Detailed information for compound 620790

Basic information

Technical information
  • TDR Targets ID: 620790
  • Name: 5-[(4-ethoxyphenyl)-[4-(2-fluorophenyl)pipera zin-1-yl]methyl]-2-methyl-[1,3]thiazolo[2,3-e ][1,2,4]triazol-6-ol
  • MW: 467.559 | Formula: C24H26FN5O2S
  • H donors: 1 H acceptors: 3 LogP: 4.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C(c1sc2n(c1O)nc(n2)C)N1CCN(CC1)c1ccccc1F
  • InChi: 1S/C24H26FN5O2S/c1-3-32-18-10-8-17(9-11-18)21(22-23(31)30-24(33-22)26-16(2)27-30)29-14-12-28(13-15-29)20-7-5-4-6-19(20)25/h4-11,21,31H,3,12-15H2,1-2H3
  • InChiKey: DUGQJKGBEYNLLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4-ethoxyphenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methyl]-2-methyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
  • 5-[(4-ethoxyphenyl)-[4-(2-fluorophenyl)-1-piperazinyl]methyl]-2-methyl-6-thiazolo[2,3-e][1,2,4]triazolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tar DNA binding protein 0.0128 0.2612 0.3283
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.1505
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0577 0.208
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0444 0.1701
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7695
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0161 0.0226
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Brugia malayi PHD-finger family protein 0.0027 0.0307 0.103
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.2612 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0173 0.3622 0.3595
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0031
Loa Loa (eye worm) hypothetical protein 0.0044 0.0692 0.265
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.1153 0.1437
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0444 0.1564
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Echinococcus granulosus lamin dm0 0.0029 0.0357 0.0429
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0445 0.0404
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0577 0.1017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0444
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.1505
Onchocerca volvulus 0.0039 0.0577 0.6203
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0173 0.3622 0.3595
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0577 0.0708
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.112
Schistosoma mansoni glucose transport protein 0.0107 0.2128 0.8115
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0031
Brugia malayi Bromodomain containing protein 0.0081 0.1525 0.5772
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Echinococcus granulosus lamin 0.0029 0.0357 0.0429
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0904 0.3354
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0243 0.0285
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0042 0.0031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.1153 0.1437
Loa Loa (eye worm) hypothetical protein 0.0033 0.0444 0.1701
Plasmodium vivax hexose transporter 0.0107 0.2128 0.2094
Trypanosoma brucei ISWI complex protein 0.0016 0.0073 0.0579
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0577 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0031
Schistosoma mansoni hypothetical protein 0.0107 0.2128 0.8115
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0577 0.2564
Trypanosoma cruzi ISWI complex protein 0.0016 0.0073 0.0579
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0577 0.1017
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0243 0.0961
Toxoplasma gondii protein kinase, putative 0.0303 0.6557 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0177 0.0202
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0577 0.1017
Brugia malayi beta-lactamase family protein 0.0039 0.0577 0.208
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3749
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0113 0.1313
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Schistosoma mansoni protein kinase 0.0033 0.0444 0.1564
Loa Loa (eye worm) hypothetical protein 0.0029 0.0357 0.1367
Schistosoma mansoni zinc finger protein 0.0016 0.0073 0.012
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0445 0.0617
Leishmania major hypothetical protein, conserved 0.0039 0.0577 1
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0577 1
Leishmania major glucose transporter, lmgt3 0.0033 0.0454 0.7695
Mycobacterium ulcerans hypothetical protein 0.0039 0.0577 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0575 0.0705
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Schistosoma mansoni hypothetical protein 0.0016 0.0073 0.012
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0031
Brugia malayi beta-lactamase family protein 0.0039 0.0577 0.208
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Mycobacterium ulcerans beta-lactamase 0.0039 0.0577 1
Trypanosoma brucei glucose transporter 2A 0.0033 0.0454 0.7695
Brugia malayi Cam kinase protein 1 0.0033 0.0444 0.1564
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Schistosoma mansoni protein kinase 0.0033 0.0444 0.1564
Echinococcus multilocularis lamin 0.0029 0.0357 0.0429
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0577 1
Schistosoma mansoni glucose transport protein 0.0107 0.2128 0.8115
Echinococcus granulosus tar DNA binding protein 0.0128 0.2612 0.3283
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0454 0.7695
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0243 0.0201
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2381 0.9116
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0243 0.5182
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.5296 1
Toxoplasma gondii ABC1 family protein 0.0039 0.0577 0.0821
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7695
Onchocerca volvulus 0.0029 0.0357 0.3652
Loa Loa (eye worm) hypothetical protein 0.0053 0.0904 0.3462
Echinococcus multilocularis musashi 0.0029 0.0357 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0429 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0429 0.6445
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0031
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0445 0.0404
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0429 0.1855
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0577 0.0537
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0445 0.0404
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7695
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Echinococcus granulosus tumor protein p63 0.0363 0.792 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0575 0.0705
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.2128 0.3201
Plasmodium falciparum proline--tRNA ligase 0.0037 0.055 0.051
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.025 0.0293
Schistosoma mansoni zinc finger protein 0.0021 0.0177 0.0525
Schistosoma mansoni glucose transport protein 0.0107 0.2128 0.8115
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Entamoeba histolytica protein kinase, putative 0.0033 0.0444 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0577 0.2564
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0577 0.1017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0577 0.1017
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0445 0.0404
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.055 0.0779
Leishmania major hypothetical protein, conserved 0.0016 0.0073 0.0579
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0577 0.2564
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0429 0.9253
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Trypanosoma cruzi ISWI complex protein 0.0016 0.0073 0.0579
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.1643
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.078
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.2128 1
Trypanosoma brucei glucose transporter 1E 0.0033 0.0454 0.7695
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7695
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0116 0.0286
Onchocerca volvulus 0.0039 0.0577 0.6203
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.0521
