TDR Targets

Basic information

Technical information

TDR Targets ID: 705690
Name: N-(3-methoxyphenyl)-6-(4-methylpiperazin-1-yl )-1-phenylpyrazolo[4,5-e]pyrimidin-4-amine
MW: 415.491 | Formula: C23H25N7O
H donors: 1 H acceptors: 3 LogP: 3.96 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)Nc1nc(nc2c1cnn2c1ccccc1)N1CCN(CC1)C
InChi: 1S/C23H25N7O/c1-28-11-13-29(14-12-28)23-26-21(25-17-7-6-10-19(15-17)31-2)20-16-24-30(22(20)27-23)18-8-4-3-5-9-18/h3-10,15-16H,11-14H2,1-2H3,(H,25,26,27)
InChiKey: LBDYYXDLHYAFIA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-methoxyphenyl)-6-(4-methylpiperazin-1-yl)-1-phenyl-pyrazolo[4,5-e]pyrimidin-4-amine
N-(3-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-1-phenyl-4-pyrazolo[4,5-e]pyrimidinamine
(3-methoxyphenyl)-[6-(4-methylpiperazin-1-yl)-1-phenyl-pyrazolo[4,5-e]pyrimidin-4-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0065	0.0524	0.8452
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0107	0.0383
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0533	0.8592
Onchocerca volvulus		0.0029	0.0156	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0132	0.047
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0302	0.4772
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0156	0.0555
Echinococcus multilocularis	solute carrier family 22	0.003	0.0168	0.0163
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0107	0.0339
Giardia lamblia	Lysyl-tRNA synthetase	0.0048	0.0346	0.6126
Loa Loa (eye worm)	glutaminase	0.0291	0.2801	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0064	0.0511	0.1786
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.023	0.359
Trichomonas vaginalis	glucose transporter, putative	0.0066	0.0533	0.1651
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0302	0.08
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0156	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0346	0.1234
Loa Loa (eye worm)	inositol-1	0.0039	0.0263	0.0938
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0107	0.1896
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0533	0.1651
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0065	0.0524	0.1872
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0302	0.1093
Loa Loa (eye worm)	cytochrome P450 family protein	0.0034	0.0206	0.0734
Entamoeba histolytica	hypothetical protein	0.0036	0.0233	0.3373
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.0533	0.1651
Mycobacterium ulcerans	glutaminase	0.0291	0.2801	1
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0533	0.1651
Onchocerca volvulus		0.003	0.0168	0.3114
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0107	0.0358
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0084	0.1179
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.004	0.0273	0.0986
Echinococcus granulosus	solute carrier family 22	0.003	0.0168	0.0163
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0302	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0107	0.0383
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0075	0.0618	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0872	0.0867
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0036	0.0088
Onchocerca volvulus		0.003	0.0168	0.3114
Echinococcus granulosus	neuropeptide receptor A26	0.1004	1	1
Plasmodium falciparum	protein kinase 7	0.0602	0.5946	0.6589
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0872	0.308
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0036	0.0088
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0168	0.0599
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Schistosoma mansoni	glucose transporter	0.003	0.0168	0.0556
Echinococcus multilocularis		0.0015	0.0013	0.0008
Echinococcus granulosus	geminin	0.0202	0.1907	0.1903
Trypanosoma brucei	sugar transporter, putative	0.003	0.0168	0.2561
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0302	0.08
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0533	0.8592
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Echinococcus granulosus	General substrate transporter	0.0183	0.1715	0.1711
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0344	0.3343	0.3682
Schistosoma mansoni	glucose transport protein	0.0213	0.2018	0.719
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Schistosoma mansoni	sugar transporter	0.003	0.0168	0.0556
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0084	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0302	0.1077
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0233	0.0227
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.003	0.0168	0.0163
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0048	0.0346	0.5499
Brugia malayi	hypothetical protein	0.0017	0.0037	0.0087
Onchocerca volvulus		0.003	0.0168	0.3114
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0213	0.2018	0.2013
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0132	0.0096
Trichomonas vaginalis	glutaminase, putative	0.0291	0.2801	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0524	0.1872
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0533	0.8592
Trichomonas vaginalis	sugar transport protein, putative	0.003	0.0168	0.0308
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0132	0.02
Echinococcus granulosus	Sugar transporter ERD6 protein	0.003	0.0168	0.0163
Trichomonas vaginalis	glucose transporter, putative	0.0066	0.0533	0.1651
Onchocerca volvulus		0.003	0.0168	0.3114
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0213	0.2018	0.2013
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0065	0.0525	0.0862
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0107	0.0358
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.0533	0.8592
Echinococcus granulosus	lamin	0.0029	0.0156	0.015
