Detailed information for compound 721232

Basic information

Technical information
  • TDR Targets ID: 721232
  • Name: 3-[2-(2-iodophenoxy)ethyl]quinazolin-4-one
  • MW: 392.191 | Formula: C16H13IN2O2
  • H donors: 0 H acceptors: 1 LogP: 3.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccccc1OCCn1cnc2c(c1=O)cccc2
  • InChi: 1S/C16H13IN2O2/c17-13-6-2-4-8-15(13)21-10-9-19-11-18-14-7-3-1-5-12(14)16(19)20/h1-8,11H,9-10H2
  • InChiKey: NXECQRLQLZUBHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-(2-iodophenoxy)ethyl]-4-quinazolinone
  • ZINC05077572

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni malate dehydrogenase 0.0216 0.0679 0.0675
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0001
Toxoplasma gondii exonuclease III APE 0.0041 0.0078 0.0123
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1768 0.6008 1
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0013 0.0009
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0014 0.0103
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0013 0.0086
Echinococcus granulosus cytosolic malate dehydrogenase 0.0216 0.0679 0.0675
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0128
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0216 0.0679 0.8698
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0128
Schistosoma mansoni cpg binding protein 0.0033 0.0052 0.0048
Loa Loa (eye worm) hypothetical protein 0.0042 0.0082 0.0818
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0013 0.0086
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0078 0.098
Loa Loa (eye worm) hypothetical protein 0.0091 0.0249 0.2496
Brugia malayi hypothetical protein 0.0022 0.0013 0.0086
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0078 0.084
Echinococcus granulosus lactate dehydrogenase protein 0.0091 0.0249 0.0245
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0013 0.0128
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0197 0.0615 0.0611
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0078 0.0853
Entamoeba histolytica malate dehydrogenase, putative 0.0091 0.0249 0.3549
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0078 0.1095
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0197 0.0615 0.0611
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0128
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0128
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.1576 0.1572
Trypanosoma cruzi malate dehydrogenase, putative 0.0091 0.0249 0.3631
Echinococcus granulosus lactate dehydrogenase a 0.0091 0.0249 0.0245
Brugia malayi Bromodomain containing protein 0.0063 0.0153 0.1494
Schistosoma mansoni L-lactate dehydrogenase 0.0091 0.0249 0.0245
Leishmania major mitochondrial malate dehydrogenase 0.0091 0.0249 0.3631
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0014 0.001
Echinococcus granulosus neuropeptide s receptor 0.0477 0.1576 0.1572
Echinococcus granulosus cpg binding protein 0.0033 0.0052 0.0048
Brugia malayi hypothetical protein 0.0022 0.0013 0.0086
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0118 0.0114
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0078 0.1095
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0118 0.1372
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0014 0.0145
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1768 0.6008 1
Schistosoma mansoni cpg binding protein 0.0033 0.0052 0.0048
Schistosoma mansoni L-lactate dehydrogenase 0.0091 0.0249 0.0245
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0944
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0103 0.0292 0.2926
Schistosoma mansoni microtubule-associated protein tau 0.293 1 1
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0216 0.0679 0.0675
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0023 0.0019
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0013 0.0009
Trichomonas vaginalis malate dehydrogenase, putative 0.0169 0.0519 0.661
Brugia malayi PXA domain containing protein 0.0022 0.0013 0.0086
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0677 0.6777
Schistosoma mansoni hypothetical protein 0.006 0.0144 0.014
Schistosoma mansoni zinc finger protein 0.0022 0.0013 0.0008
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0013 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0004 0.0042
Leishmania major malate dehydrogenase, putative 0.0091 0.0249 0.3631
Plasmodium vivax malate dehydrogenase, putative 0.0091 0.0249 0.0408
Echinococcus multilocularis malate dehydrogenase 0.0091 0.0249 0.0245
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0201 0.2008
Echinococcus granulosus expressed protein 0.0427 0.1405 0.1402
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0013 0.0009
Echinococcus granulosus L lactate dehydrogenase B chain 0.0091 0.0249 0.0245
Echinococcus granulosus cytosolic malate dehydrogenase 0.0216 0.0679 0.0675
Schistosoma mansoni phosphoglucomutase 0.0025 0.0023 0.0019
Echinococcus multilocularis lactate dehydrogenase a 0.0091 0.0249 0.0245
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.1393 0.1389
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0091 0.0249 0.3631
Loa Loa (eye worm) hypothetical protein 0.0049 0.0106 0.1059
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0216 0.0679 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Leishmania major ribonuclease H1, putative 0.0025 0.0023 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0106 0.0102
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.003 0.0385
