TDR Targets

Basic information

Technical information

TDR Targets ID: 623830
Name: N'-(1,3-dimethyl-2,6-dioxopyrimidin-4-yl)-2-m ethoxybenzohydrazide
MW: 304.301 | Formula: C14H16N4O4
H donors: 2 H acceptors: 3 LogP: 0.72 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1C(=O)NNc1cc(=O)n(c(=O)n1C)C
InChi: 1S/C14H16N4O4/c1-17-11(8-12(19)18(2)14(17)21)15-16-13(20)9-6-4-5-7-10(9)22-3/h4-8,15H,1-3H3,(H,16,20)
InChiKey: HKLXCRYTKDFMMZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-(1,3-dimethyl-2,6-dioxo-pyrimidin-4-yl)-2-methoxy-benzohydrazide
N'-(1,3-dimethyl-2,6-dioxo-4-pyrimidinyl)-2-methoxybenzohydrazide
N'-(2,6-diketo-1,3-dimethyl-pyrimidin-4-yl)-2-methoxy-benzohydrazide
ZINC02706487

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0335	0.0479
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0268	0.0254
Mycobacterium tuberculosis	Probable oxidoreductase	0.013	0.4983	0.4845
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0378	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0611	0.0341
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.013	0.4983	0.4845
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0567	0.0443
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0018	0.0268	0.0254
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0268	0.0254
Mycobacterium tuberculosis	Conserved protein	0.0039	0.1161	0.0918
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0611	0.1656
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0335	1
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.1675	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0611	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1161	0.0971
Brugia malayi	Thioredoxin reductase	0.0051	0.1675	0.1788
Brugia malayi	Bromodomain containing protein	0.0083	0.3001	0.3263
Trypanosoma brucei	trypanothione reductase	0.0051	0.1675	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.1161	0.1322
Schistosoma mansoni	ap endonuclease	0.002	0.0378	0.0216
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0291	0.0024
Onchocerca volvulus		0.0039	0.1161	0.2348
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0611	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1161	0.0971
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.1188	0.1362
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0378	0.1017
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0378	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0335	0.0326
Mycobacterium tuberculosis	Conserved protein	0.0039	0.1161	0.0918
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.1675	0.1559
Toxoplasma gondii	thioredoxin reductase	0.0051	0.1675	0.6798
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0611	0.0352
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.2338	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0378	0.0533
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0378	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1161	0.0971
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.3429	0.4678
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0611	0.0602
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.1675	0.2083
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0611	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.3429	0.4707
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0611	0.0602
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0312	0.012
Mycobacterium tuberculosis	Conserved protein	0.0039	0.1161	0.0918
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0268	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0335	0.0026
Brugia malayi	follicle stimulating hormone receptor	0.0226	0.9052	1
Brugia malayi	hypothetical protein	0.0129	0.4947	0.543
Mycobacterium ulcerans	hypothetical protein	0.0039	0.1161	0.4316
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0291	0.0024
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0018	0.0268	0.0254
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.2338	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.3429	0.4678
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0611	0.0602
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0268	0.0174
Trypanosoma cruzi	trypanothione reductase, putative	0.0018	0.0268	0.0254
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.1161	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1301	0.1132
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0378	0.0784
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0312	0.012
Onchocerca volvulus		0.0026	0.0611	0.1234
Brugia malayi	beta-lactamase family protein	0.0039	0.1161	0.1215
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0312	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0129	0.4947	0.5303
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0378	0.0163
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.2291	0.2994
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0378	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0335	0.0026
Brugia malayi	beta-lactamase	0.0039	0.1161	0.1215
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0117	0.4435	0.4282
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0378	0.0163
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.2338	1
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.1161	0.6349
Plasmodium falciparum	thioredoxin reductase	0.0051	0.1675	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0018	0.0268	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0078	0.2802	0.2849
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.1161	0.6442
Brugia malayi	Bromodomain containing protein	0.0042	0.1298	0.1368
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0268	0.0254
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0567	0.0495
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.2338	0.3064
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.1161	0.4316
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.3429	0.374
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.1161	1
Trichomonas vaginalis	esterase, putative	0.0039	0.1161	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.1161	0.0918
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0378	0.0075
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.3429	0.3566
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0335	0.0026
Loa Loa (eye worm)	glutathione reductase	0.0051	0.1675	0.1559
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0378	0.1017
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0378	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.1161	0.1215
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.2338	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.3429	0.4678
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0611	0.1656
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.1161	0.6442
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0335	0.0026
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.2338	1
