26 0.0464 0.4962 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0034 0.0127
Echinococcus multilocularis solute carrier family 22 0.0031 0.0253 0.051
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0212 0.0852
Schistosoma mansoni hypothetical protein 0.0033 0.0274 0.0602
Echinococcus granulosus GPCR family 2 0.0033 0.0274 0.0552
Leishmania major glucose transporter/membrane transporter D2, putative 0.0068 0.0656 0.6465
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0034 0.0068
Mycobacterium leprae Probable pyruvate kinase PykA 0.0101 0.1013 1
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0253 0.2212
Plasmodium vivax lysine--tRNA ligase, putative 0.0049 0.0449 0.0447
Leishmania major hypothetical protein, conserved 0.0031 0.0253 0.2483
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0895 0.1803
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0714 0.7044
Schistosoma mansoni cpg binding protein 0.0032 0.0263 0.0578
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0034 0.031
Entamoeba histolytica hypothetical protein 0.0049 0.0449 0.6576
Giardia lamblia Threonyl-tRNA synthetase 0.0012 0.0053 0.0501
Giardia lamblia Prolyl-tRNA synthetase 0.0066 0.0632 0.6228
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2294 0.4624
Loa Loa (eye worm) hypothetical protein 0.0067 0.0647 0.2619
Brugia malayi hypothetical protein 0.0016 0.0091 0.036
Schistosoma mansoni pyruvate kinase 0.0101 0.1013 0.2229
Echinococcus granulosus solute carrier family 22 0.0031 0.0253 0.051
Echinococcus granulosus dnaJ subfamily B 0.0426 0.4545 0.916
Onchocerca volvulus 0.0031 0.0253 0.2483
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0067 0.0647 0.2619
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.033 0.1431
Brugia malayi pyruvate kinase, muscle isozyme 0.0021 0.015 0.06
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0253 0.0557
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0034 0.0127
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0034 0.0074
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0053 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0714 0.2895
Chlamydia trachomatis pyruvate kinase 0.0101 0.1013 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.033 0.0328
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0034 0.0068
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.033 0.0666
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0101 0.1013 0.2023
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.1303
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0714 0.1425
Onchocerca volvulus 0.0031 0.0253 0.2483
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0253 0.102
Onchocerca volvulus 0.003 0.0244 0.2392
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.033 0.0666
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0714 0.3107
Plasmodium falciparum proline--tRNA ligase 0.0076 0.075 0.0748
Brugia malayi ecdysteroid receptor 0.0011 0.0034 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Brugia malayi beta-lactamase family protein 0.0073 0.0714 0.2895
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.1303
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0037 0.0153
Brugia malayi hypothetical protein 0.0031 0.0253 0.102
Echinococcus multilocularis neutral sphingomyelinase 0.0008 0.0002 0.0005
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0053 0.0101
Loa Loa (eye worm) histone methyltransferase 0.0009 0.002 0.0071
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.075 0.7395
Loa Loa (eye worm) hypothetical protein 0.0073 0.0714 0.2895
Schistosoma mansoni glucose transporter 0.0031 0.0253 0.0557
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0037 0.0347
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0449 0.4223
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0895 0.1968
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0076 0.075 0.1128
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0067 0.0647 0.2619
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.033 0.0328
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2294 0.4624
Schistosoma mansoni hypothetical protein 0.0011 0.0038 0.0085
Trichomonas vaginalis esterase, putative 0.0073 0.0714 0.3107
Plasmodium vivax hexose transporter 0.0219 0.2294 0.2293
Plasmodium falciparum calcium-dependent protein kinase 5 0.0067 0.0647 0.0645
Loa Loa (eye worm) hypothetical protein 0.0049 0.0449 0.1818
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0127
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0034 0.0127
Echinococcus multilocularis General substrate transporter 0.0188 0.196 0.3951
Brugia malayi hypothetical protein 0.0031 0.0253 0.102
Plasmodium falciparum protein kinase 7 0.0618 0.663 0.6629
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0253 0.2212
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0053 0.0745
Schistosoma mansoni hypothetical protein 0.0033 0.0274 0.0602
Onchocerca volvulus 0.0011 0.0034 0.031
Treponema pallidum threonyl-tRNA synthetase 0.0012 0.0053 0.1545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0034 0.0127
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.033 0.1431
Trypanosoma cruzi hexose transporter 0.0068 0.0656 0.6465
Echinococcus granulosus solute carrier family 22 0.0031 0.0253 0.051
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0714 0.7044
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0034 0.0074
