TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 399.874 | Formula: C20H22ClN5O2
H donors: 0 H acceptors: 3 LogP: 3.72 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C=CCn1c(=O)n(C)c2c(c1=O)n1CC(C)CN(c1n2)c1cccc(c1C)Cl
InChi: 1S/C20H22ClN5O2/c1-5-9-24-18(27)16-17(23(4)20(24)28)22-19-25(10-12(2)11-26(16)19)15-8-6-7-14(21)13(15)3/h5-8,12H,1,9-11H2,2-4H3
InChiKey: ZCHPNUFNQHQBGM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0267	0.0963
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0232	0.2772
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0041	0.0267	0.0399
Schistosoma mansoni	leucine aminopeptidase	0.0025	0.0095	0.0095
Loa Loa (eye worm)	histone methyltransferase	0.002	0.0048	0.0172
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.0409	0.1475
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0417	0.15
Onchocerca volvulus		0.0054	0.0406	0.4854
Trypanosoma brucei	DNA polymerase kappa, putative	0.0064	0.0521	0.3856
Entamoeba histolytica	acyl-coA synthetase, putative	0.0055	0.0417	0.4577
Echinococcus granulosus	geminin	0.0391	0.4041	0.4041
Entamoeba histolytica	hypothetical protein	0.01	0.091	1
Schistosoma mansoni	cpg binding protein	0.0066	0.0541	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0232	0.0835
Trypanosoma brucei	DNA polymerase kappa, putative	0.0056	0.0426	0.3153
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0054	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0141	0.135	0.4864
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0016	0.0004	0.0004
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0055	0.0417	0.0621
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0103	0.0154
Schistosoma mansoni	pyruvate kinase	0.0038	0.0232	0.0232
Echinococcus multilocularis	geminin	0.0391	0.4041	0.4041
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0094	0.0836	0.0836
Trypanosoma brucei	DNA damage repair protein, putative	0.0026	0.0103	0.0763
Echinococcus granulosus	dna polymerase eta	0.0141	0.135	0.135
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0061	0.0486	0.0486
Brugia malayi	Aminopeptidase ZK353.6 in chromosome III	0.0025	0.0095	0.0341
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	0.0125	0.1171	0.1746
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Echinococcus granulosus	cpg binding protein	0.007	0.0582	0.0582
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.091	0.091
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0038	0.0232	0.1716
Echinococcus multilocularis	dna polymerase kappa	0.0112	0.1039	0.1039
Onchocerca volvulus		0.0055	0.0417	0.4983
Mycobacterium ulcerans	acyl-CoA synthetase	0.0055	0.0417	0.0621
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0026	0.0111	0.0938
Echinococcus multilocularis	leucine aminopeptidase protein	0.0125	0.1171	0.1171
Mycobacterium ulcerans	acyl-CoA synthetase	0.0055	0.0417	0.0621
Leishmania major	DNA polymerase eta, putative	0.0084	0.0737	0.5455
Echinococcus granulosus	microtubule associated protein 2	0.0814	0.8615	0.8615
Schistosoma mansoni	DNA polymerase IV / kappa	0.0026	0.0103	0.0103
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0025	0.0095	0.0341
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0016	0.0004	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0117	0.1088	0.1623
Plasmodium falciparum	pyruvate kinase 2	0.0019	0.0035	0.0296
Echinococcus multilocularis	leucyl aminopeptidase	0.0025	0.0095	0.0095
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0232	0.2772
Trypanosoma brucei	DNA polymerase IV, putative	0.0105	0.0959	0.7105
Schistosoma mansoni	cpg binding protein	0.007	0.0582	0.0582
Toxoplasma gondii	pyruvate kinase PyK1	0.0038	0.0232	0.1964
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0082	0.0717	0.0717
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0055	0.0417	0.4577
Toxoplasma gondii	eukaryotic initiation factor-2B, gamma subunit, putative	0.0117	0.1088	0.9218
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0232	0.0835
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0026	0.0111	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0109	0.0393
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0243	0.0363
Loa Loa (eye worm)	aminopeptidase in chromosome III	0.0025	0.0095	0.0341
Wolbachia endosymbiont of Brugia malayi	leucyl aminopeptidase	0.0125	0.1171	0.1608
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0103	0.0763
Brugia malayi	F/Y-rich N-terminus family protein	0.002	0.0045	0.0162
Leishmania major	DNA damage repair protein, putative	0.0026	0.0103	0.0763
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0232	0.0835
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.014	0.1342	0.1342
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0061	0.0486	0.0486
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0038	0.0232	0.1716
Trypanosoma brucei	unspecified product	0.0057	0.0441	0.3263
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0417	0.15
Trypanosoma brucei	DNA polymerase kappa, putative	0.009	0.0797	0.5901
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0103	0.0763
