Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.0175 | 0.041 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.0226 | 0.0548 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.0083 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.0435 | 0.4019 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0169 | 0.0392 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.11 | 0.3717 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0175 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.1123 | 0.3796 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.017 | 0.0495 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0055 | 0.0083 |
Schistosoma mansoni | smad1 5 8 and | 0.0075 | 0.0167 | 0.1404 |
Echinococcus multilocularis | Smad4 | 0.0075 | 0.0167 | 0.0381 |
Mycobacterium ulcerans | histidinol dehydrogenase | 0.2915 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0152 | 0.0435 | 0.1089 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0322 | 0.1022 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.0088 | 0.4992 |
Schistosoma mansoni | smad | 0.0075 | 0.0167 | 0.1404 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0226 | 0.1979 |
Mycobacterium ulcerans | hypothetical protein | 0.0075 | 0.0167 | 0.0113 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0075 | 0.0167 | 0.0381 |
Mycobacterium ulcerans | lipase LipD | 0.0075 | 0.0167 | 0.0113 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.0435 | 0.4019 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0075 | 0.0167 | 0.0389 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0075 | 0.0167 | 0.0113 |
Schistosoma mansoni | smad1 5 8 and | 0.0075 | 0.0167 | 0.1404 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.004 | 0.0044 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0075 | 0.0167 | 0.0389 |
Echinococcus granulosus | dna polymerase eta | 0.0042 | 0.0055 | 0.0082 |
Onchocerca volvulus | 0.0075 | 0.0167 | 0.184 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0152 | 0.0435 | 0.1089 |
Brugia malayi | MH1 domain containing protein | 0.0041 | 0.0051 | 0.0075 |
Loa Loa (eye worm) | beta-lactamase | 0.0075 | 0.0167 | 0.0388 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.0049 | 0.0068 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0064 | 0.0102 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0075 | 0.0167 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0435 | 0.1112 |
Brugia malayi | beta-lactamase family protein | 0.0075 | 0.0167 | 0.0388 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0167 | 0.0388 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0152 | 0.0435 | 0.1089 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0075 | 0.0167 | 0.038 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0075 | 0.0167 | 0.0388 |
Loa Loa (eye worm) | Smad1 | 0.0075 | 0.0167 | 0.0389 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.017 | 0.0495 | 0.0442 |
Onchocerca volvulus | 0.0259 | 0.0803 | 1 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0259 | 0.0803 | 0.211 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.034 | 0.0856 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0042 | 0.0055 | 0.0302 |
Onchocerca volvulus | 0.0164 | 0.0477 | 0.5815 | |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0243 | 0.2149 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.0055 | 0.0082 |
Echinococcus multilocularis | smad | 0.0075 | 0.0167 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 0.1553 | 0.4141 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0097 | 0.0243 | 0.0595 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0322 | 0.1022 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Echinococcus multilocularis | lamin | 0.0259 | 0.0803 | 0.2066 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.0128 | 0.0276 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0152 | 0.0435 | 0.1112 |
Brugia malayi | Bromodomain containing protein | 0.008 | 0.0184 | 0.0435 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.0055 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.1573 | 0.4194 |
Brugia malayi | MH1 domain containing protein | 0.0075 | 0.0167 | 0.0389 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0075 | 0.0167 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0167 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0477 | 0.1227 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.015 | 0.0427 | 0.1068 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0152 | 0.0435 | 0.3933 |
Brugia malayi | Smad1 | 0.0075 | 0.0167 | 0.0389 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0481 | 0.1573 | 0.4194 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0055 | 0.0099 | 0.0456 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0175 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0259 | 0.0803 | 0.2066 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0042 | 0.0055 | 0.045 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0152 | 0.0435 | 0.1112 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0075 | 0.0167 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0049 | 0.0069 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0175 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0322 | 0.1022 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0786 | 0.2629 | 0.6907 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0167 | 0.0388 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0075 | 0.0167 | 0.1404 |
