TDR Targets

Basic information

Technical information

TDR Targets ID: 768347
Name: ethyl (4Z)-4-[(3,4-dimethoxyphenyl)methyliden e]-2-methyl-1-(2-methylpropyl)-5-oxopyrrole-3 -carboxylate
MW: 373.443 | Formula: C21H27NO5
H donors: 0 H acceptors: 2 LogP: 3.54 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=C(C)N(C(=O)C1=Cc1ccc(c(c1)OC)OC)CC(C)C
InChi: 1S/C21H27NO5/c1-7-27-21(24)19-14(4)22(12-13(2)3)20(23)16(19)10-15-8-9-17(25-5)18(11-15)26-6/h8-11,13H,7,12H2,1-6H3/b16-10-
InChiKey: PRGBGBDPSXQCCH-YBEGLDIGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 4-[(3,4-dimethoxyphenyl)methylidene]-2-methyl-1-(2-methylpropyl)-5-oxopyrrole-3-carboxylate
ethyl (4Z)-4-[(3,4-dimethoxyphenyl)methylene]-1-isobutyl-2-methyl-5-oxo-pyrrole-3-carboxylate
ethyl 4-[(3,4-dimethoxyphenyl)methylene]-1-isobutyl-2-methyl-5-oxo-pyrrole-3-carboxylate
4-[(3,4-dimethoxyphenyl)methylene]-1-isobutyl-2-methyl-5-oxo-3-pyrrolecarboxylic acid ethyl ester
(4Z)-4-[(3,4-dimethoxyphenyl)methylene]-1-isobutyl-2-methyl-5-oxo-3-pyrrolecarboxylic acid ethyl ester
(4Z)-4-(3,4-dimethoxybenzylidene)-1-isobutyl-5-keto-2-methyl-2-pyrroline-3-carboxylic acid ethyl ester
4-(3,4-dimethoxybenzylidene)-1-isobutyl-5-keto-2-methyl-2-pyrroline-3-carboxylic acid ethyl ester
ethyl (4Z)-4-[(3,4-dimethoxyphenyl)methylidene]-2-methyl-1-(2-methylpropyl)-5-oxo-pyrrole-3-carboxylate
ethyl 4-[(3,4-dimethoxyphenyl)methylidene]-2-methyl-1-(2-methylpropyl)-5-oxo-pyrrole-3-carboxylate
STK168494
ZINC04700973
ZINC01170700

