Detailed information for compound 657424

Basic information

Technical information
  • TDR Targets ID: 657424
  • Name: 7-[(4-fluorophenyl)methyl]-1,3-dimethylpurine -2,6-dione
  • MW: 288.277 | Formula: C14H13FN4O2
  • H donors: 0 H acceptors: 3 LogP: 1.26 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Cn1cnc2c1c(=O)n(C)c(=O)n2C
  • InChi: 1S/C14H13FN4O2/c1-17-12-11(13(20)18(2)14(17)21)19(8-16-12)7-9-3-5-10(15)6-4-9/h3-6,8H,7H2,1-2H3
  • InChiKey: JFTHHWHLMDWVQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[(4-fluorophenyl)methyl]-1,3-dimethyl-purine-2,6-dione
  • 7-(4-fluorobenzyl)-1,3-dimethyl-xanthine
  • Oprea1_350868
  • ZINC02970599
  • ChemDiv2_003695
  • IDI1_002410
  • A2130/0089451
  • 7-(4-Fluoro-benzyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
  • BAS 01118232
  • EU-0040946
  • Oprea1_048675

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin l1 0.0035 0.005 0.005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.01 1
Brugia malayi Cathepsin L-like precursor 0.0011 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0222
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0054 0.0054
Onchocerca volvulus Cathepsin L homolog 0.0035 0.005 0.0537
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.01 0.01
Brugia malayi Cathepsin L-like precursor 0.0035 0.005 0.0208
Mycobacterium ulcerans acyl-CoA synthetase 0.012 0.0225 0.0626
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0052 0.1975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0054 0.0054
Loa Loa (eye worm) ctsf protein 0.0035 0.005 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0052 0.0213
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0016 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.005 0.0373
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0052 0.0387
Echinococcus granulosus cysteine protease 0.0018 0.0016 0.0016
Mycobacterium ulcerans beta-lactamase 0.0036 0.0054 0.0008
Onchocerca volvulus 0.0035 0.005 0.0537
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0222 0.0917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0016 0.053
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0222 0.0917
Brugia malayi Cathepsin L-like precursor 0.0023 0.0027 0.0111
Echinococcus granulosus cathepsin L 0.0018 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.005 0.0373
Trypanosoma cruzi major cysteine proteinase, putative 0.0104 0.0192 0.7656
Brugia malayi beta-lactamase 0.0036 0.0054 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0035 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.005 0.0373
Onchocerca volvulus 0.0036 0.0054 0.0573
Leishmania major cathepsin L-like protease 0.0132 0.0249 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0016 0.0016
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.012 0.0225 0.0626
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.012 0.0225 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0222
Loa Loa (eye worm) oxidoreductase 0.0035 0.0052 0.0213
Echinococcus multilocularis tumor protein p63 0.07 0.141 0.141
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0249 1
Schistosoma mansoni hypothetical protein 0.0125 0.0235 0.0235
Schistosoma mansoni transcription factor LCR-F1 0.0185 0.0358 0.0358
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0054 0.0008
Brugia malayi MH2 domain containing protein 0.0119 0.0222 0.0917
Onchocerca volvulus 0.012 0.0225 0.2403
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0153 0.0401
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0249 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.005 0.0208
Onchocerca volvulus 0.0036 0.0054 0.0573
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0016 0.053
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0052 0.0036
Loa Loa (eye worm) hypothetical protein 0.009 0.0163 0.0673
Schistosoma mansoni cathepsin s 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0054 0.206
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.005 0.2337
Loa Loa (eye worm) hypothetical protein 0.0035 0.005 0.0208
Mycobacterium tuberculosis Conserved protein 0.0036 0.0054 0.0044
Brugia malayi cathepsin L-like precursor 0.0023 0.0027 0.0111
Entamoeba histolytica hypothetical protein 0.0185 0.0358 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0052 0.0213
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0012
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0121 0.0226 0.905
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0054 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0153 0.0401
Brugia malayi AMP-binding enzyme family protein 0.012 0.0225 0.0929
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0035 0.0052 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.005 0.0373
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0054 0.0054
Echinococcus granulosus tumor protein p63 0.07 0.141 0.141
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0016 0.0066
Schistosoma mansoni hypothetical protein 0.0185 0.0358 0.0358
Entamoeba histolytica cysteine protease, putative 0.0035 0.005 0.1006
Brugia malayi beta-lactamase family protein 0.0036 0.0054 0.0222
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0054 0.0222
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0052 0.0036
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1391 0.2822 1
Mycobacterium ulcerans acyl-CoA synthetase 0.012 0.0225 0.0626
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0052 0.1975
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.005 0.0373
Onchocerca volvulus 0.0036 0.0054 0.0573
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.005 0.0373
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0052 0.0213
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0054 0.0044
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0052 0.0387
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0003 0.0012
Trypanosoma cruzi cruzipain precursor, putative 0.0132 0.0249 1
Echinococcus multilocularis cathepsin L 0.0018 0.0016 0.0016
Plasmodium vivax unspecified product 0.0018 0.0016 0.0817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.005 0.0373
Mycobacterium ulcerans hypothetical protein 0.012 0.0225 0.0626
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0244 0.0478 0.1972
