Detailed information for compound 629700

Basic information

Technical information
  • TDR Targets ID: 629700
  • Name: 2-[(2-fluorophenyl)-phenylsulfonylamino]-N-[2 -[(4-methylphenyl)methylsulfanyl]ethyl]acetam ide
  • MW: 472.595 | Formula: C24H25FN2O3S2
  • H donors: 1 H acceptors: 3 LogP: 4.58 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccccc1)c1ccccc1F)NCCSCc1ccc(cc1)C
  • InChi: 1S/C24H25FN2O3S2/c1-19-11-13-20(14-12-19)18-31-16-15-26-24(28)17-27(23-10-6-5-9-22(23)25)32(29,30)21-7-3-2-4-8-21/h2-14H,15-18H2,1H3,(H,26,28)
  • InChiKey: YZSLNCSQXXOTRO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2-fluorophenyl)-phenylsulfonyl-amino]-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide
  • 2-[(2-fluorophenyl)-phenylsulfonylamino]-N-[2-[(4-methylphenyl)methylthio]ethyl]acetamide
  • 2-[(2-fluorophenyl)-phenylsulfonyl-amino]-N-[2-[(4-methylbenzyl)thio]ethyl]acetamide
  • 2-[(2-fluorophenyl)-phenylsulfonyl-amino]-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.4862 0.4843
Onchocerca volvulus 0.0009 0.0168 0.0132
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.1207 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0009 0.0168 0.1113
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.1329 0.7093
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0082 0.0348
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0628 0.4572
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0808 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0009 0.0168 0.0139
Schistosoma mansoni cpg binding protein 0.0031 0.0906 0.0906
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0082 0.0348
Toxoplasma gondii hypothetical protein 0.0009 0.0176 0.0763
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.4862 0.7033
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0009 0.0168 0.0137
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0628 0.4572
Plasmodium vivax importin-beta 2, putative 0.0028 0.0808 0.6071
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0628 0.4572
Echinococcus granulosus importin subunit beta 1 0.0028 0.0808 0.0774
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Loa Loa (eye worm) hypothetical protein 0.0009 0.0168 0.0131
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0104 0.0067
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0085 0.0085
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0206 0.6898 0.6886
Echinococcus multilocularis importin 5 0.0005 0.0037 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0082 0.0348
Loa Loa (eye worm) hypothetical protein 0.0007 0.0085 0.0048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1498 0.1467
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0368
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.055 0.6652
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0085 0.0085
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0176 0.0203
Schistosoma mansoni importin-beta 2 0.0005 0.0037 0.0037
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0009 0.0168 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Leishmania major DNA damage repair protein, putative 0.0006 0.0073 0.0054
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0009 0.0168 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1498 0.1498
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0009 0.0168 0.0714
Echinococcus multilocularis cpg binding protein 0.0031 0.0906 0.0872
Plasmodium vivax transportin, putative 0.0005 0.0037 0.0267
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1961 0.1961
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.1329 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1498 0.213
Onchocerca volvulus 0.0009 0.0168 0.0132
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0168 0.0199
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.055 0.4382
Echinococcus granulosus cpg binding protein 0.0031 0.0906 0.0872
Brugia malayi AMP-binding enzyme family protein 0.0206 0.6898 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.1329 1
Brugia malayi N-terminal motif family protein 0.019 0.6332 0.9176
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0009 0.0168 0.0137
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0085 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.055 0.0723
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.02 0.6677 1
Echinococcus multilocularis son of sevenless 1 0.0007 0.0085 0.0048
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0085 0.0048
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0085 0.0048
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0168 0.1007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0082 0.0348
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0073 0.0456
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0168 0.019
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0206 0.6898 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0082 0.0348
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0628 0.0841
Echinococcus granulosus long chain fatty acid transport protein 4 0.02 0.6677 0.6665
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0085 0.0048
Schistosoma mansoni hypothetical protein 0.0297 1 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0104 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0082 0.0348
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0168 0.0144
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0073 0.0456
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0176 0.014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0009 0.0168 0.0139
Loa Loa (eye worm) hypothetical protein 0.0009 0.0168 0.0131
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0082 0.0348
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0176 0.0203
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0168 0.0199
Brugia malayi RasGEF domain containing protein 0.0007 0.0085 0.007
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0009 0.0168 0.019
Brugia malayi RasGEF domain containing protein 0.0007 0.0085 0.007
Echinococcus granulosus transportin 1 0.0005 0.0037 0.0001
Leishmania major DNA polymerase kappa, putative 0.0006 0.0073 0.0054
Brugia malayi N-terminal motif family protein 0.0007 0.0085 0.007
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0009 0.0168 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1498 0.1467
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Mycobacterium ulcerans DNA polymerase IV 0.002 0.055 0.0699
Brugia malayi N-terminal motif family protein 0.0007 0.0085 0.007
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.055 0.0748
Onchocerca volvulus 0.0009 0.0168 0.0132
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.055 0.055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1498 0.1467
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.055 0.3966
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0161 0.018
