Detailed information for compound 659636

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 350.368 | Formula: C20H18N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1oc(=Nc1ccc(cc1)C)c(c2)C(=O)NC(=O)C
  • InChi: 1S/C20H18N2O4/c1-12-7-9-15(10-8-12)22-20-16(19(24)21-13(2)23)11-14-5-4-6-17(25-3)18(14)26-20/h4-11H,1-3H3,(H,21,23,24)/b22-20-
  • InChiKey: KAZOUUXGNDLWRJ-XDOYNYLZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0073 0.1245 0.124
Leishmania major ribonuclease H1, putative 0.0121 0.2161 0.5885
Loa Loa (eye worm) beta-lactamase 0.0073 0.1245 0.1238
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0033 0.0478 0.1346
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0034 0.0043
Brugia malayi Choline O-acetyltransferase 0.0033 0.0478 0.0473
Schistosoma mansoni lamin 0.0027 0.0358 0.0418
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0033 0.0478 0.1346
Brugia malayi Zinc knuckle family protein 0.001 0.0034 0.0028
Echinococcus granulosus geminin 0.0172 0.3139 0.4051
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0033 0.0478 0.1346
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0217 0.0281
Brugia malayi hypothetical protein 0.002 0.0217 0.0212
Trypanosoma brucei ingi protein (ORF1) 0.0131 0.2359 0.2728
Schistosoma mansoni hypothetical protein 0.0412 0.7748 0.9056
Schistosoma mansoni lipoxygenase 0.002 0.0217 0.0254
Loa Loa (eye worm) hypothetical protein 0.0016 0.0143 0.0136
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0143 0.0185
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0358 0.0352
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2145 0.2139
Schistosoma mansoni scy1(yeast) protein kinase-like 0.001 0.0034 0.0039
Giardia lamblia Ribonuclease H 0.0121 0.2161 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0808 0.08
Trichomonas vaginalis reverse transcriptases, putative 0.001 0.0034 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0478 0.1346
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1245 0.1607
Loa Loa (eye worm) hypothetical protein 0.0073 0.1245 0.1238
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0034 0.0043
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.214 0.9871
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0904 0.1167
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1245 0.5761
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0033 0.0478 0.0522
Mycobacterium tuberculosis Conserved protein 0.0073 0.1245 0.1409
Loa Loa (eye worm) hypothetical protein 0.002 0.0217 0.021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0888 0.2099
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.055 0.0252
Brugia malayi Choline O-acetyltransferase 0.0033 0.0478 0.0473
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0478 0.1346
Mycobacterium ulcerans beta-lactamase 0.0073 0.1245 0.5817
Schistosoma mansoni rab6-interacting 0.002 0.0217 0.0254
Mycobacterium tuberculosis Conserved protein 0.0073 0.1245 0.1409
Brugia malayi RNase H family protein 0.0121 0.2161 0.2157
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1245 0.5761
Trichomonas vaginalis esterase, putative 0.0073 0.1245 0.5761
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0088 0.0113
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1245 0.1422
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0217 0.0281
Schistosoma mansoni hypothetical protein 0.0035 0.05 0.0585
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1245 0.5761
Onchocerca volvulus 0.0073 0.1245 0.5694
Schistosoma mansoni hypothetical protein 0.001 0.0034 0.0039
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1245 0.1409
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0033 0.0478 0.0471
Schistosoma mansoni polycystin 1-related 0.002 0.0217 0.0254
Echinococcus granulosus lamin 0.0027 0.0358 0.0462
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0034 0.0043
Brugia malayi reverse transcriptase 0.001 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.0073 0.1245 0.1238
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0033 0.0478 0.0617
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.214 0.5812
Echinococcus granulosus dnaJ subfamily B 0.0412 0.7748 1
Trypanosoma brucei ribonuclease H1 0.0121 0.2161 0.2497
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1245 0.124
Loa Loa (eye worm) hypothetical protein 0.0013 0.0088 0.008
Schistosoma mansoni choline o-acyltransferase 0.0033 0.0478 0.0559
Treponema pallidum ribonuclease H (rnhA) 0.0121 0.2161 1
Trypanosoma cruzi ribonuclease H1, putative 0.0121 0.2161 0.6439
Trypanosoma cruzi ribonuclease H1, putative 0.0121 0.2161 0.6439
Schistosoma mansoni hypothetical protein 0.0454 0.8555 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.214 0.2763
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.8838 1
Schistosoma mansoni hypothetical protein 0.001 0.0034 0.0039
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0182 0.3338 0.4308
Brugia malayi hypothetical protein 0.001 0.0034 0.0028
Trypanosoma brucei RNA helicase, putative 0.0454 0.8555 1
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1245 0.1409
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0217 0.0281
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0034 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0478 0.1346
Schistosoma mansoni lipoxygenase 0.0056 0.0904 0.1056
Brugia malayi hypothetical protein 0.001 0.0034 0.0028
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0182 0.3338 1
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Echinococcus granulosus cpg binding protein 0.0031 0.0423 0.0546
Schistosoma mansoni hypothetical protein 0.0172 0.3139 0.3669
Schistosoma mansoni protein kinase 0.001 0.0034 0.0039
Loa Loa (eye worm) hypothetical protein 0.0013 0.0078 0.007
Schistosoma mansoni loxhd1 0.002 0.0217 0.0254
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0217 0.0281