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0153 0.0401
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.012 0.0225 0.0929
Onchocerca volvulus Cathepsin F homolog 0.0035 0.005 0.0537
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.01 0.01
Onchocerca volvulus 0.0059 0.01 0.1069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0111
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.0454 0.1483
Onchocerca volvulus 0.0035 0.005 0.0537
Entamoeba histolytica hypothetical protein 0.0185 0.0358 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0054 0.041
Echinococcus multilocularis cysteine protease 0.0035 0.005 0.005
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0256 0.0256
Brugia malayi AMP-binding enzyme family protein 0.012 0.0225 0.0929
Leishmania major hypothetical protein, conserved 0.0036 0.0054 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0054 0.206
Mycobacterium ulcerans hypothetical protein 0.0036 0.0054 0.0008
Mycobacterium tuberculosis Conserved protein 0.0036 0.0054 0.0044
Echinococcus granulosus survival motor neuron protein 1 0.1196 0.2424 0.2424
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0016 0.053
Mycobacterium ulcerans transcriptional regulator 0.1391 0.2822 1
Onchocerca volvulus 0.0035 0.0052 0.0551
Onchocerca volvulus 0.0035 0.005 0.0537
Mycobacterium ulcerans TetR family transcriptional regulator 0.1391 0.2822 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0225 0.0929
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0035 0.0052 0.1525
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0052 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0052 0.0213
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.005 0.005
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0054 0.1616
Onchocerca volvulus 0.0035 0.0052 0.0551
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0054 0.0044
Onchocerca volvulus 0.0102 0.0189 0.2015
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0054 0.0008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.005 0.005
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.005 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0003 0.0012
Mycobacterium ulcerans lipase LipD 0.0036 0.0054 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0185 0.0358 0.0358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.005 0.0208
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0054 0.0044
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0235 0.0235
Leishmania major 4-coumarate:coa ligase-like protein 0.012 0.0225 0.8777
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0185 0.0358 0.0358
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.005 0.1006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0213
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0027 0.0027
Brugia malayi hypothetical protein 0.0185 0.0358 0.1476
Echinococcus granulosus cathepsin l1 0.0023 0.0027 0.0027
Brugia malayi AMP-binding enzyme family protein 0.012 0.0225 0.0929
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0054 0.041
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0054 0.3173
Mycobacterium ulcerans fatty-acid-CoA ligase 0.012 0.0225 0.0626
Onchocerca volvulus 0.0035 0.005 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Mycobacterium tuberculosis Conserved protein 0.0036 0.0054 0.0044
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.0821 0.3386
Loa Loa (eye worm) hypothetical protein 0.0059 0.01 0.0413
Trichomonas vaginalis esterase, putative 0.0036 0.0054 0.041
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0054 0.041
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0027 0.032
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0035 0.0052 0.0213
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.012 0.0225 0.0626
Brugia malayi Cathepsin L-like precursor 0.0035 0.005 0.0208
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0235 0.0235
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.012 0.0225 0.0626
Echinococcus multilocularis cysteine protease 0.0035 0.005 0.005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0096 0.0096
Onchocerca volvulus 0.0244 0.0478 0.5101
Brugia malayi Pre-SET motif family protein 0.0059 0.01 0.0413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0153 0.0401
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0016 0.053
Trichomonas vaginalis set domain proteins, putative 0.0469 0.0937 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0054 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Loa Loa (eye worm) hypothetical protein 0.009 0.0163 0.0673
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1391 0.2822 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0052 0.0036
Brugia malayi Cathepsin L-like precursor 0.0035 0.005 0.0208
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.005 0.005
Onchocerca volvulus 0.0023 0.0027 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Onchocerca volvulus 0.0469 0.0937 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0016 0.0016
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0035 0.0052 0.0052
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.012 0.0225 0.0626
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0111
Plasmodium vivax acetyl-CoA synthetase, putative 0.0035 0.0052 0.3041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Echinococcus multilocularis microtubule associated protein 2 0.4903 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.012 0.0225 0.8777
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.005 0.005
Onchocerca volvulus 0.0035 0.005 0.0537
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.009 0.0163 0.0437
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.005 0.2337
Entamoeba histolytica acyl-coA synthetase, putative 0.012 0.0225 0.6122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0222
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.009 0.0163 0.5
Toxoplasma gondii ABC1 family protein 0.0036 0.0054 0.0675
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.009 0.0163 0.0673
Brugia malayi hypothetical protein 0.1196 0.2424 1
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0256 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0225 0.0929
