Detailed information for compound 609560

Basic information

Technical information
  • TDR Targets ID: 609560
  • Name: 2-phenylsulfanyl-N-(5-propan-2-yl-1,3,4-thiad iazol-2-yl)butanamide
  • MW: 321.461 | Formula: C15H19N3OS2
  • H donors: 1 H acceptors: 3 LogP: 4.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)Nc1nnc(s1)C(C)C)Sc1ccccc1
  • InChi: 1S/C15H19N3OS2/c1-4-12(20-11-8-6-5-7-9-11)13(19)16-15-18-17-14(21-15)10(2)3/h5-10,12H,4H2,1-3H3,(H,16,18,19)
  • InChiKey: YRTRKWFULMEHIJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-phenylsulfanyl-butanamide
  • N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-(phenylthio)butanamide
  • N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-(phenylthio)butyramide
  • Oprea1_297470

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.0263
Loa Loa (eye worm) fli-1 protein 0.024 0.3163 0.4583
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0142 0.0206
Brugia malayi hypothetical protein 0.01 0.122 0.1768
Schistosoma mansoni cpg binding protein 0.003 0.0262 0.0262
Schistosoma mansoni pyruvate kinase 0.0033 0.029 0.029
Loa Loa (eye worm) RNA binding protein 0.0065 0.0738 0.1069
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.125 0.125
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0072 0.0362
Brugia malayi hypothetical protein 0.0251 0.3314 0.4802
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.078 0.078
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.029 0.0954
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.4474 0.6482
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.029 0.0236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.3102 0.3102
Brugia malayi beta-lactamase family protein 0.0074 0.0872 0.1263
Schistosoma mansoni thyroid hormone receptor 0.0134 0.1693 0.1693
Schistosoma mansoni smad 0.0018 0.0083 0.0083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0236 0.3102 0.4493
Brugia malayi hypothetical protein 0.0154 0.1977 0.2865
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0142 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0872 0.116
Loa Loa (eye worm) pyruvate kinase 0.0033 0.029 0.0421
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.4474 0.6482
Schistosoma mansoni hypothetical protein 0.0073 0.0852 0.0852
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.3102 0.3102
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0142 0.0468
Plasmodium falciparum ataxin-2 like protein, putative 0.0154 0.1977 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0154 0.1977 0.6497
Toxoplasma gondii LsmAD domain-containing protein 0.0154 0.1977 1
Trypanosoma brucei PAB1-binding protein , putative 0.0154 0.1977 0.6497
Loa Loa (eye worm) hypothetical protein 0.0074 0.0872 0.1263
Mycobacterium tuberculosis Conserved protein 0.0074 0.0872 0.116
Schistosoma mansoni cpg binding protein 0.0032 0.0287 0.0287
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.6903 1
Chlamydia trachomatis pyruvate kinase 0.0033 0.029 0.5
Brugia malayi MH1 domain containing protein 0.0018 0.0083 0.0121
Echinococcus multilocularis pyruvate kinase 0.0017 0.0072 0.0072
Schistosoma mansoni Smad4 0.0018 0.0083 0.0083
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.029 0.0066
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0083 0.0083
Loa Loa (eye worm) beta-lactamase 0.0074 0.0872 0.1263
Schistosoma mansoni hypothetical protein 0.0069 0.0799 0.0799
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0872 0.1263
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0142 0.0206
Brugia malayi MH2 domain containing protein 0.0018 0.0083 0.0121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0142 0.0468
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.029 0.1469
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0262 0.038
Schistosoma mansoni hypothetical protein 0.0034 0.0312 0.0312
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0655 0.3313
Schistosoma mansoni cpg binding protein 0.0032 0.0287 0.0287
Toxoplasma gondii Alpha-galactosidase 0.0014 0.004 0.0203
Entamoeba histolytica hypothetical protein 0.0073 0.0852 1
Leishmania major pyruvate kinase 0.0033 0.029 0.0954
Loa Loa (eye worm) transcription factor SMAD2 0.0257 0.3403 0.4929
Echinococcus multilocularis pyruvate kinase 0.0026 0.0196 0.0196
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1577 0.1577
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0263 0.0263
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.1332 0.1929
Toxoplasma gondii ABC1 family protein 0.0074 0.0872 0.4408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.3102 0.3102
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.4474 0.6482
Brugia malayi Fli-1 protein 0.024 0.3163 0.4583
Echinococcus multilocularis tumor protein p63 0.0691 0.9407 0.9407
Loa Loa (eye worm) hypothetical protein 0.0251 0.3314 0.4802
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0872 0.5082
Echinococcus granulosus pyruvate kinase 0.0033 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0123 0.1538 0.2229
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.3102 0.3102