Schistosoma mansoni importin beta-1 0.0028 0.0808 0.0808
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0176 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0168 0.0137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0168 0.0131
Trypanosoma cruzi hypothetical protein 0.0007 0.0085 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0176 0.014
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.055 0.6652
Plasmodium vivax acetyl-CoA synthetase, putative 0.0009 0.0168 0.1247
Loa Loa (eye worm) hypothetical protein 0.002 0.055 0.0515
Echinococcus multilocularis translational activator gcn1 0.0005 0.0037 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0085 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Echinococcus multilocularis dna polymerase eta 0.002 0.055 0.0515
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0073 0.0456
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0168 0.1007
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0168 0.0144
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0009 0.0168 0.0137
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0073 0.0531
Trypanosoma brucei unspecified product 0.002 0.055 0.6652
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0074 0.0074
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Trypanosoma cruzi hypothetical protein 0.0007 0.0085 0.0019
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0168 0.1689
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0176 0.0176
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0176 0.014
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0009 0.0168 0.0139
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0176 0.0146
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0104 0.0104
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0009 0.0168 0.1689
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.055 0.055
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.1329 0.1297
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0037 0.0001
Leishmania major DNA polymerase kappa, putative 0.002 0.055 0.0782
Schistosoma mansoni dep domain containing protein 0.0009 0.0176 0.0176
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.6332 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0165 0.0128
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0085 0.0368
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0073 0.0456
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0009 0.0168 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0073 0.0456
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0085 0.0048
Plasmodium falciparum importin beta, putative 0.0028 0.0808 0.6588
Mycobacterium ulcerans DNA polymerase IV 0.002 0.055 0.0699
Loa Loa (eye worm) hypothetical protein 0.0009 0.0176 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0082 0.0348
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.055 0.0724
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0085 0.0085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1498 0.1467
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0808 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0009 0.0168 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0168 0.019
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0168 0.0144
Entamoeba histolytica acyl-CoA synthetase, putative 0.0009 0.0168 0.1113
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.02 0.6677 1
Loa Loa (eye worm) hypothetical protein 0.019 0.6332 0.6319
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0176 0.014
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.055 0.0723
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0165 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0073 0.0193
Echinococcus multilocularis dna polymerase kappa 0.002 0.055 0.0515
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0082 0.0348
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.1329 0.7093
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.4722 0.4702
Loa Loa (eye worm) hypothetical protein 0.0006 0.0073 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0168 0.019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0082 0.0348
Onchocerca volvulus 0.0009 0.0176 0.0146
Echinococcus multilocularis snurportin 1 0.0297 1 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0085 0.0085
Brugia malayi RNA, U transporter 1 0.0079 0.2559 0.3677
Giardia lamblia DINP protein human, muc B family 0.002 0.055 0.4208
Schistosoma mansoni cpg binding protein 0.0031 0.0906 0.0906
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0168 0.0144
Brugia malayi hypothetical protein 0.0009 0.0176 0.0203
Entamoeba histolytica hypothetical protein 0.0023 0.0628 0.5051
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0073 0.0456
Trichomonas vaginalis helicase, putative 0.0007 0.0082 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0009 0.0168 0.1113
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0168 0.0199
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0176 0.014
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0009 0.0168 0.0131
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0082 0.0348
Schistosoma mansoni acetyl-CoA synthetase 0.0009 0.0168 0.0168
Toxoplasma gondii propionate-CoA ligase 0.0009 0.0168 0.0714
Loa Loa (eye worm) hypothetical protein 0.0009 0.0168 0.0131
Loa Loa (eye worm) hypothetical protein 0.0009 0.0176 0.014
Onchocerca volvulus 0.0009 0.0168 0.0132
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.055 0.0724
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.055 0.6652
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0085 0.0048
Loa Loa (eye worm) hypothetical protein 0.0007 0.0085 0.0048
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.055 0.0515
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0168 0.019
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0085 0.0048
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.1207 1
Brugia malayi polk-prov protein 0.0006 0.0073 0.0052
Echinococcus granulosus dna polymerase eta 0.002 0.055 0.0515
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0335 0.3863
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0009 0.0168 0.0131
Trypanosoma brucei unspecified product 0.0014 0.0335 0.3863
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0085 0.0085
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.055 0.6652
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.055 0.0515
Brugia malayi Importin beta-1 subunit 0.0028 0.0808 0.1124
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Leishmania major importin beta-1 subunit, putative 0.0023 0.0628 0.0902
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0082 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0082 0.0348
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0168 0.019
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0009 0.0168 0.0139
