Detailed information for compound 631108

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.136 | Formula: C11H12IN3O2
  • H donors: 1 H acceptors: 3 LogP: 1.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(C=N2C=NN=C2)cc(c1O)I
  • InChi: 1S/C11H11IN4O2/c1-2-18-10-4-8(3-9(12)11(10)17)5-15-16-6-13-14-7-16/h3-7,17H,2H2,1H3/b15-5+
  • InChiKey: YRKWOFGIXDAGMX-PJQLUOCWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0018 0.0045 0.3637
Echinococcus granulosus short transient receptor potential channel 6 0.013 0.0717 0.0837
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0154 0.0154
Echinococcus granulosus peregrin 0.0035 0.0151 0.0176
Echinococcus multilocularis short transient receptor potential channel 6 0.013 0.0717 0.0717
Echinococcus multilocularis muscleblind protein 0.0156 0.0872 0.0872
Echinococcus multilocularis peregrin 0.0035 0.0151 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Onchocerca volvulus Alhambra homolog 0.003 0.0121 1
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0038 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0692 0.0806
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0045 0.2148
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0149 0.083 0.0967
Echinococcus granulosus TRP transient receptor potential channel 0.0073 0.0376 0.0439
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0344 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0038 0.0008
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0038 0.0018
Toxoplasma gondii TIM10 family protein, putative 0.0046 0.0214 0.2699
Loa Loa (eye worm) hypothetical protein 0.009 0.0476 0.0554
Plasmodium falciparum phd finger protein, putative 0.003 0.0121 0.4446
Toxoplasma gondii thioredoxin reductase 0.0048 0.0225 0.2865
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0009
Leishmania major cathepsin L-like protease 0.0018 0.0045 0.0118
Leishmania major trypanothione reductase 0.0048 0.0225 0.2865
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0045 0.0411
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0078 0.0612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0045 0.2148
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0043 0.0286
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0045 0.0051
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0174 0.0203
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0174 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0045 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0089
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.001 0.0009
Treponema pallidum NADH oxidase 0.0017 0.0038 0.5
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0225 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0038 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0002 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0543 0.0632
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0038 0.0013
Brugia malayi Cathepsin L-like precursor 0.0012 0.001 0.0009
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0078 0.0612
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0002 0.0002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0044
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.1425 0.1663
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0592 0.8468
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Schistosoma mansoni zinc finger protein 0.0032 0.0131 0.0151
Brugia malayi Cathepsin L-like precursor 0.0018 0.0045 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0045 0.2148
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0045 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0315 0.0365
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0078 0.0089
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0121 0.1274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Brugia malayi Latrophilin receptor protein 2 0.0032 0.013 0.015
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0037 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0183 0.0212
Schistosoma mansoni hypothetical protein 0.0044 0.0199 0.023
Brugia malayi PHD-finger family protein 0.0014 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0156 0.0872 0.1016
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0174 0.4444
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0779 0.0908
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0045 0.0045
Echinococcus multilocularis GPCR, family 2 0.0032 0.013 0.013
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0154 0.0154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0779 0.091
Leishmania major cathepsin L-like protease 0.0068 0.0344 0.4684
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0779 0.0779
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0779 0.0908
Plasmodium vivax hypothetical protein, conserved 0.003 0.0121 0.4446
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0048
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0022 0.0024
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.015
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0038 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0048
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0078 0.0612
Brugia malayi follicle stimulating hormone receptor 0.0249 0.1425 0.1663
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0045 0.3637
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0592 0.8468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Schistosoma mansoni hypothetical protein 0.0069 0.0352 0.0409
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.013 0.013
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0154 0.0177
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0174 0.0201
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0344 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0543 0.0632
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0192 0.0224
Brugia malayi Cathepsin L-like precursor 0.0018 0.0045 0.0051
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0038 0.0029
Schistosoma mansoni hypothetical protein 0.0167 0.0934 0.1089
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0038 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0045 0.0252
Echinococcus granulosus GPCR family 2 0.0032 0.013 0.0152
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0045 0.2148
Brugia malayi Cathepsin L-like precursor 0.0018 0.0045 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.013 0.015
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0046 0.0214 0.0248
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0257 0.7171
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0078 0.0612
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0391 0.0457
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0154 0.0179
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0073 0.0376 0.0376
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0154 0.0177
Echinococcus multilocularis geminin 0.0167 0.0934 0.0934
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0225 0.0261
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0078 0.062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0692 1
Echinococcus multilocularis cysteine protease 0.0018 0.0045 0.0045
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0199 0.023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0002 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0692 1
Leishmania major cathepsin L-like protease 0.0018 0.0045 0.0118
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0592 0.8758
Echinococcus multilocularis muscleblind protein 1 0.0156 0.0872 0.0872
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0201
Brugia malayi PHD-finger family protein 0.003 0.0121 0.0139
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0692 0.0806
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0037 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0779 0.091
Brugia malayi glutathione reductase 0.0048 0.0225 0.0261
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0223 0.0223
