Detailed information for compound 677912

Basic information

Technical information
  • TDR Targets ID: 677912
  • Name: N-(4-ethoxyphenyl)-N-(1-oxo-1-pyrrolidin-1-yl propan-2-yl)methanesulfonamide
  • MW: 340.438 | Formula: C16H24N2O4S
  • H donors: 0 H acceptors: 3 LogP: 1.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)N(S(=O)(=O)C)C(C(=O)N1CCCC1)C
  • InChi: 1S/C16H24N2O4S/c1-4-22-15-9-7-14(8-10-15)18(23(3,20)21)13(2)16(19)17-11-5-6-12-17/h7-10,13H,4-6,11-12H2,1-3H3
  • InChiKey: QPZQRWVOKHGHSY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-ethoxyphenyl)-N-(1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl)methanesulfonamide
  • N-(4-ethoxyphenyl)-N-(1-methyl-2-oxo-2-1-pyrrolidinylethyl)methanesulfonamide
  • N-(4-ethoxyphenyl)-N-(2-keto-1-methyl-2-pyrrolidin-1-yl-ethyl)methanesulfonamide
  • N-(4-ethoxyphenyl)-N-(1-oxo-1-pyrrolidin-1-yl-propan-2-yl)methanesulfonamide
  • Oprea1_669289
  • Oprea1_178305
  • BAS 03448824
  • EU-0045735
  • AN-988/40889399

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0106 0.1304 0.1341
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0022
Leishmania major hypothetical protein, conserved 0.0416 0.5859 1
Toxoplasma gondii NADPH-glutathione reductase 0.0042 0.0362 0.2276
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.1563 0.1764
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0274 0.3776 0.8914
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.0454 0.074
Plasmodium vivax glutathione reductase, putative 0.012 0.1515 1
Echinococcus granulosus dnaJ subfamily B 0.0397 0.558 0.574
Loa Loa (eye worm) thioredoxin reductase 0.012 0.1515 0.1709
Echinococcus granulosus SAM and MBT domain containing protein 0.0093 0.1115 0.1147
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.252 0.2503
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.252 0.2503
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0048 0.0454 0.0572
Schistosoma mansoni cpg binding protein 0.0028 0.0159 0.0142
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0189 0.252 0.6321
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0265 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0362 0.0582
Leishmania major DNA damage repair protein, putative 0.0029 0.0179 0.027
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0179 0.027
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1424 0.1405
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1424 0.1445
Echinococcus granulosus thioredoxin glutathione reductase 0.0121 0.153 0.1573
Brugia malayi nuclear hormone receptor 0.0025 0.012 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.012 0.0112
Onchocerca volvulus 0.009 0.1063 0.0955
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.1115 0.1127
Trypanosoma brucei DNA polymerase eta, putative 0.0169 0.223 0.3784
Echinococcus multilocularis microtubule associated protein 2 0.068 0.9722 1
Giardia lamblia DNA damage repair protein 0.0029 0.0179 0.0399
Mycobacterium tuberculosis Probable dehydrogenase 0.0274 0.3776 0.8931
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0362 0.0582
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0493 0.0808
Trypanosoma cruzi DNA polymerase eta, putative 0.0169 0.223 0.3784
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0362 0.0582
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0362 0.0582
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.012 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0416 0.5859 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0622 0.0795
Trypanosoma cruzi DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0042 0.0362 1
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0179 0.027
Trypanosoma brucei unspecified product 0.0065 0.0704 0.1169
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0094 0.1133 0.1146
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0265 0.0279
Plasmodium vivax DNA repair protein REV1, putative 0.0029 0.0179 0.1055
Schistosoma mansoni hypothetical protein 0.0569 0.8103 0.8331
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0112
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.012 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1563 0.1589
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0622 0.0619
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0951 0.0958
Onchocerca volvulus 0.0189 0.252 0.2429
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0265 0.0273
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0265 0.0244
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.3974 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0112
Brugia malayi hypothetical protein 0.0296 0.409 0.4657
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0112
Loa Loa (eye worm) glutaminase 0.0533 0.7573 0.8642
Plasmodium vivax thioredoxin reductase, putative 0.012 0.1515 1
Echinococcus multilocularis tar DNA binding protein 0.0124 0.1563 0.1607
Trypanosoma cruzi DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0131 0.1666 0.3911
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1424 0.3547
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0265 0.0417
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.012 0.0112
Schistosoma mansoni thyroid hormone receptor 0.0025 0.012 0.0101
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0189 0.252 0.6321
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.012 0.0101
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.012 0.0101
Plasmodium vivax SET domain protein, putative 0.009 0.1063 0.6974
Brugia malayi TAR-binding protein 0.0124 0.1563 0.1764
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.012 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1063 0.1074
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0265 0.0616
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0179 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0704 0.1169