Schistosoma mansoni ets-related 0.024 0.3163 0.3163
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.051 0.6903 1
Echinococcus granulosus dnaJ subfamily B 0.0434 0.5849 0.5849
Entamoeba histolytica hypothetical protein 0.0073 0.0852 1
Plasmodium vivax SET domain protein, putative 0.003 0.0263 0.1328
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.1241 0.1241
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.6903 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0287 0.0287
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0872 0.1263
Schistosoma mansoni smad1 5 8 and 0.0018 0.0083 0.0083
Echinococcus granulosus smad 0.0018 0.0083 0.0083
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0142 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0312 0.0452
Leishmania major hypothetical protein, conserved 0.0154 0.1977 0.6497
Toxoplasma gondii exonuclease III APE 0.0022 0.0142 0.072
Echinococcus granulosus tumor protein p63 0.0691 0.9407 0.9407
Echinococcus multilocularis microtubule associated protein 2 0.0734 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.6903 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.0263
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.125 0.125
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.1332 0.1929
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0263 0.0263
Schistosoma mansoni pyruvate kinase 0.0017 0.0072 0.0072
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1555 0.1555
Loa Loa (eye worm) hypothetical protein 0.0074 0.0872 0.1263
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0312 0.0452
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0872 0.116
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1577 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0083 0.0083
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0072 0.0362
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0738 0.0738
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.029 0.0954
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0238 0.0238
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0312 0.0452
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0872 0.0872
Loa Loa (eye worm) MH2 domain-containing protein 0.0257 0.3403 0.4929
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.1577 0.7976
Schistosoma mansoni hypothetical protein 0.0196 0.256 0.256
Onchocerca volvulus Huntingtin homolog 0.0123 0.1538 0.3029
Loa Loa (eye worm) hypothetical protein 0.0033 0.029 0.0421
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0872 0.5082
Mycobacterium ulcerans lipase LipD 0.0074 0.0872 0.5082
Leishmania major hypothetical protein, conserved 0.0074 0.0872 0.2864
Brugia malayi Ets-domain containing protein 0.0079 0.0935 0.1355
Echinococcus multilocularis smad 0.0018 0.0083 0.0083
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0549 0.0796
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.125 0.125
Echinococcus granulosus pyruvate kinase 0.0033 0.029 0.029
Onchocerca volvulus Huntingtin homolog 0.0123 0.1538 0.3029
Giardia lamblia Pyruvate kinase 0.0033 0.029 1
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0072 0.0362
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.1577 0.5182
Echinococcus granulosus geminin 0.0196 0.256 0.256
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0935 0.1355
Loa Loa (eye worm) hypothetical protein 0.0023 0.0154 0.0224
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0872 0.1263
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.3314 0.3314
Plasmodium falciparum pyruvate kinase 0.0033 0.029 0.1469
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.029 0.0954
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0738 0.1069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2728 0.3952
Schistosoma mansoni pyruvate kinase 0.0033 0.029 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.6903 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0312 0.0312
Echinococcus granulosus GPCR family 2 0.0034 0.0312 0.0312
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.4724 0.6843
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0872 0.0872
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.125 0.125
Echinococcus granulosus pyruvate kinase 0.0017 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0124 0.1555 0.1555
Brugia malayi Ets-domain containing protein 0.0079 0.0935 0.1355
Brugia malayi MH2 domain containing protein 0.0018 0.0083 0.0121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.3102 0.3102
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0154 0.0224
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0738 0.0738
Mycobacterium ulcerans beta-lactamase 0.0074 0.0872 0.5082
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0263 0.1328
Mycobacterium tuberculosis Conserved protein 0.0074 0.0872 0.116
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.1577 0.1577
Trichomonas vaginalis set domain proteins, putative 0.0237 0.3126 0.4528
Loa Loa (eye worm) hypothetical protein 0.0108 0.1332 0.1929
