Detailed information for compound 623654

Basic information

Technical information
  • TDR Targets ID: 623654
  • Name: ethyl 2-[[4-amino-5-[(3,4-dimethoxybenzoyl)am ino]-6-oxo-3H-pyrimidin-2-yl]sulfanyl]acetate
  • MW: 408.429 | Formula: C17H20N4O6S
  • H donors: 3 H acceptors: 5 LogP: 1.74 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CSc1nc(N)c(c(n1)O)NC(=O)c1ccc(c(c1)OC)OC
  • InChi: 1S/C17H20N4O6S/c1-4-27-12(22)8-28-17-20-14(18)13(16(24)21-17)19-15(23)9-5-6-10(25-2)11(7-9)26-3/h5-7H,4,8H2,1-3H3,(H,19,23)(H3,18,20,21,24)
  • InChiKey: MJUQFBFNXIISBW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[[4-amino-5-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-6-oxo-3H-pyrimidin-2-yl]thio]acetic acid ethyl ester
  • 2-[[4-amino-5-[(3,4-dimethoxybenzoyl)amino]-6-keto-3H-pyrimidin-2-yl]thio]acetic acid ethyl ester
  • ethyl 2-[[4-amino-5-[(3,4-dimethoxyphenyl)carbonylamino]-6-oxo-3H-pyrimidin-2-yl]sulfanyl]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0095 0.0142
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0191 0.0252
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0988 0.284
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0312 0.055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0095 0.0089
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.06 0.7532
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0095 0.0089
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0195 0.015
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0591 0.1498
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0393 0.0315
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0195 0.2496
Onchocerca volvulus 0.0014 0.0195 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.06 0.0631
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0393 0.0956
Schistosoma mansoni hypothetical protein 0.0035 0.0674 0.1726
Onchocerca volvulus 0.0014 0.0195 0.0268
Loa Loa (eye worm) sugar transporter 0.0102 0.2249 0.377
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0393 0.502
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0393 0.0909
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0988 0.2764
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0576 0.1458
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0591 0.0624
Brugia malayi nuclear receptor NHR-88 0.001 0.0095 0.0089
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0095 0.0142
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0584 0.148
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0095 0.0142
Schistosoma mansoni nuclear hormone receptor 0.001 0.0095 0.0142
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0195 0.2496
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0195 0.0007
Schistosoma mansoni hypothetical protein 0.0067 0.1425 0.3782
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0191 0.0151
Plasmodium falciparum protein kinase 7 0.0289 0.661 0.6594
Trypanosoma brucei glucose transporter, putative 0.0032 0.06 0.7532
Schistosoma mansoni protein kinase 0.0031 0.0591 0.1498
Loa Loa (eye worm) hypothetical protein 0.0031 0.0591 0.0936
Schistosoma mansoni hypothetical protein 0.0164 0.3697 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0393 0.0909
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2249 0.6036
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0782 0.2021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0782 0.2021
Brugia malayi ecdysteroid receptor 0.001 0.0095 0.0089
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0695 0.0652
Trypanosoma brucei sugar transporter, putative 0.0014 0.0195 0.203
Onchocerca volvulus 0.0014 0.0191 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.3818 0.5583
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0095 0.0142
Toxoplasma gondii exonuclease III APE 0.002 0.0328 0.0215
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0576 0.1458
Trichomonas vaginalis sugar transporter, putative 0.0032 0.06 0.0631
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni glucose transport protein 0.0102 0.2249 0.6036
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2563 0.4307
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0393 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Leishmania major glucose transporter, lmgt2 0.0032 0.06 0.6077
Schistosoma mansoni ap endonuclease 0.002 0.0328 0.078
Loa Loa (eye worm) hypothetical protein 0.001 0.0095 0.0089
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0008 0.0046 0.0006
Loa Loa (eye worm) hypothetical protein 0.0067 0.1425 0.2362
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0591 0.0548
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0393 0.0956
Trypanosoma brucei glucose transporter 2A 0.0032 0.06 0.7532
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0191 0.0253
Trypanosoma brucei glucose transporter, putative 0.0032 0.06 0.7532
Schistosoma mansoni glucose transporter 0.0014 0.0195 0.0415
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2563 0.4307
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.5893 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0195 0.0166
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0782 0.2021
Trypanosoma brucei glucose transporter 1E 0.0032 0.06 0.7532
Loa Loa (eye worm) hypothetical protein 0.0131 0.2916 0.4911
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Echinococcus multilocularis dna repair and recombination protein rad54 0.0008 0.0046 0.0006
Loa Loa (eye worm) sugar transporter 0.0014 0.0195 0.0259
Onchocerca volvulus Putative transporter 0.0014 0.0195 0.0268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni protein kinase 0.0031 0.0591 0.1498
Trypanosoma brucei glucose transporter, putative 0.0032 0.06 0.7532
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0328 0.0284
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0546 0.1375
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0095 0.0142
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0191 0.0151
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0095 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0191 0.0253
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.3195 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.6688 0.8338
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.0008 0.0046 0.0006
Loa Loa (eye worm) hypothetical protein 0.0048 0.0988 0.1614
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0988 0.284
Onchocerca volvulus 0.0014 0.0195 0.0268
Onchocerca volvulus 0.0014 0.0195 0.0268
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.3818 0.5583
Schistosoma mansoni glucose transport protein 0.0102 0.2249 0.6036
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0782 0.2021
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0191 0.0403
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0591 0.0548
