Detailed information for compound 695333

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.874 | Formula: C20H22ClN5O2
  • H donors: 0 H acceptors: 3 LogP: 3.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(=O)n(C)c2c(c1=O)n1CC(C)CN(c1n2)c1cccc(c1C)Cl
  • InChi: 1S/C20H22ClN5O2/c1-5-9-24-18(27)16-17(23(4)20(24)28)22-19-25(10-12(2)11-26(16)19)15-8-6-7-14(21)13(15)3/h5-8,12H,1,9-11H2,2-4H3
  • InChiKey: ZCHPNUFNQHQBGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.0055 0.0417 0.4577
Echinococcus multilocularis leucine aminopeptidase protein 0.0125 0.1171 0.1171
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0095 0.0701
Trichomonas vaginalis DNA polymerase eta, putative 0.0112 0.1039 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0406 0.1462
Mycobacterium ulcerans hypothetical protein 0.0117 0.1088 0.1623
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0103 0.0763
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0409 0.1475
Trypanosoma brucei DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Brugia malayi Protein kinase domain containing protein 0.01 0.091 0.3278
Schistosoma mansoni hypothetical protein 0.0943 1 1
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0232 0.2229
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0486 0.0486
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0095 0.0701
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0095 0.0701
Leishmania major pyruvate kinase 0.0038 0.0232 0.1716
Schistosoma mansoni hypothetical protein 0.0391 0.4041 0.4041
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0117 0.1088 0.9218
Schistosoma mansoni terminal deoxycytidyl transferase 0.0082 0.0717 0.0717
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0025 0.0095 0.0341
Trypanosoma brucei DNA polymerase IV, putative 0.0105 0.0959 0.7105
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0417 0.0621
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0055 0.0417 0.0621
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0232 0.1716
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.0717 0.1069
Loa Loa (eye worm) hypothetical protein 0.0041 0.0267 0.0963
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0232 0.1964
Trypanosoma brucei DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Schistosoma mansoni hypothetical protein 0.0326 0.3346 0.3346
Echinococcus multilocularis pyruvate kinase 0.0038 0.0232 0.0232
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0637 0.6704 1
Onchocerca volvulus 0.0055 0.0417 0.4983
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0103 0.0763
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0109 0.0393
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0417 0.15
Loa Loa (eye worm) MBCTL1 0.0061 0.0486 0.175
Giardia lamblia Pyruvate kinase 0.0038 0.0232 0.2586
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.0717 0.2582
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0125 0.1171 0.867
Entamoeba histolytica protein kinase, putative 0.01 0.091 1
Echinococcus multilocularis dna polymerase eta 0.0141 0.135 0.135
Giardia lamblia DINP protein human, muc B family 0.009 0.0797 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0417 0.0621
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0417 0.15
Plasmodium falciparum M17 leucyl aminopeptidase 0.0125 0.1171 1
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0111 0.082
Entamoeba histolytica protein kinase, putative 0.01 0.091 1
Leishmania major DNA polymerase kappa, putative 0.0026 0.0103 0.0763
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.091 0.674
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0406 0.0406
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0232 0.1979
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0125 0.1171 0.867
Echinococcus granulosus dna polymerase kappa 0.0112 0.1039 0.1039
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0417 0.0621
Trypanosoma cruzi DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0232 0.0346
Plasmodium vivax DNA repair protein REV1, putative 0.0026 0.0103 0.088
Schistosoma mansoni hypothetical protein 0.0391 0.4041 0.4041
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0095 0.0095
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0486 0.0486
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0055 0.0417 0.0621
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0232 0.0835
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0417 0.3085
Plasmodium falciparum DNA repair protein REV1, putative 0.0026 0.0103 0.088
Schistosoma mansoni cpg binding protein 0.007 0.0582 0.0582
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0406 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0409 0.0409
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0541 0.1949
Echinococcus multilocularis pyruvate kinase 0.0019 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0797 0.5901
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0095 0.0701
Entamoeba histolytica acyl-coA synthetase, putative 0.0055 0.0417 0.4577
Onchocerca volvulus 0.0054 0.0406 0.4854
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0082 0.0717 0.0717
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0103 0.0763
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0111 0.0165
Onchocerca volvulus 0.0066 0.0541 0.6473
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0025 0.0095 0.0341
Loa Loa (eye worm) hypothetical protein 0.0061 0.0486 0.175
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0836 0.0836
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0045 0.0162
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0417 0.3085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0409 0.0409
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0417 0.0621
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0521 0.3856
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0273 0.2776 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0267 0.0963
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0095 0.0095
Echinococcus multilocularis pyruvate kinase 0.0038 0.0232 0.0232
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0041 0.0267 0.0399
Entamoeba histolytica hypothetical protein 0.01 0.091 1
Echinococcus granulosus dual specificity 0.01 0.091 0.091
Echinococcus multilocularis pyruvate kinase 0.003 0.0146 0.0146
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0125 0.1171 0.1608
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0111 0.0165