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.0434 0.5849 0.5849
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0872 0.116
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0142 0.0206
Brugia malayi beta-lactamase 0.0074 0.0872 0.1263
Loa Loa (eye worm) hypothetical protein 0.0074 0.0872 0.1263
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0142 0.0206
Loa Loa (eye worm) hypothetical protein 0.0074 0.0872 0.1263
Trypanosoma brucei pyruvate kinase 1 0.0033 0.029 0.0954
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0312 0.0312
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0872 0.1263
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0872 0.1263
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.029 0.0421
Schistosoma mansoni thyroid hormone receptor 0.0134 0.1693 0.1693
Leishmania major pyruvate kinase 0.0033 0.029 0.0954
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.1577 0.1577
Schistosoma mansoni hypothetical protein 0.0051 0.0549 0.0549
Echinococcus multilocularis Smad4 0.0018 0.0083 0.0083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1577 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.3102 0.3102
Loa Loa (eye worm) Smad1 0.0018 0.0083 0.0121
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.004 0.004
Brugia malayi hypothetical protein 0.0123 0.1538 0.2229
Onchocerca volvulus 0.0074 0.0872 0.1446
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.029 0.0421
Trichomonas vaginalis esterase, putative 0.0074 0.0872 0.1263
Echinococcus granulosus pyruvate kinase 0.0017 0.0072 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.4474 0.6482
Schistosoma mansoni ap endonuclease 0.0022 0.0142 0.0142
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.029 0.0421
Schistosoma mansoni microtubule-associated protein tau 0.0734 1 1
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0872 1
Brugia malayi Pre-SET motif family protein 0.003 0.0263 0.038
Onchocerca volvulus Glucosylceramidase homolog 0.0335 0.4474 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0236 0.3102 0.4493
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.1693 0.1693
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0142 0.0142
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.029 0.0421
Echinococcus multilocularis GPCR, family 2 0.0034 0.0312 0.0312
Echinococcus granulosus pyruvate kinase 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0154 0.1977 0.2865
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0751 0.0751
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0083 0.0121
Echinococcus granulosus Smad4 0.0018 0.0083 0.0083
Mycobacterium ulcerans hypothetical protein 0.0074 0.0872 0.5082
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0872 0.1263
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0872 0.116
Brugia malayi RNA binding protein 0.0065 0.0738 0.1069
Schistosoma mansoni hypothetical protein 0.0034 0.0312 0.0312
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.029 0.0066
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0142 0.0468
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.125 0.125
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0738 0.1069
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.4474 0.6482
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0852 0.0852
Brugia malayi hypothetical protein 0.0073 0.0852 0.1234
Loa Loa (eye worm) pyruvate kinase 0.0033 0.029 0.0421
Brugia malayi Pre-SET motif family protein 0.0209 0.2728 0.3952
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.4724 0.6843
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.051 0.6903 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.029 0.1469
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0312 0.0312
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0872 0.116
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0872 0.116
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0231 0.3044 1
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.4474 0.6482
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0142 0.0468
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0263 0.0263
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.1332 0.1929
Loa Loa (eye worm) hypothetical protein 0.0123 0.1538 0.2229
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0069 0.0799 0.0799
Plasmodium falciparum ataxin-2 like protein, putative 0.0154 0.1977 1
Plasmodium vivax ataxin-2 like protein, putative 0.0154 0.1977 1
Onchocerca volvulus 0.0101 0.1241 0.2323
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0738 0.0738
Brugia malayi MH1 domain containing protein 0.0018 0.0083 0.0121
Schistosoma mansoni ap endonuclease 0.0022 0.0142 0.0142
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.029 0.0066
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0142 0.0142
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0872 0.0872
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0872 0.0872
Loa Loa (eye worm) hypothetical protein 0.0074 0.0872 0.1263
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0852 0.0852
