Detailed information for compound 705572

Basic information

Technical information
  • TDR Targets ID: 705572
  • Name: 6-(4-ethylpiperazin-1-yl)-N-(3-methoxyphenyl) -1-phenylpyrazolo[4,5-e]pyrimidin-4-amine
  • MW: 429.517 | Formula: C24H27N7O
  • H donors: 1 H acceptors: 3 LogP: 4.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)c1nc(Nc2cccc(c2)OC)c2c(n1)n(nc2)c1ccccc1
  • InChi: 1S/C24H27N7O/c1-3-29-12-14-30(15-13-29)24-27-22(26-18-8-7-11-20(16-18)32-2)21-17-25-31(23(21)28-24)19-9-5-4-6-10-19/h4-11,16-17H,3,12-15H2,1-2H3,(H,26,27,28)
  • InChiKey: YKIKBOAGJHUGAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-ethylpiperazin-1-yl)-N-(3-methoxyphenyl)-1-phenyl-pyrazolo[4,5-e]pyrimidin-4-amine
  • 6-(4-ethyl-1-piperazinyl)-N-(3-methoxyphenyl)-1-phenyl-4-pyrazolo[4,5-e]pyrimidinamine
  • [6-(4-ethylpiperazin-1-yl)-1-phenyl-pyrazolo[4,5-e]pyrimidin-4-yl]-(3-methoxyphenyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis musashi 0.0029 0.0156 0.015
Trypanosoma brucei glucose transporter 1E 0.0066 0.0533 0.8592
Mycobacterium tuberculosis Conserved protein 0.0043 0.0302 0.1093
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0346 0.1193
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0168 0.2561
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0533 0.8592
Schistosoma mansoni hypothetical protein 0.0202 0.1907 0.6794
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0872 0.0867
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0263 0.0657
Echinococcus granulosus solute carrier family 22 0.003 0.0168 0.0163
Plasmodium falciparum protein kinase 6 0.0905 0.9 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0346 0.0561
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Brugia malayi major facilitator superfamily protein 0.003 0.0168 0.0556
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0276 0.2654 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0263 0.4131
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0013 0.0008
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0533 0.8592
Mycobacterium ulcerans sugar transporter 0.003 0.0168 0.0556
Onchocerca volvulus 0.003 0.0168 0.3114
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0084 0.027
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0168 0.0163
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0107 0.0339
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0511 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0524 0.0519
Leishmania major hypothetical protein, conserved 0.003 0.0168 0.2561
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0511 0.0506
Schistosoma mansoni hypothetical protein 0.0202 0.1907 0.6794
Toxoplasma gondii facilitative glucose transporter GT1 0.0213 0.2018 0.3379
Trypanosoma brucei glucose transporter, putative 0.0066 0.0533 0.8592
Mycobacterium tuberculosis Conserved protein 0.0043 0.0302 0.1093
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0263 0.4059
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Mycobacterium tuberculosis Conserved protein 0.0043 0.0302 0.1093
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0093 0.0288
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0168 0.0556
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2018 0.2013
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0168 0.4683
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0524 0.0519
Schistosoma mansoni lamin 0.0029 0.0156 0.0511
Onchocerca volvulus 0.003 0.0168 0.3114
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0273 0.5227
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0511 0.0506
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0107 0.0339
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.0536
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0511 0.1786
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0036 0.0088
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0346 1
Brugia malayi Sugar transporter family protein 0.003 0.0168 0.0556
Echinococcus multilocularis lamin dm0 0.0029 0.0156 0.015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0263 0.4131
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0132 0.1964
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0346 0.5499
Onchocerca volvulus Putative transporter 0.003 0.0168 0.3114
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0273 0.0986
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2018 0.2013
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Brugia malayi beta-lactamase 0.0043 0.0302 0.1036
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0533 0.8592
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2018 0.2013
Plasmodium vivax CDK-related protein kinase 6, putative 0.0905 0.9 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0168 0.0163
Entamoeba histolytica protein kinase, putative 0.0065 0.0524 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0344 0.3343 0.3682
Mycobacterium ulcerans beta-lactamase 0.0043 0.0302 0.1036
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0302 0.1093
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0168 0.0136
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0346 0.0341
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2018 0.2013
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0084 0.0043
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0346 0.0341
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0201 0.0718
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0302 0.08
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0084 0.0256
