Detailed information for compound 620790

Basic information

Technical information
  • TDR Targets ID: 620790
  • Name: 5-[(4-ethoxyphenyl)-[4-(2-fluorophenyl)pipera zin-1-yl]methyl]-2-methyl-[1,3]thiazolo[2,3-e ][1,2,4]triazol-6-ol
  • MW: 467.559 | Formula: C24H26FN5O2S
  • H donors: 1 H acceptors: 3 LogP: 4.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C(c1sc2n(c1O)nc(n2)C)N1CCN(CC1)c1ccccc1F
  • InChi: 1S/C24H26FN5O2S/c1-3-32-18-10-8-17(9-11-18)21(22-23(31)30-24(33-22)26-16(2)27-30)29-14-12-28(13-15-29)20-7-5-4-6-19(20)25/h4-11,21,31H,3,12-15H2,1-2H3
  • InChiKey: DUGQJKGBEYNLLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4-ethoxyphenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methyl]-2-methyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
  • 5-[(4-ethoxyphenyl)-[4-(2-fluorophenyl)-1-piperazinyl]methyl]-2-methyl-6-thiazolo[2,3-e][1,2,4]triazolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0357 0.1367
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0243 0.0285
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0042 0.0031
Mycobacterium ulcerans lipase LipD 0.0039 0.0577 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0445 0.0617
Trypanosoma cruzi ISWI complex protein 0.0016 0.0073 0.0579
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0577 0.2564
Echinococcus granulosus General substrate transporter 0.0092 0.1787 0.2238
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0445 0.0404
Schistosoma mansoni hypothetical protein 0.0016 0.0073 0.012
Mycobacterium tuberculosis Conserved protein 0.0039 0.0577 0.1017
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0575 0.0705
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0176 0.0641
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.093
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0444 0.1564
Echinococcus multilocularis musashi 0.0029 0.0357 0.0429
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0429 1
Brugia malayi beta-lactamase family protein 0.0039 0.0577 0.208
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0429 0.9253
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0022
Onchocerca volvulus 0.0039 0.0577 0.6203
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Schistosoma mansoni protein kinase 0.0033 0.0444 0.1564
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0577 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.025 0.0293
Schistosoma mansoni zinc finger protein 0.0016 0.0073 0.012
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0444 0.1701
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Leishmania major hypothetical protein, conserved 0.0016 0.0073 0.0579
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Onchocerca volvulus 0.0053 0.0904 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0053 0.0201
Trypanosoma brucei ISWI complex protein 0.0016 0.0073 0.0579
Schistosoma mansoni zinc finger protein 0.0021 0.0177 0.0525
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Brugia malayi Bromodomain containing protein 0.0041 0.0633 0.2298
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.3749
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0031
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0162
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2381 0.9116
Schistosoma mansoni hypothetical protein 0.0107 0.2128 0.8115
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Loa Loa (eye worm) hypothetical protein 0.0046 0.0739 0.2827
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.0521
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0904 0.3354
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.112
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0444 0.1927
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0445 0.0617
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0577 0.1017
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0243 0.1963
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0445 0.0404
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0042 0.0031
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0357 0.1367
Loa Loa (eye worm) beta-lactamase 0.0039 0.0577 0.2209
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0444 0.054
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Schistosoma mansoni lamin 0.0029 0.0357 0.1225
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0398 0.0481
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0116 0.0286
Loa Loa (eye worm) sugar transporter 0.0015 0.0042 0.0162
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0131 0.0501
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0243 0.5182
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0575 0.0705
Loa Loa (eye worm) sugar transporter 0.0107 0.2128 0.8146
Entamoeba histolytica protein kinase, putative 0.0033 0.0444 1
Mycobacterium leprae Probable lipase LipE 0.0039 0.0577 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0577 1
Brugia malayi beta-lactamase 0.0039 0.0577 0.208
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0577 0.2209
Trichomonas vaginalis esterase, putative 0.0039 0.0577 0.2564
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2381 0.9116
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0577 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0577 0.0708
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0031
Brugia malayi Sugar transporter family protein 0.0107 0.2128 0.8115
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0243 0.0961
Echinococcus granulosus zinc finger protein 0.0021 0.0177 0.0202
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1505
Schistosoma mansoni protein kinase 0.0033 0.0444 0.1564
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0445 0.0404
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.055 0.0779
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0116 0.0124
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0031
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.1505
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Loa Loa (eye worm) RNA binding protein 0.0128 0.2612 1
Leishmania major protein kinase, putative 0.0033 0.0444 0.7517
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.1153 0.1437
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7695
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0577 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0173 0.3622 0.3595
Echinococcus multilocularis General substrate transporter 0.0092 0.1787 0.2238
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0031
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0113 0.1313
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0042 0.0031
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0445 0.0404
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.078
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0068
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0577 0.1017
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0445 0.0617
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0243 0.0201
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0161 0.0226
Toxoplasma gondii ABC1 family protein 0.0039 0.0577 0.0821
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0577 0.208
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0577 0.208
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0577 0.2564
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0444 0.1564
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0053 0.004
Leishmania major glucose transporter, lmgt1 0.0033 0.0454 0.7695
Echinococcus multilocularis tar DNA binding protein 0.0128 0.2612 0.3283
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Onchocerca volvulus 0.0029 0.0357 0.3652
Schistosoma mansoni hypothetical protein 0.0022 0.0203 0.0625
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0577 0.2564
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.1643
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0243 0.0308
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7695