Schistosoma mansoni hypothetical protein 0.0034 0.0312 0.0312
Echinococcus multilocularis pyruvate kinase 0.0017 0.0072 0.0072
Brugia malayi Smad1 0.0018 0.0083 0.0121
Loa Loa (eye worm) hypothetical protein 0.003 0.0263 0.038
Trypanosoma cruzi PAB1-binding protein , putative 0.0154 0.1977 0.6497
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.6903 1
Onchocerca volvulus 0.0051 0.0549 0.0681
Loa Loa (eye worm) hypothetical protein 0.0068 0.0776 0.1125
Echinococcus multilocularis pyruvate kinase 0.0017 0.0072 0.0072
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.125 0.125
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.4474 0.6482
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.125 0.125
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0083 0.0083
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.5849 0.5849
Onchocerca volvulus 0.0074 0.0872 0.1446
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.3314 0.3314
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0083 0.0083
Echinococcus multilocularis geminin 0.0196 0.256 0.256
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0034 0.0312 0.0452
Echinococcus granulosus tar DNA binding protein 0.0065 0.0738 0.0738
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.078 0.078
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.0263
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0083 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0074 0.086 0.1246
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.086 0.1246
Entamoeba histolytica hypothetical protein 0.0073 0.0852 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0083 0.0121
Onchocerca volvulus 0.0237 0.3126 0.6798
Schistosoma mansoni gabp alpha 0.0079 0.0935 0.0935
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0872 0.2864
Brugia malayi beta-lactamase family protein 0.0074 0.0872 0.1263
Echinococcus granulosus cpg binding protein 0.0032 0.0287 0.0287
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0154 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.051 0.6903 1
Onchocerca volvulus 0.0074 0.0872 0.1446
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0738 0.1069
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0872 0.2864
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.3102 0.3102
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0852 0.0852
Schistosoma mansoni smad1 5 8 and 0.0018 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0068 0.078 0.1131
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0872 0.1263
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.6428 1
Brugia malayi TAR-binding protein 0.0065 0.0738 0.1069
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0142 0.4903
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0872 0.2864
Schistosoma mansoni hypothetical protein 0.0034 0.0312 0.0312
Leishmania major hypothetical protein, conserved 0.0231 0.3044 1
Schistosoma mansoni survival motor neuron protein 0.0051 0.0549 0.0549
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1555 0.1555
Loa Loa (eye worm) pyruvate kinase 0.0033 0.029 0.0421
Mycobacterium ulcerans pyruvate kinase 0.0033 0.029 0.1032
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0872 0.4408
Schistosoma mansoni hypothetical protein 0.0074 0.086 0.086
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0142 0.072
Loa Loa (eye worm) hypothetical protein 0.0101 0.1241 0.1798
Echinococcus multilocularis pyruvate kinase 0.0033 0.029 0.029
Toxoplasma gondii melibiase subfamily protein 0.0102 0.125 0.6321
Entamoeba histolytica hypothetical protein 0.0073 0.0852 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.0872 0.116
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0738 0.0738
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1577 1
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0935 0.0935
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1577 0.1577
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0263 0.0263
Echinococcus multilocularis pyruvate kinase 0.0033 0.029 0.029
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0872 0.116
Mycobacterium leprae Probable lipase LipE 0.0074 0.0872 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0142 0.072
Brugia malayi Melibiase family protein 0.0068 0.078 0.1131
Giardia lamblia Pyruvate kinase 0.0017 0.0072 0.2462
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0069 0.0799 0.0799
Brugia malayi MH2 domain containing protein 0.0257 0.3403 0.4929
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0312 0.0312
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0935 0.0935
Loa Loa (eye worm) hypothetical protein 0.0074 0.0872 0.1263
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0231 0.3044 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.1577 0.2283
Brugia malayi CXXC zinc finger family protein 0.003 0.0262 0.038
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.078 0.1131
Schistosoma mansoni hypothetical protein 0.0196 0.256 0.256

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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