TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 257.331 | Formula: C15H19N3O
H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCCn1nc(c(c1O)C(=N)c1ccccc1)C
InChi: 1S/C15H19N3O/c1-3-4-10-18-15(19)13(11(2)17-18)14(16)12-8-6-5-7-9-12/h5-9,16,19H,3-4,10H2,1-2H3
InChiKey: GRAPJHTUIALJIR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0022	0.0058	0.0047
Echinococcus granulosus	7tm_1 domain containing protein	0.0022	0.0058	0.0099
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Brugia malayi	hypothetical protein	0.0431	0.4361	0.7474
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0115	0.0197
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.1919	0.3289
Leishmania major	cathepsin L-like protease	0.0079	0.0659	0.6716
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0143	0.0143
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0058	0.0099
Echinococcus multilocularis	geminin	0.0168	0.1591	0.1591
Brugia malayi	RE15519p	0.0022	0.0058	0.0099
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.011	0.0982	1
Loa Loa (eye worm)	ctsf protein	0.0027	0.0115	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0381
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Giardia lamblia	Cathepsin B precursor	0.0099	0.0869	0.8852
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0222	1
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0058	0.0099
Plasmodium vivax	SET domain protein, putative	0.003	0.0143	0.6429
Giardia lamblia	Hypothetical protein	0.011	0.0982	1
Onchocerca volvulus		0.0037	0.0222	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus granulosus	g-protein coupled receptor	0.0022	0.0058	0.0099
Brugia malayi	cathepsin B-like cysteine proteinase	0.0293	0.2907	0.4981
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0115	0.0497
Echinococcus granulosus	peroxidasin	0.0025	0.0097	0.0166
Onchocerca volvulus		0.0025	0.0097	0.0115
Plasmodium vivax	unspecified product	0.0018	0.0021	0.0949
Echinococcus multilocularis	cysteine protease	0.0027	0.0115	0.0115
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.011	0.0982	0.4246
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.011	0.0982	0.3378
Echinococcus granulosus	RUN	0.0019	0.003	0.0052
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0022	0.0058	0.0099
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0222	0.0952
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0058	0.0058
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0058	0.0058
Brugia malayi	hypothetical protein	0.0119	0.1083	0.1857
Echinococcus granulosus	7TM GPCR rhodopsin	0.0022	0.0058	0.0099
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0099	0.0869	0.2991
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0143	0.1644
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Trypanosoma cruzi	cruzipain precursor, putative	0.0079	0.0659	0.2269
Onchocerca volvulus		0.0431	0.4361	0.7461
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0058	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Loa Loa (eye worm)	hypothetical protein	0.003	0.0143	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0018	0.0021	0.0036
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0058	0.0058
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0058	0.0058
Leishmania major	cathepsin L-like protease	0.0079	0.0659	0.6716
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0022	0.0058	0.0058
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0114	0.1027	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Onchocerca volvulus	Dual oxidase homolog	0.0025	0.0097	0.0115
Onchocerca volvulus		0.0022	0.0058	0.0047
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.0196	0.2001
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0115	0.0115
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0143	0.0245
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.2907	0.4981
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0097	0.0166
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0222	0.0952
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0018	0.0021	0.0215
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0058	0.0099
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0222	0.5
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.011	0.0982	1
Giardia lamblia	Cathepsin B precursor	0.0099	0.0869	0.8852
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0115	0.0197
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0222	0.0952
Schistosoma mansoni	peroxidasin	0.0025	0.0097	0.0166
Loa Loa (eye worm)	cysteine protease	0.0027	0.0115	0.0197
Echinococcus granulosus	allatostatin A receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	amine GPCR	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0431	0.4361	0.7474
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0058	0.0099
Echinococcus granulosus	chromatin regulatory protein sir2	0.011	0.0982	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus multilocularis	cathepsin b	0.0293	0.2907	0.2907
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0058	0.0099
Schistosoma mansoni	rab6-interacting	0.0019	0.003	0.0052
Onchocerca volvulus		0.0027	0.0115	0.0146
Echinococcus granulosus	cathepsin l1	0.0027	0.0115	0.0197
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0196	0.085
Schistosoma mansoni	rab6-interacting	0.0019	0.003	0.0052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0058	0.0099
Onchocerca volvulus		0.0037	0.0222	0.0331
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.011	0.0982	0.1683
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0022	0.0058	0.0058
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.011	0.0982	0.4246
Schistosoma mansoni	amine GPCR	0.0022	0.0058	0.0099
Schistosoma mansoni	lipoxygenase	0.0114	0.1027	0.176
Schistosoma mansoni	hypothetical protein	0.0022	0.0058	0.0099
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0115	0.0197