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0409	0.0409
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0041	0.0267	0.0399
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0243	0.0363
Trichomonas vaginalis	pyruvate kinase, putative	0.0038	0.0232	0.2229
Trypanosoma brucei	DNA polymerase kappa, putative	0.0064	0.0521	0.3856
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0243	0.0363
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0211	0.2108	0.2108
Mycobacterium ulcerans	DNA polymerase IV	0.0112	0.1039	0.1551
Schistosoma mansoni	pyruvate kinase	0.0019	0.0035	0.0035
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0409	0.0409
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0026	0.0103	0.0873
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0112	0.1039	1
Echinococcus granulosus	leucyl aminopeptidase	0.0025	0.0095	0.0095
Echinococcus granulosus	L aminoadipate semialdehyde	0.0094	0.0836	0.0836
Echinococcus granulosus	leucine aminopeptidase protein	0.0125	0.1171	0.1171
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0033	0.0183	0.1552
Brugia malayi	Aminopeptidase W07G4.4 in chromosome V	0.0025	0.0095	0.0341
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0055	0.0417	0.0621
Plasmodium falciparum	acyl-CoA synthetase	0.0041	0.0267	0.2285
Trypanosoma brucei	DNA polymerase eta, putative	0.0141	0.135	1
Leishmania major	pyruvate kinase	0.0038	0.0232	0.1716
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0273	0.2776	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.0061	0.0486	0.0486
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0232	0.2772
Toxoplasma gondii	leucyl aminopeptidase LAP	0.0125	0.1171	0.9921
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0025	0.0095	0.0701
Schistosoma mansoni	DNA polymerase eta	0.0141	0.135	0.135
Mycobacterium ulcerans	molybdopterin-guanine dinucleotide biosynthesis protein A	0.0117	0.1088	0.1623
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.009	0.0797	0.1189
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0016	0.0004	0.0004
Onchocerca volvulus		0.0066	0.0541	0.6473
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0267	0.0963
Brugia malayi	ImpB/MucB/SamB family protein	0.0082	0.0717	0.2582
Echinococcus multilocularis	dna polymerase eta	0.0141	0.135	0.135
Plasmodium vivax	DNA repair protein REV1, putative	0.0026	0.0103	0.088
Schistosoma mansoni	microtubule-associated protein tau	0.0814	0.8615	0.8615
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0055	0.0417	0.0621
Echinococcus multilocularis	microtubule associated protein 2	0.0814	0.8615	0.8615
Brugia malayi	Protein kinase domain containing protein	0.01	0.091	0.3278
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0417	0.15
Loa Loa (eye worm)	MBCTL1	0.0061	0.0486	0.175
Brugia malayi	cytosol aminopeptidase	0.0025	0.0095	0.0341
Onchocerca volvulus		0.0094	0.0836	1
Mycobacterium ulcerans	hypothetical protein	0.0117	0.1088	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0267	0.0963
Trypanosoma brucei	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0267	0.0963
Mycobacterium ulcerans	hypothetical protein	0.0055	0.0417	0.0621
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.0409	0.1475
Loa Loa (eye worm)	aminopeptidase in chromosome V	0.0025	0.0095	0.0341
Mycobacterium tuberculosis	Probable aminopeptidase PepB	0.0125	0.1171	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0406	0.1462
Echinococcus multilocularis	cpg binding protein	0.007	0.0582	0.0582
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0035	0.0035
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.01	0.091	0.3278
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0111	0.0945
Loa Loa (eye worm)	mbt repeat family protein	0.0054	0.0406	0.1462
Schistosoma mansoni	hypothetical protein	0.0391	0.4041	0.4041
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0094	0.0836	0.3011
Leishmania major	DNA polymerase eta, putative	0.0141	0.135	1
Leishmania major	pyruvate kinase	0.0038	0.0232	0.1716
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.01	0.091	0.674
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.002	0.0048	0.0048
Schistosoma mansoni	sex comb on midleg homolog	0.0054	0.0406	0.0406
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0117	0.1088	0.1623
Loa Loa (eye worm)	pyruvate kinase-PB	0.0026	0.0109	0.0393
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0082	0.0717	0.0717
Echinococcus granulosus	ankyrin repeat domain containing protein 17	0.0025	0.0095	0.0095
Brugia malayi	polk-prov protein	0.0056	0.0426	0.1534
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0038	0.0232	0.0346
Echinococcus granulosus	dual specificity	0.01	0.091	0.091
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0035	0.0035
Trypanosoma cruzi	DNA damage repair protein, putative	0.0026	0.0103	0.0763
Trypanosoma brucei	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Giardia lamblia	Pyruvate kinase	0.0038	0.0232	0.2586
Schistosoma mansoni	sex comb on midleg homolog	0.0054	0.0406	0.0406
