Detailed information for compound 631731

Basic information

Technical information
  • TDR Targets ID: 631731
  • Name: 4-[(4-dimethylaminophenyl)methylideneamino]-5 -(4-methylphenyl)-2H-1,2,4-triazole-3-thione
  • MW: 337.442 | Formula: C18H19N5S
  • H donors: 0 H acceptors: 2 LogP: 3.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1nnc(n1N=Cc1ccc(cc1)N(C)C)S
  • InChi: 1S/C18H19N5S/c1-13-4-8-15(9-5-13)17-20-21-18(24)23(17)19-12-14-6-10-16(11-7-14)22(2)3/h4-12H,1-3H3,(H,21,24)/b19-12+
  • InChiKey: KXTAYXQSKSJNEV-XDHOZWIPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(4-dimethylaminophenyl)methyleneamino]-5-(4-methylphenyl)-2H-1,2,4-triazole-3-thione
  • 4-[(4-dimethylaminobenzylidene)amino]-5-(4-methylphenyl)-2H-1,2,4-triazole-3-thione
  • STOCK3S-07104
  • Oprea1_019898

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0514 0.3433
Schistosoma mansoni hypothetical protein 0.0041 0.056 0.0606
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0106
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.2371 0.3317
Mycobacterium tuberculosis Conserved protein 0.0071 0.1233 0.1277
Onchocerca volvulus 0.0032 0.0363 0.2942
Mycobacterium tuberculosis Probable dehydrogenase 0.019 0.3838 0.3976
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0083 0.1497 0.1551
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0033 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0032 0.0363 0.1021
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.012 0.0168
Onchocerca volvulus 0.0071 0.1233 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0106 0.0109
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1233 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.006 0.006
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0304 0.0838
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0106
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1233 0.1277
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1233 0.1277
Schistosoma mansoni ran 0.0021 0.012 0.013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1233 0.1277
Toxoplasma gondii ABC1 family protein 0.0071 0.1233 0.8233
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0304 0.2028
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1233 0.1277
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.012 0.0331
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0024
Brugia malayi Ets-domain containing protein 0.0021 0.0128 0.0128
Schistosoma mansoni smad1 5 8 and 0.0032 0.0374 0.0405
Loa Loa (eye worm) hypothetical protein 0.0071 0.1233 0.1233
Loa Loa (eye worm) thioredoxin reductase 0.0083 0.1497 0.1497
Echinococcus multilocularis ets variant gene 4 0.0021 0.0128 0.0179
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0514 0.0514
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0017 0.0047
Schistosoma mansoni hypothetical protein 0.0041 0.056 0.0606
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0032 0.0363 0.0376
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0304 0.0782
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0304 0.2028
Brugia malayi MH2 domain containing protein 0.0032 0.0374 0.0374
Brugia malayi DNA-binding protein D-ETS-3 0.0021 0.0128 0.0128
Toxoplasma gondii thioredoxin reductase 0.0083 0.1497 1
Onchocerca volvulus 0.0048 0.0717 0.5816
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0024
Plasmodium falciparum thioredoxin reductase 0.0029 0.0304 0.2028
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0042 0.0593 0.0593
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0374 0.0524
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1233 0.8233
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0021 0.0128 0.0128
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0181 0.3625 1
Echinococcus multilocularis musashi 0.0027 0.0269 0.0377
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0017 0.0113
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.4801 0.6718
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0593 0.083
Loa Loa (eye worm) Smad1 0.0032 0.0374 0.0374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0033 0.0034
Schistosoma mansoni hypothetical protein 0.0041 0.056 0.0606
Entamoeba histolytica Ran family GTPase 0.0021 0.012 0.0659
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0304 0.0855
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0181 0.3625 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0593 0.083
Echinococcus granulosus importin subunit beta 1 0.0028 0.0281 0.0393
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1233 0.1233
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.1497 0.4131
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.2371 0.3317
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.012 0.0801
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0304 0.0855