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0084 0.0079
Echinococcus multilocularis geminin 0.0202 0.1907 0.1903
Echinococcus multilocularis neuropeptide receptor A26 0.1004 1 1
Toxoplasma gondii sugar transporter ST2 0.003 0.0168 0.0261
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0533 0.8592
Giardia lamblia Sugar-proton symporter 0.003 0.0168 0.196
Onchocerca volvulus 0.003 0.0168 0.3114
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0168 0.0308
Leishmania major glucose transporter, lmgt3 0.0066 0.0533 0.8592
Loa Loa (eye worm) cytochrome P450 0.0015 0.0013 0.0046
Giardia lamblia Hexose transporter 0.003 0.0168 0.196
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0156 0.0555
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0168 0.2561
Trichomonas vaginalis esterase, putative 0.0043 0.0302 0.08
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0263 0.0258
Schistosoma mansoni protein kinase 0.0065 0.0524 0.1834
Entamoeba histolytica protein kinase, putative 0.0065 0.0524 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0524 0.1872
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0525 0.0534
Loa Loa (eye worm) beta-lactamase 0.0043 0.0302 0.1077
Trypanosoma cruzi hexose transporter, putative 0.003 0.0168 0.2561
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0132 0.1964
Loa Loa (eye worm) hypothetical protein 0.0043 0.0302 0.1077
Trypanosoma cruzi hexose transporter 0.0066 0.0533 0.8592
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0302 0.1093
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0084 0.0256
Brugia malayi hypothetical protein 0.003 0.0168 0.0556
Brugia malayi Cytochrome P450 family protein 0.0034 0.0206 0.0691
Schistosoma mansoni glucose transport protein 0.0213 0.2018 0.719
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0263 0.4131
Brugia malayi major facilitator superfamily protein 0.003 0.0168 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0168 0.0308
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0525 0.0534
Leishmania major hypothetical protein, conserved 0.0043 0.0302 0.4772
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0107 0.0339
Toxoplasma gondii exonuclease III APE 0.0022 0.0084 0.012
Plasmodium vivax hexose transporter 0.0213 0.2018 0.2202
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0107 0.0339
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0346 0.1193
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0302 0.1093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0872 0.308
Echinococcus multilocularis solute carrier family 22 0.003 0.0168 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0872 0.308
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Mycobacterium ulcerans lipase LipD 0.0043 0.0302 0.1036
Entamoeba histolytica hypothetical protein 0.0048 0.0346 0.594
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0618 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0302 0.1036
Onchocerca volvulus 0.003 0.0168 0.3114
Onchocerca volvulus 0.003 0.0168 0.3114
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0525 0.0534
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0302 0.1036
Entamoeba histolytica hypothetical protein 0.0036 0.0233 0.3373
Toxoplasma gondii sugar transporter ST1 0.003 0.0168 0.0261
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0132 0.0096
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0346 0.1193
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0084 0.0301
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0165
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Brugia malayi intermediate filament protein 0.0029 0.0156 0.0511
Trypanosoma cruzi sugar transporter, putative 0.003 0.0168 0.2561
Schistosoma mansoni protein kinase 0.0065 0.0524 0.1834
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0525 0.0534
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0093 0.1575
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0383
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0511 0.1571
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0533 0.1651
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0107 0.1561
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0233 0.0227
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0021 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0302 0.0285
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0302 0.1036
Brugia malayi hypothetical protein 0.003 0.0168 0.0556
Schistosoma mansoni hypothetical protein 0.0036 0.0233 0.0788
Mycobacterium ulcerans hypothetical protein 0.0024 0.0107 0.0339
Schistosoma mansoni glutaminase 0.0291 0.2801 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0206 0.0734
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0263 0.0896
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.2018 0.7116
Leishmania major hypothetical protein, conserved 0.0026 0.0132 0.1964
Schistosoma mansoni inositol monophosphatase 0.0039 0.0263 0.0896
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0302 0.5798
Echinococcus multilocularis neuropeptide s receptor 0.1004 1 1
Schistosoma mansoni lamin 0.0029 0.0156 0.0511
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0286 0.0744
Plasmodium falciparum hexose transporter 0.0213 0.2018 0.2202
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0618 1
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0168 0.0261
Trichomonas vaginalis glucose transporter, putative 0.003 0.0168 0.0308
