Detailed information for compound 647587

Basic information

Technical information
  • TDR Targets ID: 647587
  • Name: 4-bromo-N-[(2,3-dimethoxyphenyl)methyl]anilin e
  • MW: 322.197 | Formula: C15H16BrNO2
  • H donors: 1 H acceptors: 0 LogP: 4.03 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1OC)CNc1ccc(cc1)Br
  • InChi: 1S/C15H16BrNO2/c1-18-14-5-3-4-11(15(14)19-2)10-17-13-8-6-12(16)7-9-13/h3-9,17H,10H2,1-2H3
  • InChiKey: SFLHEDGTQWMZHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-bromophenyl)-(2,3-dimethoxybenzyl)amine
  • Oprea1_223552
  • (4-Bromo-phenyl)-(2,3-dimethoxy-benzyl)-amine
  • ZINC00263306
  • Oprea1_842164
  • BAS 01125371

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis protein dispatched 1 0.0047 0.0348 0.0379
Loa Loa (eye worm) hypothetical protein 0.0091 0.0838 0.083
Schistosoma mansoni regulator of G protein signaling 0.0091 0.0838 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0838 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1152 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0214 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Loa Loa (eye worm) hypothetical protein 0.0041 0.0283 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Mycobacterium ulcerans hypothetical protein 0.0072 0.0628 0.5438
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Echinococcus granulosus regulator of G protein signaling 3 0.0091 0.0838 0.0931
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0823 0.8985 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0826 0.0918
Loa Loa (eye worm) hypothetical protein 0.0091 0.0838 0.083
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0838 1
Leishmania major hypothetical protein, conserved 0.0025 0.0097 0.0828
Echinococcus multilocularis regulator of G protein signaling 3 0.0091 0.0838 0.0917
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0628 0.0626
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1001 0.2014
Trypanosoma brucei trypanothione reductase 0.0046 0.034 0.5397
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0034 0.0064
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0823 0.8985 0.8985
Loa Loa (eye worm) PXA domain-containing protein 0.0091 0.0838 0.083
Mycobacterium tuberculosis Conserved protein 0.0072 0.0628 0.1261
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0628 0.0696
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Brugia malayi beta-lactamase family protein 0.0072 0.0628 0.0628
Echinococcus granulosus regulator of G protein signaling 7 0.0091 0.0838 0.0931
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1133 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0034 0.0381
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0628 0.1261
Plasmodium vivax glutathione reductase, putative 0.0046 0.034 0.5397
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1354 0.1505
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0034 0.0509
Leishmania major DNA polymerase kappa, putative 0.0019 0.0034 0.0277
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0283 0.0274
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.034 0.0376
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0091 0.0838 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0002 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0628 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0628 0.748
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0823 0.8985 0.8984
Brugia malayi hypothetical protein 0.0091 0.0838 0.0838
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0089
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.1152 0.128
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0628 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0628 0.1261
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0091 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0628 0.062
Echinococcus granulosus dna polymerase eta 0.0019 0.0034 0.0035
Leishmania major hypothetical protein, conserved 0.0072 0.0628 0.5438
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0214 0.0236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0826 0.0904
Echinococcus multilocularis Regulator of G protein signaling 20 0.0091 0.0838 0.0917
Echinococcus multilocularis axis inhibition protein axin 0.0091 0.0838 0.0917
Loa Loa (eye worm) hypothetical protein 0.0091 0.0838 0.083
Brugia malayi Thioredoxin reductase 0.0046 0.034 0.034
Echinococcus multilocularis dna polymerase eta 0.0019 0.0034 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Schistosoma mansoni regulator of G protein signaling 0.0091 0.0838 0.0836
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.4963 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0034 0.0277
Loa Loa (eye worm) hypothetical protein 0.0096 0.0894 0.0886
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0894 0.0978
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.1152 1
Brugia malayi hypothetical protein 0.0091 0.0838 0.0838
Brugia malayi hypothetical protein 0.0025 0.0097 0.0097
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0002 0.5
Loa Loa (eye worm) glutathione reductase 0.0046 0.034 0.0331
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1152 0.115
Schistosoma mansoni regulator of G protein signaling 0.0091 0.0838 0.0836
Plasmodium falciparum glutathione reductase 0.0046 0.034 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0034 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0838 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0097 0.1522
Echinococcus granulosus regulator of G protein signaling 3 0.0091 0.0838 0.0931
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0826 0.0918
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0015 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0628 0.748
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0034 0.0509
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0091 0.0838 0.0931
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0034 0.0509
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0047 0.0039
