Detailed information for compound 619381

Basic information

Technical information
  • TDR Targets ID: 619381
  • Name: 2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-[(3 -fluoro-4-methylphenyl)amino]prop-2-enenitril e
  • MW: 369.843 | Formula: C19H13ClFN3S
  • H donors: 1 H acceptors: 2 LogP: 5.77 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=CNc1ccc(c(c1)F)C)c1scc(n1)c1ccc(cc1)Cl
  • InChi: 1S/C19H13ClFN3S/c1-12-2-7-16(8-17(12)21)23-10-14(9-22)19-24-18(11-25-19)13-3-5-15(20)6-4-13/h2-8,10-11,23H,1H3/b14-10+
  • InChiKey: JUDCHNDOWXZNGU-GXDHUFHOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-[(3-fluoro-4-methylphenyl)amino]prop-2-enenitrile
  • (E)-2-[4-(4-chlorophenyl)thiazol-2-yl]-3-[(3-fluoro-4-methyl-phenyl)amino]prop-2-enenitrile
  • 2-[4-(4-chlorophenyl)thiazol-2-yl]-3-[(3-fluoro-4-methyl-phenyl)amino]prop-2-enenitrile
  • (E)-2-[4-(4-chlorophenyl)-2-thiazolyl]-3-[(3-fluoro-4-methylphenyl)amino]prop-2-enenitrile
  • 2-[4-(4-chlorophenyl)-2-thiazolyl]-3-[(3-fluoro-4-methylphenyl)amino]prop-2-enenitrile
  • (E)-2-[4-(4-chlorophenyl)thiazol-2-yl]-3-[(3-fluoro-4-methyl-phenyl)amino]acrylonitrile
  • 2-[4-(4-chlorophenyl)thiazol-2-yl]-3-[(3-fluoro-4-methyl-phenyl)amino]acrylonitrile
  • 2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-[(3-fluoro-4-methyl-phenyl)amino]prop-2-enenitrile
  • (E)-2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-[(3-fluoro-4-methyl-phenyl)amino]prop-2-enenitrile
  • ZINC04135169

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0235 0.0758 0.7564
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0181 0.1805
Loa Loa (eye worm) hypothetical protein 0.0156 0.0474 0.2815
Mycobacterium tuberculosis Conserved protein 0.0074 0.0181 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.0621 0.6203
Mycobacterium tuberculosis Conserved protein 0.0074 0.0181 0.0562
Plasmodium vivax hypothetical protein 0.0051 0.0095 0.5089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0256 0.0833 0.832
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0085 0.0265
Echinococcus multilocularis survival motor neuron protein 1 0.0489 0.167 0.1653
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0073 0.0175 0.1746
Schistosoma mansoni cpg binding protein 0.0031 0.0026 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0181 0.0655
Loa Loa (eye worm) hypothetical protein 0.0074 0.0181 0.1051
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0006 0.0017
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0302 0.1001 0.3993
Loa Loa (eye worm) phosphatidylinositol 3 0.0302 0.1001 0.5978
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0181 0.0655
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0196 0.0617 0.6166
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0302 0.1001 0.2775
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0181 0.0562
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0181 0.1051
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0051 0.0095 0.0075
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0302 0.1001 0.5978
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.1001 1
Echinococcus multilocularis expressed conserved protein 0.0094 0.0252 0.0232
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0095 0.0895
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0181 0.1805
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0118 0.0337 0.3368
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0272 0.1597
Echinococcus multilocularis cpg binding protein 0.0031 0.0026 0.0006
Echinococcus multilocularis Zinc finger, PHD finger 0.0073 0.0175 0.0155
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0181 0.1051
Echinococcus granulosus muscleblind protein 0.0156 0.0474 0.0455
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0148 0.0857
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0181 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0095 0.0535
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0171 0.0528 0.5245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0085 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0256 0.0833 0.832
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.1623 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0073 0.0175 0.0155
Leishmania major hypothetical protein, conserved 0.0035 0.0041 0.0113
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0195 0.0613 0.365
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0235 0.0758 0.4522
Toxoplasma gondii non-specific serine/threonine protein kinase 0.015 0.0453 0.4961
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0073 0.0175 0.1746
Brugia malayi TAR-binding protein 0.0065 0.0148 0.0857
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0051 0.0095 0.0075
Schistosoma mansoni hypothetical protein 0.0094 0.0252 0.0946
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0085 0.0218 0.0638
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0148 0.0524
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0041 0.2061
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0051 0.0095 0.0895
Leishmania major phosphatidylinositol 3-kinase, putative 0.0073 0.0175 0.0485
Leishmania major hypothetical protein, unknown function 0.0051 0.0095 0.0263
Brugia malayi RNA binding protein 0.0065 0.0148 0.0857
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0135 0.04 0.3963
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0073 0.0175 0.9663
Echinococcus multilocularis serine protein kinase ATM 0.0135 0.04 0.0381
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0235 0.0758 0.2215
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0118 0.0337 0.1991
Brugia malayi Augmenter of liver regeneration 0.0035 0.0041 0.0209
Entamoeba histolytica hypothetical protein 0.0037 0.0047 0.0468
Echinococcus granulosus geminin 0.0177 0.055 0.0531
Entamoeba histolytica hypothetical protein 0.022 0.0704 0.7032
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0302 0.1001 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0265 0.0866 0.8654
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0085 0.0065
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0235 0.0758 0.2215
Entamoeba histolytica hypothetical protein 0.0037 0.0047 0.0468
