TDR Targets

Basic information

Technical information

TDR Targets ID: 622148
Name: 4-chloro-N-[2-(2-methylphenyl)-5,5-dioxo-4,6- dihydrothieno[3,4-d]pyrazol-3-yl]benzamide
MW: 401.867 | Formula: C19H16ClN3O3S
H donors: 1 H acceptors: 4 LogP: 2.83 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C(=O)Nc1c2CS(=O)(=O)Cc2nn1c1ccccc1C
InChi: 1S/C19H16ClN3O3S/c1-12-4-2-3-5-17(12)23-18(15-10-27(25,26)11-16(15)22-23)21-19(24)13-6-8-14(20)9-7-13/h2-9H,10-11H2,1H3,(H,21,24)
InChiKey: OBQIQUKWWSXWOF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-chloro-N-[5,5-diketo-2-(2-methylphenyl)-4,6-dihydrothieno[3,4-d]pyrazol-3-yl]benzamide
Oprea1_826260

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0397	0.0749	0.2164
Giardia lamblia	Phosphatidylinositol 4-kinase	0.007	0.0092	0.0876
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0066	0.0425
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0006	0.0038
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0035	0.0473
Leishmania major	hypothetical protein, unknown function	0.007	0.0092	0.0254
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.007	0.0092	0.1264
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0088	0.0128	0.8659
Loa Loa (eye worm)	TAR-binding protein	0.0128	0.0207	0.1332
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.007	0.0092	0.0264
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0066	0.0425
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.007	0.0092	1
Loa Loa (eye worm)	hypothetical protein	0.0206	0.0364	0.2342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0749	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.007	0.0092	0.1221
Entamoeba histolytica	hypothetical protein	0.0206	0.0364	0.4653
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.007	0.0092	0.1221
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0051	0.0327
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0364	0.0683	0.0683
Trichomonas vaginalis	PIKK family atypical protein kinase	0.008	0.0112	0.1491
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.008	0.0516
Entamoeba histolytica	hypothetical protein	0.007	0.0092	0.0876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0364	0.0683	0.9119
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.0207	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0364	0.0683	0.9119
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.007	0.0092	0.0092
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0397	0.0749	0.4824
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.0188	0.1212
Loa Loa (eye worm)	phosphatidylinositol 3	0.0397	0.0749	0.4824
Loa Loa (eye worm)	hypothetical protein	0.01	0.0152	0.0976
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.007	0.0092	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0724	0.966
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0364	0.0683	0.1974
Brugia malayi	jmjC domain containing protein	0.0057	0.0066	0.0425
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.007	0.0092	0.0876
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0019	0.0123
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.4997	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.007	0.0092	0.1221
Brugia malayi	RNA binding protein	0.0128	0.0207	0.1332
Schistosoma mansoni	hypothetical protein	0.0034	0.0019	0.0123
Trypanosoma cruzi	hypothetical protein, conserved	0.1747	0.3463	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.008	0.0516
Echinococcus granulosus	tumor protein p63	0.0684	0.1325	0.1325
Loa Loa (eye worm)	hypothetical protein	0.005	0.0051	0.0327
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0364	0.0683	0.1896
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.0207	0.1332
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.007	0.0092	0.0876
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0364	0.0683	0.4399
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0051	0.0327
Mycobacterium tuberculosis	Conserved hypothetical protein	0.007	0.0092	0.6199
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.007	0.0092	0.0092
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.007	0.0092	0.1221
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.007	0.0092	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0385	0.0724	1
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0026	0.0026
Onchocerca volvulus		0.007	0.0092	0.6032
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.007	0.0092	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0375	0.0704	0.939
Onchocerca volvulus		0.01	0.0152	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0364	0.0683	0.9119
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0066	0.0066
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0206	0.0364	0.4653
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0028	0.0081
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.007	0.0092	0.1264
Mycobacterium tuberculosis	Probable dehydrogenase	0.0088	0.0128	0.8659
Loa Loa (eye worm)	subtilase	0.0797	0.1554	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.007	0.0092	0.1221
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.0188	0.1212
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.007	0.0092	0.0092
Loa Loa (eye worm)	phosphatidylinositol 3	0.007	0.0092	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0226	0.0404	0.5396
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.007	0.0092	0.0589
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.008	0.0222
Loa Loa (eye worm)	RNA binding protein	0.0128	0.0207	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0375	0.0704	0.939
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0088	0.0128	0.8659
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0397	0.0749	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0051	0.0327
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.007	0.0092	0.0589
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.007	0.0092	0.0264
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0377	0.0709	0.9459
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.007	0.0092	0.0589
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0397	0.0749	1
Brugia malayi	intermediate filament protein	0.0028	0.0006	0.0038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0375	0.0704	0.9389
Schistosoma mansoni	lamin	0.0028	0.0006	0.0038
Loa Loa (eye worm)	phosphatidylinositol kinase	0.007	0.0092	0.0589
Echinococcus multilocularis	serine protein kinase ATM	0.0206	0.0364	0.0364
Echinococcus multilocularis	lamin	0.0028	0.0006	0.0006
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0364	0.0683	0.9119
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0005	0.0031
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.0239	0.0239
Mycobacterium tuberculosis	Probable reductase	0.0088	0.0128	0.8659
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0387	0.0729	0.9729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0206	0.0364	0.4855
Brugia malayi	TAR-binding protein	0.0128	0.0207	0.1332
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.007	0.0092	0.0264
Echinococcus multilocularis	tar DNA binding protein	0.0128	0.0207	0.0207
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.007	0.0092	0.0876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0226	0.0404	0.5396
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0035	0.0473