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0022	0.0058	0.0099
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0058	0.0099
Toxoplasma gondii	NAC domain-containing protein	0.0035	0.0196	0.226
Schistosoma mansoni	lozenge	0.0054	0.0398	0.0683
Loa Loa (eye worm)	TAR-binding protein	0.0199	0.1919	0.3289
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0058	0.0058
Schistosoma mansoni	hypothetical protein	0.0034	0.0187	0.032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0051	0.022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0058	0.0058
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0222	0.0222
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.0957	0.164
Leishmania major	cathepsin L-like protease	0.0027	0.0115	0.1171
Onchocerca volvulus		0.003	0.0143	0.0194
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0187	0.0187
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1083	0.1814
Schistosoma mansoni	cathepsin F (C01 family)	0.0021	0.0051	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.1919	0.3289
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0115	0.0146
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0058	0.0099
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0097	0.0166
Echinococcus multilocularis	tar DNA binding protein	0.0199	0.1919	0.1919
Echinococcus multilocularis	transcription factor btf3	0.0035	0.0196	0.0196
Echinococcus multilocularis	G protein coupled receptor 139	0.0022	0.0058	0.0058
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus multilocularis	cysteine protease	0.0027	0.0115	0.0115
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0298	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Plasmodium vivax	vivapain-2	0.0027	0.0115	0.5175
Onchocerca volvulus		0.0022	0.0058	0.0047
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0115	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0957	0.164
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0115	0.0497
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.0659	0.2269
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0022	0.0058	0.0099
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0058	0.0058
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0022	0.0058	0.0099
Echinococcus granulosus	somatostatin receptor	0.0022	0.0058	0.0099
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0114	0.1027	0.176
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0058	0.0058
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0099	0.0869	0.149
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0143	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0058	0.0099
Onchocerca volvulus		0.0022	0.0058	0.0047
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.003	0.1357
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0187	0.0187
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0222	0.0961
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0058	0.0099
Echinococcus multilocularis	serotonin receptor	0.0022	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0381
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0022	0.0058	0.0099
Brugia malayi	putative neuropeptide receptor NPR1	0.0022	0.0058	0.0099
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0115	0.0197
Onchocerca volvulus		0.0022	0.0058	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0115	0.0396
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0222	0.0961
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0222	0.0381
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.0196	0.0337
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0058	0.0099
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.003	0.003
Brugia malayi	ORL1-like opioid receptor	0.0022	0.0058	0.0099
Echinococcus multilocularis	RUN	0.0019	0.003	0.003
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.0957	0.164
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0022	0.0058	0.0099
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0058	0.0099
Toxoplasma gondii	cathepsin B	0.0099	0.0869	1
Onchocerca volvulus		0.0037	0.0222	0.0331
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0022	0.0058	0.0099
Brugia malayi	Serotonin receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0143	0.0245
Onchocerca volvulus		0.0022	0.0058	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0099	0.0869	0.8852
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1083	0.1857
Schistosoma mansoni	myosin xvIII	0.0022	0.0058	0.0099
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.2312	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0058	0.0099
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0058	0.0058
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0058	0.0058
Onchocerca volvulus		0.0027	0.0115	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0381
Echinococcus multilocularis	neuropeptide receptor A26	0.0022	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0022	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0196	0.085
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0058	0.0058
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0022	0.0058	0.0099
Echinococcus multilocularis	somatostatin receptor	0.0022	0.0058	0.0058
Onchocerca volvulus		0.0022	0.0058	0.0047
Echinococcus multilocularis	Protein lozenge	0.0054	0.0398	0.0398
Loa Loa (eye worm)	cathepsin B	0.0099	0.0869	0.149
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2907	0.4981
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0298	0.0511
Leishmania major	cysteine peptidase A (CPA)	0.0027	0.0115	0.1171
Echinococcus granulosus	neuropeptide receptor A26	0.0022	0.0058	0.0099
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0196	0.085
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0021	0.0215
Schistosoma mansoni	hypothetical protein	0.0019	0.003	0.0052