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.1127
Echinococcus multilocularis solute carrier family 22 0.0014 0.0195 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.3818 0.5583
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0988 0.2653
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.5893 0.8777
Onchocerca volvulus 0.0014 0.0195 0.0268
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2249 0.6036
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0782 0.091
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2249 0.6036
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0702 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Brugia malayi steroid hormone receptor 0.001 0.0095 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0095 0.0142
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.372 0.3691
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0393 0.0956
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0591 0.0616
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0191 0.1967
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0393 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Brugia malayi hypothetical protein 0.0131 0.2916 0.4911
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2249 0.6036
Onchocerca volvulus Huntingtin homolog 0.0131 0.2916 0.7577
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.6688 0.837
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0347 0.7981 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0191 0.0252
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0591 0.1498
Echinococcus granulosus SPRY domain containing protein 0.0008 0.0046 0.0006
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0195 0.0007
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0191 0.2437
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0099 0.217 0.2677
Leishmania major protein kinase, putative 0.0031 0.0591 0.5982
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0656 0.1678
Loa Loa (eye worm) hypothetical protein 0.001 0.0095 0.0089
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0576 0.0668
Schistosoma mansoni thyroid hormone receptor 0.001 0.0095 0.0142
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.215 0.3601
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0591 0.0548
Schistosoma mansoni hypothetical protein 0.0102 0.2249 0.6036
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0591 0.7404
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0095 0.0142
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0695 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0195 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0095 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0008 0.0046 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0656 0.1678
Toxoplasma gondii sugar transporter ST3 0.0014 0.0195 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0988 0.1614
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0782 0.2021
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0095 0.0142
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.1127
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.3818 0.5583
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0591 0.0548
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0988 0.1614
Echinococcus granulosus solute carrier family 22 0.0014 0.0195 0.0415
Loa Loa (eye worm) hypothetical protein 0.0048 0.0988 0.1614
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0584 0.0924
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0328 0.3841
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.4031 0.5911
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0195 0.2496
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0584 0.148
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0782 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0195 0.0415
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0191 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Brugia malayi MH2 domain containing protein 0.0116 0.2563 0.4307
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0095 0.0142
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0328 0.0356
Schistosoma mansoni glucose transport protein 0.0102 0.2249 0.6036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0095 0.0089
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0782 0.2021
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0195 0.0259
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0584 0.148
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0095 0.0142
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0191 0.0252
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0191 0.2437
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0191 0.0253
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0782 0.0928
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0988 0.1187
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0195 0.0415
Plasmodium falciparum hexose transporter 0.0102 0.2249 0.2213
Onchocerca volvulus 0.0014 0.0195 0.0268
Schistosoma mansoni hypothetical protein 0.0031 0.0584 0.148
Echinococcus granulosus FTZ F1 alpha 0.001 0.0095 0.0142
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0591 0.0548
Entamoeba histolytica protein kinase, putative 0.0031 0.0591 0.0687
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.3818 1
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0191 0.1929
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0195 0.0259
Echinococcus multilocularis dna repair and recombination protein rad54 0.0008 0.0046 0.0006
Loa Loa (eye worm) type III restriction enzyme 0.0008 0.0046 0.0004
Echinococcus granulosus solute carrier family 22 0.0014 0.0195 0.0415
Mycobacterium ulcerans hypothetical protein 0.0048 0.0988 0.284
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6688 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0191 0.0253
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0328 0.0171
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0584 0.148
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0576 0.091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6688 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0095 0.0089
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0191 0.0151
Loa Loa (eye worm) hypothetical protein 0.0014 0.0191 0.0252
Onchocerca volvulus 0.0014 0.0195 0.0268
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0191 0.0151
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0191 0.0252
Entamoeba histolytica protein kinase, putative 0.0031 0.0591 0.0687
Trypanosoma brucei glucose transporter, putative 0.0032 0.06 0.7532
Onchocerca volvulus 0.0014 0.0195 0.0268
Loa Loa (eye worm) hypothetical protein 0.001 0.0095 0.0089