Echinococcus granulosus | GPCR family 2 | 0.0152 | 0.0435 | 0.1089 |
Onchocerca volvulus | 0.0075 | 0.0167 | 0.184 | |
Schistosoma mansoni | DNA polymerase eta | 0.0042 | 0.0055 | 0.0302 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0322 | 0.1022 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0475 | 0.1553 | 0.4054 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0055 | 0.0082 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0075 | 0.0167 | 0.038 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.0427 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0075 | 0.0167 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0075 | 0.0167 | 0.0113 |
Mycobacterium leprae | conserved hypothetical protein | 0.0075 | 0.0167 | 0.0167 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0075 | 0.0167 | 0.0113 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.004 | 0.0044 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0175 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0175 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.015 | 0.0427 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0167 | 0.0388 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0226 | 0.0536 |
Toxoplasma gondii | ABC1 family protein | 0.0075 | 0.0167 | 0.9538 |
Leishmania major | hypothetical protein, conserved | 0.0075 | 0.0167 | 0.1164 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0226 | 0.0536 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0075 | 0.0167 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.0167 | 0.0113 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0075 | 0.0167 | 0.0113 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0481 | 0.1573 | 0.4194 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0323 | 0.0811 |
Brugia malayi | beta-lactamase family protein | 0.0075 | 0.0167 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1046 | 0.2767 |
Brugia malayi | MH1 domain containing protein | 0.0041 | 0.0051 | 0.0075 |
Brugia malayi | hypothetical protein | 0.015 | 0.0427 | 0.109 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0259 | 0.0803 | 0.211 |
Brugia malayi | beta-lactamase | 0.0075 | 0.0167 | 0.0388 |
Schistosoma mansoni | Smad4 | 0.0075 | 0.0167 | 0.1404 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0175 | 0.0402 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0175 | 0.0121 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0139 | 0.0387 | 0.0984 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.0175 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0075 | 0.0167 | 0.0389 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0075 | 0.0167 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0167 | 0.0388 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.11 | 0.3717 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0075 | 0.0167 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0075 | 0.0167 | 0.0167 |
Schistosoma mansoni | lamin | 0.0259 | 0.0803 | 0.7624 |
Echinococcus granulosus | Smad4 | 0.0075 | 0.0167 | 0.0381 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0152 | 0.0435 | 0.3933 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0065 | 0.0112 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0055 | 0.0082 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0475 | 0.1553 | 0.4054 |
Echinococcus multilocularis | GPCR, family 2 | 0.0152 | 0.0435 | 0.1089 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0075 | 0.0167 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.0787 | 0.2065 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0042 | 0.0055 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0051 | 0.0075 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0427 | 0.394 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.0083 | 0.0083 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.0226 | 0.0548 |
Echinococcus granulosus | lamin dm0 | 0.0259 | 0.0803 | 0.2066 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0323 | 0.0811 |
Echinococcus granulosus | intermediate filament protein | 0.0259 | 0.0803 | 0.2066 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.0055 | 0.045 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0152 | 0.0435 | 0.4206 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0175 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0175 | 0.0121 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0075 | 0.0167 | 0.0113 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0226 | 0.1979 |
Onchocerca volvulus | 0.0259 | 0.0803 | 1 | |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0125 | 0.034 | 0.0838 |
Brugia malayi | hypothetical protein | 0.0475 | 0.1553 | 0.4141 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0175 | 0.041 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0139 | 0.0387 | 0.0984 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0055 | 0.045 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0152 | 0.0435 | 0.1112 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0125 | 0.034 | 0.0838 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.0128 | 0.0276 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.0427 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.015 | 0.0427 | 0.394 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.0083 | 0.0029 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0042 | 0.0055 | 0.0302 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.0167 | 0.0113 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.0055 | 0.0082 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.0167 | 0.0113 |
