Detailed information for compound 630570

Basic information

Technical information
  • TDR Targets ID: 630570
  • Name: N-(3-chloro-4-fluorophenyl)-3-(3-chlorophenyl )prop-2-enamide
  • MW: 310.15 | Formula: C15H10Cl2FNO
  • H donors: 1 H acceptors: 1 LogP: 4.54 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(c(c1)Cl)F)C=Cc1cccc(c1)Cl
  • InChi: 1S/C15H10Cl2FNO/c16-11-3-1-2-10(8-11)4-7-15(20)19-12-5-6-14(18)13(17)9-12/h1-9H,(H,19,20)/b7-4+
  • InChiKey: ILNLWKJAHYNKGK-QPJJXVBHSA-N  

Network

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Synonyms

  • (E)-N-(3-chloro-4-fluorophenyl)-3-(3-chlorophenyl)prop-2-enamide
  • (E)-N-(3-chloro-4-fluoro-phenyl)-3-(3-chlorophenyl)prop-2-enamide
  • N-(3-chloro-4-fluoro-phenyl)-3-(3-chlorophenyl)prop-2-enamide
  • (E)-N-(3-chloro-4-fluoro-phenyl)-3-(3-chlorophenyl)acrylamide
  • N-(3-chloro-4-fluoro-phenyl)-3-(3-chlorophenyl)acrylamide
  • ZINC00433649