Brugia malayi	hypothetical protein	0.003	0.0168	0.0556
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0263	0.0896
Brugia malayi	Sugar transporter family protein	0.0213	0.2018	0.719
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Trypanosoma brucei	cytochrome P450, putative	0.0034	0.0206	0.3185
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0302	0.1077
Schistosoma mansoni	ap endonuclease	0.0022	0.0084	0.0256
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0168	0.0308
Plasmodium falciparum	lysine--tRNA ligase	0.0048	0.0346	0.0334
Trypanosoma brucei	glucose transporter 2A	0.0066	0.0533	0.8592
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0213	0.2018	0.2013
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0046	0.0119
Brugia malayi	Cam kinase protein 1	0.0065	0.0524	0.1834
Schistosoma mansoni	serine/threonine protein kinase	0.0065	0.0524	0.1834
Leishmania major	glucose transporter, lmgt2	0.0066	0.0533	0.8592
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0084	0.1179
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Onchocerca volvulus		0.0029	0.0156	0.2479
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0065	0.0524	0.0519
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0065	0.0525	0.0862
Leishmania major	protein kinase, putative	0.0065	0.0524	0.8452
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0065	0.0524	0.0519
Toxoplasma gondii	protein kinase, putative	0.0602	0.5946	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.01	0.0872	0.3112
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.003	0.0168	0.0587
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0302	0.1077
Brugia malayi	Cytochrome P450 family protein	0.0033	0.0201	0.0675
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0107	0.0339
Mycobacterium ulcerans	integral membrane transport protein	0.003	0.0168	0.0556
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0064	0.0511	0.9697
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0065	0.0524	0.0519
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0034	0.0206	0.0691
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0107	0.0339
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Echinococcus multilocularis	lamin	0.0029	0.0156	0.015
Onchocerca volvulus		0.003	0.0168	0.3114
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0302	0.1077
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0213	0.2018	0.2013
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.003	0.0168	0.0556
Onchocerca volvulus		0.003	0.0168	0.3114
Loa Loa (eye worm)	sugar transporter	0.0213	0.2018	0.7203
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0872	0.0867
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0302	0.1093
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0065	0.0524	0.0519
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Schistosoma mansoni	sugar transporter	0.003	0.0168	0.0556
Schistosoma mansoni	glucose transport protein	0.0213	0.2018	0.719
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.01	0.0872	0.308
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0065	0.0524	0.1834
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Plasmodium falciparum	proline--tRNA ligase	0.0075	0.0618	0.0639
Brugia malayi	beta-lactamase family protein	0.0043	0.0302	0.1036
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0075	0.0618	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0036	0.0088
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0263	0.0657
Echinococcus granulosus	calcium dependent protein kinase	0.0061	0.0484	0.0478
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0048	0.0346	0.6681
Entamoeba histolytica	hypothetical protein	0.0036	0.0233	0.3373
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0533	0.8592
Onchocerca volvulus		0.003	0.0168	0.3114
Onchocerca volvulus		0.0043	0.0302	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0302	0.1093
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.003	0.0168	0.0587
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0302	0.1036
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0168	0.0556
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0064	0.0511	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0075	0.0618	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0168	0.0599
Toxoplasma gondii	sugar transporter ST3	0.003	0.0168	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0058	0.0207
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0075	0.0618	0.102
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0302	0.4772
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0035	0.0221	0.4181
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.003	0.0168	0.0556
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.0263	0.0258
Brugia malayi	Sugar transporter family protein	0.003	0.0168	0.0556
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0021	0.0028
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0107	0.0339
Loa Loa (eye worm)	sugar transporter	0.003	0.0168	0.0599
Brugia malayi	Inositol-1	0.0039	0.0263	0.0896
Schistosoma mansoni	hypothetical protein	0.0213	0.2018	0.719
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0511	0.1824
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0168	0.0308
Schistosoma mansoni	sugar transporter	0.003	0.0168	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0165
Onchocerca volvulus		0.003	0.0168	0.3114
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0064	0.0511	0.1786
Echinococcus multilocularis	synaptic vesicle 2 protein	0.003	0.0168	0.0163
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0065	0.0524	0.0519
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0302	0.08
