Detailed information for compound 624410

Basic information

Technical information
  • TDR Targets ID: 624410
  • Name: 2,6,8-trimethyl-4-[(4-methylphenyl)methylsulf anyl]pyrimido[5,6-e]pyrimidine-5,7-dione
  • MW: 342.415 | Formula: C17H18N4O2S
  • H donors: 0 H acceptors: 4 LogP: 2.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CSc1nc(C)nc2c1c(=O)n(C)c(=O)n2C
  • InChi: 1S/C17H18N4O2S/c1-10-5-7-12(8-6-10)9-24-15-13-14(18-11(2)19-15)20(3)17(23)21(4)16(13)22/h5-8H,9H2,1-4H3
  • InChiKey: DZRRETYTCHQKAC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,6,8-trimethyl-4-[(4-methylphenyl)methylthio]pyrimido[5,6-e]pyrimidine-5,7-dione
  • 2,6,8-trimethyl-4-[(4-methylbenzyl)thio]pyrimido[5,6-e]pyrimidine-5,7-quinone
  • ZINC04138843

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0057 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1365 0.1363
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Leishmania major DNA polymerase kappa, putative 0.0006 0.0057 0.0026
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0068 0.0029
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.1211 1
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0214 0.6953 0.6941
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0152 0.0113
Echinococcus granulosus dna polymerase eta 0.0019 0.0495 0.0458
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.001 0.0182 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0057 0.0096
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0084 0.0633
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.001 0.0182 0.0137
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.0068 0.0016
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0152 0.0113
Onchocerca volvulus 0.001 0.0182 0.0198
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0152 0.0113
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0006 0.0068 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0084 0.0633
Loa Loa (eye worm) hypothetical protein 0.001 0.0182 0.0143
Loa Loa (eye worm) hypothetical protein 0.001 0.0182 0.0143
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0152 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0084 0.0633
Schistosoma mansoni DNA polymerase eta 0.0019 0.0495 0.0493
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1967 0.1965
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.001 0.0182 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0297 0.3355
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0057 0.0149
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0084 0.0633
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0152 0.0158
Echinococcus granulosus cpg binding protein 0.0032 0.091 0.0874
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0495 0.0493
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0182 0.0137
Onchocerca volvulus 0.001 0.0182 0.0198
Trypanosoma brucei acetyl-CoA synthetase, putative 0.001 0.0182 0.1851
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.001 0.0182 0.0176
Schistosoma mansoni cpg binding protein 0.003 0.0853 0.0851
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0152 0.0158
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.001 0.0182 0.0143
Schistosoma mansoni hypothetical protein 0.0306 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.4874 0.4873
Loa Loa (eye worm) hypothetical protein 0.0019 0.0495 0.0458
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.1334 0.7093
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.001 0.0182 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0084 0.0633
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.1334 0.7093
Schistosoma mansoni dishevelled 0.0009 0.0152 0.015
Leishmania major DNA damage repair protein, putative 0.0006 0.0057 0.0026
Brugia malayi acetyl-Coenzyme A synthetase 2 0.001 0.0182 0.02
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Plasmodium vivax transportin, putative 0.0005 0.0039 0.0264
Brugia malayi AMP-binding enzyme family protein 0.001 0.0182 0.02
Onchocerca volvulus 0.001 0.0182 0.0198
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.001 0.0182 0.1851
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0182 0.0209
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0495 0.0599
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0495 0.0615
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0214 0.6953 1
Brugia malayi N-terminal motif family protein 0.0179 0.5802 0.8068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0495 0.0599
Plasmodium falciparum acetyl-CoA synthetase, putative 0.001 0.0182 0.1216
Schistosoma mansoni acetyl-CoA synthetase 0.001 0.0182 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0182 0.0209
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.063 0.0831
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.4874 0.4854
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.001 0.0182 0.0137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0084 0.0633
Loa Loa (eye worm) hypothetical protein 0.0009 0.0152 0.0113
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0152 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0084 0.0633
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0106 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0057 0.0227
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0495 0.5915
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Trichomonas vaginalis helicase, putative 0.0007 0.0084 0.0633
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0495 0.0615
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.001 0.0182 0.0176
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.1211 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0152 0.0158
Trypanosoma brucei unspecified product 0.0013 0.0297 0.3355
Brugia malayi AMP-binding enzyme family protein 0.001 0.0182 0.02
Toxoplasma gondii propionate-CoA ligase 0.001 0.0182 0.0781
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.001 0.0182 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0084 0.0633
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.001 0.0182 0.0181
Brugia malayi RasGEF domain containing protein 0.0006 0.0068 0.0041
Leishmania major DNA polymerase eta, putative 0.0006 0.0057 0.0026
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0809 0.0773
Entamoeba histolytica acyl-CoA synthetase, putative 0.001 0.0182 0.1216
Onchocerca volvulus 0.001 0.0182 0.0198
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0495 0.0668
Loa Loa (eye worm) hypothetical protein 0.0179 0.5802 0.5786
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0068 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Echinococcus multilocularis cpg binding protein 0.0032 0.091 0.0874
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0106 0.0068