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.0034 0.0043
Trichomonas vaginalis reverse transcriptases, putative 0.001 0.0034 0.0155
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0008 0.001
Loa Loa (eye worm) inositol-1 0.0037 0.055 0.0543
Schistosoma mansoni cpg binding protein 0.0029 0.0392 0.0458
Brugia malayi Inositol-1 0.0037 0.055 0.0545
Schistosoma mansoni hypothetical protein 0.0016 0.0143 0.0168
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0033 0.0478 0.0522
Brugia malayi beta-lactamase 0.0073 0.1245 0.124
Brugia malayi Zinc knuckle family protein 0.001 0.0034 0.0028
Mycobacterium ulcerans hypothetical protein 0.0073 0.1245 0.5817
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.001 0.0034 0.0155
Schistosoma mansoni phosphoglucomutase 0.0121 0.2161 0.2526
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Echinococcus multilocularis cpg binding protein 0.0031 0.0423 0.0546
Mycobacterium leprae Probable lipase LipE 0.0073 0.1245 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0143 0.0185
Echinococcus multilocularis choline O acetyltransferase 0.0033 0.0478 0.0617
Trypanosoma brucei hypothetical protein, conserved 0.0131 0.2359 0.2728
Brugia malayi hypothetical protein 0.001 0.0034 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.214 1
Onchocerca volvulus 0.0029 0.0392 0.1683
Echinococcus multilocularis RNA directed DNA polymerase 0.001 0.0034 0.0043
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1245 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1245 0.5761
Onchocerca volvulus Ribonuclease H1 homolog 0.0121 0.2161 1
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0131 0.2359 0.2728
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.214 1
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0033 0.0478 0.0473
Schistosoma mansoni hypothetical protein 0.0016 0.0143 0.0168
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.7748 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0034 0.0043
Mycobacterium tuberculosis Possible maturase 0.001 0.0034 0.0038
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0033 0.0478 0.0473
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.055 0.2572
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1245 0.1455
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1245 0.1607
Toxoplasma gondii ABC1 family protein 0.0073 0.1245 0.4312
Echinococcus granulosus GPCR family 2 0.0016 0.0143 0.0185
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0904 0.1167
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Trichomonas vaginalis ribonuclease H1, putative 0.0121 0.2161 1
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0143 0.0185
Loa Loa (eye worm) hypothetical protein 0.0027 0.0358 0.035
Schistosoma mansoni phosphoglucomutase 0.0121 0.2161 0.2526
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1245 0.3666
Echinococcus granulosus lamin dm0 0.0027 0.0358 0.0462
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.001 0.0034 0.0155
Echinococcus multilocularis lamin dm0 0.0027 0.0358 0.0462
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0476 0.382
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0033 0.0478 0.1346
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0143 0.0138
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0808 0.0802
Brugia malayi hypothetical protein 0.001 0.0034 0.0028
Mycobacterium ulcerans lipase LipD 0.0073 0.1245 0.5817
Onchocerca volvulus 0.0073 0.1245 0.5694
Brugia malayi reverse transcriptase 0.001 0.0034 0.0028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0358 0.035
Loa Loa (eye worm) hypothetical protein 0.0073 0.1245 0.1238
Schistosoma mansoni inositol monophosphatase 0.0037 0.055 0.0643
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.214 0.2502
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0808 0.0802
Schistosoma mansoni rab6-interacting 0.002 0.0217 0.0254
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0392 0.0384
Echinococcus granulosus ribonuclease H1 0.0121 0.2161 0.2789
Leishmania major hypothetical protein, conserved 0.0073 0.1245 0.2681
Loa Loa (eye worm) hypothetical protein 0.0013 0.0078 0.007
Echinococcus granulosus KRAB A domain containing protein 0.001 0.0034 0.0043
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1245 0.1409
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0478 0.1346
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1245 0.5761
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0143 0.0136
Schistosoma mansoni hypothetical protein 0.0016 0.0143 0.0168
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0478 0.0522
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.214 0.2422
Echinococcus multilocularis RUN 0.002 0.0217 0.0281
Echinococcus granulosus RUN 0.002 0.0217 0.0281
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0217 0.0281
Loa Loa (eye worm) hypothetical protein 0.0073 0.1245 0.1238
Loa Loa (eye worm) choline O-acetyltransferase 0.0033 0.0478 0.0471
Onchocerca volvulus 0.0033 0.0478 0.209
Schistosoma mansoni inositol monophosphatase 0.0037 0.055 0.0643
Schistosoma mansoni lamin 0.0027 0.0358 0.0418
Brugia malayi reverse transcriptase 0.001 0.0034 0.0028
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0033 0.0478 0.1346
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0182 0.3338 1
Schistosoma mansoni choline o-acyltransferase 0.0033 0.0478 0.0559
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0034 0.0043
Loa Loa (eye worm) hypothetical protein 0.0051 0.0808 0.08
Echinococcus multilocularis ribonuclease H1 0.0121 0.2161 0.2789
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.055 0.071
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0033 0.0478 0.0522
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0033 0.0478 0.0522
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.055 0.2547