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0232 0.1716
Chlamydia trachomatis pyruvate kinase 0.0038 0.0232 0.1142
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0232 0.0835
Schistosoma mansoni leucine aminopeptidase 0.0025 0.0095 0.0095
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0095 0.0341
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0232 0.2772
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0409 0.0409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0409 0.0409
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0486 0.0486
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0111 0.0165
Echinococcus granulosus pyruvate kinase 0.0038 0.0232 0.0232
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0095 0.0701
Mycobacterium ulcerans hypothetical protein 0.0026 0.0103 0.0154
Trypanosoma brucei chrX additional, unordered contigs 0.0026 0.0103 0.0763
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.01 0.091 0.3278
Brugia malayi mbt repeat family protein 0.0054 0.0406 0.1462
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0095 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0521 0.3856
Loa Loa (eye worm) hypothetical protein 0.01 0.0904 0.3258
Echinococcus multilocularis dnaJ subfamily B 0.0943 1 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0232 0.0346
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0409 0.0409
Trypanosoma brucei DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0035 0.0296
Echinococcus granulosus pyruvate kinase 0.0019 0.0035 0.0035
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0095 0.0095
Echinococcus granulosus pyruvate kinase 0.0019 0.0035 0.0035
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0048 0.0048
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0125 0.1171 0.867
Mycobacterium ulcerans DNA polymerase IV 0.0112 0.1039 0.1551
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0112 0.1039 1
Echinococcus multilocularis geminin 0.0391 0.4041 0.4041
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0103 0.0763
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0232 0.2229
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0637 0.6704 1
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0232 0.2772
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0095 0.0701
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0393
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0125 0.1171 0.867
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0025 0.0095 0.0095
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0232 0.1716
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0637 0.6704 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0004 0.0004
Brugia malayi ImpB/MucB/SamB family protein 0.0141 0.135 0.4864
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0103 0.0763
Schistosoma mansoni DNA polymerase eta 0.0141 0.135 0.135
Trypanosoma brucei DNA polymerase IV, putative 0.0112 0.1039 0.7698
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0004 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0417 0.0621
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0004 0.0004
Treponema pallidum licC protein (licC) 0.0117 0.1088 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0737 0.5455
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0637 0.6704 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0082 0.0717 0.0717
Toxoplasma gondii leucyl aminopeptidase LAP 0.0125 0.1171 0.9921
Leishmania major DNA polymerase kappa, putative 0.009 0.0797 0.5901
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0109 0.12
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0025 0.0095 0.0341
Leishmania major DNA polymerase eta, putative 0.0141 0.135 1
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0035 0.0294
Loa Loa (eye worm) hypothetical protein 0.0141 0.135 0.4864
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0125 0.1171 0.1746
Echinococcus granulosus dna polymerase eta 0.0141 0.135 0.135
Loa Loa (eye worm) hypothetical protein 0.0041 0.0267 0.0963
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0082 0.0717 0.0717
Echinococcus multilocularis dna polymerase kappa 0.0112 0.1039 0.1039
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0095 0.0701
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0111 0.0945
Schistosoma mansoni microtubule-associated protein tau 0.0814 0.8615 0.8615
Schistosoma mansoni pyruvate kinase 0.0038 0.0232 0.0232
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0111 0.0945
Loa Loa (eye worm) hypothetical protein 0.0041 0.0267 0.0963
Plasmodium falciparum acyl-CoA synthetase 0.0041 0.0267 0.2285
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0033 0.0183 0.1552
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0406 0.0406
Mycobacterium ulcerans hypothetical protein 0.0117 0.1088 0.1623
Entamoeba histolytica hypothetical protein 0.0026 0.0111 0.1216
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0103 0.0763
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0111 0.082
Echinococcus granulosus microtubule associated protein 2 0.0814 0.8615 0.8615
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0409 0.1475
Echinococcus multilocularis dual specificity 0.01 0.091 0.091
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0486 0.175
Echinococcus granulosus pyruvate kinase 0.0038 0.0232 0.0232
Leishmania major DNA damage repair protein, putative 0.0026 0.0103 0.0763
Loa Loa (eye worm) hypothetical protein 0.0056 0.0426 0.1534
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.0103 0.0873
Loa Loa (eye worm) hypothetical protein 0.0094 0.0836 0.3011
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0103 0.0763
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0004 0.0004
Echinococcus multilocularis pyruvate kinase 0.0019 0.0035 0.0035
Echinococcus granulosus pyruvate kinase 0.0019 0.0035 0.0035
Trypanosoma brucei unspecified product 0.0105 0.0959 0.7105
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.15
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.01 0.091 0.674
Entamoeba histolytica deoxycytidyl transferase, putative 0.0082 0.0717 0.7876
Trypanosoma brucei DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.009 0.0797 0.1189
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0117 0.1088 0.1623
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0004 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0417 0.15