Schistosoma mansoni transient receptor potential channel 0.0197 0.1115 0.13
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0048
Loa Loa (eye worm) glutathione reductase 0.0048 0.0225 0.0261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0043 0.0074
Loa Loa (eye worm) ctsf protein 0.0018 0.0045 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0045 0.2148
Trypanosoma cruzi ISWI complex protein 0.0032 0.0131 0.3068
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1444 0.8562 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0078 0.0089
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0038 0.0008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0002 0.0002
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1444 0.8562 0.8562
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0051
Brugia malayi isocitrate dehydrogenase 0.0017 0.0037 0.0042
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0225 0.2869
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0692 1
Leishmania major cathepsin L-like protease 0.0018 0.0045 0.0118
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0045 0.0051
Echinococcus multilocularis neuropeptide s receptor 0.0494 0.2887 0.2887
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0779 0.0908
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0045 0.0411
Echinococcus granulosus zinc finger protein 0.0041 0.0185 0.0216
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0121 0.0141
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0078 0.4154
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0174 0.0174
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0665 0.958
Leishmania major cathepsin L-like protease 0.0018 0.0045 0.0118
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0043 0.0087
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0183 0.0212
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.015
Loa Loa (eye worm) fibroinase 0.0018 0.0045 0.0051
Loa Loa (eye worm) hypothetical protein 0.0124 0.0677 0.0789
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.013 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Brugia malayi Bromodomain containing protein 0.0081 0.0421 0.049
Echinococcus granulosus short transient receptor potential channel 6 0.013 0.0717 0.0837
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0225 0.6118
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0174 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0535 0.0625
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0174 0.0201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0018
Brugia malayi map kinase activated protein kinase protein 2 0.1444 0.8562 1
Trypanosoma brucei trypanothione reductase 0.0048 0.0225 0.6118
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0174 0.0201
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0214 0.2699
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0692 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0214 0.9419
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0002 0.0002
Brugia malayi Bromodomain containing protein 0.0158 0.0884 0.103
Plasmodium vivax vivapain-2 0.0018 0.0045 0.0411
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0223 0.0258
Echinococcus granulosus cathepsin l1 0.0018 0.0045 0.0053
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0038 0.1709
Brugia malayi Cathepsin L-like precursor 0.0018 0.0045 0.0051
Echinococcus multilocularis neuropeptide receptor A26 0.0494 0.2887 0.2887
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0174 0.0174
Onchocerca volvulus 0.0018 0.0045 0.3637
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0045 0.0053
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0038 0.1709
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0018
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0592 0.8468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0154 0.0177
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0081 0.0422 0.0491
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.013 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0002 0.0002
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0121 0.0139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0018
Echinococcus multilocularis zinc finger protein 0.0041 0.0185 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0045 0.2148
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0008
Brugia malayi Cathepsin L-like precursor 0.0012 0.001 0.0009
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0002 0.0002
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0045 0.0053
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0078 0.4154
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0344 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0038 0.0029
Schistosoma mansoni hypothetical protein 0.003 0.0121 0.0139
Leishmania major hypothetical protein, conserved 0.0032 0.0131 0.1437
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0022 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0045 0.2148
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0078 0.4154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0018
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0174 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0037 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0002 0.0002
Schistosoma mansoni transient receptor potential channel 4 0.0197 0.1115 0.13
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0078 0.062
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0665 1
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0046 0.0214 0.0248
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0012 0.0011
Plasmodium falciparum glutathione reductase 0.0048 0.0225 1
Schistosoma mansoni serine/threonine protein kinase 0.1444 0.8562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0045 0.2148
Brugia malayi Cathepsin L-like precursor 0.0018 0.0045 0.0051
Brugia malayi jmjC domain containing protein 0.0041 0.0183 0.0212
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0126 0.0691 0.0691
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0174 0.2082
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0183 0.0212
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0665 0.958
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0045 0.0118
Mycobacterium ulcerans hypothetical protein 0.0023 0.0078 0.0612
Plasmodium vivax vivapain-2 0.0018 0.0045 0.0411
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0045 0.2148
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0002 0.0002
Echinococcus granulosus geminin 0.0167 0.0934 0.1091
Brugia malayi jmjC domain containing protein 0.01 0.0535 0.0623
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0154 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0038 0.0008
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0045 0.3637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Echinococcus granulosus expressed protein 0.0046 0.0214 0.025
Echinococcus multilocularis transient receptor potential gamma protein 0.0197 0.1115 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0174 1
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0214 0.9419
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0692 0.0808
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0352 0.0409
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0779 0.0779
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0174 0.0174
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0042
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0692 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0038 0.0018
Echinococcus granulosus transient receptor potential ion channel A 0.019 0.1076 0.1256
Onchocerca volvulus 0.0023 0.0078 0.6399
Trypanosoma cruzi ISWI complex protein 0.0032 0.0131 0.3068
Loa Loa (eye worm) hypothetical protein 0.0073 0.0376 0.0437
Brugia malayi Cathepsin L-like precursor 0.0018 0.0045 0.0051
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0038 0.0018