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0042 0.0362 0.2276
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.1563 0.1764
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.012 0.0101
Trypanosoma brucei unspecified product 0.0065 0.0704 0.1169
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1563 0.1589
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.012 0.0112
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0031 0.0199 0.0203
Onchocerca volvulus 0.0296 0.409 0.4019
Schistosoma mansoni microtubule-associated protein tau 0.068 0.9722 1
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.1063 0.1094
Trypanosoma brucei chrX additional, unordered contigs 0.0029 0.0179 0.027
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0042 0.0362 0.045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.012 0.0123
Trichomonas vaginalis mercuric reductase, putative 0.0042 0.0362 0.0341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0362 0.0582
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.252 0.2503
Mycobacterium tuberculosis Probable reductase 0.0274 0.3776 0.8931
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0042 0.0362 0.2276
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.3974 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.012 0.0123
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.036 0.0579
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.012 0.0101
Treponema pallidum NADH oxidase 0.0042 0.0362 0.086
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0623 0.062
Brugia malayi mbt repeat family protein 0.0093 0.1115 0.1251
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0362 0.0582
Brugia malayi Thioredoxin reductase 0.012 0.1515 0.1709
Echinococcus multilocularis SAM and MBT domain containing protein 0.0093 0.1115 0.1147
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.0604 0.0583
Trypanosoma brucei glucosidase, putative 0.0035 0.0265 0.0417
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0042 0.0362 0.045
Mycobacterium ulcerans hypothetical protein 0.0029 0.0179 0.0209
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0951 0.1064
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1424 0.1405
Schistosoma mansoni SET domain protein 0.0036 0.0273 0.0259
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0042 0.0362 0.2276
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1424 0.1604
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.4088 0.6965
Mycobacterium ulcerans hypothetical protein 0.0048 0.0454 0.0572
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0088 0.0443
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0048 0.0454 0.1027
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0704 0.1169
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0265 0.0244
Schistosoma mansoni alpha-glucosidase 0.0136 0.1749 0.1781
Loa Loa (eye worm) glutaminase 2 0.0533 0.7573 0.8642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3974 0.396
Loa Loa (eye worm) hypothetical protein 0.0082 0.0951 0.1064
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.012 0.0123
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0274 0.3776 0.8931
Schistosoma mansoni cpg binding protein 0.0029 0.0183 0.0166
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.012 0.0101
Echinococcus multilocularis polycomb protein SCMH1 0.0093 0.1115 0.1147
Loa Loa (eye worm) hypothetical protein 0.0093 0.1115 0.1251
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1424 0.1405
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.012 0.0123
Trypanosoma brucei polo-like protein kinase 0.0114 0.1424 0.2401
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.2072 0.2347
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0704 0.1169
Trichomonas vaginalis set domain proteins, putative 0.0699 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.012 0.0112
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0274 0.3776 0.8931
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.1063 0.6974
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.036 0.0579
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.012 0.0123
Loa Loa (eye worm) MBCTL1 0.0106 0.1304 0.1467
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0579 0.0558
Brugia malayi jmjC domain containing protein 0.006 0.0623 0.0688
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.012 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0622 0.0795
Leishmania major DNA polymerase eta, putative 0.0104 0.1276 0.2149
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.0454 0.074
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0305 0.4226 1
Giardia lamblia Kinase, PLK 0.0114 0.1424 0.3547
Echinococcus multilocularis thioredoxin glutathione reductase 0.0121 0.153 0.1573
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0362 0.0582
Trypanosoma brucei trypanothione reductase 0.012 0.1515 0.2558
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0589 0.3796
Trypanosoma brucei DNA polymerase IV, putative 0.0094 0.1133 0.1904
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.012 0.0112
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2072 0.2132
Schistosoma mansoni nuclear hormone receptor 0.0025 0.012 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0416 0.5859 1
Mycobacterium ulcerans glutaminase 0.0533 0.7573 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1803 0.3051
Echinococcus granulosus tar DNA binding protein 0.0124 0.1563 0.1607
Brugia malayi Pre-SET motif family protein 0.009 0.1063 0.1192
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0088 0.0443
Trypanosoma brucei unspecified product 0.0094 0.1133 0.1904
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1563 0.1589
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0265 0.1631