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.2128 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0116 0.0124
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Plasmodium falciparum proline--tRNA ligase 0.0037 0.055 0.051
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0577 0.2564
Echinococcus granulosus intermediate filament protein 0.0029 0.0357 0.0429
Brugia malayi intermediate filament protein 0.0029 0.0357 0.1225
Loa Loa (eye worm) hypothetical protein 0.0044 0.0692 0.265
Brugia malayi Bromodomain containing protein 0.0081 0.1525 0.5772
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0173 0.3622 0.5495
Echinococcus multilocularis tumor protein p63 0.0363 0.792 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.1421 0.5442
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0031
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Onchocerca volvulus 0.0029 0.0357 0.3652
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0577 0.208
Plasmodium falciparum hexose transporter 0.0107 0.2128 0.2094
Brugia malayi TAR-binding protein 0.0128 0.2612 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0173 0.3622 0.3595
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0357 0.1367
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0042 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0577 0.2564
Trypanosoma cruzi hexose transporter 0.0033 0.0454 0.7695
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1505
Loa Loa (eye worm) hypothetical protein 0.0053 0.0904 0.3462
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0445 0.0404
Schistosoma mansoni bromodomain containing protein 0.0068 0.124 0.4662
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7695
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.055 0.051
Echinococcus multilocularis lamin dm0 0.0029 0.0357 0.0429
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0203 0.0777
Mycobacterium tuberculosis Conserved protein 0.0039 0.0577 0.1017
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0243 0.0201
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0357 0.1225
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7695
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0577 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Brugia malayi beta-lactamase family protein 0.0039 0.0577 0.208
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0243 0.078
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0429 0.6445
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0577 0.1017
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0577 0.1017
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Mycobacterium ulcerans beta-lactamase 0.0039 0.0577 1
Echinococcus multilocularis lamin 0.0029 0.0357 0.0429
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0243 0.0285
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0116 0.0124
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0577 0.1017
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0444 0.7517
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.0521
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0444 0.1701
Schistosoma mansoni glucose transport protein 0.0107 0.2128 0.8115
Schistosoma mansoni lamin 0.0029 0.0357 0.1225
Schistosoma mansoni protein kinase 0.0033 0.0444 0.1564
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0454 0.7695
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.025 0.0293
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0243 0.5
Leishmania major glucose transporter, lmgt3 0.0033 0.0454 0.7695
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.025 0.0806
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.5296 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0116 0.0286
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0577 0.1017
Mycobacterium tuberculosis Conserved protein 0.0039 0.0577 0.1017
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0161 0.0226
Brugia malayi RNA binding protein 0.0128 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.1643
Trypanosoma brucei glucose transporter 1E 0.0033 0.0454 0.7695
Plasmodium vivax CDK-related protein kinase 6, putative 0.0454 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0345 0.1321
Schistosoma mansoni glucose transport protein 0.0107 0.2128 0.8115
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3749
Echinococcus multilocularis zinc finger protein 0.0021 0.0177 0.0202
Loa Loa (eye worm) TAR-binding protein 0.0128 0.2612 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0116 0.0286
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Schistosoma mansoni intermediate filament proteins 0.0029 0.0357 0.1225
Loa Loa (eye worm) hypothetical protein 0.0041 0.0634 0.2429
Brugia malayi MH2 domain containing protein 0.0118 0.2381 0.9102
Brugia malayi PHD-finger family protein 0.0027 0.0307 0.103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0444
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0031
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0116 0.0286
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Echinococcus granulosus tar DNA binding protein 0.0128 0.2612 0.3283
Onchocerca volvulus 0.0039 0.0577 0.6203
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Entamoeba histolytica protein kinase, putative 0.0033 0.0444 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0577 0.0708
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0022
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7695
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3749
Trypanosoma brucei glucose transporter 2A 0.0033 0.0454 0.7695
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.2128 0.3201
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0031
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0162
Trypanosoma cruzi ISWI complex protein 0.0016 0.0073 0.0579
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0445 0.0404
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Onchocerca volvulus 0.0039 0.0577 0.6203
Toxoplasma gondii protein kinase, putative 0.0303 0.6557 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.1153 0.1437
Leishmania major hypothetical protein, conserved 0.0039 0.0577 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.3749
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.2612 1
Brugia malayi Cam kinase protein 1 0.0033 0.0444 0.1564
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Mycobacterium ulcerans hypothetical protein 0.0039 0.0577 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.078
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.2128 0.267
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0398 0.0481
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0116 0.0124
Leishmania major glucose transporter, lmgt2 0.0033 0.0454 0.7695
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0577 0.1017
Echinococcus granulosus tumor protein p63 0.0363 0.792 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0042 0.5
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0577 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0445 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Echinococcus granulosus lamin 0.0029 0.0357 0.0429
Loa Loa (eye worm) hypothetical protein 0.0033 0.0444 0.1701
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.2612 1
Echinococcus granulosus lamin dm0 0.0029 0.0357 0.0429
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7695
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3749
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0577 1
Plasmodium falciparum protein kinase 7 0.0303 0.6557 0.6542
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Plasmodium vivax hexose transporter 0.0107 0.2128 0.2094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0429 0.1855
Schistosoma mansoni glucose transport protein 0.0107 0.2128 0.8115
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0445 0.0404
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.1505

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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