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0187	0.0187
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0058	0.0099
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0222	0.0952
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0021	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1797	0.3079
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Brugia malayi	Dopamine receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0187	0.032
Leishmania major	silent information regulator 2, putative	0.011	0.0982	1
Onchocerca volvulus		0.0022	0.0058	0.0047
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0022	0.0058	0.0047
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0021	0.0036
Schistosoma mansoni	hypothetical protein	0.0034	0.0187	0.032
Schistosoma mansoni	amine GPCR	0.0022	0.0058	0.0099
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0115	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0097	0.0166
Plasmodium vivax	vivapain-3	0.0018	0.0021	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0058	0.0099
Brugia malayi	G protein-coupled receptor	0.0022	0.0058	0.0099
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0572	0.5835	1
Entamoeba histolytica	cysteine proteinase 2	0.0018	0.0021	0.0215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Echinococcus multilocularis	sex peptide receptor	0.0022	0.0058	0.0058
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0058	0.0099
Onchocerca volvulus		0.0027	0.0115	0.0146
Onchocerca volvulus		0.0025	0.0097	0.0115
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus multilocularis	chromatin regulatory protein sir2	0.011	0.0982	0.0982
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0199	0.1919	0.3289
Schistosoma mansoni	lipoxygenase	0.008	0.0667	0.1143
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0058	0.0058
Onchocerca volvulus		0.0022	0.0058	0.0047
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0018	0.0021	0.1073
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.011	0.0982	1
Loa Loa (eye worm)	animal heme peroxidase	0.0025	0.0097	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1083	0.1857
Echinococcus granulosus	GPCR family 2	0.0034	0.0187	0.032
Onchocerca volvulus		0.0027	0.0115	0.0146
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0298	0.0511
Plasmodium vivax	vivapain-1	0.0018	0.0021	0.0949
Schistosoma mansoni	polycystin 1-related	0.0019	0.003	0.0052
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0058	0.0058
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0058	0.0099
Brugia malayi	hypothetical protein	0.0019	0.003	0.0052
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	hypothetical protein	0.0022	0.0058	0.0099
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0115	0.0197
Brugia malayi	beta-lactamase	0.0037	0.0222	0.0381
Leishmania major	hypothetical protein, conserved	0.0037	0.0222	0.2264
Schistosoma mansoni	hypothetical protein	0.0034	0.0187	0.032
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0022	0.0058	0.0058
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0298	0.0511
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.2011	0.3446
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0187	0.032
Echinococcus multilocularis	allatostatin A receptor	0.0022	0.0058	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0115	0.0497
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Onchocerca volvulus		0.0022	0.0058	0.0047
Brugia malayi	G-protein coupled receptor	0.0022	0.0058	0.0099
Brugia malayi	TAR-binding protein	0.0199	0.1919	0.3289
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0099	0.0869	0.8852
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0058	0.0058
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.003	0.1535
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0058	0.0099
Brugia malayi	hypothetical protein	0.0025	0.0097	0.0166
Brugia malayi	RNA binding protein	0.0199	0.1919	0.3289
Schistosoma mansoni	opsin-like receptor	0.0022	0.0058	0.0099
Onchocerca volvulus		0.0027	0.0115	0.0146
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0222	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0058	0.0099
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0222	0.0952
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0022	0.0058	0.0058
Echinococcus multilocularis	neuropeptide s receptor	0.0022	0.0058	0.0058
Schistosoma mansoni	chromatin regulatory protein sir2	0.011	0.0982	0.1683
Entamoeba histolytica	hypothetical protein	0.0035	0.0196	0.2001
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0097	0.0166
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0058	0.0099
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Schistosoma mansoni	peroxidasin	0.0025	0.0097	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0099	0.0869	0.3759
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0058	0.0099
Echinococcus granulosus	neuropeptide s receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0572	0.5835	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0025	0.0097	0.0166
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0222	0.0952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Onchocerca volvulus		0.0022	0.0058	0.0047
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0058	0.0058
Onchocerca volvulus		0.0025	0.0097	0.0115
Echinococcus granulosus	cathepsin b	0.0293	0.2907	0.4981
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0298	0.0511
Plasmodium falciparum	basic transcription factor 3b, putative	0.0035	0.0196	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0115	0.0197
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0018	0.0021	0.0036
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.1919	0.3289
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0298	0.0298
Brugia malayi	Pre-SET motif family protein	0.003	0.0143	0.0245