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	acyl-CoA synthetase	0.0112	0.0678	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0149	0.0949	0.5842
Brugia malayi	Pax transcription activation domain interacting protein	0.0041	0.0175	0.033
Brugia malayi	RNA recognition motif domain containing protein	0.0528	0.3656	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.065	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0678	0.1855
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0044	0.0193	0.0193
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0044	0.0193	0.0527
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0123	0.0123
Schistosoma mansoni	acetyl-CoA synthetase	0.0044	0.0193	0.0393
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0135	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0175	0.0478
Echinococcus granulosus	intermediate filament protein	0.0026	0.0067	0.0067
Brugia malayi	hypothetical protein	0.0041	0.0175	0.033
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0149	0.0949	1
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0044	0.0193	0.0335
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0123	0.0123
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0041	0.0175	0.0233
Echinococcus granulosus	lamin	0.0026	0.0067	0.0067
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0329	0.0673
Mycobacterium ulcerans	acyl-CoA synthetase	0.0149	0.0949	0.4698
Onchocerca volvulus		0.0036	0.0135	0.0524
Schistosoma mansoni	hypothetical protein	0.0074	0.0406	0.0828
Loa Loa (eye worm)	glutaminase	0.0278	0.1867	0.5107
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0044	0.0193	0.0714
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0044	0.0193	0.0421
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0044	0.0193	0.0335
Entamoeba histolytica	hypothetical protein	0.0226	0.1499	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0149	0.0949	0.5842
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0041	0.0175	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0226	0.1499	0.3061
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0106	0.0634	0.3622
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0135	0.0368
Schistosoma mansoni	DNA ligase IV	0.0041	0.0175	0.0357
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0135	0.0135
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0175	0.0233
Echinococcus granulosus	lamin dm0	0.0026	0.0067	0.0067
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0135	0.0135
Giardia lamblia	Replication factor C, subunit 1	0.0041	0.0175	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0123	0.0335
Schistosoma mansoni	hypothetical protein	0.0034	0.0123	0.025
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0135	0.0275
Brugia malayi	hypothetical protein	0.0226	0.1499	0.4009
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0406	0.111
Schistosoma mansoni	tar DNA-binding protein	0.0528	0.3656	0.7464
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0041	0.0175	0.6951
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0044	0.0193	0.0335
Onchocerca volvulus		0.0044	0.0193	0.0973
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0207	0.136	0.3719
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0044	0.0193	0.038
Brugia malayi	AMP-binding enzyme family protein	0.0149	0.0949	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0678	0.1855
Schistosoma mansoni	microtubule-associated protein tau	0.0701	0.4899	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0193	0.0527
Brugia malayi	intermediate filament protein	0.0026	0.0067	0.003
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0193	0.0335
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0039	0.0039
Trichomonas vaginalis	antibiotic synthetase, putative	0.0044	0.0193	0.0335
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0125	0.0774	0.0774
Echinococcus granulosus	replication factor c subunit 1	0.0041	0.0175	0.0175
Echinococcus multilocularis	lamin	0.0026	0.0067	0.0067
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0044	0.0193	0.0421
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0044	0.0193	1
Onchocerca volvulus		0.0036	0.0135	0.0524
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0175	0.0233
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0067	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0169	0.0462
Onchocerca volvulus		0.0036	0.0135	0.0524
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0135	0.0846	0.0846
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0044	0.0193	0.0421
Schistosoma mansoni	hypothetical protein	0.0034	0.0123	0.025
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0949	0.2594
Schistosoma mansoni	lamin	0.0026	0.0067	0.0136
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0175	0.6951
Brugia malayi	hypothetical protein	0.0041	0.0175	0.033
Loa Loa (eye worm)	RNA binding protein	0.0528	0.3656	1
Plasmodium vivax	replication factor C subunit 1, putative	0.0041	0.0175	0.0743
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0044	0.0193	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0039	0.0039
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0041	0.0175	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0193	0.0527
Brugia malayi	RNA binding protein	0.0528	0.3656	1
Onchocerca volvulus		0.0149	0.0949	0.6819
Mycobacterium ulcerans	acyl-CoA synthetase	0.0149	0.0949	0.4698
Leishmania major	4-coumarate:coa ligase-like protein	0.0149	0.0949	1
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.0846	0.1727
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0193	0.0335
Leishmania major	4-coumarate:coa ligase-like protein	0.0149	0.0949	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0226	0.1499	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0182	0.0499
Mycobacterium ulcerans	glutaminase	0.0278	0.1867	1
Loa Loa (eye worm)	TAR-binding protein	0.0528	0.3656	1
Schistosoma mansoni	tar DNA-binding protein	0.0528	0.3656	0.7464
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0712	0.1949
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0678	0.1855
Onchocerca volvulus		0.0044	0.0193	0.0973
Loa Loa (eye worm)	hypothetical protein	0.007	0.0383	0.1046
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0193	0.0335
Trichomonas vaginalis	glutaminase, putative	0.0278	0.1867	1
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0193	0.038
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0149	0.0949	0.4698
Onchocerca volvulus		0.0044	0.0193	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0175	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0175	0.0478
Brugia malayi	DKFZp564C0469 protein	0.0041	0.0175	0.033
Toxoplasma gondii	ATPase, AAA family protein	0.0041	0.0175	0.6951
Entamoeba histolytica	hypothetical protein	0.0226	0.1499	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.065	0.1649
Onchocerca volvulus		0.0044	0.0193	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0063	0.0173
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0304	0.0304
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0125	0.0774	0.0774
Schistosoma mansoni	topbp1	0.0041	0.0175	0.0357
Schistosoma mansoni	hypothetical protein	0.0125	0.0774	0.158
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0175	0.0233
Trichomonas vaginalis	replication factor C large subunit, putative	0.0041	0.0175	0.0233
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0044	0.0193	0.0714
Schistosoma mansoni	lamin	0.0026	0.0067	0.0136
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0044	0.0193	0.0335
Schistosoma mansoni	zinc finger protein	0.0019	0.0018	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0067	0.0183
Schistosoma mansoni	chromosome transmission fidelity factor	0.0041	0.0175	0.0357
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0149	0.0949	0.4698
Echinococcus multilocularis	lamin dm0	0.0026	0.0067	0.0067
Brugia malayi	Bromodomain containing protein	0.0075	0.0413	0.0992
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0044	0.0193	0.0134
Echinococcus multilocularis	microtubule associated protein 2	0.0701	0.4899	0.4899
Entamoeba histolytica	hypothetical protein	0.0226	0.1499	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0712	0.1949
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0175	0.0233
Onchocerca volvulus		0.0041	0.0175	0.0836
Echinococcus multilocularis	replication factor c subunit 1	0.0041	0.0175	0.0175
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0149	0.0949	1
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0123	0.0185