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0191 0.2437
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0191 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0032 0.06 0.0631
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0008 0.0046 0.0585
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2249 0.6036
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0576 0.091
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0191 0.0253
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1425 0.2362
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0988 0.284
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0988 1
Schistosoma mansoni hypothetical protein 0.0164 0.3697 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0195 0.0415
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0576 0.1283
Onchocerca volvulus 0.0014 0.0191 0.0256
Entamoeba histolytica hypothetical protein 0.0035 0.0674 0.0792
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.5893 0.8777
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0328 0.0284
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0702 0.066
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0095 0.0089
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0312 0.055
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.372 0.3691
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0095 0.0142
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0702 0.1829
Echinococcus multilocularis solute carrier family 22 0.0014 0.0195 0.0415
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0328 0.078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0095 0.0089
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0195 0.1976
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0988 0.284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0095 0.0089
Echinococcus multilocularis GPCR, family 2 0.0031 0.0584 0.148
Schistosoma mansoni hypothetical protein 0.0031 0.0584 0.148
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0191 0.0253
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.5893 0.8777
Entamoeba histolytica hypothetical protein 0.0035 0.0674 0.0792
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0782 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0656 0.1678
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0095 0.0089
Trypanosoma cruzi hexose transporter, putative 0.0032 0.06 0.7676
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.4031 0.5911
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0656 0.1678
Brugia malayi hypothetical protein 0.0014 0.0195 0.0259
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0095 0.0142
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0328 1
Entamoeba histolytica hypothetical protein 0.0099 0.217 0.2677
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.3818 0.5583
Giardia lamblia DNA repair protein RAD52 0.0347 0.7981 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0591 0.0936
Loa Loa (eye worm) hypothetical protein 0.0025 0.0442 0.0681
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Echinococcus granulosus geminin 0.0164 0.3697 1
Echinococcus multilocularis 0.0008 0.0046 0.0006
Brugia malayi nuclear hormone receptor 0.001 0.0095 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0095 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0095 0.0089
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0327 0.021
Leishmania major glucose transporter, lmgt3 0.0032 0.06 0.6077
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0191 0.0151
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0095 0.0142
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0095 0.0089
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0191 0.2437
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0095 0.0142
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0695 0.7035
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0782 0.0754
Brugia malayi recombination factor GdRad54 0.0008 0.0046 0.0004
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0191 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0988 0.1614
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0695 0.0786
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0782 0.1262
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0195 0.0007
Brugia malayi major facilitator superfamily protein 0.0014 0.0195 0.0259
Echinococcus multilocularis dna repair and recombination protein rad54 0.0008 0.0046 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0988 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.1127
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.3195 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Toxoplasma gondii sugar transporter ST2 0.0014 0.0195 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0095 0.0089
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0095 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0095 0.0142
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0191 0.0151
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0584 0.0924
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0674 0.1726
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0674 0.1726
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0191 0.0252
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0195 0.0259
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0576 0.0489
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Onchocerca volvulus 0.0048 0.0988 0.2397
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0008 0.0046 0.0585
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0095 0.0089
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0988 0.1614
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0095 0.0089
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0576 0.1458
Toxoplasma gondii sugar transporter ST1 0.0014 0.0195 0.0007
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0195 0.0268
Schistosoma mansoni ap endonuclease 0.002 0.0328 0.078
Schistosoma mansoni coup transcription factor 0.001 0.0095 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0584 0.0924
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0782 0.2021
Echinococcus granulosus SPRY domain containing protein 0.0008 0.0046 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0576 0.091
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2249 0.6036
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0264 0.338
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0328 0.0212
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0191 0.0253
Brugia malayi Cam kinase protein 1 0.0031 0.0591 0.0936
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0393 0.0597
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0095 0.0142
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0328 0.0329