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0302 0.1001 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0282 0.0926 0.9254
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0051 0.0095 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0181 0.1805
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0073 0.0175 0.0631
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0181 0.1805
Onchocerca volvulus 0.0074 0.0181 0.639
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0085 0.0065
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0282 0.0927 0.2569
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0051 0.0095 0.0277
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0142 0.0424 0.4234
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0139 0.0487
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0148 0.0524
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0302 0.1001 0.2923
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0118 0.0337 0.3368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0277 0.0907 0.9066
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0135 0.04 0.3998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0218 0.2183
Echinococcus granulosus microtubule associated protein 2 0.0713 0.2477 0.2462
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0118 0.0337 0.1291
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.002 0.0146
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0235 0.0758 0.7564
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0096 0.0257 0.1792
Mycobacterium tuberculosis Conserved protein 0.0074 0.0181 0.0562
Trypanosoma cruzi target of rapamycin kinase 3 0.0282 0.0927 0.2706
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0135 0.04 0.1548
Schistosoma mansoni hypothetical protein 0.0051 0.0095 0.0305
Loa Loa (eye worm) hypothetical protein 0.0074 0.0181 0.1051
Leishmania major phosphatidylinositol 3-kinase, putative 0.0235 0.0758 0.2103
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0265 0.0866 0.2529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0095 0.0535
Loa Loa (eye worm) hypothetical protein 0.0074 0.0181 0.1051
Brugia malayi FAT domain containing protein 0.01 0.0271 0.1596
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0041 0.002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0051 0.0095 0.0987
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0265 0.0866 0.2529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.1001 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0051 0.0095 0.0947
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0067 0.0156 0.0454
Loa Loa (eye worm) hypothetical protein 0.0085 0.0218 0.1278
Brugia malayi beta-lactamase family protein 0.0074 0.0181 0.1051
Schistosoma mansoni hypothetical protein 0.01 0.0272 0.1025
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0051 0.0095 0.0277
Loa Loa (eye worm) hypothetical protein 0.0489 0.167 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.0148 0.0128
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0265 0.0866 0.8654
Echinococcus granulosus serine protein kinase ATM 0.0135 0.04 0.0381
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0148 0.0857
Brugia malayi Importin beta-1 subunit 0.003 0.002 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0977 0.3425 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2805 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0051 0.0095 0.0075
Toxoplasma gondii ABC1 family protein 0.0074 0.0181 0.194
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0073 0.0175 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0095 0.0947
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0051 0.0095 0.5089
Trichomonas vaginalis conserved hypothetical protein 0.015 0.0453 0.4527
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0135 0.04 0.1168
Brugia malayi SH2 domain containing protein 0.0393 0.1326 0.7933
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0135 0.04 0.0381
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0265 0.0866 0.5169
Plasmodium vivax importin-beta 2, putative 0.003 0.002 0.0829
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0302 0.1001 0.2775
Brugia malayi beta-lactamase family protein 0.0074 0.0181 0.1051
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0302 0.1001 0.0983
Schistosoma mansoni hypothetical protein 0.01 0.0271 0.1024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0256 0.0833 0.8323
Leishmania major phosphatidylinositol kinase related protein, putative 0.0051 0.0095 0.0263
Toxoplasma gondii target of rapamycin (TOR), putative 0.0277 0.0907 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0277 0.0907 0.9066
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0073 0.0175 0.1746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.04 0.3998
Onchocerca volvulus 0.0051 0.0095 0.2977
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0118 0.0337 0.3368
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0181 0.0562
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0302 0.1001 0.2923
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.022 0.0704 0.7032
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0181 0.0528
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0235 0.0758 0.2103
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0073 0.0175 0.051
Brugia malayi Muscleblind-like protein 0.0156 0.0474 0.2815
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0118 0.0337 0.0984
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0181 0.0161
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0095 0.0535
Onchocerca volvulus 0.0051 0.0095 0.2977
Brugia malayi beta-lactamase 0.0074 0.0181 0.1051
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0181 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0051 0.0095 0.0987
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.1057 0.6314
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0041 0.0386
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.002 0.0161
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0095 0.0535
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0118 0.0337 0.333
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0085 0.0476