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0044	0.0193	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0044	0.0193	0.0421
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0175	0.0233
Plasmodium vivax	acyl-CoA synthetase, putative	0.0112	0.0678	1
Brugia malayi	MH2 domain containing protein	0.0116	0.0712	0.1823
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0044	0.0193	0.0527
Entamoeba histolytica	acyl-coA synthetase, putative	0.0149	0.0949	0.5842
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0135	0.0135
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.0846	0.1727
Trypanosoma cruzi	FHA domain containing protein, putative	0.0041	0.0175	0.6951
Schistosoma mansoni	hypothetical protein	0.0021	0.0026	0.0052
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0044	0.0193	0.0421
Onchocerca volvulus		0.0207	0.136	1
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0193	0.038
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0044	0.0193	0.0421
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0112	0.0678	1
Brugia malayi	AMP-binding enzyme family protein	0.0149	0.0949	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0175	0.0478
Schistosoma mansoni	hypothetical protein	0.0226	0.1499	0.3061
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0678	0.1855
Toxoplasma gondii	propionate-CoA ligase	0.0044	0.0193	1
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0026	0.007
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0044	0.0193	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0368
Echinococcus multilocularis	tar DNA binding protein	0.0528	0.3656	0.3656
Leishmania major	acetyl-CoA synthetase, putative	0.0044	0.0193	0.0714
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0135	0.0368
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0044	0.0193	1
Brugia malayi	beta-lactamase	0.0036	0.0135	0.0218
Brugia malayi	AMP-binding enzyme family protein	0.0149	0.0949	0.2479
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0044	0.0193	0.0352
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0044	0.0193	0.0714
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0041	0.0175	0.6951
Leishmania major	acetyl-CoA synthetase, putative	0.0044	0.0193	0.0714
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0044	0.0193	0.0335
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0112	0.0678	0.3938
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0044	0.0193	1
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0044	0.0193	0.0335
Brugia malayi	topoisomerase	0.0041	0.0175	0.033
Treponema pallidum	DNA ligase (lig)	0.0041	0.0175	0.5
Schistosoma mansoni	hypothetical protein	0.0034	0.0123	0.025
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0041	0.0175	0.0233
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0112	0.0678	0.3137
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0044	0.0193	0.0421
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0193	0.038
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0106	0.0634	0.3622
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0304	0.0304
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0123	0.0123
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0106	0.0634	0.3622
Brugia malayi	beta-lactamase family protein	0.0036	0.0135	0.0218
Echinococcus multilocularis	zinc finger protein	0.0019	0.0018	0.0018
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0226	0.1499	0.1499
Schistosoma mansoni	tar DNA-binding protein	0.0528	0.3656	0.7464
Schistosoma mansoni	hypothetical protein	0.0034	0.0123	0.025
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0044	0.0193	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0175	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0123	0.0335
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0149	0.0949	0.5898
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0368
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0041	0.0175	0.033
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.065	0.1649
Echinococcus multilocularis	nibrin	0.0041	0.0175	0.0175
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0193	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0949	0.2594
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0193	0.0335
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0149	0.0949	0.4698
Brugia malayi	glutaminase DH11.1	0.0278	0.1867	0.5031
Echinococcus multilocularis	tumor protein p63	0.1414	1	1
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0041	0.0175	0.0496
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0044	0.0193	0.0335
Trichomonas vaginalis	antibiotic synthetase, putative	0.0044	0.0193	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0949	0.2594
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0044	0.0193	0.0421
Schistosoma mansoni	tar DNA-binding protein	0.0528	0.3656	0.7464
Schistosoma mansoni	cellular tumor antigen P53	0.0207	0.136	0.2776
Echinococcus granulosus	zinc finger protein	0.0019	0.0018	0.0018
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0193	0.0335
Echinococcus granulosus	GPCR family 2	0.0034	0.0123	0.0123
Echinococcus multilocularis	musashi	0.0026	0.0067	0.0067
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0067	0.0183
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0044	0.0193	1
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0044	0.0193	0.0421
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0406	0.0971
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0039	0.008
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0044	0.0193	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0368
Echinococcus granulosus	microtubule associated protein 2	0.0701	0.4899	0.4899
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0175	0.0478
Schistosoma mansoni	glutaminase	0.0278	0.1867	0.3811
Loa Loa (eye worm)	oxidoreductase	0.0044	0.0193	0.0527
Brugia malayi	TAR-binding protein	0.0528	0.3656	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0041	0.0175	0.0233
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0044	0.0193	0.038
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0041	0.0175	0.6951
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0123	0.0185
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0193	0.038
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0678	0.1855
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0044	0.0193	0.0335
Schistosoma mansoni	topbp1	0.0041	0.0175	0.0357
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.065	0.1777
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.1515	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0106	0.0634	0.3622
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0528	0.3656	1
Loa Loa (eye worm)	glutaminase 2	0.0278	0.1867	0.5107
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0193	0.0335
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0041	0.0175	0.0233
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0044	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0152	0.0416
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0123	0.0123
Brugia malayi	Bromodomain containing protein	0.0038	0.0151	0.0265
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0004	0.0012
Mycobacterium ulcerans	hypothetical protein	0.0149	0.0949	0.4698
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0193	0.0335
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0038	0.0149	0.0105
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0149	0.0949	0.4698
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0044	0.0193	0.0335
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0175	0.6951
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0044	0.0193	0.0421
Leishmania major	4-coumarate:coa ligase-like protein	0.0149	0.0949	1
Schistosoma mansoni	tar DNA-binding protein	0.0528	0.3656	0.7464
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0067	0.0136
Entamoeba histolytica	hypothetical protein	0.0226	0.1499	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0135	0.0218
Echinococcus granulosus	nibrin	0.0041	0.0175	0.0175
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0044	0.0193	0.0193
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0067	0.003
Mycobacterium ulcerans	acyl-CoA synthetase	0.0149	0.0949	0.4698
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0123	0.0123
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0135	0.0275
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0149	0.0949	0.5898
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0044	0.0193	1
Echinococcus granulosus	tar DNA binding protein	0.0528	0.3656	0.3656

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 768347