Schistosoma mansoni ap endonuclease 0.0041 0.0078 0.0074
Echinococcus multilocularis muscleblind protein 0.0309 0.0999 0.0995
Brugia malayi jmjC domain containing protein 0.0197 0.0615 0.6145
Brugia malayi MAP kinase sur-1 0.0053 0.0118 0.1143
Echinococcus multilocularis lactate dehydrogenase protein 0.0091 0.0249 0.0245
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0014 0.001
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0144 0.0233
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0027 0.003 0.0385
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0045 0.0041
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0078 0.0074
Brugia malayi CXXC zinc finger family protein 0.003 0.004 0.0356
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.0365 0.3652
Schistosoma mansoni hypothetical protein 0.0175 0.0539 0.0535
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0216 0.0679 0.6784
Loa Loa (eye worm) hypothetical protein 0.0073 0.0188 0.1882
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0045 0.0041
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0118 0.0114
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0091 0.0249 0.0245
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0118 0.0189
Onchocerca volvulus 0.003 0.004 0.022
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0118 0.1685
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0011 0.0105
Echinococcus granulosus jumonji domain containing protein 0.0084 0.0226 0.0221
Schistosoma mansoni hypothetical protein 0.0424 0.1393 0.1389
Trypanosoma cruzi malate dehydrogenase, putative 0.0091 0.0249 0.3631
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0013 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0118 0.1372
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0013 0.0009
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0013 0.0086
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0045 0.0041
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0078 0.0743
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0106 0.0102
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0118 0.0114
Plasmodium falciparum malate dehydrogenase 0.0091 0.0249 0.0408
Trypanosoma brucei protein kinase, putative 0.0053 0.0118 0.1685
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0095 0.0263 0.2602
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0425 0.1398 1
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1768 0.6008 1
Trypanosoma brucei RNA helicase, putative 0.0093 0.0258 0.3764
Echinococcus granulosus lactate dehydrogenase a 0.0091 0.0249 0.0245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.01 0.0096
Schistosoma mansoni malate dehydrogenase 0.0091 0.0249 0.0245
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0118 0.1372
Trichomonas vaginalis malate dehydrogenase, putative 0.0044 0.0089 0.0999
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0013 0.0009
Brugia malayi jmjC domain containing protein 0.0077 0.0201 0.1974
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0023 0.0019
Echinococcus multilocularis cpg binding protein 0.0033 0.0052 0.0048
Plasmodium vivax SET domain protein, putative 0.0031 0.0045 0.0069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0155 0.0151
Trichomonas vaginalis ribonuclease H1, putative 0.0025 0.0023 0.0133
Loa Loa (eye worm) hypothetical protein 0.0309 0.0999 1
Toxoplasma gondii lactate dehydrogenase LDH2 0.0091 0.0249 0.0408
Leishmania major malate dehydrogenase 0.0091 0.0249 0.3631
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0011 0.0012
Echinococcus multilocularis lactate dehydrogenase a 0.0091 0.0249 0.0245
Brugia malayi RNase H family protein 0.0025 0.0023 0.0188
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0078 0.0123
Leishmania major cytosolic malate dehydrogenase 0.0216 0.0679 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.01 0.0096
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0118 0.1447
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0091 0.0249 0.0408
Leishmania major malate dehydrogenase, putative 0.0091 0.0249 0.3631
Loa Loa (eye worm) hypothetical protein 0.0095 0.0263 0.2634
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0144 0.1446
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0078 0.1095
Echinococcus multilocularis microtubule associated protein 2 0.293 1 1
Entamoeba histolytica malate dehydrogenase, putative 0.0216 0.0679 1
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0013 0.0009
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0013 0.0009
Brugia malayi Bromodomain containing protein 0.0079 0.0209 0.2058
Trichomonas vaginalis set domain proteins, putative 0.0245 0.0779 1
Trypanosoma cruzi ribonuclease H1, putative 0.0025 0.0023 0.0278
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0023 0.0019
Brugia malayi AF-10 protein 0.002 0.0005 0.0008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0078 0.0092
Schistosoma mansoni hypothetical protein 0.0093 0.0258 0.0254
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1768 0.6008 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.01 0.0998
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0091 0.0249 0.3631
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0013 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.01 0.0096
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0128
Echinococcus multilocularis zinc finger protein 0.0022 0.0013 0.0008