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.6465
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0185 0.0183
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0066 0.0632 0.1273
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0253 0.2212
Schistosoma mansoni glucose transport protein 0.0219 0.2294 0.5048
Schistosoma mansoni hypothetical protein 0.007 0.0685 0.1507
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.033 0.0656
Echinococcus multilocularis pyruvate kinase 0.0101 0.1013 0.2042
Loa Loa (eye worm) sugar transporter 0.0219 0.2294 0.9319
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0034 0.0074
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0067 0.0647 0.6373
Schistosoma mansoni glucose transport protein 0.0219 0.2294 0.5048
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0034 0.0127
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.6465
Brugia malayi nuclear receptor NHR-88 0.0011 0.0034 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0714 0.7044
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0253 0.051
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0714 0.1425
Schistosoma mansoni ap endonuclease 0.0038 0.033 0.0726
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0034 0.0127
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0053 0.0206
Plasmodium falciparum hexose transporter 0.0219 0.2294 0.2293
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0034 0.0127
Loa Loa (eye worm) hypothetical protein 0.0066 0.0632 0.256
Schistosoma mansoni inositol monophosphatase 0.0038 0.033 0.0727
Leishmania major hypothetical protein, conserved 0.0011 0.0037 0.0347
Plasmodium vivax sugar transporter, putative 0.0031 0.0253 0.0251
Echinococcus granulosus traf and tnf receptor associated protein 0.0008 0.0002 0.0005
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.075 0.7395
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0127
Schistosoma mansoni cript-related 0.0008 0.0002 0.0005
Echinococcus multilocularis pyruvate kinase 0.0079 0.0783 0.1578
Echinococcus granulosus General substrate transporter 0.0188 0.196 0.3951
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0253 0.1095
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0656 0.6465
Echinococcus granulosus geminin 0.0334 0.3546 0.7147
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.033 0.3243
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0185 0.1807
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0053 0.0051
Echinococcus granulosus neutral sphingomyelinase 0.0008 0.0002 0.0005
Echinococcus multilocularis calcium dependent protein kinase 0.0063 0.0602 0.1213
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0043 0.0384 0.1666
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0053 0.0051
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0714 0.1425
Plasmodium falciparum lysine--tRNA ligase 0.0049 0.0449 0.0447
Schistosoma mansoni inositol monophosphatase 0.0038 0.033 0.0727
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0632 0.139
Schistosoma mansoni hypothetical protein 0.0033 0.0274 0.0602
Schistosoma mansoni sugar transporter 0.0031 0.0253 0.0557
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0185 0.0183
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.002 0.004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0034 0.0127
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0008 0.0002 0.0005
Trichomonas vaginalis pyruvate kinase, putative 0.0101 0.1013 0.4411
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0274 0.0552
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0714 0.2895
Schistosoma mansoni protein kinase 0.0067 0.0647 0.1423
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0034 0.0068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1039 0.4215
Loa Loa (eye worm) beta-lactamase 0.0073 0.0714 0.2895
Trypanosoma brucei glucose transporter 1E 0.0068 0.0656 0.6465
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0171 0.1369
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0066 0.0632 0.256
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0067 0.0647 0.0973
Trichomonas vaginalis pyruvate kinase, putative 0.0101 0.1013 0.4411
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0034 0.0068
Toxoplasma gondii sugar transporter ST1 0.0031 0.0253 0.0379
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.033 0.3245
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0053 0.0116
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.1303
Loa Loa (eye worm) hypothetical protein 0.0073 0.0714 0.2895
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0034 0.0074
Echinococcus granulosus calcium dependent protein kinase 0.0063 0.0602 0.1213
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.033 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0127
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0053 0.0051
Loa Loa (eye worm) inositol-1 0.0038 0.033 0.1334
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.033 0.1431
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0034 0.0068
Schistosoma mansoni sugar transporter 0.0031 0.0253 0.0557
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0053 0.0107
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0253 0.102
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0034 0.0074
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0501
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0127