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.0533	0.1651
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0533	0.8592
Echinococcus multilocularis	General substrate transporter	0.0183	0.1715	0.1711
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0065	0.0525	0.0534
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0302	0.5798
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0302	0.1036
Echinococcus granulosus	solute carrier family 22	0.003	0.0168	0.0163
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Echinococcus granulosus	lamin dm0	0.0029	0.0156	0.015
Schistosoma mansoni	ap endonuclease	0.0022	0.0084	0.0256
Trypanosoma cruzi	glucose transporter, putative	0.003	0.0168	0.2561
Brugia malayi	Cytochrome P450 family protein	0.0034	0.0206	0.0691
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0533	0.8592
Leishmania major	glucose transporter, lmgt1	0.0066	0.0533	0.8592
Brugia malayi	glutaminase DH11.1	0.0291	0.2801	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0035	0.0221	0.0789
Onchocerca volvulus		0.0043	0.0302	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0132	0.1964
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Schistosoma mansoni	protein kinase	0.0065	0.0524	0.1834
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0168	0.0556
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0048	0.0346	0.0962
Brugia malayi	hypothetical protein	0.0036	0.0233	0.0788
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0048	0.0346	0.5499
Toxoplasma gondii	ABC1 family protein	0.0043	0.0302	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0165
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0107	0.0339
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0302	0.1036
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0302	0.08
Echinococcus granulosus	intermediate filament protein	0.0029	0.0156	0.015
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0039	0.0263	1
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0093	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0107	0.1561
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0065	0.0525	0.0534
Echinococcus granulosus	solute carrier family 22	0.003	0.0168	0.0163
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Plasmodium vivax	lysine--tRNA ligase, putative	0.0048	0.0346	0.0334
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0533	0.8592
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0107	0.0526
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0872	0.0867
Onchocerca volvulus		0.0043	0.0302	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0107	0.0526
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0168	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0052	0.039	0.1392
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0065	0.0524	0.0519
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0263	0.4131
Echinococcus multilocularis	solute carrier family 22	0.003	0.0168	0.0163
Onchocerca volvulus		0.003	0.0168	0.3114
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0107	0.0339
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0026	0.013	0.0465
Echinococcus multilocularis	calcium dependent protein kinase	0.0061	0.0484	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0511	0.1824
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0107	0.0526
Plasmodium vivax	sugar transporter, putative	0.003	0.0168	0.0136
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0107	0.1896
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0302	0.4772
Trichomonas vaginalis	CAMK family protein kinase	0.0065	0.0524	0.162
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0156	0.0555
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0084	0.1179
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0065	0.0525	0.0534
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0065	0.0525	0.0534
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0048	0.0346	0.1193
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0107	0.1561
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0168	0.0308
Onchocerca volvulus		0.003	0.0168	0.3114
Trichomonas vaginalis	esterase, putative	0.0043	0.0302	0.08
Leishmania major	myo-inositol/proton symporter (MIT)	0.003	0.0168	0.2561
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0156	0.0555
Leishmania major	glucose transporter, lmgt3	0.0066	0.0533	0.8592
Loa Loa (eye worm)	cytochrome P450	0.0015	0.0013	0.0046
Giardia lamblia	Hexose transporter	0.003	0.0168	0.196
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0084	0.0079
Echinococcus multilocularis	geminin	0.0202	0.1907	0.1903
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0084	0.0256
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0302	0.08
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0084	0.0043
Loa Loa (eye worm)	cytochrome P450 family protein	0.0033	0.0201	0.0718
Echinococcus multilocularis	lysyl tRNA synthetase	0.0048	0.0346	0.0341
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.0533	0.8592
Giardia lamblia	Sugar-proton symporter	0.003	0.0168	0.196
Echinococcus multilocularis	neuropeptide receptor A26	0.1004	1	1
Toxoplasma gondii	sugar transporter ST2	0.003	0.0168	0.0261
Entamoeba histolytica	protein kinase, putative	0.0065	0.0524	1
Echinococcus multilocularis	solute carrier family 22	0.003	0.0168	0.0163
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0213	0.2018	0.2013
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0905	0.9	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.0533	0.8592
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Brugia malayi	beta-lactamase	0.0043	0.0302	0.1036
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0213	0.2018	0.2013