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0344 0.3343 0.5613
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0206 0.3185
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0165
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0206 0.0734
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0263 0.0657
Onchocerca volvulus 0.003 0.0168 0.3114
Schistosoma mansoni intermediate filament proteins 0.0029 0.0156 0.0511
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0046 0.0126
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0511 0.1786
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0525 0.0534
Entamoeba histolytica hypothetical protein 0.0036 0.0233 0.3373
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0132 0.0096
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0263 0.0421
Schistosoma mansoni sugar transporter 0.003 0.0168 0.0556
Onchocerca volvulus 0.003 0.0168 0.3114
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0168 0.0556
Loa Loa (eye worm) hypothetical protein 0.0043 0.0302 0.1077
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0302 0.1093
Brugia malayi beta-lactamase family protein 0.0043 0.0302 0.1036
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0084 0.0043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0165
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0168 0.0308
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0863 0.8574 0.8574
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0233 0.0788
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0019
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0346 0.1193
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0084 0.1179
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0302 0.0296
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0533 0.8592
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0525 0.0862
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0533 0.8592
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0618 0.0639
Leishmania major cytochrome p450-like protein 0.0034 0.0206 0.3185
Brugia malayi hypothetical protein 0.0026 0.0132 0.0426
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Loa Loa (eye worm) hypothetical protein 0.0043 0.0302 0.1077
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Loa Loa (eye worm) glutaminase 2 0.0291 0.2801 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0206 0.3185
Echinococcus multilocularis lamin 0.0029 0.0156 0.015
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Loa Loa (eye worm) hypothetical protein 0.0043 0.0302 0.1077
Onchocerca volvulus 0.003 0.0168 0.3114
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0206 0.0691
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0107 0.0339
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0524 0.0519
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0511 0.9697
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0302 0.1093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0872 0.0867
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0524 0.0519
Onchocerca volvulus 0.003 0.0168 0.3114
Loa Loa (eye worm) sugar transporter 0.0213 0.2018 0.7203
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2018 0.2013
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0168 0.0556
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0168 0.0587
Toxoplasma gondii protein kinase, putative 0.0602 0.5946 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0872 0.3112
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0524 0.0519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0168 0.0556
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0107 0.0339
Brugia malayi Cytochrome P450 family protein 0.0033 0.0201 0.0675
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0302 0.1077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0084 0.1179
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Brugia malayi Cam kinase protein 1 0.0065 0.0524 0.1834
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0046 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0524 0.1834
Leishmania major glucose transporter, lmgt2 0.0066 0.0533 0.8592
Trypanosoma brucei glucose transporter 2A 0.0066 0.0533 0.8592
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0213 0.2018 0.2013
Leishmania major protein kinase, putative 0.0065 0.0524 0.8452
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0525 0.0862
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0524 0.0519
Onchocerca volvulus 0.0029 0.0156 0.2479
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0533 0.8592
Echinococcus granulosus lamin 0.0029 0.0156 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0107 0.0358
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0525 0.0862
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0168 0.0163
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0533 0.1651
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2018 0.2013
Onchocerca volvulus 0.003 0.0168 0.3114
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0132 0.02
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0168 0.0308
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0346 0.0334
Schistosoma mansoni ap endonuclease 0.0022 0.0084 0.0256
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0206 0.3185
Loa Loa (eye worm) hypothetical protein 0.0043 0.0302 0.1077
Brugia malayi hypothetical protein 0.003 0.0168 0.0556
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Schistosoma mansoni inositol monophosphatase 0.0039 0.0263 0.0896