Trypanosoma brucei unspecified product 0.0013 0.0297 0.3355
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0495 0.0635
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.4874 0.6769
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.001 0.0182 0.0137
Brugia malayi Importin beta-1 subunit 0.0029 0.0809 0.1078
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0809 1
Brugia malayi RasGEF domain containing protein 0.0006 0.0068 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0057 0.0227
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0182 0.0209
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0152 0.0113
Brugia malayi AMP-binding enzyme family protein 0.001 0.0182 0.02
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0211 0.686 1
Brugia malayi hypothetical protein 0.0009 0.0152 0.0158
Echinococcus granulosus long chain fatty acid transport protein 4 0.0214 0.6953 0.6941
Brugia malayi RasGEF domain containing protein 0.0006 0.0068 0.0041
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0152 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0152 0.0113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0182 0.0137
Brugia malayi CXXC zinc finger family protein 0.003 0.0853 0.114
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 1 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0084 0.0633
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0495 0.5915
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0068 0.0029
Leishmania major importin beta-1 subunit, putative 0.0023 0.063 0.0866
Schistosoma mansoni dishevelled 0.0009 0.0152 0.015
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0495 0.0458
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0152 0.0113
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.063 0.472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1365 0.1331
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0214 0.6953 1
Schistosoma mansoni zinc finger protein 0.0005 0.0039 0.0037
Schistosoma mansoni cpg binding protein 0.0032 0.091 0.0908
Schistosoma mansoni importin-beta 2 0.0005 0.0039 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Mycobacterium ulcerans fatty-acid-CoA ligase 0.001 0.0182 0.0176
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0495 0.3887
Leishmania major DNA polymerase kappa, putative 0.0019 0.0495 0.0668
Loa Loa (eye worm) hypothetical protein 0.001 0.0182 0.0143
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0068 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1365 0.1331
Echinococcus multilocularis snurportin 1 0.0306 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0152 0.0113
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Echinococcus granulosus importin subunit beta 1 0.0029 0.0809 0.0773
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0057 0.0227
Onchocerca volvulus 0.003 0.0853 0.1369
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.1334 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0167 0.0128
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0068 0.0066
Schistosoma mansoni dep domain containing protein 0.0009 0.0152 0.015
Onchocerca volvulus 0.0009 0.0152 0.0146
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0068 0.0029
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0152 0.015
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0068 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0495 0.5915
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0495 0.0635
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0057 0.0096
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.1334 1
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0057 0.0395
Brugia malayi N-terminal motif family protein 0.0006 0.0068 0.0041
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.001 0.0182 0.0137
Brugia malayi AMP-binding enzyme family protein 0.001 0.0182 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0084 0.0633
Toxoplasma gondii hypothetical protein 0.0009 0.0152 0.0618
Loa Loa (eye worm) oxidoreductase 0.001 0.0182 0.0143
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.001 0.0182 0.0181
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.1865 1
Entamoeba histolytica hypothetical protein 0.0023 0.063 0.5038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0495 0.0635
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.4733 0.4713
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0057 0.0227
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0495 0.0638
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0152 0.0113
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0068 0.0029
Loa Loa (eye worm) acetyltransferase 0.0151 0.4874 0.4854
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0495 0.0638
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0084 0.0633
Plasmodium falciparum importin beta, putative 0.0029 0.0809 0.6571
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Echinococcus granulosus son of sevenless 1 0.0006 0.0068 0.0029
Plasmodium vivax importin-beta 2, putative 0.0029 0.0809 0.6055
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0297 0.3355
Trichomonas vaginalis hypothetical protein 0.0005 0.0039 0.0292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1365 0.1331
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0152 0.0113
Brugia malayi AMP-binding enzyme family protein 0.0221 0.7182 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0221 0.7182 0.7171
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0057 0.0096
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0152 0.0113
Onchocerca volvulus 0.001 0.0182 0.0198
Schistosoma mansoni FFA transport protein 0.0214 0.6953 0.6952
Trichomonas vaginalis antibiotic synthetase, putative 0.001 0.0182 0.1361
Loa Loa (eye worm) hypothetical protein 0.0009 0.0152 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Loa Loa (eye worm) AMP-binding enzyme family protein 0.001 0.0182 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0152 0.0113
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0068 0.0509
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0182 0.0137
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0152 0.0113
Trypanosoma brucei unspecified product 0.0019 0.0495 0.5915
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0068 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0509
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0853 0.0817
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0809 1
Schistosoma mansoni cpg binding protein 0.0032 0.091 0.0908
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0057 0.0227
Trypanosoma cruzi hypothetical protein 0.0006 0.0068 0.0016