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0135 0.1044
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0024 0.0246 0.0358
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.027 0.3199
Loa Loa (eye worm) hypothetical protein 0.0098 0.1277 0.1989
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.007 0.0078
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0175 0.0246
Treponema pallidum NADH oxidase 0.0016 0.0135 0.1044
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0063 0.0125
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.007 0.007
Brugia malayi Ets-domain containing protein 0.0011 0.0063 0.0067
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.007 0.0139
Echinococcus granulosus muscleblind protein 0.0149 0.1975 0.395
Entamoeba histolytica hypothetical protein 0.0024 0.0246 0.2819
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0024 0.0246 0.0358
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0051 0.0048
Toxoplasma gondii thioredoxin reductase 0.0047 0.0557 0.7781
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0557 0.3295
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.007 0.007
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0063 0.0125
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0063 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0046
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0135 0.027
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0343 0.0512
Trichomonas vaginalis importin beta-1, putative 0.0021 0.0202 0.2115
Plasmodium falciparum thioredoxin reductase 0.0016 0.0135 0.1044
Plasmodium falciparum thioredoxin reductase 0.0047 0.0557 0.7781
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0046
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0135 0.1044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0051 0.0051
Echinococcus multilocularis dnaJ subfamily B 0.0367 0.5 0.5
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0135 0.1044
Schistosoma mansoni nuclear hormone receptor 0.001 0.0051 0.0102
Echinococcus granulosus GPCR family 2 0.0031 0.0343 0.0686
Mycobacterium tuberculosis Probable reductase 0.0106 0.1384 0.8889
Plasmodium falciparum glutathione reductase 0.0047 0.0557 0.7781
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1044
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0063 0.0125
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1277 0.1989
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0696 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0557 0.7781
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1044
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0051 0.0048
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0175 0.0243
Brugia malayi transcription factor E74 isoform 0.0011 0.0063 0.0067
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0024 0.0246 0.2819
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0246 0.2819
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0225 0.2478
Loa Loa (eye worm) hypothetical protein 0.0024 0.0246 0.0356
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1044
Schistosoma mansoni thyroid hormone receptor 0.001 0.0051 0.0102
Echinococcus multilocularis synaptojanin 1 0.0011 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0276 0.3741 0.7482
Loa Loa (eye worm) hypothetical protein 0.0149 0.1975 0.3097
Brugia malayi nuclear receptor NHR-88 0.001 0.0051 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0051 0.0046
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.007 0.0076
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1549 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0135 0.1044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0202 0.2115
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0557 0.0557
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0696 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0051 0.0048
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0135 0.1044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0696 0.1392
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0051 0.0048
Brugia malayi hypothetical protein 0.0015 0.0114 0.0148
Brugia malayi Ets-domain containing protein 0.0075 0.0955 0.1482
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0051 0.0102
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0051 0.0102
Schistosoma mansoni hypothetical protein 0.0067 0.0845 0.1689
Toxoplasma gondii exonuclease III APE 0.0057 0.0696 1
Schistosoma mansoni gabp alpha 0.0075 0.0955 0.1911
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0076 0.0088
Schistosoma mansoni hypothetical protein 0.0367 0.5 1
Echinococcus granulosus geminin 0.0168 0.2238 0.4476
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0135 0.1044
Echinococcus granulosus sphingomyelin synthase protein 1 0.0024 0.0246 0.0492
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0135 0.1044
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0063 0.0065
Schistosoma mansoni ap endonuclease 0.0057 0.0696 0.1392
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.007 0.0076
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0051 0.0102
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0051 0.0102
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0063 0.0065
Onchocerca volvulus Putative neutral sphingomyelinase 0.0011 0.007 0.0862
Schistosoma mansoni coup transcription factor 0.001 0.0051 0.0102
Schistosoma mansoni nocturnin 0.0011 0.007 0.0139
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.027 0.3199
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0063 0.0063
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0019 0.0175 0.1686
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0696 1
Echinococcus multilocularis cpg binding protein 0.0027 0.0289 0.0289
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1384 0.8889
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.027 0.3199
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0063 0.0065
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0051 0.0102
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0135 0.1044
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1975 0.1975
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0052 0.0052
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0051 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0246 0.2819
Schistosoma mansoni ets 0.0011 0.0063 0.0125
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1549 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0051 0.0051
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0246 0.2819
Entamoeba histolytica hypothetical protein 0.0024 0.0246 0.2819
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0051 0.0051
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1549 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0051 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0046
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0696 1
Schistosoma mansoni synaptojanin 0.0011 0.007 0.0139
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0063 0.0063
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0343 0.0512
Brugia malayi steroid hormone receptor 0.001 0.0051 0.0048
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0175 0.1686
Brugia malayi Thioredoxin reductase 0.0047 0.0557 0.0851
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0051 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0343 0.051
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0246 0.2819
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0051 0.0048
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0696 0.1069
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0845 0.1306