Brugia malayi Sugar transporter family protein 0.0213 0.2018 0.719
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0346 0.5499
Brugia malayi hypothetical protein 0.0017 0.0037 0.0087
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2018 0.2013
Onchocerca volvulus 0.003 0.0168 0.3114
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0233 0.0227
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0168 0.0163
Schistosoma mansoni sugar transporter 0.003 0.0168 0.0556
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Loa Loa (eye worm) hypothetical protein 0.0043 0.0302 0.1077
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0084 0.0079
Trypanosoma brucei glucose transporter, putative 0.0066 0.0533 0.8592
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0168 0.0308
Trichomonas vaginalis glutaminase, putative 0.0291 0.2801 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0524 0.1872
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0132 0.0096
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Echinococcus granulosus neuropeptide receptor A26 0.1004 1 1
Plasmodium falciparum protein kinase 7 0.0602 0.5946 0.6589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0872 0.308
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0036 0.0088
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0618 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0872 0.0867
Onchocerca volvulus 0.003 0.0168 0.3114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0036 0.0088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0302 0.0296
Echinococcus granulosus solute carrier family 22 0.003 0.0168 0.0163
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0273 0.0986
Echinococcus granulosus General substrate transporter 0.0183 0.1715 0.1711
Trypanosoma brucei glucose transporter, putative 0.0066 0.0533 0.8592
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0344 0.3343 0.3682
Schistosoma mansoni glucose transport protein 0.0213 0.2018 0.719
Schistosoma mansoni glucose transporter 0.003 0.0168 0.0556
Echinococcus multilocularis 0.0015 0.0013 0.0008
Trypanosoma brucei sugar transporter, putative 0.003 0.0168 0.2561
Echinococcus granulosus geminin 0.0202 0.1907 0.1903
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0302 0.08
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0168 0.0599
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0302 0.1093
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0206 0.0734
Entamoeba histolytica hypothetical protein 0.0036 0.0233 0.3373
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0524 0.1872
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0533 0.1651
Loa Loa (eye worm) inositol-1 0.0039 0.0263 0.0938
Loa Loa (eye worm) hypothetical protein 0.0048 0.0346 0.1234
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0107 0.1896
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0084 0.1179
Onchocerca volvulus 0.003 0.0168 0.3114
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0107 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0533 0.1651
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0533 0.1651
Mycobacterium ulcerans glutaminase 0.0291 0.2801 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0168 0.0163
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0156 0.0555
Loa Loa (eye worm) hypothetical protein 0.0026 0.0132 0.047
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0302 0.4772
Trypanosoma brucei glucose transporter, putative 0.0066 0.0533 0.8592
Onchocerca volvulus 0.0029 0.0156 0.2479
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0524 0.8452
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0383
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0156 0.0511
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0511 0.1786
Trypanosoma cruzi hexose transporter, putative 0.0036 0.023 0.359
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0302 0.08
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0533 0.1651
Loa Loa (eye worm) glutaminase 0.0291 0.2801 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0107 0.0339
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0346 0.6126
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0525 0.0534
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0084 0.1179
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0555
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0524 0.162
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0302 0.4772
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0107 0.1896
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0107 0.1561
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0525 0.0534
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0346 0.1193
Echinococcus multilocularis solute carrier family 22 0.003 0.0168 0.0163
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0524 0.0519
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0263 0.4131
Loa Loa (eye worm) hypothetical protein 0.0052 0.039 0.1392
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0107 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0168 0.0308
Plasmodium vivax sugar transporter, putative 0.003 0.0168 0.0136
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0484 0.0478
Loa Loa (eye worm) hypothetical protein 0.0064 0.0511 0.1824
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0107 0.0526
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.013 0.0465
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0107 0.0339