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.003	0.0168	0.0136
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0302	0.1093
Echinococcus granulosus	lysyl tRNA synthetase	0.0048	0.0346	0.0341
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0344	0.3343	0.3682
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0302	0.1036
Chlamydia trachomatis	lysine--tRNA ligase	0.0048	0.0346	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0064	0.0511	0.1786
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0036	0.0088
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0064	0.0511	0.0506
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0273	0.5227
Loa Loa (eye worm)	hypothetical protein	0.0028	0.015	0.0536
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0107	0.0339
Onchocerca volvulus		0.003	0.0168	0.3114
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0213	0.2018	0.2013
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0273	0.0986
Leishmania major	lysyl-tRNA synthetase, putative	0.0048	0.0346	0.5499
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Onchocerca volvulus	Putative transporter	0.003	0.0168	0.3114
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0263	0.4131
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0132	0.1964
Brugia malayi	Sugar transporter family protein	0.003	0.0168	0.0556
Echinococcus multilocularis	lamin dm0	0.0029	0.0156	0.015
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0302	0.1093
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0039	0.0263	0.4059
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0093	0.0288
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0302	0.1093
Schistosoma mansoni	lamin	0.0029	0.0156	0.0511
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0065	0.0524	0.0519
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0213	0.2018	0.2013
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.003	0.0168	0.4683
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0168	0.0556
Giardia lamblia	Prolyl-tRNA synthetase	0.0064	0.0511	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0065	0.0524	0.0519
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0107	0.0339
Echinococcus granulosus	synaptic vesicle 2 protein	0.003	0.0168	0.0163
Toxoplasma gondii	facilitative glucose transporter GT1	0.0213	0.2018	0.3379
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0533	0.8592
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0064	0.0511	0.0506
Schistosoma mansoni	hypothetical protein	0.0202	0.1907	0.6794
Leishmania major	hypothetical protein, conserved	0.003	0.0168	0.2561
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Brugia malayi	major facilitator superfamily protein	0.003	0.0168	0.0556
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0276	0.2654	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Toxoplasma gondii	lysine-tRNA ligase	0.0048	0.0346	0.0561
Mycobacterium ulcerans	sugar transporter	0.003	0.0168	0.0556
Onchocerca volvulus		0.003	0.0168	0.3114
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0084	0.027
Echinococcus granulosus	cytochrome P450 2K1	0.0015	0.0013	0.0008
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.0533	0.8592
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0263	0.4131
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.003	0.0168	0.2561
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0048	0.0346	0.1193
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0302	0.1093
Echinococcus multilocularis	musashi	0.0029	0.0156	0.015
Trypanosoma brucei	glucose transporter 1E	0.0066	0.0533	0.8592
Plasmodium falciparum	protein kinase 6	0.0905	0.9	1
Echinococcus granulosus	solute carrier family 22	0.003	0.0168	0.0163
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0872	0.0867
Schistosoma mansoni	hypothetical protein	0.0202	0.1907	0.6794
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.0533	0.8592
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0263	0.0657
Leishmania major	cytochrome p450-like protein	0.0034	0.0206	0.3185
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Brugia malayi	hypothetical protein	0.0026	0.0132	0.0426
Plasmodium vivax	proline--tRNA ligase, putative	0.0075	0.0618	0.0639
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0065	0.0525	0.0862
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.0533	0.8592
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0066	0.0533	0.8592
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0302	0.0296
Trypanosoma cruzi	cytochrome P450, putative	0.0034	0.0206	0.3185
Loa Loa (eye worm)	glutaminase 2	0.0291	0.2801	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0302	0.1077
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Brugia malayi	beta-lactamase family protein	0.0043	0.0302	0.1036
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0084	0.0043
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.003	0.0168	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0302	0.1077
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0302	0.1093
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0039	0.0263	0.0421
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Onchocerca volvulus		0.003	0.0168	0.3114
Schistosoma mansoni	sugar transporter	0.003	0.0168	0.0556
Entamoeba histolytica	hypothetical protein	0.0036	0.0233	0.3373
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0132	0.0096
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0084	0.1179
Brugia malayi	lysyl-tRNA synthetase	0.0048	0.0346	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0005	0.0019
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0233	0.0788
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0863	0.8574	0.8574