Brugia malayi | MH2 domain containing protein | 0.11 | 0.3717 | 1 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.0427 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0075 | 0.0167 | 0.0113 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0479 | 0.1565 | 0.1519 |
Brugia malayi | MH2 domain containing protein | 0.0075 | 0.0167 | 0.0389 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0075 | 0.0167 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0058 | 0.0093 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.0083 | 0.0157 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0164 | 0.0477 | 0.4433 |
Schistosoma mansoni | survival motor neuron protein | 0.0097 | 0.0243 | 0.2149 |
Mycobacterium ulcerans | beta-lactamase | 0.0075 | 0.0167 | 0.0113 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0226 | 0.1979 |
Schistosoma mansoni | intermediate filament proteins | 0.0259 | 0.0803 | 0.7624 |
Brugia malayi | intermediate filament protein | 0.0259 | 0.0803 | 0.211 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0075 | 0.0167 | 0.0388 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 0.2915 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0075 | 0.0167 | 1 |
Loa Loa (eye worm) | nuclear factor I | 0.0041 | 0.0051 | 0.0075 |
Schistosoma mansoni | lamin | 0.0259 | 0.0803 | 0.7624 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.0055 | 0.0083 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.0167 | 0.1164 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.0175 | 0.1482 |
Echinococcus granulosus | lamin | 0.0259 | 0.0803 | 0.2066 |
Echinococcus multilocularis | dna polymerase eta | 0.0042 | 0.0055 | 0.0082 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0075 | 0.0167 | 0.1561 |
Giardia lamblia | DINP protein human, muc B family | 0.0042 | 0.0055 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0075 | 0.0167 | 0.1404 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.0083 | 0.0157 |
Echinococcus granulosus | smad | 0.0075 | 0.0167 | 0.0381 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0055 | 0.045 |
Echinococcus multilocularis | musashi | 0.0259 | 0.0803 | 0.2066 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0055 | 0.045 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0075 | 0.0167 | 0.0113 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0075 | 0.0167 | 0.1403 |
Onchocerca volvulus | 0.0075 | 0.0167 | 0.184 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0226 | 0.0536 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0226 | 0.0536 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.0141 | 0.1149 |
Onchocerca volvulus | 0.0097 | 0.0243 | 0.2818 | |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.0427 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0152 | 0.0435 | 0.1089 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0055 | 0.045 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0045 | 0.0064 | 0.0547 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0329 | 0.1046 | 0.2767 |
Loa Loa (eye worm) | intermediate filament protein | 0.0259 | 0.0803 | 0.211 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0064 | 0.0102 |
Plasmodium vivax | hypothetical protein, conserved | 0.0075 | 0.0167 | 0.9538 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0045 | 0.0064 | 0.0102 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.0435 | 0.4019 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0175 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0075 | 0.0167 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0175 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.0803 | 0.211 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0075 | 0.0167 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0167 | 0.0388 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.0167 | 0.1164 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.0435 | 0.4019 |
Echinococcus multilocularis | tumor protein p63 | 0.1123 | 0.3796 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0075 | 0.0167 | 0.0389 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0481 | 0.1573 | 0.4194 |
Schistosoma mansoni | hypothetical protein | 0.0329 | 0.1046 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HD50 (functional) | = 17.6 uM kg-1 | Hypnotic dose was determined by observing loss of righting reflex for a minimum period of 30 sec in 50% of treated mice after i.v. administration. | ChEMBL. | 9171876 |
IC50 (binding) | = 39 nM | The concentration of the compound required to inhibit 50% of binding of [35S]-TBPS to Gamma-aminobutyric-acid A receptor to rat whole brain membranes. | ChEMBL. | 9171876 |
POT (functional) | = 380 nM | Concentration required to potentiate GABA-evoked currents in voltage-clamped bovine chromaffin cells by 300% | ChEMBL. | 9171876 |
SD (functional) | = 11.7 min | Effect on interval between loss of righting reflex and return to righting reflex (sleep duration) was measured at a dose twice that of hypnotic dose. | ChEMBL. | 9171876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.