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0293	0.2907	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0022	0.0058	0.0058
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0143	0.0245
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0239	0.2336	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0115	0.0197
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0058	0.0099
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.1919	0.3289
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0115	0.0497
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	0.0115	0.5855
Loa Loa (eye worm)	runx1	0.0054	0.0398	0.0683
Echinococcus granulosus	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0058	0.0099
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0222	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0601	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Brugia malayi	beta-NAC-like protein	0.0035	0.0196	0.0337
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0115	0.0115
Echinococcus granulosus	sex peptide receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0143	0.0245
Brugia malayi	follicle stimulating hormone receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0058	0.0099
Plasmodium vivax	vivapain-2	0.0027	0.0115	0.5175
Schistosoma mansoni	hypothetical protein	0.0073	0.0601	0.1029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0196	0.0676
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0115	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus multilocularis	cathepsin b	0.0293	0.2907	0.2907
Brugia malayi	beta-lactamase family protein	0.0037	0.0222	0.0381
Brugia malayi	G protein-coupled receptor F59B2.13	0.0022	0.0058	0.0099
Onchocerca volvulus	Peroxidasin homolog	0.0025	0.0097	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.003	0.0052
Onchocerca volvulus		0.0022	0.0058	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.1919	0.3289
Echinococcus granulosus	cysteine protease	0.0018	0.0021	0.0036
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0222	0.0961
Echinococcus granulosus	cathepsin L cysteine protease	0.0018	0.0021	0.0036
Onchocerca volvulus	Peroxidase homolog	0.0025	0.0097	0.0115
Brugia malayi	hypothetical protein	0.0019	0.003	0.0052
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.0957	0.164
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	0.0115	0.5855
Brugia malayi	Protein kinase domain containing protein	0.0572	0.5835	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0019	0.003	0.0052
Schistosoma mansoni	chromatin regulatory protein sir2	0.011	0.0982	0.1683
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1083	0.1814
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0022	0.0058	0.0058
Brugia malayi	Serotonin receptor	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0222	0.0952
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0051	0.0087
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0572	0.5835	1
Schistosoma mansoni	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus multilocularis	cathepsin L	0.0018	0.0021	0.0021
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0222	0.0952
Leishmania major	basic transcription factor 3a, putative	0.0035	0.0196	0.2001
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0115	0.0197
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.0196	0.8839
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0115	0.0497
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0022	0.0058	0.0099
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.003	0.0052
Trypanosoma cruzi	cysteine protease, putative	0.0018	0.0021	0.0073
Schistosoma mansoni	chromatin regulatory protein sir2	0.011	0.0982	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0222	0.0381
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0021	0.0073
Onchocerca volvulus	Peroxidasin homolog	0.0025	0.0097	0.0115
Loa Loa (eye worm)	animal heme peroxidase	0.0025	0.0097	0.0166
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0298	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0019	0.003	0.0052
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0572	0.5835	0.5835
Onchocerca volvulus		0.0027	0.0115	0.0146
Trichomonas vaginalis	esterase, putative	0.0037	0.0222	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0087
Echinococcus granulosus	fmrfamide receptor	0.0022	0.0058	0.0099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0022	0.0058	0.0099
Loa Loa (eye worm)	RNA binding protein	0.0199	0.1919	0.3289
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.2907	0.4981
Echinococcus granulosus	G protein coupled receptor 139	0.0022	0.0058	0.0099
Toxoplasma gondii	ABC1 family protein	0.0037	0.0222	0.2557
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0381
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0115	0.1171
Onchocerca volvulus		0.0022	0.0058	0.0047
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0115	0.0497
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.0115	0.0146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0021	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0115	0.0197
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0222	0.0765
Leishmania major	cathepsin L-like protease	0.0079	0.0659	0.6716
Brugia malayi	N-terminal motif family protein	0.0187	0.1797	0.3079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.011	0.0982	0.3378
Brugia malayi	Doublecortin family protein	0.0019	0.003	0.0052
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.0659	0.2269
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.011	0.0982	0.0982
Echinococcus granulosus	tar DNA binding protein	0.0199	0.1919	0.3289
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Schistosoma mansoni	transcription factor btf3	0.0035	0.0196	0.0337