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0168 0.0199
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0168 0.0137
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0073 0.0193
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Schistosoma mansoni dishevelled 0.0009 0.0176 0.0176
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0176 0.0176
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0009 0.0168 0.1113
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.055 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0082 0.0348
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0037 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0165 0.0128
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1859 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0009 0.0168 0.0714
Onchocerca volvulus 0.0029 0.0849 0.1224
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0168 0.0137
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0009 0.0168 0.0137
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.4862 0.4862
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0104 0.0067
Echinococcus multilocularis long chain fatty acid transport protein 4 0.02 0.6677 0.6665
Loa Loa (eye worm) hypothetical protein 0.0009 0.0176 0.014
Brugia malayi DIX domain containing protein 0.0009 0.0176 0.0203
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0849 0.0815
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0176 0.014
Leishmania major DNA polymerase eta, putative 0.0006 0.0073 0.0054
Echinococcus granulosus importin 5 0.0005 0.0037 0.0001
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0085 0.0368
Loa Loa (eye worm) acetyltransferase 0.0147 0.4862 0.4843
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0176 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0168 0.0137
Entamoeba histolytica hypothetical protein 0.0007 0.0085 0.0406
Entamoeba histolytica acyl-coA synthetase, putative 0.0009 0.0168 0.1113
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.1329 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.055 0.0748
Brugia malayi RasGEF domain containing protein 0.0007 0.0085 0.007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0009 0.0168 0.0137
Schistosoma mansoni FFA transport protein 0.02 0.6677 0.6677
Loa Loa (eye worm) oxidoreductase 0.0009 0.0168 0.0131
Echinococcus granulosus Protein son of sevenless 0.0007 0.0085 0.0048
Mycobacterium ulcerans hypothetical protein 0.0009 0.0168 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0335 0.3863
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.1207 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0168 0.0137
Leishmania major fatty acid transporter protein-like protein 0.0197 0.6588 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0073 0.0193
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Schistosoma mansoni bromodomain containing protein 0.0005 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0335 0.3863
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0073 0.0456
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0085 0.0019
Brugia malayi kap beta 3 protein 0.0005 0.0037 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0808 0.0774
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0197 0.6588 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0009 0.0168 0.0139
Schistosoma mansoni dishevelled 0.0009 0.0176 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0073 0.03
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0197 0.6588 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0085 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.055 0.0723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1498 0.1498
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1498 0.1467
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0808 0.0774
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0085 0.0368
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0085 0.0406
Mycobacterium ulcerans acetyl-CoA synthetase 0.0009 0.0168 0.0139
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0009 0.0168 0.0139
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0176 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0082 0.0348
Echinococcus granulosus son of sevenless 1 0.0007 0.0085 0.0048
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0009 0.0168 0.0139
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.055 0.0723
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0104 0.0067
Schistosoma mansoni DNA polymerase eta 0.002 0.055 0.055
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.055 0.0782
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0168 0.019
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0168 0.0199
Schistosoma mansoni zinc finger protein 0.0005 0.0037 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0082 0.0348
Echinococcus granulosus translational activator gcn1 0.0005 0.0037 0.0001
Onchocerca volvulus 0.0009 0.0168 0.0132
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0073 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0168 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1498 0.1498
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0176 0.0176
Leishmania major DNA polymerase eta, putative 0.002 0.055 0.0782
Trypanosoma brucei unspecified product 0.0014 0.0335 0.3863
Schistosoma mansoni cpg binding protein 0.0029 0.0849 0.0849
Schistosoma mansoni bromodomain containing protein 0.0005 0.0037 0.0037
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.055 0.0515
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0085 0.0048
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0009 0.0168 0.0139
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0808 0.4229
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0168 0.0199
Brugia malayi CXXC zinc finger family protein 0.0029 0.0849 0.1184
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0176 0.014
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0176 0.014
Echinococcus granulosus dna polymerase kappa 0.002 0.055 0.0515
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0176 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0168 0.019
Echinococcus multilocularis transportin 1 0.0005 0.0037 0.0001
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0009 0.0168 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0082 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.055 0.6652
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0176 0.014
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0009 0.0168 0.0137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0168 0.0131
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.055 0.3966
Brugia malayi hypothetical protein 0.0009 0.0176 0.0203

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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