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0082	0.0717	0.2582
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0016	0.0004	0.0004
Entamoeba histolytica	pyruvate kinase, putative	0.0026	0.0109	0.12
Brugia malayi	follicle stimulating hormone receptor	0.0273	0.2776	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0055	0.0417	0.3085
Trypanosoma brucei	DNA polymerase IV, putative	0.0112	0.1039	0.7698
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0061	0.0486	0.0486
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0038	0.0232	0.0835
Brugia malayi	CXXC zinc finger family protein	0.0066	0.0541	0.1949
Echinococcus granulosus	pyruvate kinase	0.0019	0.0035	0.0035
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0055	0.0417	0.0621
Mycobacterium leprae	conserved hypothetical protein	0.0026	0.0111	0.0165
Echinococcus multilocularis	dual specificity	0.01	0.091	0.091
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0103	0.0763
Echinococcus granulosus	leucyl aminopeptidase	0.0025	0.0095	0.0095
Trypanosoma brucei	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.009	0.0797	0.5901
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0409	0.0409
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0117	0.1088	0.1623
Echinococcus multilocularis	pyruvate kinase	0.0038	0.0232	0.0232
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0082	0.0717	0.7876
Plasmodium falciparum	M17 leucyl aminopeptidase	0.0125	0.1171	1
Echinococcus granulosus	pyruvate kinase	0.0019	0.0035	0.0035
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	0.0125	0.1171	0.867
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0637	0.6704	1
Trypanosoma brucei	aminopeptidase, putative	0.0025	0.0095	0.0701
Trypanosoma brucei	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Trypanosoma brucei	DNA polymerase kappa, putative	0.0056	0.0426	0.3153
Brugia malayi	AMP-binding enzyme family protein	0.0055	0.0417	0.15
Plasmodium falciparum	DNA repair protein REV1, putative	0.0026	0.0103	0.088
Mycobacterium leprae	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0637	0.6704	1
Brugia malayi	mbt repeat family protein	0.0054	0.0406	0.1462
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0111	0.0945
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0066	0.0541	0.1949
Toxoplasma gondii	pyruvate kinase PyKII	0.0019	0.0035	0.0294
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0111	0.082
Leishmania major	4-coumarate:coa ligase-like protein	0.0055	0.0417	0.3085
Trypanosoma brucei	DNA polymerase IV, putative	0.0112	0.1039	0.7698
Brugia malayi	ImpB/MucB/SamB family protein	0.0141	0.135	0.4864
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Trypanosoma cruzi	DNA damage repair protein, putative	0.0026	0.0103	0.0763
Schistosoma mansoni	hypothetical protein	0.0391	0.4041	0.4041
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0409	0.0409
Trypanosoma brucei	pyruvate kinase 1	0.0038	0.0232	0.1716
Echinococcus granulosus	SAM and MBT domain containing protein	0.0054	0.0406	0.0406
Giardia lamblia	DNA damage repair protein	0.0026	0.0103	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0267	0.0963
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0055	0.0417	0.4577
Mycobacterium ulcerans	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	0.0637	0.6704	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0084	0.0737	0.6242
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0025	0.0095	0.0701
Mycobacterium ulcerans	acyl-CoA synthetase	0.0055	0.0417	0.0621
Entamoeba histolytica	protein kinase, putative	0.01	0.091	1
Leishmania major	DNA polymerase kappa, putative	0.0026	0.0103	0.0763
Entamoeba histolytica	protein kinase, putative	0.01	0.091	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0409	0.0409
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0026	0.0111	0.0165
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0055	0.0417	0.0621
Trypanosoma brucei	chrX additional, unordered contigs	0.0026	0.0103	0.0763
Trypanosoma brucei	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0211	0.2108	0.2108
Echinococcus multilocularis	pyruvate kinase	0.0038	0.0232	0.0232
Echinococcus multilocularis	pyruvate kinase	0.003	0.0146	0.0146
Plasmodium vivax	acyl-CoA synthetase, putative	0.0041	0.0267	0.2285
Trypanosoma brucei	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.0637	0.6704	1
Echinococcus granulosus	pyruvate kinase	0.0019	0.0035	0.0035
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0082	0.0717	0.0717
Loa Loa (eye worm)	hypothetical protein	0.01	0.0904	0.3258
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0055	0.0417	0.0621
Mycobacterium ulcerans	leucyl aminopeptidase	0.0125	0.1171	0.1746
Mycobacterium ulcerans	pyruvate kinase	0.0038	0.0232	0.0346
Leishmania major	DNA polymerase kappa, putative	0.009	0.0797	0.5901
Trypanosoma cruzi	DNA polymerase eta, putative	0.0084	0.0737	0.5455
Entamoeba histolytica	hypothetical protein	0.0026	0.0111	0.1216
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0103	0.0763
Loa Loa (eye worm)	hypothetical protein	0.01	0.0904	0.3258