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0045 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0002 0.0002
Echinococcus granulosus muscleblind protein 0.0156 0.0872 0.1018
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0043 0.0286
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.015
Toxoplasma gondii cathepsin CPL 0.0018 0.0045 0.0118
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0159 0.0159
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0043 1
Plasmodium vivax glutathione reductase, putative 0.0048 0.0225 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0174 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0223 0.026
Echinococcus granulosus transient receptor potential gamma protein 0.0197 0.1115 0.1302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Echinococcus granulosus neuropeptide receptor A26 0.0494 0.2887 0.3371
Giardia lamblia PHD finger protein 15 0.003 0.0121 0.6104
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0037 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0045 0.2148
Entamoeba histolytica cysteine protease, putative 0.0018 0.0045 0.2148
Onchocerca volvulus 0.0012 0.001 0.0681
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0022 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0779 0.0908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Brugia malayi cathepsin L-like precursor 0.0012 0.001 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0174 0.4444
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0045 0.0411
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Plasmodium falciparum thioredoxin reductase 0.0017 0.0038 0.0029
Loa Loa (eye worm) hypothetical protein 0.0067 0.0337 0.0391
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0225 0.0263
Schistosoma mansoni bromodomain containing protein 0.0134 0.0736 0.0858
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0161 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0078 0.0612
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0121 0.0121
Schistosoma mansoni transient receptor potential channel 0.013 0.0717 0.0835
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0089
Brugia malayi PHD-finger family protein 0.0053 0.0253 0.0293
Leishmania major cathepsin L-like protease 0.0068 0.0344 0.4684
Brugia malayi Transient-receptor-potential like protein 0.0073 0.0376 0.0437
Echinococcus multilocularis short transient receptor potential channel 6 0.013 0.0717 0.0717
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0018
Loa Loa (eye worm) hypothetical protein 0.0197 0.1115 0.13
Onchocerca volvulus 0.0018 0.0045 0.3637
Loa Loa (eye worm) hypothetical protein 0.0156 0.0872 0.1016
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0078 0.0624
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.015
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0154 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0045 0.0051
Plasmodium falciparum thioredoxin reductase 0.0048 0.0225 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0078 0.062
Schistosoma mansoni hypothetical protein 0.0032 0.0131 0.0151
Echinococcus multilocularis cysteine protease 0.0018 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0154 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0045 0.2148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0045 0.2148
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0038 0.0042
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1444 0.8562 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0535 0.0535
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0078 0.0089
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0692 0.0692
Brugia malayi Bromodomain containing protein 0.0035 0.0151 0.0174
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0412 0.048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0692 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0078 0.0612
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0002 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0665 0.958
Loa Loa (eye worm) hypothetical protein 0.0086 0.0452 0.0526
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0045 0.0051
Leishmania major cathepsin L-like protease 0.0018 0.0045 0.0118
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0045 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0078 0.0624
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0174 0.4444
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0121 0.0139
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0225 0.0225
Onchocerca volvulus 0.0018 0.0045 0.3637
Echinococcus granulosus cathepsin l1 0.0012 0.001 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0048
Mycobacterium tuberculosis Probable reductase 0.0109 0.0592 0.8468
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0038 0.5
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0037 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0045 0.2148
Brugia malayi Thioredoxin reductase 0.0048 0.0225 0.0261
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0002 0.0002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0038 0.0038
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0012 0.0011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0543 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Onchocerca volvulus 0.0018 0.0045 0.3637
Leishmania major cathepsin L-like protease 0.0068 0.0344 0.4684
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0592 0.8468
Loa Loa (eye worm) cysteine protease 0.0018 0.0045 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0344 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0045 0.2148
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0121 0.1274
Loa Loa (eye worm) hypothetical protein 0.0052 0.0251 0.0291
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0045 0.3637
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0038 0.0029
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0592 0.8468
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0779 0.0908
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0038 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0089
Onchocerca volvulus 0.0018 0.0045 0.3637
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0038 0.0029
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0044
Trypanosoma brucei ISWI complex protein 0.0032 0.0131 0.3068
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0183 0.0214
Loa Loa (eye worm) hypothetical protein 0.0069 0.0352 0.0409
Plasmodium falciparum glutathione reductase 0.0017 0.0038 0.0029
Schistosoma mansoni hypothetical protein 0.0167 0.0934 0.1089
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0002 0.0002
Onchocerca volvulus 0.0018 0.0045 0.3637
Loa Loa (eye worm) hypothetical protein 0.0101 0.0543 0.0632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0344 1
Brugia malayi Muscleblind-like protein 0.0156 0.0872 0.1016
Schistosoma mansoni transient receptor potential channel 0.013 0.0717 0.0835
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0174 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0309 0.8853
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0174 0.0203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0002 0.0002
Echinococcus granulosus neuropeptide s receptor 0.0494 0.2887 0.3371
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0046 0.0214 0.0248
Echinococcus multilocularis expressed protein 0.0046 0.0214 0.0214
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0126 0.0691 0.0807
Echinococcus multilocularis transient receptor potential ion channel A 0.019 0.1076 0.1076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0002 0.0002
Schistosoma mansoni zinc finger protein 0.0041 0.0185 0.0214
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0048
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.013 0.0152
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0078 0.0612

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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