Loa Loa (eye worm) hypothetical protein 0.0103 0.1039 0.4215
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Brugia malayi hypothetical protein 0.0031 0.0253 0.102
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0038 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0034 0.0127
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0034 0.0074
Plasmodium vivax proline--tRNA ligase, putative 0.0076 0.075 0.0748
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0034 0.0127
Echinococcus multilocularis pyruvate kinase 0.0052 0.0481 0.0969
Schistosoma mansoni pyruvate kinase 0.0052 0.0481 0.1058
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.6465
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.6465
Plasmodium falciparum calcium-dependent protein kinase 2 0.0067 0.0647 0.0645
Schistosoma mansoni sugar transporter 0.0031 0.0253 0.0557
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0244 0.0983
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0287 0.057
Mycobacterium tuberculosis Conserved protein 0.0073 0.0714 0.1425
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0034 0.0068
Onchocerca volvulus 0.0031 0.0253 0.2483
Brugia malayi major facilitator superfamily protein 0.0031 0.0253 0.102
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0714 0.3107
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0008 0.0002 0.0005
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0053 0.0501
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0714 0.144
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0714 0.6938
Mycobacterium tuberculosis Conserved protein 0.0073 0.0714 0.1425
Loa Loa (eye worm) hypothetical protein 0.0073 0.0714 0.2895
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0253 0.2483
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0714 0.0712
Mycobacterium ulcerans beta-lactamase 0.0073 0.0714 0.6938
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0034 0.0068
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0253 0.051
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0714 0.1425
Plasmodium vivax pyruvate kinase 2, putative 0.0052 0.0481 0.0479
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0034 0.0074
Schistosoma mansoni sugar transporter 0.0031 0.0253 0.0557
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0034 0.0127
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.6465
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.033 0.3002
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0011 0.0037 0.0053
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0353 0.3757 0.3756
Toxoplasma gondii pyruvate kinase PyK1 0.0101 0.1013 0.1525
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0253 0.0502
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0253 0.2483
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0049 0.0449 0.1951
Leishmania major hypothetical protein, conserved 0.0011 0.0037 0.0347
Onchocerca volvulus 0.0073 0.0714 0.7044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0034 0.0127
Echinococcus granulosus pyruvate kinase 0.0101 0.1013 0.2042
Onchocerca volvulus Putative transporter 0.0031 0.0253 0.2483
Toxoplasma gondii sugar transporter ST2 0.0031 0.0253 0.0379
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0685 0.2775
Echinococcus multilocularis geminin 0.0334 0.3546 0.7147
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.033 0.4825
Echinococcus granulosus pyruvate kinase 0.0052 0.0481 0.0969
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Brugia malayi Sugar transporter family protein 0.0219 0.2294 0.9319
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0127
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0185 0.0276
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Schistosoma mansoni protein kinase 0.0067 0.0647 0.1423
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.033 0.9995
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0053 0.0107
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0353 0.3757 0.5666
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0034 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Giardia lamblia Lysyl-tRNA synthetase 0.0049 0.0449 0.4423
Echinococcus granulosus solute carrier family 22 0.0031 0.0253 0.051
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0743
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0067 0.0647 0.0645
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0274 0.1103
Leishmania major hypothetical protein, conserved 0.0024 0.0185 0.1807
Brugia malayi follicle stimulating hormone receptor 0.0234 0.2462 1
Schistosoma mansoni hypothetical protein 0.0426 0.4545 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0274 0.0552
Loa Loa (eye worm) pyruvate kinase 0.0101 0.1013 0.411
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1039 0.4215
Onchocerca volvulus 0.0031 0.0253 0.2483
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0034 0.0127
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0714 0.3107
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0895 0.1803
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0034 0.0068
Loa Loa (eye worm) hypothetical protein 0.0073 0.0714 0.2895
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0253 0.7222
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.075 0.7395
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0034 0.0068
Onchocerca volvulus 0.0031 0.0253 0.2483
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0008 0.0002 0.0005