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0034 0.0043
Echinococcus granulosus intermediate filament protein 0.0027 0.0358 0.0462
Loa Loa (eye worm) hypothetical protein 0.0027 0.0348 0.034
Echinococcus multilocularis geminin 0.0172 0.3139 0.4051
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.05 0.0495
Schistosoma mansoni cpg binding protein 0.0031 0.0423 0.0495
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.214 0.2763
Schistosoma mansoni phosphoglucomutase 0.0121 0.2161 0.2526
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.055 0.5
Brugia malayi RNase H family protein 0.0121 0.2161 0.2157
Schistosoma mansoni hypothetical protein 0.0172 0.3139 0.3669
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1245 0.1409
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1245 0.3666
Loa Loa (eye worm) hypothetical protein 0.002 0.0217 0.021
Brugia malayi intermediate filament protein 0.0027 0.0358 0.0352
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0182 0.3338 0.4308
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1245 0.1409
Echinococcus granulosus RNA directed DNA polymerase 0.001 0.0034 0.0043
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.055 0.1564
Echinococcus multilocularis musashi 0.0027 0.0358 0.0462
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Schistosoma mansoni intermediate filament proteins 0.0027 0.0358 0.0418
Onchocerca volvulus 0.0027 0.0358 0.1523
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0217 0.5
Brugia malayi beta-lactamase family protein 0.0073 0.1245 0.124
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0358 0.035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1245 0.1455
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1014 0.1186
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1245 0.1238
Brugia malayi CXXC zinc finger family protein 0.0029 0.0392 0.0386
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1245 0.1409
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0217 0.0281
Schistosoma mansoni cpg binding protein 0.0031 0.0423 0.0495
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.055 0.1564
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0476 0.0538
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.055 0.2547
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0034 0.0043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0143 0.0185
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.001 0.0034 0.0043
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0033 0.0478 0.0617
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0478 0.1346
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0143 0.0138
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.214 0.2502
Onchocerca volvulus 0.002 0.0217 0.0864
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0121 0.2161 1
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0034 0.0039
Mycobacterium tuberculosis Conserved protein 0.0073 0.1245 0.1409
Schistosoma mansoni hypothetical protein 0.0016 0.0143 0.0168
Loa Loa (eye worm) doublecortin family protein 0.002 0.0217 0.021
Echinococcus multilocularis lamin 0.0027 0.0358 0.0462
Trypanosoma brucei unspecified product 0.0131 0.2359 0.2728
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Echinococcus granulosus choline O acetyltransferase 0.0033 0.0478 0.0617
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.214 1
Brugia malayi Doublecortin family protein 0.002 0.0217 0.0212
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0033 0.0478 0.0471
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0182 0.3338 1
Trypanosoma brucei ingi protein (ORF1) 0.0131 0.2359 0.2728
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0088 0.0113
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2145 0.2139
Toxoplasma gondii ribonuclease HI protein 0.0121 0.2161 1
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1245 0.5817
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.0034 0.0043
Loa Loa (eye worm) hypothetical protein 0.0529 1 1
Onchocerca volvulus 0.0033 0.0478 0.209
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.0034 0.0043
Echinococcus multilocularis GPCR, family 2 0.0016 0.0143 0.0185
Brugia malayi RNase H family protein 0.0121 0.2161 0.2157
Loa Loa (eye worm) hypothetical protein 0.0035 0.05 0.0493
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0033 0.0478 0.1346
Onchocerca volvulus 0.0033 0.0478 0.209
Onchocerca volvulus 0.0027 0.0358 0.1523
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0008 0.001
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1245 0.1409
Schistosoma mansoni hypothetical protein 0.002 0.0217 0.0254
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0034 0.0043
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1245 0.5817
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1245 0.1238
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0034 0.0028
Onchocerca volvulus 0.0033 0.0478 0.209
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.055 0.071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0478 0.0471
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0115 0.011
Brugia malayi hypothetical protein 0.002 0.0217 0.0212
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.0034 0.0043
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.055 0.2547
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.055 0.0607
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0115 0.0108
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.055 0.2547
Onchocerca volvulus 0.0073 0.1245 0.5694
Brugia malayi MH2 domain containing protein 0.012 0.2145 0.2141
Onchocerca volvulus 0.002 0.0217 0.0864
Loa Loa (eye worm) hypothetical protein 0.0073 0.1245 0.1238

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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