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0078 0.0092
Trypanosoma brucei malate dehydrogenase-related 0.0091 0.0249 0.3631
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0013 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.1576 0.1572
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.0201 0.0196
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.004 0.0396
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0078 0.0853
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0011 0.0012
Echinococcus multilocularis lactate dehydrogenase a 0.0091 0.0249 0.0245
Brugia malayi RNase H family protein 0.0025 0.0023 0.0188
Trypanosoma brucei ribonuclease H1 0.0025 0.0023 0.0278
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0005 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0118 0.1372
Schistosoma mansoni hypothetical protein 0.0095 0.0263 0.0259
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0005 0.0001
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.1768 0.6008 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.01 0.0096
Plasmodium falciparum phd finger protein, putative 0.006 0.0144 0.0233
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0144 0.014
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0047 0.0429
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Mycobacterium ulcerans malate dehydrogenase 0.0216 0.0679 0.1013
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0013 0.0009
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0143 0.0232
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0118 0.1685
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0118 0.0114
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0005 0.0001
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0144 0.014
Plasmodium falciparum lactate dehydrogenase, putative 0.0091 0.0249 0.0408
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0009
Trichomonas vaginalis malate dehydrogenase, putative 0.0091 0.0249 0.3087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.01 0.0096
Brugia malayi Pre-SET motif family protein 0.0215 0.0677 0.6763
Echinococcus granulosus malate dehydrogenase 0.0091 0.0249 0.0245
Schistosoma mansoni bromodomain containing protein 0.0067 0.0167 0.0163
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0216 0.0679 0.4555
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0009
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0118 0.1685
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0009
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0216 0.0679 1
Leishmania major glycosomal malate dehydrogenase 0.0091 0.0249 0.3631
Brugia malayi RNase H family protein 0.0025 0.0023 0.0188
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0013 0.0128
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0118 0.0114
Brugia malayi PHD-finger family protein 0.0027 0.0031 0.0274
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0095 0.0263 0.0259
Echinococcus multilocularis peregrin 0.0063 0.0153 0.0149
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0045 0.0069
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0013 0.0086
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0014 0.001
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0095 0.0263 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0014 0.001
Schistosoma mansoni hypothetical protein 0.0095 0.0263 0.0259
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0216 0.0679 0.8698
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.01 0.096
Echinococcus granulosus zinc finger protein 0.0022 0.0013 0.0008
Toxoplasma gondii malate dehydrogenase MDH 0.0091 0.0249 0.0408
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0009
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0091 0.0249 0.0378
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0065 0.0061
Schistosoma mansoni malate dehydrogenase 0.0216 0.0679 0.0675
Schistosoma mansoni malate dehydrogenase 0.0091 0.0249 0.0245
Loa Loa (eye worm) apoptosis regulator protein 0.0095 0.0263 0.2634
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0095 0.0263 0.0259
Loa Loa (eye worm) malate dehydrogenase 0.0091 0.0249 0.2496
Loa Loa (eye worm) hypothetical protein 0.0309 0.0999 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0004 0.0042
Loa Loa (eye worm) malate dehydrogenase 0.0216 0.0679 0.6798
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0216 0.0679 1
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.1576 0.1572
Trypanosoma brucei glycosomal malate dehydrogenase 0.0091 0.0249 0.3631
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0017 0.0013
Brugia malayi PXA domain containing protein 0.0022 0.0013 0.0086
Schistosoma mansoni hypothetical protein 0.0095 0.0263 0.0259
Schistosoma mansoni apoptosis regulator bax 0.0095 0.0263 0.0259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0042
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.003 0.0385
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0095 0.0263 0.0259
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0118 0.1181
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0106 0.0102
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0091 0.0249 0.3631
Schistosoma mansoni cpg binding protein 0.003 0.004 0.0035
Schistosoma mansoni phosphoglucomutase 0.0025 0.0023 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.01 0.0096
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0144 0.014
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0013 0.0128