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0111 0.0938
Brugia malayi CXXC zinc finger family protein 0.0066 0.0541 0.1949
Echinococcus multilocularis cpg binding protein 0.007 0.0582 0.0582
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.091 0.674
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0406 0.0406
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0082 0.0717 0.2582
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0048 0.0048
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0406 0.4854
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.009 0.0797 0.5901
Mycobacterium ulcerans leucyl aminopeptidase 0.0125 0.1171 0.1746
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0417 0.3085
Trypanosoma brucei DNA polymerase IV, putative 0.0112 0.1039 0.7698
Brugia malayi cytosol aminopeptidase 0.0025 0.0095 0.0341
Loa Loa (eye worm) hypothetical protein 0.0041 0.0267 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0521 0.3856
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.1088 0.1623
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0836 0.3011
Schistosoma mansoni cpg binding protein 0.007 0.0582 0.0582
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0111 0.0165
Giardia lamblia DNA damage repair protein 0.0026 0.0103 0.0897
Trypanosoma brucei DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0426 0.3153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.01 0.091 0.674
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0409 0.0409
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0103 0.0763
Schistosoma mansoni pyruvate kinase 0.0038 0.0232 0.0232
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0055 0.0417 0.0621
Trypanosoma cruzi DNA polymerase eta, putative 0.0141 0.135 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0243 0.0363
Echinococcus granulosus cpg binding protein 0.007 0.0582 0.0582
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0406 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Trypanosoma brucei DNA polymerase eta, putative 0.0141 0.135 1
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0232 0.0835
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0406 0.1462
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0486 0.0486
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0125 0.1171 1
Echinococcus granulosus geminin 0.0391 0.4041 0.4041
Leishmania major DNA polymerase eta, putative 0.0084 0.0737 0.5455
Trypanosoma brucei DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0232 0.0835
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0836 0.0836
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0232 0.2772
Brugia malayi mbt repeat family protein 0.0054 0.0406 0.1462
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0041 0.0267 0.1479
Entamoeba histolytica protein kinase domain containing protein 0.01 0.091 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0232 0.1716
Plasmodium falciparum pyruvate kinase 0.0038 0.0232 0.1979
Brugia malayi polk-prov protein 0.0056 0.0426 0.1534
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0232 0.0346
Brugia malayi follicle stimulating hormone receptor 0.0273 0.2776 1
Schistosoma mansoni cpg binding protein 0.0066 0.0541 0.0541
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0125 0.1171 0.1746
Trypanosoma brucei DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.15
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0035 0.0296
Loa Loa (eye worm) hypothetical protein 0.0038 0.0232 0.0835
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.1088 0.1623
Trypanosoma brucei unspecified product 0.0057 0.0441 0.3263
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0836 0.0836
Echinococcus granulosus leucine aminopeptidase protein 0.0125 0.1171 0.1171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0243 0.0363
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.1342 0.1342
Echinococcus multilocularis microtubule associated protein 2 0.0814 0.8615 0.8615
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0406 0.0406
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0111 0.0938
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0417 0.0621
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0243 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0426 0.3153
Trypanosoma brucei unspecified product 0.0057 0.0441 0.3263
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.15
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.0267 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Schistosoma mansoni serine/threonine protein kinase 0.01 0.091 0.091
Leishmania major pyruvate kinase 0.0038 0.0232 0.1716
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0486 0.0486
Mycobacterium ulcerans DNA polymerase IV 0.0112 0.1039 0.1551
Trypanosoma cruzi DNA polymerase kappa, putative 0.0112 0.1039 0.7698
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0095 0.0701
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0084 0.0737 0.6242
Loa Loa (eye worm) histone methyltransferase 0.002 0.0048 0.0172
Loa Loa (eye worm) hypothetical protein 0.01 0.0904 0.3258
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0025 0.0095 0.0341
Mycobacterium ulcerans hypothetical protein 0.0055 0.0417 0.0621
Echinococcus multilocularis pyruvate kinase 0.0019 0.0035 0.0035
Schistosoma mansoni pyruvate kinase 0.0019 0.0035 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0055 0.0417 0.4577
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.2108 0.2108
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0232 0.0835
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.2108 0.2108
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0406 0.0406
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0243 0.0363
Onchocerca volvulus 0.0094 0.0836 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.118 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0041 0.0267 0.2285
Schistosoma mansoni DNA polymerase IV / kappa 0.0026 0.0103 0.0103
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0417 0.0621
Chlamydia trachomatis cytosol aminopeptidase 0.0125 0.1171 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0055 0.0417 0.0621
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0409 0.0409
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0025 0.0095 0.0095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0112 0.1039 0.7698

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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