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.034 0.068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0826 0.0825
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.1152 0.2318
Mycobacterium ulcerans lipase LipD 0.0072 0.0628 0.5438
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0628 0.5438
Schistosoma mansoni hypothetical protein 0.004 0.0266 0.0264
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0628 0.0686
Brugia malayi hypothetical protein 0.0039 0.0255 0.0255
Mycobacterium tuberculosis Probable reductase 0.0106 0.1001 0.2014
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0068 0.0073
Echinococcus granulosus expressed protein 0.0091 0.0838 0.0931
Schistosoma mansoni regulator of G protein signaling 0.0091 0.0838 0.0836
Schistosoma mansoni serine/threonine protein kinase 0.0914 1 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0068 0.0074
Echinococcus multilocularis axis inhibition protein axin 0.0091 0.0838 0.0917
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0914 1 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0091 0.0838 0.083
Brugia malayi glutathione reductase 0.0046 0.034 0.034
Plasmodium falciparum thioredoxin reductase 0.0046 0.034 1
Echinococcus multilocularis zinc finger protein 0.0019 0.0036 0.0037
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0007
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0034 0.0509
Brugia malayi beta-lactamase family protein 0.0072 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0051 0.0386 0.0378
Mycobacterium tuberculosis Conserved protein 0.0072 0.0628 0.1261
Loa Loa (eye worm) hypothetical protein 0.0072 0.0628 0.062
Treponema pallidum NADH oxidase 0.0016 0.0002 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0628 0.0626
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0034 0.0509
Brugia malayi Regulator of G protein signaling domain containing protein 0.0091 0.0838 0.0838
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.034 0.037
Schistosoma mansoni bromodomain containing protein 0.0062 0.0511 0.051
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0034 0.0277
Schistosoma mansoni hypothetical protein 0.002 0.0047 0.0045
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.0042 0.0287 0.0279
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0097 0.1522
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0628 0.1261
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0628 0.1261
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0034 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0255 0.0253
Echinococcus granulosus beta-adrenergic receptor kinase 0.0093 0.0863 0.0958
Brugia malayi Bromodomain containing protein 0.0073 0.0639 0.0639
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0826 0.0825
Schistosoma mansoni regulator of G protein signaling 0.0091 0.0838 0.0836
Echinococcus granulosus Regulator of G protein signaling 20 0.0091 0.0838 0.0931
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1152 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0911 0.0909
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0628 0.1261
Onchocerca volvulus 0.0072 0.0628 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0097 0.2821
Brugia malayi regulator of G-protein signaling rgs-7 0.0091 0.0838 0.0838
Leishmania major DNA polymerase eta, putative 0.0019 0.0034 0.0277
Schistosoma mansoni z-protein (S1r protein) 0.0091 0.0838 0.0836
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0838 1
Trypanosoma brucei unspecified product 0.0019 0.0034 0.0509
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0097 0.2821
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0034 0.0034
Toxoplasma gondii thioredoxin reductase 0.0046 0.034 0.2935
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1001 0.2014
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0039 0.0255 0.0253
Brugia malayi regulator of G-protein signaling egl-10 0.0091 0.0838 0.0838
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0863 0.0861
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0034 0.0032
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0093 0.0863 0.0855
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0283 0.0312
Entamoeba histolytica hypothetical protein 0.0091 0.0838 0.935
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0091 0.0838 0.0917
Echinococcus granulosus axis inhibition protein axin 0.0091 0.0838 0.0931
Loa Loa (eye worm) RGS-3 protein 0.0091 0.0838 0.083
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0097 0.1522
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0838 1
Echinococcus granulosus expressed conserved protein 0.009 0.0829 0.0921
Loa Loa (eye worm) hypothetical protein 0.0091 0.0838 0.083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0039 0.0255 0.2567
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0034 0.0025
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0091 0.0838 0.0836
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0008 0.0007
Echinococcus multilocularis beta adrenergic receptor kinase 0.0093 0.0863 0.0944
Loa Loa (eye worm) hypothetical protein 0.0072 0.0628 0.062
Loa Loa (eye worm) hypothetical protein 0.0091 0.0838 0.083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0826 0.0826
Entamoeba histolytica hypothetical protein 0.0039 0.0255 0.2567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0826 0.0904
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Entamoeba histolytica hypothetical protein 0.0039 0.0255 0.2567
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0034 0.0035
Echinococcus granulosus zinc finger protein 0.0019 0.0036 0.0038
Schistosoma mansoni hypothetical protein 0.004 0.0266 0.0264
Schistosoma mansoni DNA polymerase eta 0.0019 0.0034 0.0032
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0894 0.0993
Echinococcus multilocularis regulator of G protein signaling 7 0.0091 0.0838 0.0917
Brugia malayi beta-lactamase 0.0072 0.0628 0.0628
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0823 0.8985 0.9851