Plasmodium vivax lactate dehydrogenase 0.0091 0.0249 0.0408
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0013 0.0009
Trypanosoma cruzi ribonuclease H1, putative 0.0025 0.0023 0.0278
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0128
Brugia malayi lactate dehydrogenase. 0.0091 0.0249 0.2464
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0013 0.0009
Onchocerca volvulus 0.0031 0.0045 0.0297
Brugia malayi Pre-SET motif family protein 0.0031 0.0045 0.0414
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0014 0.001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0118 0.1685
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0118 0.1685
Plasmodium vivax hypothetical protein, conserved 0.006 0.0144 0.0233
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0155 0.0151
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0201 0.0196
Schistosoma mansoni hypothetical protein 0.0175 0.0539 0.0535
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0013 0.0086
Brugia malayi Muscleblind-like protein 0.0309 0.0999 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0013 0.0009
Brugia malayi PHD-finger family protein 0.0023 0.0018 0.0135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0034 0.003
Onchocerca volvulus 0.0245 0.0779 1
Schistosoma mansoni jumonji domain containing protein 0.0157 0.0476 0.0472
Echinococcus multilocularis expressed protein 0.0427 0.1405 0.1402
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0144 0.0233
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0078 0.1095
Trypanosoma brucei unspecified product 0.0027 0.003 0.0385
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0095 0.0263 0.0259
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0078 0.0123
Onchocerca volvulus Alhambra homolog 0.006 0.0144 0.1607
Echinococcus multilocularis malate dehydrogenase 0.0091 0.0249 0.0245
Echinococcus granulosus peregrin 0.0063 0.0153 0.0149
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0065 0.0061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0158 0.0154
Echinococcus multilocularis ribonuclease H1 0.0025 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.01 0.0096
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0078 0.0782
Echinococcus multilocularis geminin 0.0175 0.0539 0.0535
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0014 0.0145
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0216 0.0679 0.0675
Brugia malayi PHD-finger family protein 0.006 0.0144 0.1409
Echinococcus granulosus ribonuclease H1 0.0025 0.0023 0.0019
Giardia lamblia Malate dehydrogenase 0.0216 0.0679 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.0188 0.0184
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0013 0.0009
Schistosoma mansoni phosphoglucomutase 0.0025 0.0023 0.0019
Trypanosoma brucei cytosolic malate dehydrogenase 0.0216 0.0679 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0144 0.1446
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0013 0.0009
Plasmodium falciparum L-lactate dehydrogenase 0.0091 0.0249 0.0408
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0009
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0216 0.0679 0.8698
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Brugia malayi Bromodomain containing protein 0.004 0.0073 0.0692
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1768 0.6008 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0734
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1768 0.6008 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0013 0.0009
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1768 0.6008 1
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.0226 0.0221
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0005 0.0012
Toxoplasma gondii lactate dehydrogenase LDH1 0.0091 0.0249 0.0408
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0013 0.0009
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0013 0.0009
Trichomonas vaginalis malate dehydrogenase, putative 0.0216 0.0679 0.8698
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0004 0.0042
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0013 0.0009
Toxoplasma gondii ribonuclease HI protein 0.0025 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0042
Giardia lamblia PHD finger protein 15 0.006 0.0144 0.1851
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0118 0.1685
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0201 0.0196
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0118 0.1685
Echinococcus granulosus muscleblind protein 0.0309 0.0999 0.0995
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0078 0.0074
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0091 0.0249 0.2464
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0091 0.0249 0.3631
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0013 0.0009
Echinococcus multilocularis muscleblind protein 1 0.0309 0.0999 0.0995
Schistosoma mansoni ap endonuclease 0.0041 0.0078 0.0074
Echinococcus granulosus geminin 0.0175 0.0539 0.0535
Echinococcus granulosus dnaJ subfamily B 0.0424 0.1393 0.1389
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0013 0.0009
Echinococcus granulosus malate dehydrogenase 0.0091 0.0249 0.0245
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0216 0.0679 0.8698
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.003 0.0385

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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