Echinococcus multilocularis	geminin	0.0178	0.7026	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0268	0.0254
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.1161	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.2291	0.2994
Echinococcus granulosus	zinc finger protein	0.0022	0.0429	0.0239
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.1161	0.0918
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0611	0.1656
Mycobacterium ulcerans	beta-lactamase	0.0039	0.1161	0.4316
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0378	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.3429	0.4707
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0378	0.0784
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0117	0.4435	0.4282
Echinococcus multilocularis	zinc finger protein	0.0022	0.0429	0.0239
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.1675	0.2083
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0611	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.1161	0.1322
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0341	0.0033
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0335	0.0479
Onchocerca volvulus		0.0039	0.1161	0.2348
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0611	0.1801
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.1188	0.1362
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0019	0.0312	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1161	0.0971
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0291	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1161	0.0971
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.2338	0.3101
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.1161	0.0918
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.1161	0.1369
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0611	0.1801
Schistosoma mansoni	bromodomain containing protein	0.007	0.2457	0.3276
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.1161	0.4316
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0117	0.4435	0.4282
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0611	0.0341
Loa Loa (eye worm)	beta-lactamase	0.0039	0.1161	0.0971
Schistosoma mansoni	zinc finger protein	0.0022	0.0429	0.0292
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.1161	0.1369
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0479	0.019
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.1161	1
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0611	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0047	0.15	0.1359
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0268	0.0254
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.1161	0.0918
Onchocerca volvulus	Huntingtin homolog	0.0129	0.4947	1
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0312	0.0066
Plasmodium falciparum	glutathione reductase	0.0051	0.1675	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0479	0.0364
Brugia malayi	beta-lactamase family protein	0.0039	0.1161	0.1215
Onchocerca volvulus	Huntingtin homolog	0.0129	0.4947	1
Mycobacterium leprae	Probable lipase LipE	0.0039	0.1161	0.126
Toxoplasma gondii	exonuclease III APE	0.002	0.0378	0.0533
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0611	0.1656
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0117	0.4435	0.8746
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.1161	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.2338	0.2128
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0312	0.012
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0611	0.1656
Toxoplasma gondii	ABC1 family protein	0.0039	0.1161	0.4316
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0611	0.1656
Mycobacterium tuberculosis	Probable reductase	0.0117	0.4435	0.4282
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0226	0.9052	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.1161	0.0918
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.1161	0.6442
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.1675	0.1446
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0611	0.1801
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0312	0.012
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0335	0.0069
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0268	0.0254
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0268	0.0254
Brugia malayi	PHD-finger family protein	0.0027	0.0677	0.0676
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.1161	0.126
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0611	0.0341
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0018	0.0268	0.0054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.3429	0.4707
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0291	0.0024
Mycobacterium tuberculosis	Probable dehydrogenase	0.0117	0.4435	0.4282
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0378	0.1017
Schistosoma mansoni	hypothetical protein	0.0178	0.7026	1
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0378	0.0343
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0018	0.0268	0.0221
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0268	0.0254
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.2338	0.3064
Plasmodium vivax	glutathione reductase, putative	0.0051	0.1675	1
Leishmania major	hypothetical protein, conserved	0.0039	0.1161	0.4415
Brugia malayi	glutathione reductase	0.0051	0.1675	0.1788
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0268	0.0254
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0611	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.1161	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0335	0.0026
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0378	0.0697
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.2338	0.3101
Leishmania major	trypanothione reductase	0.0051	0.1675	0.6853
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.1161	0.0918
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.013	0.4983	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.013	0.4983	0.4845
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.3429	0.4678
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1411	0.1257
Schistosoma mansoni	ap endonuclease	0.002	0.0378	0.0216
Onchocerca volvulus		0.0039	0.1161	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1161	0.0971
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0018	0.0268	0.0174
Schistosoma mansoni	hypothetical protein	0.0178	0.7026	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0567	0.0443
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0268	0.0254
Echinococcus granulosus	geminin	0.0178	0.7026	1
Mycobacterium ulcerans	lipase LipD	0.0039	0.1161	0.4316
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.1675	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0117	0.4435	0.4282
Loa Loa (eye worm)	hypothetical protein	0.0129	0.4947	0.5303
Echinococcus granulosus	histone lysine methyltransferase setb	0.0019	0.0312	0.0066
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.1161	0.0971

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 623830