TDR Targets

Basic information

Technical information

TDR Targets ID: 667673
Name: ethyl 2-[(5E)-5-[(2-hydroxy-3-nitrophenyl)met hylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acet ate
MW: 352.319 | Formula: C14H12N2O7S
H donors: 1 H acceptors: 6 LogP: 2.69 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)CN1C(=O)S/C(=C/c2cccc(c2O)[N+](=O)[O-])/C1=O
InChi: 1S/C14H12N2O7S/c1-2-23-11(17)7-15-13(19)10(24-14(15)20)6-8-4-3-5-9(12(8)18)16(21)22/h3-6,18H,2,7H2,1H3/b10-6+
InChiKey: NNPVNSCMBITYJA-UXBLZVDNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-[(5E)-5-[(2-hydroxy-3-nitro-phenyl)methylene]-2,4-dioxo-thiazolidin-3-yl]acetate
2-[(5E)-5-[(2-hydroxy-3-nitrophenyl)methylene]-2,4-dioxo-3-thiazolidinyl]acetic acid ethyl ester
2-[(5E)-5-(2-hydroxy-3-nitro-benzylidene)-2,4-diketo-thiazolidin-3-yl]acetic acid ethyl ester
ethyl 2-[(5E)-5-[(2-hydroxy-3-nitro-phenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethanoate
SMR000298714
ethyl [5-(2-hydroxy-3-nitrobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
STK089524
MLS000690002