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.001 0.0182 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1365 0.1363
Mycobacterium ulcerans acetyl-CoA synthetase 0.001 0.0182 0.0176
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.001 0.0182 0.0176
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.063 0.472
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1365 0.1363
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0068 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0084 0.0633
Entamoeba histolytica hypothetical protein 0.0006 0.0068 0.0246
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1365 0.1857
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.5802 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.001 0.0182 0.0176
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0167 0.0128
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0084 0.0633
Echinococcus granulosus dna polymerase kappa 0.0019 0.0495 0.0458
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0084 0.0633
Leishmania major acetyl-CoA synthetase, putative 0.001 0.0182 0.0209
Leishmania major DNA polymerase eta, putative 0.0019 0.0495 0.0668
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0495 0.0458
Loa Loa (eye worm) hypothetical protein 0.001 0.0182 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0084 0.0633
Schistosoma mansoni bromodomain containing protein 0.0005 0.0039 0.0037
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0068 0.0029
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.001 0.0182 0.0137
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.001 0.0182 0.0137
Brugia malayi N-terminal motif family protein 0.0006 0.0068 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0297 0.3355
Echinococcus multilocularis son of sevenless 1 0.0006 0.0068 0.0029
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.001 0.0182 0.0176
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0068 0.0066
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0068 0.0509
Brugia malayi DIX domain containing protein 0.0009 0.0152 0.0158
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0163 0.0174
Brugia malayi AMP-binding enzyme family protein 0.001 0.0182 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0068 0.0066
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.001 0.0182 0.02
Mycobacterium ulcerans hypothetical protein 0.001 0.0182 0.0176
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0068 0.0066
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0106 0.0068
Loa Loa (eye worm) hypothetical protein 0.0006 0.0068 0.0029
Schistosoma mansoni importin beta-1 0.0029 0.0809 0.0808
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0084 0.0633
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.001 0.0182 0.0176
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0495 0.3708
Brugia malayi AMP-binding enzyme family protein 0.001 0.0182 0.02
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0495 0.0493
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0058 0.0056
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0495 0.3708
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.1211 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0068 0.0066
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0106 0.0068
Loa Loa (eye worm) hypothetical protein 0.0006 0.0068 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0182 0.0137
Brugia malayi polk-prov protein 0.0006 0.0057 0.0025
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.1334 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0495 0.0635
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0495 0.0458
Loa Loa (eye worm) hypothetical protein 0.0006 0.0057 0.0018
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.001 0.0182 0.0176
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0152 0.0146
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0495 0.0458
Brugia malayi RNA, U transporter 1 0.0081 0.2561 0.353
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.001 0.0182 0.1216
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Loa Loa (eye worm) hypothetical protein 0.0029 0.0809 0.0773
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.1334 0.13
Leishmania major fatty acid transporter protein-like protein 0.0211 0.686 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Entamoeba histolytica acyl-coA synthetase, putative 0.001 0.0182 0.1216
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0495 0.5915
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0495 0.5915
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1365 0.1331
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0068 0.0246
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.001 0.0182 0.0781
Leishmania major acetyl-CoA synthetase, putative 0.001 0.0182 0.0209
Entamoeba histolytica acyl-CoA synthetase, putative 0.001 0.0182 0.1216
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0182 0.0176
Trypanosoma cruzi hypothetical protein 0.0006 0.0068 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0182 0.0137
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0495 0.0635
Trichomonas vaginalis importin beta-1, putative 0.0023 0.063 0.472
Echinococcus multilocularis dna polymerase eta 0.0019 0.0495 0.0458
Loa Loa (eye worm) hypothetical protein 0.001 0.0182 0.0143
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0809 0.4219
Echinococcus granulosus Protein son of sevenless 0.0006 0.0068 0.0029
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.001 0.0182 0.0209
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.001 0.0182 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0057 0.0227
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0211 0.686 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0084 0.0633
Schistosoma mansoni bromodomain containing protein 0.0005 0.0039 0.0037
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0167 0.0128
Giardia lamblia DINP protein human, muc B family 0.0019 0.0495 0.3794
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0221 0.7182 1
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0057 0.0227
Trichomonas vaginalis antibiotic synthetase, putative 0.001 0.0182 0.1361
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0106 0.0104
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.001 0.0182 0.0781
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.001 0.0182 0.0137
Brugia malayi hypothetical protein 0.0009 0.0152 0.0158
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.001 0.0182 0.0181
Plasmodium vivax acetyl-CoA synthetase, putative 0.001 0.0182 0.1336
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1365 0.1331

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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