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0047 0.0027
Echinococcus granulosus survival motor neuron protein 1 0.0489 0.167 0.1653
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0073 0.0175 0.0485
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.0087
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.046 0.1566 0.1549
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0051 0.0095 0.0277
Schistosoma mansoni importin beta-1 0.003 0.002 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0135 0.04 0.2369
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0135 0.04 0.1168
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.01 0.0271 0.0252
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0115 0.1215
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0181 0.0562
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0074 0.0181 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.1001 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.0758 0.7578
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0041 0.035
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0051 0.0095 0.0075
Echinococcus multilocularis 0.0051 0.0095 0.0075
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0181 0.0562
Schistosoma mansoni hypothetical protein 0.0318 0.1057 0.422
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0073 0.0175 1
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0041 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0277 0.0907 0.9066
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0092 0.0244 0.2392
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0302 0.1001 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.04 0.3998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0277 0.0907 0.9066
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0215 0.0684 0.6839
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0085 0.0265
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.046 0.1566 0.1549
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0181 0.1758
Loa Loa (eye worm) hypothetical protein 0.0135 0.04 0.2369
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0085 0.0065
Brugia malayi CXXC zinc finger family protein 0.003 0.002 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.0758 0.7578
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0187 0.0586 0.0567
Trichomonas vaginalis esterase, putative 0.0074 0.0181 0.1805
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.002 0.0146
Echinococcus granulosus snurportin 1 0.0318 0.1057 0.1039
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0148 0.0524
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0073 0.0175 0.1699
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0085 0.0065
Loa Loa (eye worm) hypothetical protein 0.0051 0.0095 0.0535
Schistosoma mansoni survival motor neuron protein 0.01 0.0272 0.1025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0261 0.0852 0.8512
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0181 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0277 0.0907 0.9066
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0051 0.0095 0.0305
Onchocerca volvulus 0.01 0.0272 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0051 0.0095 0.0305
Leishmania major hypothetical protein, conserved 0.1027 0.3606 1
Entamoeba histolytica protein kinase rad3, putative 0.0135 0.04 0.3998
Entamoeba histolytica hypothetical protein 0.0135 0.04 0.3998
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.046 0.1566 0.6294
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0051 0.0095 0.5266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0261 0.0852 0.8512
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0148 0.0524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0568 0.5674
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0041 0.0119
Loa Loa (eye worm) hypothetical protein 0.0078 0.0193 0.1126
Schistosoma mansoni hypothetical protein 0.0037 0.0047 0.011
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0073 0.0175 0.1015
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0051 0.0095 0.0947
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0041 0.0209
Leishmania major phosphatidylinositol kinase, putative 0.0051 0.0095 0.0263
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.002 0.0085
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0181 0.5
Schistosoma mansoni hypothetical protein 0.0177 0.055 0.2157
Mycobacterium ulcerans beta-lactamase 0.0074 0.0181 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0073 0.0175 0.1875
Entamoeba histolytica hypothetical protein 0.0051 0.0095 0.0947
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0041 0.0386
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0047 0.0027
Mycobacterium ulcerans lipase LipD 0.0074 0.0181 0.5
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0051 0.0095 0.5089
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.01 0.0273 0.0253
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0181 0.0562
Loa Loa (eye worm) hypothetical protein 0.0074 0.0181 0.1051
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0235 0.0758 0.3006
Entamoeba histolytica hypothetical protein 0.0051 0.0095 0.0947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0256 0.0833 0.8323
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0181 0.0528
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0041 0.0119
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0095 0.5089
Schistosoma mansoni hypothetical protein 0.0177 0.055 0.2157
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0218 0.2183
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0051 0.0095 0.5089
Brugia malayi hypothetical protein 0.0489 0.167 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.01 0.0273 0.0253
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0118 0.0337 0.3368
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0073 0.0175 0.0631
Leishmania major hypothetical protein, conserved 0.0074 0.0181 0.0501
Leishmania major hypothetical protein, conserved 0.0026 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0393 0.1326 0.7933
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0135 0.04 0.0381