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.007	0.0092	0.1264
Brugia malayi	glutathione reductase	0.0039	0.0028	0.0182
Entamoeba histolytica	hypothetical protein	0.007	0.0092	0.0876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0092	0.1221
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.008	0.0231
Loa Loa (eye worm)	phosphatidylinositol 3	0.007	0.0092	0.0589
Schistosoma mansoni	lamin	0.0028	0.0006	0.0038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0238	0.043	0.5736
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0206	0.0364	0.2342
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.007	0.0092	0.0092
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.0207	0.1332
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0397	0.0749	0.0749
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0298	0.0551	0.0551
Entamoeba histolytica	hypothetical protein	0.007	0.0092	0.0876
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0223	0.1434
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.007	0.0092	0.1221
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.007	0.0092	0.0092
Echinococcus granulosus	intermediate filament protein	0.0028	0.0006	0.0006
Plasmodium vivax	hypothetical protein	0.007	0.0092	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.0239	0.154
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.008	0.0516
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.008	0.1069
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.007	0.0092	0.1221
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0387	0.0729	0.9729
Giardia lamblia	Hypothetical protein	0.007	0.0092	0.0876
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0088	0.0128	0.8659
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.007	0.0092	0.0589
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0028	0.0182
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.007	0.0092	0.1221
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0387	0.0729	0.9729
Trypanosoma cruzi	target of rapamycin kinase 3	0.0387	0.0729	0.2106
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0066	0.0066
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.007	0.0092	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0387	0.0729	0.9729
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.007	0.0092	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0724	0.966
Leishmania major	phosphatidylinositol 3-kinase, putative	0.007	0.0092	0.0254
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0206	0.0364	0.2342
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.007	0.0092	0.0589
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0397	0.0749	0.4824
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.007	0.0092	0.0589
Loa Loa (eye worm)	phosphatidylinositol 3	0.007	0.0092	0.0589
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0135	0.0223	0.0644
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.007	0.0092	0.0589
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0229	0.0411	0.5678
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0035	0.0035
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0006	0.0038
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0298	0.0551	0.0551
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.007	0.0092	0.0589
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0206	0.0364	0.1051
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0029	0.0029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0135	0.0223	0.2973
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0206	0.0364	0.0364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0724	0.966
Echinococcus granulosus	serine protein kinase ATM	0.0206	0.0364	0.0364
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.007	0.0092	0.1221
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0375	0.0704	0.9389
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.007	0.0092	0.1221
Loa Loa (eye worm)	hypothetical protein	0.0159	0.027	0.1738
Brugia malayi	RNA recognition motif domain containing protein	0.0128	0.0207	0.1332
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.007	0.0092	0.0876
Schistosoma mansoni	cellular tumor antigen P53	0.01	0.0152	0.0976
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.007	0.0092	0.0092
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0724	0.966
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.007	0.0092	0.0589
Onchocerca volvulus		0.0028	0.0006	0.0389
Leishmania major	phosphatidylinositol 4-kinase, putative	0.007	0.0092	0.0254
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0387	0.0729	0.9729
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.007	0.0092	0.0589
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0397	0.0749	0.2164
Toxoplasma gondii	FATC domain-containing protein	0.0206	0.0364	0.5026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0377	0.0709	0.9459
Loa Loa (eye worm)	acetyltransferase	0.0144	0.0239	0.154
Brugia malayi	MH2 domain containing protein	0.0118	0.0188	0.1212
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.007	0.0092	0.0589
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.0231	0.0231
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0066	0.0425
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.007	0.0092	0.0876
Plasmodium vivax	hypothetical protein, conserved	0.007	0.0092	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.007	0.0092	0.0589
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0206	0.0364	0.0364
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0028	0.3084
Plasmodium falciparum	glutathione reductase	0.0039	0.0028	0.3084
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.007	0.0092	0.0092
Leishmania major	phosphatidylinositol kinase, putative	0.007	0.0092	0.0254
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0364	0.0683	0.1896
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0025	0	0.5
Entamoeba histolytica	protein kinase rad3, putative	0.0206	0.0364	0.4653
Brugia malayi	Subtilase family protein	0.0797	0.1554	1
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.007	0.0092	0.0092
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0226	0.0404	0.5396
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.008	0.0231
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0206	0.0364	0.4855
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.007	0.0092	0.0876
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0364	0.0683	0.4399
Loa Loa (eye worm)	phosphatidylinositol 3	0.0364	0.0683	0.4399
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0252	0.0457	0.6095
Loa Loa (eye worm)	hypothetical protein	0.007	0.0092	0.0589
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.007	0.0092	0.0876
Brugia malayi	jmjC domain containing protein	0.0057	0.0066	0.0425
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.0207	0.1332
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.007	0.0092	0.0254
Loa Loa (eye worm)	hypothetical protein	0.007	0.0092	0.0589
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0028	0.039
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0098	0.0148	1
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0028	0.3084
Trichomonas vaginalis	conserved hypothetical protein	0.0229	0.0411	0.5485
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0028	0.1912
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.007	0.0092	0.1221