Schistosoma mansoni cript-related 0.0011 0.007 0.0139
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0557 0.7781
Onchocerca volvulus 0.0011 0.007 0.0862
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0051 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0051 0.0048
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0955 0.148
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0076
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0051 0.0102
Onchocerca volvulus 0.0026 0.0269 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1384 0.8889
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0246 0.2819
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0135 0.027
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0696 0.1071
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.007 0.007
Echinococcus granulosus protein C ets 2 0.0011 0.0063 0.0125
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0557 0.1114
Brugia malayi Ets-domain containing protein 0.0075 0.0955 0.1482
Trypanosoma brucei inositol phosphorylceramide synthase 0.0024 0.0246 0.2819
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0051 0.0048
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0557 0.0848
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.007 0.0078
Plasmodium vivax glutathione reductase, putative 0.0047 0.0557 0.7781
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0051 0.0048
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0686
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0686
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0696 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0175 0.1686
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0063 0.0063
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0135 0.0135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0051 0.0051
Entamoeba histolytica hypothetical membrane-spanning protein 0.0024 0.0246 0.2819
Schistosoma mansoni cpg binding protein 0.0026 0.0269 0.0537
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1384 0.8889
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1226 0.2453
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1044
Schistosoma mansoni cpg binding protein 0.0027 0.0289 0.0578
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0696 1
Plasmodium falciparum glutathione reductase 0.0016 0.0135 0.1044
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0052 0.0104
Leishmania major trypanothione reductase 0.0047 0.0557 0.7781
Brugia malayi Importin beta-1 subunit 0.0026 0.027 0.0396
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.007 0.0078
Schistosoma mansoni hypothetical protein 0.0011 0.007 0.0139
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.007 0.0139
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0063 0.0125
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0051 0.0051
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.007 0.0078
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0135 0.1044
Plasmodium vivax sphingomyelin synthase 2, putative 0.0024 0.0246 0.2819
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0051 0.0048
Schistosoma mansoni spingomyelin synthetase-related 0.0024 0.0246 0.0492
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.007 0.0076
Schistosoma mansoni carbon catabolite repressor protein 0.0011 0.007 0.0139
Brugia malayi Fli-1 protein 0.0229 0.3081 0.4851
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0246 0.2819
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0696 0.4235
Schistosoma mansoni ap endonuclease 0.0057 0.0696 0.1392
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.007 0.007
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0246 0.2819
Entamoeba histolytica hypothetical protein 0.0024 0.0246 0.2819
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0051 0.0048
Echinococcus multilocularis snurportin 1 0.0276 0.3741 0.3741
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0051 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0246 0.0356
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0051 0.0046
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.007 0.0078
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.007 0.0078
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0696 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0065
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0063 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0051 0.0046
Plasmodium falciparum importin beta, putative 0.0026 0.027 0.3199
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0175 0.0351
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0063 0.0063
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0696 1
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0135 0.1044
Loa Loa (eye worm) hypothetical protein 0.0463 0.633 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0269 0.0391
Trypanosoma brucei trypanothione reductase 0.0047 0.0557 0.7781
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0076
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0076 0.0088
Echinococcus granulosus importin subunit beta 1 0.0026 0.027 0.054
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0246 0.2819
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0024 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0026 0.027 0.0393
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0051 0.0102
Echinococcus multilocularis importin subunit beta 1 0.0026 0.027 0.027
Brugia malayi Muscleblind-like protein 0.0149 0.1975 0.3098
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.007 0.0078
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0686
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0051 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0051 0.0048
Brugia malayi hypothetical protein 0.0023 0.0225 0.0324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1226 0.2453
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0046
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0135 0.1044
Schistosoma mansoni hypothetical protein 0.0168 0.2238 0.4476
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0135 0.0182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1226 0.2453
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1277 0.1991
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0696 0.0696
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0246 0.0358
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0051 0.0051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0051 0.0102
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0051 0.0102
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0246 0.2819
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0135 0.1044
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.007 0.0076
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1226 0.1912
Schistosoma mansoni cpg binding protein 0.0027 0.0289 0.0578
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0246 0.2819
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0696 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0051 0.0102
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0696 1
Echinococcus granulosus snurportin 1 0.0276 0.3741 0.7482
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0063 0.0067
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0463 0.633 1
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0135 0.1044
Schistosoma mansoni importin beta-1 0.0026 0.027 0.054
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0246 0.2819
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0696 1
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0063 0.0125