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0265 0.0866 0.8654
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.2477 0.2462
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0118 0.0337 0.3368
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0047 0.011
Brugia malayi RNA, U transporter 1 0.0085 0.0218 0.1274
Echinococcus multilocularis muscleblind protein 1 0.0156 0.0474 0.0455
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.01 0.0271 0.0252
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0282 0.0927 0.9253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0549 0.5486
Giardia lamblia GTOR 0.0302 0.1001 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0085 0.0476
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0235 0.0758 0.074
Loa Loa (eye worm) hypothetical protein 0.0074 0.0181 0.1051
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0271 0.2712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0643 0.642
Echinococcus multilocularis snurportin 1 0.0318 0.1057 0.1039
Plasmodium falciparum importin beta, putative 0.003 0.002 0.0858
Schistosoma mansoni cpg binding protein 0.0031 0.0026 0.0025
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0041 0.002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0073 0.0175 0.1875
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0051 0.0095 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0282 0.0926 0.9254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0256 0.0833 0.8323
Entamoeba histolytica hypothetical protein 0.0051 0.0095 0.0947
Loa Loa (eye worm) hypothetical protein 0.015 0.0453 0.2687
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0051 0.0095 0.0277
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0181 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0187 0.0586 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0549 0.5486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0256 0.0833 0.8323
Loa Loa (eye worm) RNA binding protein 0.0065 0.0148 0.0857
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0051 0.0095 0.0987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.0758 0.7578
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0095 0.0535
Entamoeba histolytica hypothetical protein 0.0037 0.0047 0.0468
Toxoplasma gondii FATC domain-containing protein 0.0135 0.04 0.4374
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0051 0.0095 0.0947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0256 0.0833 0.832
Brugia malayi hypothetical protein 0.0037 0.0047 0.0247
Loa Loa (eye worm) phosphatidylinositol kinase 0.0051 0.0095 0.0535
Echinococcus granulosus expressed conserved protein 0.0094 0.0252 0.0232
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0135 0.04 0.2369
Loa Loa (eye worm) beta-lactamase 0.0074 0.0181 0.1051
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0051 0.0095 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0148 0.0524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0169 0.169
Loa Loa (eye worm) phosphatidylinositol 3 0.0235 0.0758 0.4522
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0148 0.0128
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0265 0.0866 0.8654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0277 0.0907 0.9066
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0073 0.0175 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.0758 0.7578
Entamoeba histolytica hypothetical protein 0.0037 0.0047 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0277 0.0907 0.9066
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0181 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.0758 0.7578
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0073 0.0175 0.1015
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.2477 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0095 0.0947
Loa Loa (eye worm) hypothetical protein 0.0187 0.0586 0.3486
Onchocerca volvulus 0.0074 0.0181 0.639
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0095 0.0535
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0073 0.0175 0.1746
Mycobacterium ulcerans hypothetical protein 0.0074 0.0181 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0095 0.0535
Echinococcus multilocularis muscleblind protein 0.0156 0.0474 0.0455
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0148 0.0857
Schistosoma mansoni fkbp-rapamycin associated protein 0.0135 0.04 0.1548
Onchocerca volvulus 0.0074 0.0181 0.639
Loa Loa (eye worm) phosphatidylinositol 3 0.0415 0.1404 0.8399
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0302 0.1001 1
Mycobacterium leprae Probable lipase LipE 0.0074 0.0181 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0067 0.0156 0.09
Leishmania major phosphatidylinositol 4-kinase, putative 0.0051 0.0095 0.0263
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0041 0.1991
Trichomonas vaginalis PIKK family atypical protein kinase 0.0282 0.0926 0.9254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0549 0.5486
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0235 0.0758 0.074
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0073 0.0175 0.0155
Echinococcus multilocularis geminin 0.0177 0.055 0.0531
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0151 0.0455 0.3974
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0181 0.1805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0282 0.0926 0.9254
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0073 0.0175 0.1746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0282 0.0926 0.9254
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0181 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.04 0.3998
Loa Loa (eye worm) hypothetical protein 0.0156 0.0474 0.2815
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0051 0.0095 0.5266
Echinococcus granulosus cpg binding protein 0.0031 0.0026 0.0006
Loa Loa (eye worm) hypothetical protein 0.01 0.0271 0.1596
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0187 0.0586 0.3486
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0302 0.1001 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0196 0.0617 0.6166

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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