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	transcriptional regulator	0.011	0.0982	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Leishmania major	cathepsin L-like protease	0.0027	0.0115	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0115	0.0497
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0131	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0022	0.0058	0.0099
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0298	0.0298
Schistosoma mansoni	adenoreceptor	0.0022	0.0058	0.0099
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0115	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	amine GPCR	0.0022	0.0058	0.0099
Brugia malayi	Pre-SET motif family protein	0.0208	0.2011	0.3446
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0381
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0051	0.0087
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0293	0.2907	0.4981
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0058	0.0099
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0222	0.0961
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0115	0.0497
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0222	0.2264
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0222	0.0381
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0058	0.0099
Echinococcus multilocularis	orexin receptor type 2	0.0022	0.0058	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0021	0.0091
Echinococcus multilocularis	g-protein coupled receptor	0.0022	0.0058	0.0058
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0021	0.0215
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0222	0.0381
Schistosoma mansoni	histamine h1 receptor	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0115	0.0497
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0115	0.0197
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0058	0.0099
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0572	0.5835	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0022	0.0058	0.0099
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	serine/threonine protein kinase	0.0572	0.5835	1
Onchocerca volvulus		0.0021	0.0051	0.0036
Onchocerca volvulus		0.0027	0.0115	0.0146
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0058	0.0099
Brugia malayi	Dopamine receptor protein 1	0.0022	0.0058	0.0099
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0222	0.0381
Loa Loa (eye worm)	TYRA-2 protein	0.0022	0.0058	0.0099
Brugia malayi	transcriptional regulator, Sir2 family protein	0.011	0.0982	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0058	0.0099
Brugia malayi	GnHR receptor homolog	0.0022	0.0058	0.0099
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0022	0.0058	0.0099
Onchocerca volvulus		0.0022	0.0058	0.0047
Trypanosoma cruzi	major cysteine proteinase, putative	0.0064	0.0501	0.1725
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0187	0.1797	0.3043
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.003	0.003
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	fibroinase	0.0027	0.0115	0.0197
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0222	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0431	0.4361	0.7474
Giardia lamblia	Cathepsin B precursor	0.0099	0.0869	0.8852
Brugia malayi	sulfakinin receptor protein	0.0022	0.0058	0.0099
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0143	0.0143
Echinococcus granulosus	cathepsin b	0.0293	0.2907	0.4981
Loa Loa (eye worm)	animal heme peroxidase	0.0025	0.0097	0.0166
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0058	0.0099
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Brugia malayi	neuropeptide F receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0381
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0115	0.0115
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0222	0.0952
Echinococcus granulosus	orexin receptor type 2	0.0022	0.0058	0.0099
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0222	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0222	1
Brugia malayi	beta-lactamase family protein	0.0037	0.0222	0.0381
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Schistosoma mansoni	hypothetical protein	0.0034	0.0187	0.032
Echinococcus multilocularis	dro:myosuppressin receptor	0.0022	0.0058	0.0058
Entamoeba histolytica	transcription factor BTF3, putative	0.0035	0.0196	0.2001
Echinococcus granulosus	neuropeptide FF receptor 2	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0022	0.0058	0.0047
Schistosoma mansoni	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0115	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0115	0.0146
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0022	0.0058	0.0058
Entamoeba histolytica	cysteine proteinase 1, putative	0.0018	0.0021	0.0215
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0187	0.032
Onchocerca volvulus		0.0022	0.0058	0.0047
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0022	0.0058	0.0099
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0601	0.1029
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0022	0.0058	0.0099
Leishmania major	cathepsin L-like protease	0.0027	0.0115	0.1171
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0058	0.0058
Leishmania major	cathepsin L-like protease	0.0027	0.0115	0.1171
Schistosoma mansoni	hypothetical protein	0.0168	0.1591	0.2726
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0021	0.0215
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Onchocerca volvulus		0.0022	0.0058	0.0047
Brugia malayi	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus granulosus	cathepsin l1	0.0021	0.0051	0.0087
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	amine GPCR	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Mycobacterium ulcerans	lipase LipD	0.0037	0.0222	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0018	0.0021	0.0073
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0058	0.0058
Brugia malayi	RNA recognition motif domain containing protein	0.0199	0.1919	0.3289