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.012 0.0112
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1424 0.2401
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0112
Brugia malayi CXXC zinc finger family protein 0.0028 0.0159 0.0157
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.012 0.0123
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.558 0.574
Toxoplasma gondii thioredoxin reductase 0.012 0.1515 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3974 0.396
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0094 0.1133 0.1166
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0042 0.0362 1
Schistosoma mansoni alpha glucosidase 0.0035 0.0265 0.0251
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0622 0.0619
Onchocerca volvulus 0.0082 0.0951 0.0842
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.036 0.0579
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3974 0.396
Onchocerca volvulus 0.0093 0.1115 0.1007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0094 0.1133 0.2813
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1424 0.2401
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0622 0.1028
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.012 0.0101
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0094 0.1133 0.2644
Plasmodium falciparum glutathione reductase 0.012 0.1515 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Schistosoma mansoni cpg binding protein 0.0029 0.0183 0.0166
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.0604 0.0583
Trypanosoma brucei DNA polymerase IV, putative 0.0094 0.1133 0.1904
Leishmania major hypothetical protein, conserved 0.0058 0.0604 0.0997
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.012 0.0112
Echinococcus granulosus polycomb protein SCMH1 0.0093 0.1115 0.1147
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0991 0.102
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.252 0.2503
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.037 0.5184 0.5332
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0179 0.027
Trichomonas vaginalis DNA polymerase eta, putative 0.0094 0.1133 0.1114
Loa Loa (eye worm) RNA binding protein 0.0124 0.1563 0.1764
Giardia lamblia NADH oxidase lateral transfer candidate 0.0042 0.0362 0.086
Mycobacterium tuberculosis Conserved hypothetical protein 0.0094 0.1133 0.2644
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0622 0.402
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0951 0.0979
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0265 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0604 0.0997
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.06 0.0617
Echinococcus multilocularis dna polymerase eta 0.0169 0.223 0.2294
Echinococcus granulosus dna polymerase eta 0.0169 0.223 0.2294
Schistosoma mansoni myelin transcription factor 1 myt1 0.0106 0.1304 0.1322
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3974 0.396
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0362 0.0582
Onchocerca volvulus 0.0028 0.0159 0.004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0622 0.0795
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0622 0.1428
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0362 0.0582
Brugia malayi ImpB/MucB/SamB family protein 0.0094 0.1133 0.1272
Loa Loa (eye worm) mbt repeat family protein 0.0093 0.1115 0.1251
Giardia lamblia DINP protein human, muc B family 0.0094 0.1133 0.2813
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.012 0.0123
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0088 0.0157
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0179 0.1055
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0058 0.0604 0.0997
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0094 0.1133 0.1166
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.012 0.0112
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1813 0.417
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0093 0.1115 0.1007
Trypanosoma cruzi trypanothione reductase, putative 0.012 0.1515 0.2558
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.06 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.1063 0.1094
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0265 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.012 0.0112
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0048 0.0454 0.0572
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1424 0.1464
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.012 0.0112
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0042 0.0362 0.2276
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0265 0.0616
Plasmodium falciparum thioredoxin reductase 0.012 0.1515 1
Echinococcus multilocularis citrate lyase subunit beta protein 0.0048 0.0454 0.0467
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0042 0.0362 0.0582
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0623 0.0688
Loa Loa (eye worm) glutathione reductase 0.012 0.1515 0.1709
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3974 0.396
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.2072 0.2347
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1563 0.1589
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1813 0.2372
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1424 0.1405
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0305 0.4226 1
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0189 0.252 0.2859
Schistosoma mansoni glutaminase 0.0533 0.7573 0.7784
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3974 0.396
Brugia malayi polk-prov protein 0.0029 0.0179 0.018
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1424 0.2401
Schistosoma mansoni thyroid hormone receptor 0.0025 0.012 0.0101
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0042 0.0362 0.0582
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0042 0.0362 0.0389