Loa Loa (eye worm) hypothetical protein 0.0014 0.0191 0.0252
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0591 0.1498
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni sugar transporter 0.0014 0.0195 0.0415
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0095 0.0089
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0393 0.3974
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0095 0.0142
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0695 0.8817
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0393 0.0672
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0695 0.8886
Brugia malayi hypothetical protein 0.0035 0.0674 0.1078
Brugia malayi Sugar transporter family protein 0.0014 0.0195 0.0259
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0591 0.1498
Brugia malayi Sugar transporter family protein 0.0102 0.2249 0.377
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0195 0.0268
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0782 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0576 0.091
Leishmania major DNA repair and recombination protein RAD54, putative 0.0008 0.0046 0.0463
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.3195 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0328 0.0487
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.5893 0.8777
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.5893 0.8777
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0191 0.0253
Onchocerca volvulus 0.0014 0.0195 0.0268
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0191 0.1929
Loa Loa (eye worm) hypothetical protein 0.0039 0.0782 0.1262
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0782 0.091
Echinococcus granulosus SPRY domain containing protein 0.0008 0.0046 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0328 0.4201
Trichomonas vaginalis sugar transporter, putative 0.0032 0.06 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0195 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0393 0.0597
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0988 0.284
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0095 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0095 0.0089
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0782 0.7917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0095 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0988 0.2764
Echinococcus multilocularis General substrate transporter 0.0088 0.1913 0.5116
Trichomonas vaginalis glucose transporter, putative 0.0032 0.06 0.0631
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0095 0.0142
Brugia malayi Sugar transporter family protein 0.0014 0.0195 0.0259
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0576 0.1458
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0328 0.0212
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0988 0.1187
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0095 0.0142
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0191 0.1929
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0191 0.0403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6688 1
Onchocerca volvulus 0.0014 0.0191 0.0256
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0008 0.0046 0.0004
Entamoeba histolytica hypothetical protein 0.0023 0.0393 0.0437
Brugia malayi hypothetical protein 0.0014 0.0195 0.0259
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0328 0.078
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0584 0.0924
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.3818 0.5583
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0191 0.0151
Echinococcus granulosus dna repair and recombination protein rad54 0.0008 0.0046 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Trypanosoma cruzi hexose transporter, putative 0.0032 0.06 0.7676
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0191 0.0183
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0393 0.0348
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0095 0.0142
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0191 0.0253
Echinococcus granulosus solute carrier family 22 0.0014 0.0195 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.5893 0.8777
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.6688 0.837
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2249 0.3206
Echinococcus multilocularis geminin 0.0164 0.3697 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0191 0.0253
Brugia malayi major facilitator superfamily protein 0.0014 0.0195 0.0259
Onchocerca volvulus 0.0014 0.0195 0.0268
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0195 0.0007
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0195 0.0415
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0591 0.1498
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Loa Loa (eye worm) hypothetical protein 0.001 0.0095 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6688 1
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2249 0.3167
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0782 0.2021
Schistosoma mansoni hypothetical protein 0.0031 0.0584 0.148
Schistosoma mansoni sugar transporter 0.0014 0.0195 0.0415
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0674 0.1726
Echinococcus multilocularis SPRY domain containing protein 0.0008 0.0046 0.0006
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0312 0.0405
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0191 0.0253
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0702 0.1914
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6688 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0191 0.0253
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0393 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0095 0.0089
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0988 0.284
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0195 0.0268
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2249 0.6036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0095 0.0089
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0988 0.1187
Onchocerca volvulus 0.0014 0.0195 0.0268
Trypanosoma cruzi hexose transporter 0.0032 0.06 0.7676
Echinococcus multilocularis 0.0008 0.0046 0.0006
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0591 0.0548
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0988 0.284
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0195 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0328 0.0487
Trypanosoma cruzi hexose transporter, putative 0.0032 0.06 0.7676
Trichomonas vaginalis glucose transporter, putative 0.0032 0.06 0.0631
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0191 0.1967
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0591 0.0624
Schistosoma mansoni protein kinase 0.0031 0.0591 0.1498