Onchocerca volvulus 0.003 0.0168 0.3114
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0525 0.0534
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0107 0.1561
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0093 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0263 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0156 0.015
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0302 0.08
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0872 0.0867
Onchocerca volvulus 0.0043 0.0302 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0107 0.0526
Trypanosoma brucei glucose transporter, putative 0.0066 0.0533 0.8592
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Echinococcus granulosus solute carrier family 22 0.003 0.0168 0.0163
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0346 0.0334
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0132 0.1964
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0221 0.0789
Onchocerca volvulus 0.0043 0.0302 1
Leishmania major glucose transporter, lmgt1 0.0066 0.0533 0.8592
Brugia malayi glutaminase DH11.1 0.0291 0.2801 1
Trypanosoma brucei glucose transporter, putative 0.0066 0.0533 0.8592
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0165
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0107 0.0339
Mycobacterium ulcerans hypothetical protein 0.0043 0.0302 0.1036
Brugia malayi hypothetical protein 0.0036 0.0233 0.0788
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0346 0.0962
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0346 0.5499
Toxoplasma gondii ABC1 family protein 0.0043 0.0302 0.0487
Schistosoma mansoni protein kinase 0.0065 0.0524 0.1834
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0168 0.0556
Trypanosoma brucei glucose transporter, putative 0.0066 0.0533 0.8592
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0302 0.08
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0533 0.1651
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0524 0.0519
Trypanosoma cruzi glucose transporter, putative 0.003 0.0168 0.2561
Brugia malayi Cytochrome P450 family protein 0.0034 0.0206 0.0691
Echinococcus granulosus lamin dm0 0.0029 0.0156 0.015
Schistosoma mansoni ap endonuclease 0.0022 0.0084 0.0256
Echinococcus granulosus solute carrier family 22 0.003 0.0168 0.0163
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Echinococcus multilocularis General substrate transporter 0.0183 0.1715 0.1711
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0525 0.0534
Mycobacterium leprae Probable lipase LipE 0.0043 0.0302 0.5798
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0302 0.1036
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Brugia malayi Inositol-1 0.0039 0.0263 0.0896
Schistosoma mansoni hypothetical protein 0.0213 0.2018 0.719
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Onchocerca volvulus 0.003 0.0168 0.3114
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0511 0.1786
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0168 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0168 0.0308
Schistosoma mansoni sugar transporter 0.003 0.0168 0.0556
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0165
Loa Loa (eye worm) hypothetical protein 0.0064 0.0511 0.1824
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0618 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0168 0.0599
Toxoplasma gondii sugar transporter ST3 0.003 0.0168 0.0261
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0168 0.0556
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0511 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.0599
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0302 0.1036
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0021 0.0028
Loa Loa (eye worm) sugar transporter 0.003 0.0168 0.0599
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0107 0.0339
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0168 0.0556
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0263 0.0258
Brugia malayi Sugar transporter family protein 0.003 0.0168 0.0556
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0207
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0618 0.102
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0302 0.4772
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0221 0.4181
Brugia malayi beta-lactamase family protein 0.0043 0.0302 0.1036
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0618 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0524 0.1834
Trichomonas vaginalis sugar transporter, putative 0.003 0.0168 0.0308
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0618 0.0639
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0872 0.308
Schistosoma mansoni sugar transporter 0.003 0.0168 0.0556
Schistosoma mansoni glucose transport protein 0.0213 0.2018 0.719
Onchocerca volvulus 0.003 0.0168 0.3114
Onchocerca volvulus 0.0043 0.0302 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0302 0.1093
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0168 0.0587
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0484 0.0478
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0346 0.6681
Entamoeba histolytica hypothetical protein 0.0036 0.0233 0.3373
Trypanosoma brucei glucose transporter, putative 0.0066 0.0533 0.8592
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0263 0.0657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0036 0.0088

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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