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0058	0.0058
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.003	0.0052
Entamoeba histolytica	cysteine proteinase, putative	0.0021	0.0051	0.0519
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0058	0.0099
Echinococcus granulosus	serotonin receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0058	0.0099
Echinococcus granulosus	dro:myosuppressin receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0115	0.0497
Onchocerca volvulus	Chorion peroxidase homolog	0.0025	0.0097	0.0115
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	growth hormone secretagogue receptor	0.0022	0.0058	0.0099
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0115	0.1171
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0196	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0293	0.2907	0.4981
Brugia malayi	Peroxidasin	0.0025	0.0097	0.0166
Brugia malayi	cathepsin L-like precursor	0.0021	0.0051	0.0087
Echinococcus granulosus	cathepsin L	0.0018	0.0021	0.0036
Trypanosoma cruzi	cysteine proteinase, putative	0.0018	0.0021	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0187	0.032
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0022	0.0058	0.0099
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0187	0.032
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0222	0.0765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0051	0.022
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Brugia malayi	Melatonin receptor type 1A	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0022	0.0058	0.0058
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0018	0.0021	0.0036
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0058	0.0058
Brugia malayi	Blistered cuticle protein 3	0.0025	0.0097	0.0166
Echinococcus multilocularis	serotonin receptor	0.0022	0.0058	0.0058
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0022	0.0058	0.0058
Schistosoma mansoni	opsin-like receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0022	0.0058	0.0099
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0058	0.0099
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0097	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0087
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0058	0.0099
Brugia malayi	AKH receptor	0.0022	0.0058	0.0099
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0058	0.0058
Schistosoma mansoni	neuropeptide f receptor 76f	0.0022	0.0058	0.0099
Leishmania major	cathepsin L-like protease	0.0027	0.0115	0.1171
Brugia malayi	larval opioid receptor	0.0022	0.0058	0.0099
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0058	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0115	0.0497
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0097	0.0166
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0058	0.0058
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	animal heme peroxidase	0.0025	0.0097	0.0166
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0073	0.0595	0.2048
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0058	0.0099
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0222	0.0952
Brugia malayi	Dopamine receptor protein 2	0.0022	0.0058	0.0099
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0058	0.0099
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0021	0.0051	0.0087
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0058	0.0099
Echinococcus granulosus	transcription factor btf3	0.0035	0.0196	0.0337
Schistosoma mansoni	opsin-like receptor	0.0022	0.0058	0.0099
Echinococcus granulosus	geminin	0.0168	0.1591	0.2726
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0058	0.0099
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0058	0.0099
Onchocerca volvulus	Peroxidase homolog	0.0025	0.0097	0.0115
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.0659	0.2269
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0115	0.0197
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0021	0.0036
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0298	0.0511
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0222	1
Onchocerca volvulus		0.0022	0.0058	0.0047
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0572	0.5835	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0058	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0018	0.0021	0.0215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Brugia malayi	G-protein coupled receptor	0.0022	0.0058	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0058	0.0099
Echinococcus multilocularis	peroxidasin	0.0025	0.0097	0.0097
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0659	0.6716
Schistosoma mansoni	hypothetical protein	0.0168	0.1591	0.2726
Onchocerca volvulus		0.0236	0.2312	0.3931
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0021	0.0215
Brugia malayi	putative neuropeptide receptor	0.0022	0.0058	0.0099
Brugia malayi	neuropeptide F receptor	0.0022	0.0058	0.0099
Trypanosoma cruzi	cysteine proteinase, putative	0.0018	0.0021	0.0073
Schistosoma mansoni	loxhd1	0.0019	0.003	0.0052
Loa Loa (eye worm)	melatonin receptor type 1A	0.0022	0.0058	0.0099
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0222	0.0961
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0187	0.032
Toxoplasma gondii	cathepsin CPL	0.0027	0.0115	0.1323
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.003	0.0052
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	0.0115	0.5855

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 48.7 mg kg-1	Inhibition of locomotor activity (LMA) and motor coordination in mice by intraperitoneal administration.	ChEMBL.	2888897
ED50 (functional)	> 100 mg kg-1	Inhibition of ataxia in mice by intraperitoneal administration.	ChEMBL.	2888897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 179597

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 76854