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.4801 0.6718
Mycobacterium ulcerans hypothetical protein 0.0032 0.0363 0.0934
Schistosoma mansoni smad1 5 8 and 0.0032 0.0374 0.0405
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0113
Schistosoma mansoni hypothetical protein 0.0342 0.7146 0.7734
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0304 0.0855
Brugia malayi MH2 domain containing protein 0.0032 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0123 0.2365 0.2365
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0374 0.0524
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0113
Onchocerca volvulus 0.0071 0.1233 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.1233 0.1277
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0021 0.0128 0.0179
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1233 0.1725
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0106 0.0705
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0514 0.1418
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0281 0.1877
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.012 0.012
Leishmania major fatty acid transporter protein-like protein 0.0177 0.3553 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0166 0.1344
Onchocerca volvulus 0.0027 0.0269 0.2183
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.182 1
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0177 0.3553 0.8257
Loa Loa (eye worm) glutathione reductase 0.0083 0.1497 0.1497
Echinococcus multilocularis ETS transcription factor Elf 5 0.0021 0.0128 0.0179
Brugia malayi CHE-14 protein 0.0042 0.0593 0.0593
Mycobacterium tuberculosis Probable oxidoreductase 0.0212 0.4303 0.4458
Schistosoma mansoni smad 0.0032 0.0374 0.0405
Brugia malayi Ets-domain containing protein 0.0144 0.2823 0.2823
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.1508 0.211
Echinococcus multilocularis GA binding protein alpha chain 0.0144 0.2823 0.395
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0442 0.0619
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0281 0.1877
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0212 0.4303 0.4458
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0032 0.0363 0.0843
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0514 0.2825
Brugia malayi beta-lactamase family protein 0.0071 0.1233 0.1233
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.1508 0.211
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.182 0.182
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.182 0.2546
Leishmania major GTP-binding protein, putative 0.0021 0.012 0.0338
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0269 0.0269
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0304 0.0782
Loa Loa (eye worm) fli-1 protein 0.0437 0.924 0.924
Plasmodium falciparum glutathione reductase 0.0029 0.0304 0.2028
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0071 0.1233 0.1233
Schistosoma mansoni lamin 0.0027 0.0269 0.0291
Schistosoma mansoni FFA transport protein 0.0181 0.3625 0.3923
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0304 0.2463
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0304 0.0838
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0304 0.2028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1233 0.1334
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0021 0.0128 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0363 0.0363
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0304 0.2028
Entamoeba histolytica hypothetical protein 0.0035 0.0442 0.243
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.019 0.3838 0.3976
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0136 0.0136
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0514 0.0719
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0017 0.0024
Mycobacterium tuberculosis Probable reductase 0.019 0.3838 0.3976
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0047
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.9652 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0192 0.3882 0.3882
Echinococcus granulosus long chain fatty acid transport protein 4 0.0181 0.3625 0.5073
Brugia malayi Ets-domain containing protein 0.0144 0.2823 0.2823
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.012 0.0331
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0181 0.3625 0.5073
Brugia malayi Fli-1 protein 0.0437 0.924 0.924
Echinococcus granulosus GA binding protein alpha chain 0.0144 0.2823 0.395
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1233 0.1233
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0106 0.0705
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0304 0.0425
Leishmania major importin beta-1 subunit, putative 0.0023 0.0166 0.0466
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.012 0.0801
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0717 0.0717