Loa Loa (eye worm) hypothetical protein 0.0072 0.0628 0.062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0097 0.1522
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1133 0.2279
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0863 0.0861
Entamoeba histolytica hypothetical protein 0.0091 0.0838 0.935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0826 0.0825
Brugia malayi A-kinase anchor protein 10, precursor 0.0091 0.0838 0.0838
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1354 0.1483
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1133 0.2279
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0628 0.1261
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0232
Brugia malayi PXA domain containing protein 0.0091 0.0838 0.0838
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0628 0.5438
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0628 0.0628
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0255 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0283 0.3356
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0034 0.0035
Brugia malayi CHE-14 protein 0.0041 0.0283 0.0283
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0473 0.0516
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0628 0.1261
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0002 0.0002
Loa Loa (eye worm) beta-lactamase 0.0072 0.0628 0.062
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.034 0.5397
Echinococcus granulosus regulator of G protein signaling 7 0.0091 0.0838 0.0931
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0628 0.748
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0628 0.748
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0034 0.0064
Loa Loa (eye worm) hypothetical protein 0.0072 0.0628 0.062
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.1152 0.1261
Leishmania major trypanothione reductase 0.0046 0.034 0.2935
Onchocerca volvulus 0.0072 0.0628 0.5
Echinococcus multilocularis regulator of G protein signaling 3 0.0091 0.0838 0.0917
Loa Loa (eye worm) hypothetical protein 0.0072 0.0628 0.062
Schistosoma mansoni patched 1 0.0041 0.0283 0.0281
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0283 0.0308
Loa Loa (eye worm) hypothetical protein 0.0091 0.0838 0.083
Echinococcus multilocularis regulator of G protein signaling 7 0.0091 0.0838 0.0917
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0091 0.0838 0.935
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0034 0.0277
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0894 0.0894
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0473 0.0524
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0628 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.034 0.0331
Brugia malayi Regulator of G protein signaling domain containing protein 0.0091 0.0838 0.0838
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0034 0.0381
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0826 0.0819
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1133 0.2279
Brugia malayi Bromodomain containing protein 0.0037 0.024 0.024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Schistosoma mansoni hypothetical protein 0.004 0.0266 0.0264
Mycobacterium ulcerans beta-lactamase 0.0072 0.0628 0.5438
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0008 0.0007
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0097 0.0828
Trichomonas vaginalis esterase, putative 0.0072 0.0628 0.748
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1152 0.115
Echinococcus multilocularis expressed conserved protein 0.009 0.0829 0.0907
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.1152 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0894 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1001 0.2014
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0091 0.0838 0.0836
Echinococcus multilocularis expressed protein 0.0091 0.0838 0.0917
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0008 0.0007
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0628 0.1261
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0283 0.0312
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0823 0.8985 0.8984
Toxoplasma gondii ABC1 family protein 0.0072 0.0628 0.5438
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0835 0.9121 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0034 0.0032
Echinococcus multilocularis protein patched 0.0041 0.0283 0.0308
Schistosoma mansoni hypothetical protein 0.004 0.0266 0.0264
Schistosoma mansoni zinc finger protein 0.0019 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0069 0.0592 0.0584
Brugia malayi PHD-finger family protein 0.0024 0.0094 0.0094
Onchocerca volvulus 0.0072 0.0628 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0266 0.0258
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1152 1
Schistosoma mansoni axis inhibition protein axin 0.0091 0.0838 0.0836
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.034 0.5397
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Schistosoma mansoni axis inhibition protein axin 0.0091 0.0838 0.0836
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1001 0.2014
Echinococcus granulosus axis inhibition protein axin 0.0091 0.0838 0.0931
Brugia malayi PXA domain containing protein 0.0091 0.0838 0.0838
Giardia lamblia DINP protein human, muc B family 0.0019 0.0034 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0002 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1001 0.2014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0509
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1001 0.7398
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0628 0.748
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0255 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0628 1
Echinococcus multilocularis regulator of G protein signaling 0.0091 0.0838 0.0917
Entamoeba histolytica hypothetical protein 0.0039 0.0255 0.2567
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0628 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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