Echinococcus granulosus solute carrier family 22 0.0015 0.0042 0.0031
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Loa Loa (eye worm) RNA binding protein 0.0128 0.2612 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0116 0.0124
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0131 0.0501
Plasmodium vivax CDK-related protein kinase 6, putative 0.0454 1 1
Schistosoma mansoni lamin 0.0029 0.0357 0.1225
Entamoeba histolytica protein kinase, putative 0.0033 0.0444 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0116 0.0124
Brugia malayi TAR-binding protein 0.0128 0.2612 1
Onchocerca volvulus 0.0029 0.0357 0.3652
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Loa Loa (eye worm) sugar transporter 0.0107 0.2128 0.8146
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0161 0.0226
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3749
Loa Loa (eye worm) hypothetical protein 0.0076 0.1421 0.5442
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0577 0.208
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.0521
Brugia malayi intermediate filament protein 0.0029 0.0357 0.1225
Leishmania major glucose transporter, lmgt1 0.0033 0.0454 0.7695
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0577 1
Echinococcus granulosus zinc finger protein 0.0021 0.0177 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0577 0.1017
Echinococcus granulosus intermediate filament protein 0.0029 0.0357 0.0429
Echinococcus multilocularis tumor protein p63 0.0363 0.792 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3749
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0357 0.1367
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0444 0.1927
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0068
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0444 0.054
Onchocerca volvulus 0.0039 0.0577 0.6203
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Trichomonas vaginalis esterase, putative 0.0039 0.0577 0.2564
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0243 0.0201
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2381 0.9116
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.3749
Echinococcus multilocularis solute carrier family 22 0.0015 0.0042 0.0031
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0053 0.0201
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0445 0.0404
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.093
Schistosoma mansoni lamin 0.0029 0.0357 0.1225
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0173 0.3622 0.5495
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0445 0.0404
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0445 0.0617
Schistosoma mansoni protein kinase 0.0033 0.0444 0.1564
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1505
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1505
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0116 0.0286
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0243 0.0308
Brugia malayi beta-lactamase 0.0039 0.0577 0.208
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0577 0.1017
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.025 0.0293
Echinococcus granulosus General substrate transporter 0.0092 0.1787 0.2238
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0577 0.208
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2612 1
Echinococcus multilocularis General substrate transporter 0.0092 0.1787 0.2238
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0042 0.0031
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0042 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Mycobacterium tuberculosis Conserved protein 0.0039 0.0577 0.1017
Onchocerca volvulus 0.0053 0.0904 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0634 0.2429
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7695
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0445 0.0404
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0243 0.0285
Mycobacterium leprae Probable lipase LipE 0.0039 0.0577 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0445 0.0404
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.3749
Mycobacterium ulcerans lipase LipD 0.0039 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0577 0.0708
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0116 0.0286
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7695
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0042 0.0031
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0053 0.004
Brugia malayi Sugar transporter family protein 0.0107 0.2128 0.8115
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0398 0.0481
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0398 0.0481
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0577 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0176 0.0641
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0357 0.1225
Brugia malayi MH2 domain containing protein 0.0118 0.2381 0.9102
Mycobacterium tuberculosis Conserved protein 0.0039 0.0577 0.1017
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0116 0.0124
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.078
Loa Loa (eye worm) hypothetical protein 0.0046 0.0739 0.2827
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0445 0.0404
Loa Loa (eye worm) sugar transporter 0.0015 0.0042 0.0162
Brugia malayi RNA binding protein 0.0128 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0444 0.7517
Plasmodium falciparum hexose transporter 0.0107 0.2128 0.2094
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0445 0.0617
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0116 0.0124
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0577 0.2564
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Brugia malayi Bromodomain containing protein 0.0041 0.0633 0.2298
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0243 0.078
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.2612 1
Plasmodium falciparum protein kinase 7 0.0303 0.6557 0.6542
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Loa Loa (eye worm) TAR-binding protein 0.0128 0.2612 1
Leishmania major protein kinase, putative 0.0033 0.0444 0.7517
Echinococcus multilocularis lamin dm0 0.0029 0.0357 0.0429
Schistosoma mansoni intermediate filament proteins 0.0029 0.0357 0.1225
Leishmania major glucose transporter, lmgt2 0.0033 0.0454 0.7695
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0444 0.054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0162
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0577 0.2564
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0357 0.1367
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.055 0.051
Trypanosoma cruzi hexose transporter 0.0033 0.0454 0.7695
Schistosoma mansoni hypothetical protein 0.0022 0.0203 0.0625
Loa Loa (eye worm) hypothetical protein 0.0028 0.0345 0.1321
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.2209
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0116 0.0286
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0577 0.2209
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0203 0.0777
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0042 0.0031
Loa Loa (eye worm) beta-lactamase 0.0039 0.0577 0.2209
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0577 0.1017
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.9492
Schistosoma mansoni bromodomain containing protein 0.0068 0.124 0.4662
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0243 0.1963
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7695
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0243 0.5
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2128 0.267
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0444 0.1701
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.025 0.0806
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0444 0.1564
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.1643
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.2128 0.267
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0162

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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