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0304 0.0315
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0304 0.0782
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0106
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1233 0.1725
Echinococcus granulosus geminin 0.0342 0.7146 1
Brugia malayi hypothetical protein 0.0234 0.4801 0.4801
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0514 0.417
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0304 0.2028
Schistosoma mansoni hypothetical protein 0.0342 0.7146 0.7734
Loa Loa (eye worm) transcription factor SMAD2 0.0472 1 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0281 0.1877
Schistosoma mansoni ets-related 0.0437 0.924 1
Echinococcus multilocularis expressed conserved protein 0.0092 0.1689 0.2364
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0032 0.0363 0.0934
Brugia malayi isocitrate dehydrogenase 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0269 0.0269
Brugia malayi transcription factor E74 isoform 0.0021 0.0128 0.0128
Plasmodium falciparum importin beta, putative 0.0028 0.0281 0.1877
Brugia malayi intermediate filament protein 0.0027 0.0269 0.0269
Onchocerca volvulus 0.0027 0.0269 0.2183
Brugia malayi hypothetical protein 0.0035 0.0442 0.0442
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1233 0.3175
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1233 0.8233
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0166 0.1344
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.012 0.012
Trichomonas vaginalis ran, putative 0.0021 0.012 0.0973
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0374 0.0405
Echinococcus granulosus ETS transcription factor Elf 2 0.0021 0.0128 0.0179
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0304 0.0329
Brugia malayi MH1 domain containing protein 0.0018 0.006 0.006
Echinococcus multilocularis Smad4 0.0032 0.0374 0.0524
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0304 0.2463
Leishmania major 4-coumarate:coa ligase-like protein 0.0032 0.0363 0.1021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0304 0.0838
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0281 0.1877
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0033 0.0034
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.019 0.3838 0.8919
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0304 0.0838
Schistosoma mansoni ap endonuclease 0.0039 0.0514 0.0556
Echinococcus granulosus ETS transcription factor Elf 5 0.0021 0.0128 0.0179
Schistosoma mansoni ap endonuclease 0.0039 0.0514 0.0556
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1233 0.1334
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0304 0.0304
Brugia malayi RNA, U transporter 1 0.0079 0.1407 0.1407
Brugia malayi beta-lactamase 0.0071 0.1233 0.1233
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0177 0.3553 0.3681
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1233 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0514 0.3433
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0514 0.1447
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0166 0.1344
Loa Loa (eye worm) hypothetical protein 0.0071 0.1233 0.1233
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0363 0.0363
Schistosoma mansoni hypothetical protein 0.0048 0.0717 0.0776
Echinococcus granulosus snurportin 1 0.0298 0.6189 0.866
Loa Loa (eye worm) hypothetical protein 0.0028 0.0281 0.0281
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0304 0.4661
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0514 0.0533
Entamoeba histolytica acyl-CoA synthetase, putative 0.0032 0.0363 0.1993
Echinococcus multilocularis snurportin 1 0.0298 0.6189 0.866
Loa Loa (eye worm) hypothetical protein 0.0052 0.08 0.08
Echinococcus multilocularis ewsr:fli fusion protein type 0.0021 0.0128 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0363 0.0934
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0442 0.0619
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0144 0.2823 0.2823
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1233 0.3175
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0021 0.0128 0.0138
Echinococcus multilocularis lamin 0.0027 0.0269 0.0377
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0106
Entamoeba histolytica hypothetical protein 0.0035 0.0442 0.243
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0374 0.0374
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.6189 0.6189
Loa Loa (eye worm) hypothetical protein 0.0098 0.182 0.182
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0304 0.2028
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.012 0.0801
Echinococcus granulosus ETS domain containing protein Elk 1 0.0021 0.0128 0.0179
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.019 0.3838 0.3976
Mycobacterium ulcerans lipase LipD 0.0071 0.1233 0.3175