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0253 0.0502
Echinococcus multilocularis solute carrier family 22 0.0031 0.0253 0.051
Plasmodium falciparum calcium-dependent protein kinase 3 0.0067 0.0647 0.0645
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0053 0.0206
Onchocerca volvulus 0.0031 0.0253 0.2483
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0066 0.0632 0.2747
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.033 0.1333
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Loa Loa (eye worm) hypothetical protein 0.0073 0.0714 0.2895
Brugia malayi beta-lactamase family protein 0.0073 0.0714 0.2895
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0127
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0219 0.2294 0.4624
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.033 0.0665
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.2462 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.037 0.3404
Leishmania major hypothetical protein, conserved 0.0073 0.0714 0.7044
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0034 0.0068
Echinococcus multilocularis synaptojanin 1 0.0008 0.0002 0.0005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.033 1
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0656 0.6465
Brugia malayi major facilitator superfamily protein 0.0031 0.0253 0.102
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0632 0.139
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Echinococcus granulosus pyruvate kinase 0.0052 0.0481 0.0969
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0656 0.2852
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0274 0.1103
Brugia malayi Sugar transporter family protein 0.0031 0.0253 0.102
Entamoeba histolytica pyruvate kinase, putative 0.007 0.0682 1
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0171 0.1229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0895 0.1803
Onchocerca volvulus 0.0031 0.0253 0.2483
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.033 0.4822
Echinococcus granulosus cpg binding protein 0.0032 0.0263 0.0529
Schistosoma mansoni synaptojanin 0.0008 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0334 0.3546 0.7803
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0067 0.0647 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0034 0.0127
Chlamydia trachomatis lysine--tRNA ligase 0.0049 0.0449 0.4129
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0037 0.0347
Plasmodium falciparum mitogen-activated protein kinase 2 0.0353 0.3757 0.3756
Echinococcus multilocularis pyruvate kinase 0.0052 0.0481 0.0969
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0253 0.102
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.033 0.3
Plasmodium vivax CDK-related protein kinase 6, putative 0.0928 1 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0053 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0656 0.2852
Echinococcus granulosus solute carrier family 22 0.0031 0.0253 0.051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0034 0.0127
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0219 0.2294 0.4624
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0067 0.0647 0.1303
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0449 0.4223
Brugia malayi CXXC zinc finger family protein 0.003 0.0244 0.0983
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.033 0.3243
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Toxoplasma gondii lysine-tRNA ligase 0.0049 0.0449 0.0675
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0019 0.0066
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.003 0.025 0.1008
Brugia malayi beta-lactamase 0.0073 0.0714 0.2895
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0656 0.2852
Plasmodium falciparum pyruvate kinase 0.0101 0.1013 0.1011
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0647 0.1303
Loa Loa (eye worm) hypothetical protein 0.007 0.0682 0.2764
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0647 0.1423
Onchocerca volvulus 0.0031 0.0253 0.2483
Schistosoma mansoni nocturnin 0.0008 0.0002 0.0005
Echinococcus multilocularis pyruvate kinase 0.0052 0.0481 0.0969
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Mycobacterium leprae Probable lipase LipE 0.0073 0.0714 0.6938
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Toxoplasma gondii sugar transporter ST3 0.0031 0.0253 0.0379
Mycobacterium ulcerans pyruvate kinase 0.0101 0.1013 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.002 0.004
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0656 0.2852
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0535 0.0803
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0171 0.5146
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0066 0.0632 0.1273
Mycobacterium ulcerans hypothetical protein 0.0073 0.0714 0.6938
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0034 0.0068
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.075 0.7395
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.033 0.1333
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0037 0.0153
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0067 0.0647 0.0645
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.033 0.3243
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0647 0.2811
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0656 0.6465
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0066 0.0632 0.9259