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0035	0.03	0.0242
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0197	0.0457
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Entamoeba histolytica	hypothetical protein	0.0035	0.03	0.0364
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.5875	0.5874
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0206	0.0205
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0023	0.015	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0206	0.0205
Schistosoma mansoni	hypothetical protein	0.0058	0.0579	0.0523
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0206	0.0205
Schistosoma mansoni	cpg binding protein	0.0037	0.0317	0.0259
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0031	0.003
Schistosoma mansoni	protein tyrosine phosphatase	0.0023	0.015	0.0091
Echinococcus multilocularis	hypothetical protein	0.0023	0.015	0.0148
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0362	0.4271	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0362	0.4271	1
Schistosoma mansoni	pcd6 interacting protein-related	0.0023	0.015	0.0091
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0023	0.015	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1028	0.2404
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0206	0.0148
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0362	0.4271	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0023	0.015	0.0148
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0353	0.4167	0.4166
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0023	0.015	0.0148
Entamoeba histolytica	hypothetical protein	0.0035	0.03	0.0364
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0023	0.015	0.0148
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.1227	1
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3342	0.7825
Echinococcus multilocularis		0.0023	0.015	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0025	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0293	0.0686
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0023	0.015	0.0148
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0206	0.0148
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.028	0.0222
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0023	0.015	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0362	0.4271	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0362	0.4271	1
Schistosoma mansoni	microtubule-associated protein tau	0.0833	1	1
Onchocerca volvulus		0.0034	0.028	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0471
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0362	0.4271	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0203	0.0144
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0059	0.0058
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0023	0.015	0.0347
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0023	0.015	0.0148
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0049	0.0114
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Echinococcus multilocularis	musashi	0.0027	0.0203	0.0201
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0023	0.015	0.0297
Schistosoma mansoni	lamin	0.0027	0.0203	0.0144
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.028	0.0222
Schistosoma mansoni	hypothetical protein	0.0338	0.3974	0.3938
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0028	0.0206	0.0205
Echinococcus granulosus	lamin	0.0027	0.0203	0.0201
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0028	0.0206	0.0205
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0049	0.011
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0023	0.015	0.0148
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0023	0.015	0.0148
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0353	0.4167	0.9757
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0023	0.015	0.0091
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0579	0.0523
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0023	0.015	0.0148
Echinococcus granulosus	Endonuclease G	0.002	0.0117	0.0115
Schistosoma mansoni	endonuclease related	0.002	0.0117	0.0058
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0023	0.015	0.0148
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0023	0.015	0.0148
Brugia malayi	hypothetical protein	0.0286	0.3342	0.7825
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Echinococcus multilocularis	Endonuclease G	0.002	0.0117	0.0115
Brugia malayi	hypothetical protein	0.0023	0.015	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0749	0.1752
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0023	0.015	0.0091
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0023	0.015	0.0148
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0028	0.0216	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0277	0.0646
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0023	0.015	0.0347
Onchocerca volvulus		0.0073	0.0754	0.1466
Schistosoma mansoni	lamin	0.0027	0.0203	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0025	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0749	0.1752
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Leishmania major	tyrosine specific protein phosphatase, putative	0.0023	0.015	0.0297
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0023	0.015	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0749	0.1752
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Onchocerca volvulus		0.0362	0.4271	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0023	0.015	0.0148
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0765	0.071
Onchocerca volvulus		0.0034	0.028	0.0316
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0023	0.015	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0023	0.015	0.0148
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0023	0.015	0.0148
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0023	0.015	0.0148
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0034	0.028	0.0656
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0362	0.4271	1
Onchocerca volvulus		0.0077	0.0806	0.1592
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0023	0.015	0.0148
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0023	0.015	0.0148
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.025	0.2915	0.5
Leishmania major	hypothetical protein, conserved	0.0112	0.1227	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0362	0.4271	1
Onchocerca volvulus	Huntingtin homolog	0.012	0.1332	0.2868
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0031	0.003
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0465	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0023	0.015	0.0148
Schistosoma mansoni	cpg binding protein	0.0037	0.0317	0.0259
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.028	0.0222
Echinococcus multilocularis	microtubule associated protein 2	0.0833	1	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0206	0.0205
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0112	0.1227	0.2615
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0112	0.1227	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.0069
Schistosoma mansoni	protein tyrosine phosphatase	0.0028	0.0206	0.0148
Schistosoma mansoni	hypothetical protein	0.0033	0.0277	0.0219
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0023	0.015	0.0351
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0028	0.0206	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.03	0.0298
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0023	0.015	0.0148
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0023	0.015	0.0347
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0059	0.0058
Schistosoma mansoni	protein tyrosine phosphatase	0.0023	0.015	0.0091
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0023	0.015	0.0091
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0059	0.0058
Echinococcus multilocularis	ectonucleotide	0.0028	0.0216	0.0214
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0206	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0034	0.028	0.0652
Schistosoma mansoni	cpg binding protein	0.0035	0.0293	0.0235
Onchocerca volvulus		0.0027	0.0203	0.0128
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0073	0.0754	0.1765
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0023	0.015	0.0091
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0023	0.015	0.0148
Loa Loa (eye worm)	hypothetical protein	0.012	0.1332	0.3115
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.028	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Entamoeba histolytica	hypothetical protein	0.0035	0.03	0.0364
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0028	0.0206	0.0205
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0353	0.4167	0.4166
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0112	0.1227	0.2615
Brugia malayi	hypothetical protein	0.012	0.1332	0.3118
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0023	0.015	0.0297
Schistosoma mansoni	hypothetical protein	0.0494	0.5875	0.585
Echinococcus granulosus	lamin dm0	0.0027	0.0203	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0023	0.015	0.0091
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0023	0.015	0.0148
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0073	0.0754	0.1762
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0206	0.0148
Echinococcus granulosus	geminin	0.0338	0.3974	0.3973
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.1227	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0023	0.015	0.0091
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0023	0.015	0.0148
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Echinococcus granulosus	intermediate filament protein	0.0027	0.0203	0.0201
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0059	0.0139
Brugia malayi	intermediate filament protein	0.0027	0.0203	0.0475
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Onchocerca volvulus		0.0027	0.0203	0.0128
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0059	0.0058
Brugia malayi	hypothetical protein	0.0023	0.015	0.0351
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0023	0.015	0.0148
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0023	0.015	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Loa Loa (eye worm)	hypothetical protein	0.012	0.1332	0.3115
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0023	0.015	0.0347
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0028	0.0216	0.0214
Brugia malayi	hypothetical protein	0.0035	0.03	0.0703
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0277	0.065
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0353	0.4167	0.4132
Schistosoma mansoni	hypothetical protein	0.0338	0.3974	0.3938
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.03	0.0298
Brugia malayi	hypothetical protein	0.0023	0.015	0.0351
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Entamoeba histolytica	hypothetical protein	0.0035	0.03	0.0364
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0023	0.015	0.0297
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0362	0.4271	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0059	0.0135
Brugia malayi	Protein-tyrosine phosphatase	0.0023	0.015	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0059	0.0135
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0028	0.0206	0.0205
Echinococcus multilocularis	lamin dm0	0.0027	0.0203	0.0201
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0206	0.0148
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Onchocerca volvulus	Huntingtin homolog	0.012	0.1332	0.2868
Schistosoma mansoni	hypothetical protein	0.0073	0.0754	0.0699
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0028	0.0206	0.0148
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0028	0.0206	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0465	0.1086
Echinococcus multilocularis	lamin	0.0027	0.0203	0.0201
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.3342	0.3341
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0203	0.0471
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0059	0.0139
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0023	0.015	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0216	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0059	0.0058
Echinococcus granulosus	GPCR family 2	0.0015	0.0059	0.0058
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0023	0.015	0.0297
Echinococcus multilocularis	cpg binding protein	0.0037	0.0317	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0034	0.028	0.0652
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0023	0.015	0.0148
Brugia malayi	endonuclease G, mitochondrial precursor	0.002	0.0117	0.0274
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0023	0.015	0.0091
Onchocerca volvulus		0.0035	0.0293	0.0347
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0362	0.4271	1
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0362	0.4271	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Echinococcus granulosus	ectonucleotide	0.0028	0.0216	0.0214
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.0347
Brugia malayi	Protein-tyrosine phosphatase 1	0.0023	0.015	0.0351
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0579	0.1356
Onchocerca volvulus		0.0058	0.0579	0.1042
Brugia malayi	Protein-tyrosine phosphatase	0.01	0.1084	0.2539
Loa Loa (eye worm)	hypothetical protein	0.0034	0.028	0.0652
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0023	0.015	0.0148
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.067	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0465	0.109
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0023	0.015	0.0148
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.028	0.0278
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.3342	0.3341
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0023	0.015	0.0347
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Brugia malayi	hypothetical protein	0.0023	0.015	0.0351
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.03	0.0242
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0203	0.0475
Echinococcus multilocularis	geminin	0.0338	0.3974	0.3973
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0293	0.0682
Echinococcus granulosus	cpg binding protein	0.0037	0.0317	0.0315
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0023	0.015	0.0351
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0465	0.109
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.5875	0.5874
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0203	0.0471
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0362	0.4271	1
Brugia malayi	hypothetical protein	0.0023	0.015	0.0351
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0353	0.4167	0.9757

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.1585 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.3053 uM	PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272]	ChEMBL.	No reference
Potency (functional)	3.2944 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	26.8545 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 37.6505 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Giardia lamblia

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1432188
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 667673