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0165
Trichomonas vaginalis	myo-inositol transporter, putative	0.003	0.0168	0.0308
Trichomonas vaginalis	inositol monophosphatase, putative	0.0039	0.0263	0.0657
Onchocerca volvulus		0.003	0.0168	0.3114
Loa Loa (eye worm)	CYP4Cod1	0.0034	0.0206	0.0734
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Trypanosoma cruzi	cytochrome P450, putative	0.0034	0.0206	0.3185
Loa Loa (eye worm)	hypothetical protein	0.003	0.0168	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0165
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0344	0.3343	0.5613
Toxoplasma gondii	transporter, major facilitator family protein	0.003	0.0168	0.0261
Trichomonas vaginalis	glucose transporter, putative	0.003	0.0168	0.0308
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0046	0.0126
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0065	0.0525	0.0534
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0064	0.0511	0.1786
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0156	0.0511
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0302	0.5798
Echinococcus multilocularis	neuropeptide s receptor	0.1004	1	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0132	0.1964
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0039	0.0263	0.0896
Trichomonas vaginalis	conserved hypothetical protein	0.0213	0.2018	0.7116
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0263	0.0896
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0107	0.0339
Schistosoma mansoni	hypothetical protein	0.0036	0.0233	0.0788
Loa Loa (eye worm)	cytochrome P450 family protein	0.0034	0.0206	0.0734
Schistosoma mansoni	glutaminase	0.0291	0.2801	1
Brugia malayi	hypothetical protein	0.003	0.0168	0.0556
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0042	0.0286	0.0744
Schistosoma mansoni	lamin	0.0029	0.0156	0.0511
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0075	0.0618	1
Plasmodium falciparum	hexose transporter	0.0213	0.2018	0.2202
Schistosoma mansoni	protein kinase	0.0065	0.0524	0.1834
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0065	0.0525	0.0534
Trypanosoma cruzi	sugar transporter, putative	0.003	0.0168	0.2561
Brugia malayi	intermediate filament protein	0.0029	0.0156	0.0511
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0021	0.0074
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0233	0.0227
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0302	0.1036
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0302	0.0285
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0107	0.1561
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.0533	0.1651
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0093	0.1575
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0107	0.0383
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0064	0.0511	0.1571
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0302	0.1036
Onchocerca volvulus		0.003	0.0168	0.3114
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Entamoeba histolytica	hypothetical protein	0.0048	0.0346	0.594
Mycobacterium ulcerans	lipase LipD	0.0043	0.0302	0.1036
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0075	0.0618	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0872	0.308
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0872	0.308
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0302	0.1093
Echinococcus multilocularis	solute carrier family 22	0.003	0.0168	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0165
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0168	0.0308
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0132	0.0096
Schistosoma mansoni	lysyl-tRNA synthetase	0.0048	0.0346	0.1193
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0084	0.0301
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0302	0.1036
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0065	0.0525	0.0534
Entamoeba histolytica	hypothetical protein	0.0036	0.0233	0.3373
Toxoplasma gondii	sugar transporter ST1	0.003	0.0168	0.0261
Onchocerca volvulus		0.003	0.0168	0.3114
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0168	0.0308
Leishmania major	hypothetical protein, conserved	0.0043	0.0302	0.4772
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0065	0.0525	0.0534
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0263	0.4131
Schistosoma mansoni	glucose transport protein	0.0213	0.2018	0.719
Brugia malayi	major facilitator superfamily protein	0.003	0.0168	0.0556
Brugia malayi	Cytochrome P450 family protein	0.0034	0.0206	0.0691
Brugia malayi	hypothetical protein	0.003	0.0168	0.0556
Trypanosoma cruzi	hexose transporter	0.0066	0.0533	0.8592
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0084	0.0256
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0302	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0302	0.1077
Schistosoma mansoni	lysyl-tRNA synthetase	0.0048	0.0346	0.1193
Plasmodium vivax	hexose transporter	0.0213	0.2018	0.2202
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0107	0.0339
Toxoplasma gondii	exonuclease III APE	0.0022	0.0084	0.012
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0107	0.0339
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.0263	0.0258
Schistosoma mansoni	protein kinase	0.0065	0.0524	0.1834
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0132	0.1964
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0302	0.1077
Trypanosoma cruzi	hexose transporter, putative	0.003	0.0168	0.2561
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0065	0.0524	0.1872
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0065	0.0525	0.0534
Entamoeba histolytica	protein kinase, putative	0.0065	0.0524	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 705690