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0127
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0253 0.1095
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0253 0.2483
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0253 0.1095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0034 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0034 0.0127
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0053 0.0159
Loa Loa (eye worm) pyruvate kinase-PB 0.007 0.0682 0.2764
Giardia lamblia Hexose transporter 0.0031 0.0253 0.2483
Brugia malayi pyruvate kinase 0.0021 0.015 0.06
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0895 0.1968
Onchocerca volvulus 0.0031 0.0253 0.2483
Loa Loa (eye worm) sugar transporter 0.0031 0.0253 0.102
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0037 0.0347
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0038 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0253 0.1095
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0185 0.0183
Leishmania major pyruvate kinase 0.0101 0.1013 1
Trypanosoma brucei sugar transporter, putative 0.0031 0.0253 0.2483
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0008 0.0002 0.0005
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0253 0.2483
Brugia malayi Cam kinase protein 1 0.0067 0.0647 0.2619
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0274 0.0552
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0714 0.144
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0253 0.2483
Mycobacterium tuberculosis Conserved hypothetical protein 0.0011 0.0037 0.007
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0322 0.3162
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0067 0.0647 0.0973
Onchocerca volvulus 0.0031 0.0253 0.2483
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0034 0.0127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0034 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.102
Leishmania major protein kinase, putative 0.0067 0.0647 0.6373
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0714 0.3107
Echinococcus multilocularis neuropeptide s receptor 0.0464 0.4962 1
Toxoplasma gondii exonuclease III APE 0.0038 0.033 0.0495
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.4545 0.916
Leishmania major glucose transporter, lmgt1 0.0068 0.0656 0.6465
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0034 0.0074
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0053 0.0107
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0714 0.2895
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0253 0.102
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2294 0.4624
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0034 0.0127
Trypanosoma cruzi pyruvate kinase 2, putative 0.0101 0.1013 1
Trypanosoma brucei glucose transporter, putative 0.0068 0.0656 0.6465
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Onchocerca volvulus 0.0031 0.0253 0.2483
Leishmania major glucose transporter, lmgt2 0.0068 0.0656 0.6465
Toxoplasma gondii facilitative glucose transporter GT1 0.0219 0.2294 0.3459
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.033 0.3245
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0034 0.0068
Onchocerca volvulus 0.0031 0.0253 0.2483
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0656 0.2852
Giardia lamblia Glycyl-tRNA synthetase 0.0012 0.0053 0.0501
Brugia malayi Pyruvate kinase, muscle isozyme 0.0101 0.1013 0.411
Onchocerca volvulus 0.0031 0.0253 0.2483
Schistosoma mansoni coup transcription factor 0.0011 0.0034 0.0074
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0049 0.0449 0.4423
Mycobacterium ulcerans lipase LipD 0.0073 0.0714 0.6938
Echinococcus multilocularis deoxyribonuclease 1 2 0.0008 0.0002 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0037 0.0347
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0066 0.0632 0.256
Onchocerca volvulus Pyruvate kinase homolog 0.0101 0.1013 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0467 0.4999 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0253 0.1095
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0002 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0034 0.0074
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0253 0.051
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0895 0.3628
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.033 0.3243
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0253 0.1095
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.033 0.3245
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0053 0.0206

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 3 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 6.47 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 6.96 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 7.47 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 31 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 62 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 100 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 6.57 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 3 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 31 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 62 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 100 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.22 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.60378 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.