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.2072 0.2132
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0029 0.0179 0.1055
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2072 0.2132
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0042 0.0362 0.0372
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0274 0.3776 0.8931
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1424 0.1604
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0579 0.0558
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0265 0.0417
Echinococcus granulosus dna polymerase kappa 0.0094 0.1133 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0112
Brugia malayi jmjC domain containing protein 0.0058 0.06 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1803 0.3051
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0042 0.0362 0.0372
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0042 0.0362 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0622 0.064
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1803 0.3051
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0042 0.0362 0.035
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1813 0.4261
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.3974 1
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.1115 0.1127
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0179 0.027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.012 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.012 0.0112
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0265 0.0273
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1424 0.1405
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0189 0.252 0.3308
Brugia malayi RNA binding protein 0.0124 0.1563 0.1764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.012 0.0112
Loa Loa (eye worm) hypothetical protein 0.0106 0.1304 0.1467
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0189 0.252 0.6321
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0179 0.027
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0036 0.0273 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.012 0.0112
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.012 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.012 0.0112
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0088 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.012 0.0101
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.4088 0.6965
Echinococcus multilocularis cpg binding protein 0.0029 0.0183 0.0188
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.036 0.0579
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0094 0.1133 0.1904
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0088 0.0088
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.012 0.0101
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0094 0.1133 0.1272
Echinococcus multilocularis dna polymerase kappa 0.0094 0.1133 0.1166
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0265 0.0244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.012 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1424 0.1405
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.012 0.0112
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0036 0.0273 0.0281
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1563 0.1589
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0093 0.1115 0.1127
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.012 0.0123
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1424 0.1464
Mycobacterium tuberculosis Conserved protein 0.0048 0.0454 0.1027
Echinococcus granulosus citrate lyase subunit beta protein 0.0048 0.0454 0.0467
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0031 0.0199 0.0203
Leishmania major DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0112
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0265 0.0244
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.2035 0.4788
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0614 0.8759 1
Brugia malayi mbt repeat family protein 0.0093 0.1115 0.1251
Trypanosoma brucei DNA polymerase IV, putative 0.0094 0.1133 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0622 0.064
Echinococcus granulosus FTZ F1 alpha 0.0025 0.012 0.0123
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.4088 0.6965
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.012 0.0112
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0088 0.1946
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.012 0.0123
Plasmodium falciparum glutathione reductase 0.0042 0.0362 0.2276
Brugia malayi glutaminase DH11.1 0.0533 0.7573 0.8642
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0106 0.1304 0.1341
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.06 0.0617
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1063 0.1074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.012 0.0112
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0265 0.0244
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0106 0.1304 0.1467
Trypanosoma cruzi DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Mycobacterium tuberculosis Probable oxidoreductase 0.0305 0.4226 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1063 0.1074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0362 0.0582
Leishmania major trypanothione reductase 0.012 0.1515 0.2558
Brugia malayi glutathione reductase 0.012 0.1515 0.1709
Echinococcus granulosus endonuclease exonuclease phosphatase 0.037 0.5184 0.5332
Loa Loa (eye worm) hypothetical protein 0.009 0.1063 0.1192
Entamoeba histolytica hypothetical protein 0.0023 0.0088 0.0167
Brugia malayi ImpB/MucB/SamB family protein 0.0169 0.223 0.2528
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0362 0.0582
Schistosoma mansoni hypothetical protein 0.0397 0.558 0.573