Echinococcus multilocularis protein C ets 2 0.0021 0.0128 0.0179
Brugia malayi beta-lactamase family protein 0.0071 0.1233 0.1233
Schistosoma mansoni hypothetical protein 0.0298 0.6189 0.6698
Mycobacterium tuberculosis Putative ferredoxin reductase 0.019 0.3838 0.3976
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1233 0.1277
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0136 0.0136
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0304 0.2028
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0363 0.0363
Echinococcus granulosus smad 0.0032 0.0374 0.0524
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0363 0.0376
Loa Loa (eye worm) hypothetical protein 0.0027 0.0258 0.0258
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.1853 0.2005
Echinococcus multilocularis ETS transcription factor Elf 2 0.0021 0.0128 0.0179
Leishmania major hypothetical protein, conserved 0.0071 0.1233 0.347
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0017 0.0018
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0374 0.0374
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.012 0.0801
Brugia malayi MH1 domain containing protein 0.0018 0.006 0.006
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0593 0.083
Loa Loa (eye worm) hypothetical protein 0.0032 0.0363 0.0363
Leishmania major trypanothione reductase 0.0083 0.1497 0.4215
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0304 0.2028
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1233 0.3401
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0021 0.0128 0.0128
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0514 0.3433
Schistosoma mansoni importin beta-1 0.0028 0.0281 0.0304
Entamoeba histolytica hypothetical protein 0.0035 0.0442 0.243
Loa Loa (eye worm) D-ets-2 protein 0.0021 0.0128 0.0128
Schistosoma mansoni thyroid hormone receptor 0.0133 0.2587 0.28
Mycobacterium ulcerans beta-lactamase 0.0071 0.1233 0.3175
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1233 0.3401
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.019 0.3838 0.3976
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0442 0.0479
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0363 0.0934
Loa Loa (eye worm) hypothetical protein 0.0021 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0123 0.2371 0.2566
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0304 0.0425
Entamoeba histolytica hypothetical protein 0.0035 0.0442 0.243
Loa Loa (eye worm) ets-domain-containing protein 0.0021 0.0128 0.0128
Brugia malayi Thioredoxin reductase 0.0083 0.1497 0.1497
Toxoplasma gondii exonuclease III APE 0.0039 0.0514 0.3433
Echinococcus granulosus Smad4 0.0032 0.0374 0.0524
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1233 0.1277
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0032 0.0363 0.0934
Entamoeba histolytica acyl-coA synthetase, putative 0.0032 0.0363 0.1993
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.2742 0.3837
Loa Loa (eye worm) hypothetical protein 0.0032 0.0363 0.0363
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0304 0.0838
Mycobacterium ulcerans hypothetical protein 0.0071 0.1233 0.3175
Echinococcus granulosus ETS transcription factor Elf 1 0.0021 0.0128 0.0179
Loa Loa (eye worm) hypothetical protein 0.0071 0.1233 0.1233
Brugia malayi Importin beta-1 subunit 0.0028 0.0281 0.0281
Echinococcus granulosus ETS transcription factor Elf 2 0.0021 0.0128 0.0179
Schistosoma mansoni hypothetical protein 0.0041 0.056 0.0606
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0514 0.1324
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0106 0.0272
Plasmodium vivax glutathione reductase, putative 0.0083 0.1497 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0024
Brugia malayi MH1 domain containing protein 0.0032 0.0374 0.0374
Echinococcus multilocularis protein patched 0.0042 0.0593 0.083
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0304 0.2028
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0514 0.0514
Loa Loa (eye worm) MH2 domain-containing protein 0.0472 1 1
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0363 0.0363
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0281 0.0393
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0212 0.4303 0.4458
Echinococcus granulosus protein C ets 2 0.0021 0.0128 0.0179
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0304 0.0838
Echinococcus granulosus lamin 0.0027 0.0269 0.0377
Trypanosoma brucei trypanothione reductase 0.0083 0.1497 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0192 0.3882 1
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.2742 0.3837
Loa Loa (eye worm) nuclear factor I 0.0018 0.006 0.006
Schistosoma mansoni ran 0.0021 0.012 0.013
Brugia malayi glutathione reductase 0.0083 0.1497 0.1497
Schistosoma mansoni Smad4 0.0032 0.0374 0.0405