Leishmania major	trypanothione reductase	0.0039	0.0028	0.0078
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0128	0.0207	0.1332
Entamoeba histolytica	hypothetical protein	0.007	0.0092	0.0876
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0239	0.0431	0.5756
Schistosoma mansoni	hypothetical protein	0.0159	0.027	0.1738
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0206	0.0364	0.2342
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.007	0.0092	0.0264
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0035	0.0489
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0364	0.0683	0.0683
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0028	0.0182
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0724	0.966
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.007	0.0092	0.1221
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0206	0.0364	0.4855
Giardia lamblia	GTOR	0.0397	0.0749	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.007	0.0092	0.0264
Brugia malayi	FAT domain containing protein	0.0159	0.027	0.1738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0724	0.966
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0387	0.0729	0.2023
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0411	0.2646
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0006	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0135	0.0223	0.2973
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0092	0.1221
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0025	0	0.5
Echinococcus multilocularis		0.007	0.0092	0.0092
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0397	0.0749	0.0749
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.007	0.0092	0.0589
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.007	0.0092	0.0876
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.007	0.0092	0.1221
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.007	0.0092	0.1221
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0088	0.0128	0.8659
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0797	0.1554	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0364	0.0683	0.9119
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0088	0.0128	0.8659
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0159	0.027	0.027
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0035	0.3871
Echinococcus multilocularis	tumor protein p63	0.0684	0.1325	0.1325
Trypanosoma brucei	trypanothione reductase	0.0039	0.0028	0.0377
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.007	0.0092	0.1221
Schistosoma mansoni	hypothetical protein	0.007	0.0092	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0206	0.0364	0.4855
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.007	0.0092	0.1264
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.007	0.0092	0.1264
Onchocerca volvulus		0.0028	0.0006	0.0389
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0364	0.0683	0.9119
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0035	0.0489
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.007	0.0092	0.0876
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.007	0.0092	0.0264
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0025	0	0.5
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.007	0.0092	0.0264
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.007	0.0092	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.0239	0.154
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.007	0.0092	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0028	0.3098
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.007	0.0092	0.0092
Loa Loa (eye worm)	phosphatidylinositol 3	0.007	0.0092	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0123
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0026	0.0026
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.007	0.0092	0.0092
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0028	0.3084
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0364	0.0683	0.1974
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0749	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0098	0.0148	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0159	0.027	0.027
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0029	0.0029
Leishmania major	hypothetical protein, conserved	0.1817	0.3604	1
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.007	0.0092	0.0876
Echinococcus granulosus	lysine specific demethylase 5A	0.0057	0.0066	0.0066
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0098	0.0148	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0364	0.0683	0.9119
Mycobacterium leprae	conserved hypothetical protein	0.007	0.0092	0.6199
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.008	0.008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0375	0.0704	0.939
Echinococcus multilocularis	Zinc finger, PHD finger	0.007	0.0092	0.0092
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0397	0.0749	1
Echinococcus multilocularis	lamin dm0	0.0028	0.0006	0.0006
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.007	0.0092	0.0092
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.007	0.0092	0.0264
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.027	0.3604
Onchocerca volvulus		0.007	0.0092	0.6032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0228	0.041	0.5465
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0397	0.0749	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.007	0.0092	0.1221
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.009	0.0132	0.1762
Echinococcus multilocularis	musashi	0.0028	0.0006	0.0006
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0206	0.0364	0.1051
Mycobacterium tuberculosis	Probable oxidoreductase	0.0098	0.0148	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0375	0.0704	0.9389
Echinococcus granulosus	lamin	0.0028	0.0006	0.0006
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.007	0.0092	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0724	0.966
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0375	0.0704	0.939
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0066	0.0425
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.008	0.0718
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0206	0.0364	0.2342
Leishmania major	phosphatidylinositol kinase related protein, putative	0.007	0.0092	0.0254
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0397	0.0749	0.208
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.007	0.0092	0.0589
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.007	0.0092	0.0264
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0387	0.0729	0.973
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0749	1
Brugia malayi	Thioredoxin reductase	0.0039	0.0028	0.0182
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.008	0.008
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.007	0.0092	0.1221
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.007	0.0092	0.0092
Echinococcus granulosus	tar DNA binding protein	0.0128	0.0207	0.0207
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.0207	0.1332
Echinococcus granulosus	lamin dm0	0.0028	0.0006	0.0006
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.007	0.0092	0.0264
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0397	0.0749	0.208
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0006	0.0038

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 622148