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.007 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1226 0.2453
Loa Loa (eye worm) hypothetical protein 0.0023 0.0225 0.0322
Loa Loa (eye worm) glutathione reductase 0.0047 0.0557 0.0848
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1226 0.1226
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0225 0.2478
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0135 0.1044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0051 0.0102
Leishmania major hypothetical protein, conserved 0.0023 0.0225 0.2478
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0135 0.1044
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0051 0.0051
Brugia malayi RNA, U transporter 1 0.0074 0.0931 0.1444
Schistosoma mansoni ets-related 0.0229 0.3081 0.6162
Trypanosoma cruzi importin beta-1 subunit, putative 0.0021 0.0202 0.2115
Echinococcus multilocularis ets variant gene 4 0.0011 0.0063 0.0063
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0696 1
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.007 0.0139
Schistosoma mansoni synaptojanin 0.0011 0.007 0.0139
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0063 0.0063
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0051 0.0102
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.007 0.0076
Brugia malayi Sphingomyelin synthase-related 1 0.0024 0.0246 0.0358
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0051 0.0102
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0343 0.0343
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0051 0.0102
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1384 0.8889
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0051 0.0046
Brugia malayi CXXC zinc finger family protein 0.0026 0.0269 0.0393
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0955 0.0955
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.007 0.0139
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0175 0.1686
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.007 0.0139
Brugia malayi CCR4 0.0011 0.007 0.0078
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.007 0.0078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1044
Echinococcus granulosus cpg binding protein 0.0027 0.0289 0.0578
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0686
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0696 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0343 0.0686
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1226 0.191
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1044
Echinococcus multilocularis protein C ets 2 0.0011 0.0063 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1226 0.2453
Loa Loa (eye worm) hypothetical protein 0.0064 0.0804 0.124
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0225 0.2478
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0246 0.0356
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0051 0.0046
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0225 0.2478
Loa Loa (eye worm) hypothetical protein 0.0024 0.0246 0.0356
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0065
Schistosoma mansoni hypothetical protein 0.0168 0.2238 0.4476
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0225 0.2478
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0343 0.051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0343 0.0686
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0019 0.0175 0.1686
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0046
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.007 0.0076
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0135 0.1044
Entamoeba histolytica hypothetical protein 0.0024 0.0246 0.2819
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0225 0.2478
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1384 0.8889
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0051 0.0102
Schistosoma mansoni ran 0.0019 0.0175 0.0351
Schistosoma mansoni hypothetical protein 0.0011 0.0063 0.0125
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1277 0.1991
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1044
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0024 0.0246 0.2819
Leishmania major GTP-binding protein, putative 0.0019 0.0175 0.1686
Schistosoma mansoni hypothetical protein 0.001 0.0052 0.0104
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0955 0.1911
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0135 0.1044
Schistosoma mansoni neutral sphingomyelinase 0.0011 0.007 0.0139
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0063 0.0125
Loa Loa (eye worm) hypothetical protein 0.0149 0.1975 0.3097
Entamoeba histolytica hypothetical protein 0.0021 0.0202 0.2115
Echinococcus multilocularis muscleblind protein 0.0149 0.1975 0.1975
Trichomonas vaginalis ran, putative 0.0019 0.0175 0.1686
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0076
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0011 0.007 0.0139
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0225 0.2478
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0044
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0135 0.5
Leishmania major importin beta-1 subunit, putative 0.0021 0.0202 0.2115
Echinococcus multilocularis geminin 0.0168 0.2238 0.2238
Echinococcus multilocularis GPCR, family 2 0.0031 0.0343 0.0343
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0051 0.0102
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0246 0.2819
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0135 0.1044
Schistosoma mansoni hypothetical protein 0.0011 0.0063 0.0125
Loa Loa (eye worm) hypothetical protein 0.0067 0.0845 0.1304
Entamoeba histolytica Ran family GTPase 0.0019 0.0175 0.1686
Brugia malayi glutathione reductase 0.0047 0.0557 0.0851
Echinococcus granulosus dnaJ subfamily B 0.0367 0.5 1
Onchocerca volvulus 0.0011 0.007 0.0862
Schistosoma mansoni ran 0.0019 0.0175 0.0351
Echinococcus granulosus synaptojanin 1 0.0011 0.007 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0051 0.0048
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0135 0.0442
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0175 0.0175
Schistosoma mansoni ets-related 0.0011 0.0063 0.0125
Brugia malayi nuclear hormone receptor 0.001 0.0051 0.0048
Trichomonas vaginalis hypothetical protein 0.0024 0.0246 0.2819
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0019 0.0175 0.1686
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0051 0.0048
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0276 0.3741 0.5896
Toxoplasma gondii histone lysine methyltransferase SET1 0.0049 0.0588 0.828
Loa Loa (eye worm) hypothetical protein 0.0024 0.0246 0.0356
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0202 0.2115
Plasmodium vivax sphingomyelin synthase 1, putative 0.0024 0.0246 0.2819
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1226 0.1226
Plasmodium vivax importin-beta 2, putative 0.0026 0.027 0.3199
Toxoplasma gondii hypothetical protein 0.0024 0.0246 0.2819
Schistosoma mansoni elf1 0.0011 0.0063 0.0125
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0246 0.0358
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0175 0.1686
Brugia malayi ecdysteroid receptor 0.001 0.0051 0.0048
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0024 0.0246 0.2819
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1549 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0051 0.0102
Loa Loa (eye worm) fli-1 protein 0.0229 0.3081 0.485
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0055 0.0669 0.1338
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0051 0.0048

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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