Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | conserved protein, unknown function | 0.0015 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1813 | 0.2107 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1813 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.01 | 0.5479 | 0.6369 |
Plasmodium falciparum | cysteine repeat modular protein 2 | 0.0015 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1813 | 0.3308 |
Onchocerca volvulus | 0.0078 | 0.4102 | 0.5416 | |
Brugia malayi | bZIP transcription factor family protein | 0.01 | 0.5479 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1813 | 0.2364 |
Toxoplasma gondii | GCC2 and GCC3 domain-containing protein | 0.0015 | 0 | 0.5 |
Brugia malayi | ephrin receptor 1 precursor | 0.0064 | 0.3168 | 0.5783 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0081 | 0.4277 | 0.5579 |
Toxoplasma gondii | kringle domain-containing protein | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | jun protein | 0.01 | 0.5479 | 0.6369 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.7573 | 0.7573 |
Echinococcus multilocularis | ephrin type A receptor 4 A | 0.0148 | 0.8603 | 1 |
Echinococcus granulosus | jun protein | 0.01 | 0.5479 | 0.6369 |
Plasmodium falciparum | cysteine repeat modular protein 3 | 0.0015 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3395 | 0.3395 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.01 | 0.5479 | 0.6369 |
Brugia malayi | hypothetical protein | 0.0078 | 0.4102 | 0.7486 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.4277 | 0.5579 |
Plasmodium vivax | hypothetical protein, conserved | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1813 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1813 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.5303 | 0.5303 |
Giardia lamblia | CEGP1 protein | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0132 | 0.7573 | 1 | |
Toxoplasma gondii | hypothetical protein | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1813 | 0.2107 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1813 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1813 | 0.2364 |
Plasmodium vivax | cysteine repeat modular protein 3, putative | 0.0015 | 0 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | ephrin receptor | 0.0134 | 0.7667 | 1 |
Echinococcus granulosus | ephrin type A receptor 4 A | 0.0148 | 0.8603 | 1 |
Plasmodium vivax | cysteine repeat modular protein 2, putative | 0.0015 | 0 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 4 | 0.0015 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.72 uM | Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes | ChEMBL. | 11170626 |
IC50 (functional) | = 0.72 uM | Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes | ChEMBL. | 11170626 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.