Schistosoma mansoni patched 1 0.0042 0.0593 0.0642
Mycobacterium tuberculosis Conserved protein 0.0071 0.1233 0.1277
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0514 1
Echinococcus multilocularis lamin dm0 0.0027 0.0269 0.0377
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0374 0.0524
Echinococcus granulosus intermediate filament protein 0.0027 0.0269 0.0377
Schistosoma mansoni intermediate filament proteins 0.0027 0.0269 0.0291
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1233 1
Plasmodium falciparum glutathione reductase 0.0083 0.1497 1
Plasmodium vivax thioredoxin reductase, putative 0.0083 0.1497 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0304 0.0838
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0304 0.0855
Loa Loa (eye worm) beta-lactamase 0.0071 0.1233 0.1233
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0514 0.0719
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0304 0.0838
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0363 0.0934
Echinococcus multilocularis protein dispatched 1 0.0048 0.0723 0.1012
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0047
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.012 0.0168
Echinococcus multilocularis ETS transcription factor Elf 1 0.0021 0.0128 0.0179
Schistosoma mansoni gabp alpha 0.0144 0.2823 0.3055
Echinococcus multilocularis ETS transcription factor Elf 2 0.0021 0.0128 0.0179
Plasmodium falciparum thioredoxin reductase 0.0083 0.1497 1
Brugia malayi Smad1 0.0032 0.0374 0.0374
Trichomonas vaginalis esterase, putative 0.0071 0.1233 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0304 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1233 0.1233
Mycobacterium leprae Probable lipase LipE 0.0071 0.1233 0.2865
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.182 0.2546
Schistosoma mansoni hypothetical protein 0.0035 0.0442 0.0479
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0017 0.0017
Onchocerca volvulus 0.0071 0.1233 1
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1233 0.1277
Loa Loa (eye worm) hypothetical protein 0.0021 0.0128 0.0128
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0304 0.2028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0033 0.0034
Entamoeba histolytica acyl-CoA synthetase, putative 0.0032 0.0363 0.1993
Loa Loa (eye worm) hypothetical protein 0.0071 0.1233 0.1233
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0017 0.0113
Echinococcus granulosus expressed conserved protein 0.0092 0.1689 0.2364
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1233 1
Echinococcus granulosus lamin dm0 0.0027 0.0269 0.0377
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0032 0.0363 0.0843
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0106
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0269 0.0269
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0166 0.0457
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0017 0.0113
Entamoeba histolytica hypothetical protein 0.0023 0.0166 0.091
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0032 0.0363 0.0934
Schistosoma mansoni hypothetical protein 0.0021 0.0128 0.0138
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0514 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1233 1
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0514 0.417
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0032 0.0363 0.0934
Brugia malayi MH1 domain containing protein 0.0032 0.0374 0.0374
Echinococcus multilocularis smad 0.0032 0.0374 0.0524
Schistosoma mansoni thyroid hormone receptor 0.0133 0.2587 0.28
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0374 0.0524
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0514 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0514 0.1418
Brugia malayi AMP-binding enzyme family protein 0.0192 0.3882 0.3882
Leishmania major 4-coumarate:coa ligase-like protein 0.0032 0.0363 0.1021
Schistosoma mansoni ets-related 0.0021 0.0128 0.0138
Schistosoma mansoni lamin 0.0027 0.0269 0.0291
Mycobacterium leprae conserved hypothetical protein 0.0071 0.1233 0.2865
Schistosoma mansoni ets 0.0021 0.0128 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0593 0.4809
Schistosoma mansoni smad1 5 8 and 0.0032 0.0374 0.0405
Echinococcus multilocularis geminin 0.0342 0.7146 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0304 0.0838
Loa Loa (eye worm) hypothetical protein 0.0234 0.4801 0.4801
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0269 0.0269
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0212 0.4303 1
Schistosoma mansoni elf1 0.0021 0.0128 0.0138
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.2587 0.3621
Schistosoma mansoni survival motor neuron protein 0.0048 0.0717 0.0776
Echinococcus granulosus ewsr:fli fusion protein type 0.0021 0.0128 0.0179

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.