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0195 0.0259
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0195 0.0259
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0191 0.0252
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.1127
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.06 0.0631
Onchocerca volvulus Huntingtin homolog 0.0131 0.2916 0.7577
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0591 0.1498
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0591 0.1498
Entamoeba histolytica hypothetical protein 0.0035 0.0674 0.0792
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0191 0.0253
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2249 0.6036
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.06 0.6077
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0591 0.0548
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.5893 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0591 0.1498
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6688 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0591 0.0624
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0328 0.0603
Schistosoma mansoni thyroid hormone receptor 0.001 0.0095 0.0142
Plasmodium vivax CDK-related protein kinase 6, putative 0.0434 1 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.06 0.7532
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0195 0.0007
Schistosoma mansoni sugar transporter 0.0014 0.0195 0.0415
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0702 0.066
Onchocerca volvulus 0.0014 0.0195 0.0268
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0546 0.1375
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0393 0.4748
Loa Loa (eye worm) oxidoreductase 0.0014 0.0191 0.0252
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0195 0.0415
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0591 0.0936
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0695 0.8886
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0591 0.0548
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0191 0.0151
Schistosoma mansoni hypothetical protein 0.0031 0.0584 0.148
Plasmodium vivax sugar transporter, putative 0.0014 0.0195 0.015
Trypanosoma brucei glucose transporter, putative 0.0032 0.06 0.7532
Loa Loa (eye worm) hypothetical protein 0.0014 0.0195 0.0259
Onchocerca volvulus 0.0014 0.0195 0.0268
Toxoplasma gondii protein kinase, putative 0.0289 0.661 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.06 0.7532
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0095 0.0142
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0591 0.0548
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0095 0.0089
Echinococcus granulosus General substrate transporter 0.0088 0.1913 0.5116
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0195 0.203
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0328 0.3326
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0095 0.0089
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0591 0.1498
Loa Loa (eye worm) hypothetical protein 0.0131 0.2916 0.4911
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.6688 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0095 0.0142
Leishmania major glucose transporter, lmgt1 0.0032 0.06 0.6077
Leishmania major hypothetical protein, conserved 0.0014 0.0195 0.1976
Loa Loa (eye worm) hypothetical protein 0.0098 0.215 0.3601
Loa Loa (eye worm) hypothetical protein 0.001 0.0095 0.0089
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0393 0.4711
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.1127
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.215 0.3601
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0191 0.0145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0328 0.4201
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0153 0.0188
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0328 0.0701
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0195 0.0415
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0095 0.0142
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0191 0.0151
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.372 0.5498
Plasmodium vivax hexose transporter 0.0102 0.2249 0.2213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0095 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0782 0.091
Schistosoma mansoni sugar transporter 0.0014 0.0195 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.3818 0.5583
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0393 0.0311
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0004
Echinococcus multilocularis solute carrier family 22 0.0014 0.0195 0.0415
Trypanosoma brucei glucose transporter, putative 0.0032 0.06 0.7532
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0191 0.0253
Trypanosoma brucei glucose transporter, putative 0.0032 0.06 0.7532
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0095 0.0089
Onchocerca volvulus 0.0014 0.0195 0.0268
Echinococcus granulosus GPCR family 2 0.0031 0.0584 0.148
Mycobacterium ulcerans sugar transporter 0.0014 0.0195 0.0268
Onchocerca volvulus 0.0014 0.0195 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0095 0.0089
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0191 0.0151
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0191 0.0253
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0591 0.0936
Onchocerca volvulus 0.0014 0.0191 0.0256
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0695 0.7035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6688 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.06 0.7532
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0576 0.0593
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0988 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0191 0.0252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6688 1
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0191 0.0403
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0191 0.0252
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0988 0.2653
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0195 0.0166
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0095 0.0089
Echinococcus multilocularis SPRY domain containing protein 0.0008 0.0046 0.0006
Echinococcus granulosus solute carrier family 22 0.0014 0.0195 0.0415
Entamoeba histolytica hypothetical protein 0.0035 0.0674 0.0792
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0195 0.0007
Onchocerca volvulus 0.0014 0.0195 0.0268
Brugia malayi hypothetical protein 0.0014 0.0195 0.0259
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.215 0.3601
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0191 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0095 0.0089

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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