Trypanosoma brucei	DNA polymerase kappa, putative	0.0064	0.0521	0.3856
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0061	0.0486	0.175
Plasmodium vivax	pyruvate kinase 2, putative	0.0019	0.0035	0.0296
Trichomonas vaginalis	pyruvate kinase, putative	0.0038	0.0232	0.2229
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0025	0.0095	0.0701
Chlamydia trachomatis	pyruvate kinase	0.0038	0.0232	0.1142
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0409	0.0409
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	0.0125	0.1171	0.867
Echinococcus multilocularis	leucyl aminopeptidase	0.0025	0.0095	0.0095
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0016	0.0004	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Trypanosoma brucei	DNA damage repair protein, putative	0.0026	0.0103	0.0763
Chlamydia trachomatis	cytosol aminopeptidase	0.0125	0.1171	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0041	0.0267	0.1479
Plasmodium vivax	M17 leucyl aminopeptidase, putative	0.0125	0.1171	1
Schistosoma mansoni	PwLAP aminopeptidase (M17 family)	0.0025	0.0095	0.0095
Mycobacterium ulcerans	DNA polymerase IV	0.0112	0.1039	0.1551
Plasmodium falciparum	pyruvate kinase	0.0038	0.0232	0.1979
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0094	0.0836	0.0836
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0038	0.0232	0.0346
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0025	0.0095	0.0701
Trypanosoma brucei	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0082	0.0717	0.1069
Entamoeba histolytica	protein kinase domain containing protein	0.01	0.091	1
Trypanosoma brucei	unspecified product	0.0105	0.0959	0.7105
Treponema pallidum	licC protein (licC)	0.0117	0.1088	1
Giardia lamblia	DINP protein human, muc B family	0.009	0.0797	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0836	0.3011
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0054	0.0406	0.4854
Echinococcus multilocularis	polycomb protein SCMH1	0.0054	0.0406	0.0406
Echinococcus granulosus	pyruvate kinase	0.0038	0.0232	0.0232
Echinococcus granulosus	pyruvate kinase	0.0038	0.0232	0.0232
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0025	0.0095	0.0701
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0025	0.0095	0.0701
Plasmodium vivax	pyruvate kinase, putative	0.0038	0.0232	0.1979
Schistosoma mansoni	cpg binding protein	0.007	0.0582	0.0582
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0125	0.118	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0409	0.0409
Trypanosoma brucei	pyruvate kinase 1, putative	0.0038	0.0232	0.1716
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0426	0.1534
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0061	0.0486	0.0486
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.002	0.0048	0.0048
Echinococcus granulosus	dna polymerase kappa	0.0112	0.1039	0.1039
Schistosoma mansoni	hypothetical protein	0.0326	0.3346	0.3346
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0125	0.1171	0.867
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0082	0.0717	0.0717
Trypanosoma brucei	DNA polymerase kappa, putative	0.0112	0.1039	0.7698
Schistosoma mansoni	pyruvate kinase	0.0038	0.0232	0.0232
Echinococcus multilocularis	dnaJ subfamily B	0.0943	1	1
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.01	0.091	0.674
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.01	0.091	0.674
Schistosoma mansoni	hypothetical protein	0.0943	1	1
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0035	0.0035
Leishmania major	phosphopantetheinyl transferase-like protein	0.0026	0.0111	0.082
Brugia malayi	mbt repeat family protein	0.0054	0.0406	0.1462
Echinococcus granulosus	polycomb protein SCMH1	0.0054	0.0406	0.0406
Trypanosoma brucei	unspecified product	0.0057	0.0441	0.3263
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0055	0.0417	0.0621
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0025	0.0095	0.0701
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0026	0.0111	0.0165
Echinococcus multilocularis	leucyl aminopeptidase	0.0025	0.0095	0.0095
Leishmania major	4-coumarate:coa ligase-like protein	0.0055	0.0417	0.3085
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0054	0.0406	0.0406
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0417	0.0621
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0026	0.0111	0.0165
Brugia malayi	AMP-binding enzyme family protein	0.0055	0.0417	0.15
Brugia malayi	AMP-binding enzyme family protein	0.0055	0.0417	0.15
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0243	0.0363
Trypanosoma cruzi	DNA polymerase eta, putative	0.0141	0.135	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0486	0.175
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	0.0125	0.1171	0.867
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0038	0.0232	0.0835
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.01	0.091	0.674
Trichomonas vaginalis	DNA polymerase eta, putative	0.0112	0.1039	1
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0232	0.0835

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 695333