Loa Loa (eye worm) TAR-binding protein 0.0124 0.1563 0.1764
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0189 0.252 0.2859
Echinococcus granulosus cpg binding protein 0.0029 0.0183 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0604 0.0997
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.012 0.0123
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0362 0.0582
Trichomonas vaginalis glutathione reductase, putative 0.0042 0.0362 0.0341
Plasmodium falciparum DNA repair protein REV1, putative 0.0029 0.0179 0.1055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3974 0.396
Brugia malayi steroid hormone receptor 0.0025 0.012 0.0112
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.012 0.0101
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0042 0.0362 0.0809
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0048 0.0454 0.0572
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0179 0.027
Leishmania major DNA polymerase kappa, putative 0.0029 0.0179 0.027
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0094 0.1133 0.1114
Trypanosoma cruzi DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Echinococcus granulosus microtubule associated protein 2 0.068 0.9722 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0681 0.068
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0088 0.0443
Brugia malayi nuclear receptor NHR-88 0.0025 0.012 0.0112
Plasmodium falciparum thioredoxin reductase 0.0042 0.0362 0.2276
Brugia malayi Pre-SET motif family protein 0.0614 0.8759 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.012 0.0123
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0623 0.062
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0179 0.027
Trichomonas vaginalis glutaminase, putative 0.0533 0.7573 0.7567
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1424 0.1405
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0179 0.027
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0265 0.0244
Brugia malayi ecdysteroid receptor 0.0025 0.012 0.0112
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1424 0.132
Schistosoma mansoni coup transcription factor 0.0025 0.012 0.0101
Mycobacterium ulcerans DNA polymerase IV 0.0094 0.1133 0.1472
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0362 0.0582
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0112
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.012 0.1515 0.3552
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0265 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0179 0.027
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0088 0.0167
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.252 0.2503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.012 0.0112
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.012 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.3974 0.396
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.012 0.0112
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.012 0.0123
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0159 0.0157
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.252 0.2503
Toxoplasma gondii hypothetical protein 0.0048 0.045 0.2865
Mycobacterium ulcerans DNA polymerase IV 0.0094 0.1133 0.1472
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0274 0.3776 0.8931
Echinococcus granulosus histone acetyltransferase MYST2 0.0106 0.1304 0.1341
Loa Loa (eye worm) hypothetical protein 0.0296 0.409 0.4657
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0042 0.0362 0.0582
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.3974 1
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.0454 0.074
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0088 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.1063 0.1074
Schistosoma mansoni terminal deoxycytidyl transferase 0.0094 0.1133 0.1146
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.012 0.0123
Schistosoma mansoni alpha-glucosidase 0.0136 0.1749 0.1781
Trypanosoma cruzi DNA polymerase eta, putative 0.0104 0.1276 0.2149
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0112
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0104 0.1276 0.8402
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0048 0.0454 0.0433
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0623 0.0641
Mycobacterium ulcerans hypothetical protein 0.0048 0.0454 0.0572
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0951 0.0979
Onchocerca volvulus 0.0092 0.1093 0.0985
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0265 0.0244
Schistosoma mansoni DNA polymerase IV / kappa 0.0029 0.0179 0.0162
Loa Loa (eye worm) hypothetical protein 0.0169 0.223 0.2528
Trypanosoma cruzi hypothetical protein, conserved 0.0416 0.5859 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Schistosoma mansoni jumonji domain containing protein 0.0058 0.06 0.0596
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.1063 0.1094
Mycobacterium ulcerans hypothetical protein 0.0156 0.2035 0.2666
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0088 0.0443
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.012 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.1133 0.1904
Echinococcus multilocularis histone acetyltransferase MYST2 0.0106 0.1304 0.1341
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0088 0.0113
Schistosoma mansoni DNA polymerase eta 0.0169 0.223 0.2277
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0042 0.0362 0.0582
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0305 0.4226 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0042 0.0362 0.045
Schistosoma mansoni kinase 0.0058 0.0601 0.0597
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0042 0.0362 0.2276
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.4088 0.6965
Leishmania major DNA polymerase eta, putative 0.0169 0.223 0.3784

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.