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0052 0.0036
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0035 0.0052 0.0036
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0016 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.005 0.0373
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0111
Leishmania major cathepsin L-like protease 0.0132 0.0249 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.012 0.0225 0.6122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Brugia malayi Cathepsin L-like precursor 0.0023 0.0027 0.0111
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0035 0.0052 0.0253
Onchocerca volvulus 0.0035 0.005 0.0537
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1391 0.2822 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.0256 0.0256
Plasmodium falciparum acyl-CoA synthetase 0.009 0.0163 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0035 0.0052 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0027 0.0119
Loa Loa (eye worm) hypothetical protein 0.009 0.0163 0.0673
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0035 0.0052 0.0036
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.005 0.2337
Loa Loa (eye worm) hypothetical protein 0.1196 0.2424 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0189 0.0779
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0035 0.0052 0.0036
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.005 0.0208
Loa Loa (eye worm) cysteine protease 0.0035 0.005 0.0208
Entamoeba histolytica hypothetical protein 0.0185 0.0358 1
Plasmodium vivax vivapain-3 0.0018 0.0016 0.0817
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0054 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0054 0.0008
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0052 0.1525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0003 0.0012
Onchocerca volvulus 0.0035 0.0052 0.0551
Toxoplasma gondii propionate-CoA ligase 0.0035 0.0052 0.0253
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0027 0.0111
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.01 0.01
Onchocerca volvulus 0.0035 0.0052 0.0551
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0035 0.0052 0.1043
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0035 0.0052 0.0253
Plasmodium vivax SET domain protein, putative 0.0059 0.01 0.6072
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.01 0.01
Loa Loa (eye worm) beta-lactamase 0.0036 0.0054 0.0222
Entamoeba histolytica hypothetical protein 0.0185 0.0358 1
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0052 0.0213
Mycobacterium leprae Probable lipase LipE 0.0036 0.0054 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Plasmodium vivax vivapain-2 0.0035 0.005 0.2963
Schistosoma mansoni acetyl-CoA synthetase 0.0035 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0222
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0035 0.005 0.0537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Schistosoma mansoni microtubule-associated protein tau 0.4903 1 1
Brugia malayi beta-lactamase family protein 0.0036 0.0054 0.0222
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0035 0.0052 0.0036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.012 0.0225 0.066
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0054 0.0222
Loa Loa (eye worm) fibroinase 0.0035 0.005 0.0208
Onchocerca volvulus 0.0035 0.005 0.0537
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0052 0.0063
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0054 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0052 0.0213
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0213
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.005 0.1006
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0249 1
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.005 0.0373
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.005 0.1924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0027 0.0119
Leishmania major cathepsin L-like protease 0.0132 0.0249 1
Schistosoma mansoni survival motor neuron protein 0.0244 0.0478 0.0478
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.01 0.01
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0054 0.0044
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0035 0.0052 0.0213
Plasmodium vivax acyl-CoA synthetase, putative 0.009 0.0163 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0035 0.0052 0.2422
Loa Loa (eye worm) hypothetical protein 0.009 0.0163 0.0673
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0189 0.0189
Echinococcus multilocularis survival motor neuron protein 1 0.1196 0.2424 0.2424
Brugia malayi Pre-SET motif family protein 0.0412 0.0821 0.3386
Mycobacterium ulcerans acyl-CoA synthetase 0.012 0.0225 0.0626
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0052 0.1975
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.012 0.0225 0.0626
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0054 0.041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.0249 1
Leishmania major 4-coumarate:coa ligase-like protein 0.012 0.0225 0.8777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.005 0.005
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.005 0.005
Plasmodium vivax vivapain-2 0.0035 0.005 0.2963
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0054 0.0044
Mycobacterium ulcerans fatty-acid-CoA ligase 0.009 0.0163 0.0402
Plasmodium vivax vivapain-1 0.0018 0.0016 0.0817
Entamoeba histolytica acyl-CoA synthetase, putative 0.012 0.0225 0.6122
Schistosoma mansoni hypothetical protein 0.0244 0.0478 0.0478
Brugia malayi Cathepsin L-like precursor 0.0035 0.005 0.0208
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0052 0.0063
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0052 0.1975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.005 0.0373
Brugia malayi Cathepsin L-like precursor 0.0035 0.005 0.0208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.005 0.0373
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0052 0.0063
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.01 0.01
Brugia malayi Cathepsin L-like precursor 0.0035 0.005 0.0208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.005 0.0373

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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